ES2062050T3 - Derivados de piperazinilo. - Google Patents

Derivados de piperazinilo.

Info

Publication number
ES2062050T3
ES2062050T3 ES89313371T ES89313371T ES2062050T3 ES 2062050 T3 ES2062050 T3 ES 2062050T3 ES 89313371 T ES89313371 T ES 89313371T ES 89313371 T ES89313371 T ES 89313371T ES 2062050 T3 ES2062050 T3 ES 2062050T3
Authority
ES
Spain
Prior art keywords
compounds
piperazinyl
derivatives
sterotonin
isomeres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89313371T
Other languages
English (en)
Inventor
Jens Perregaard
John Willie Stenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2062050T3 publication Critical patent/ES2062050T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

EL INVENTO SE REFIERE A NUEVOS COMPUESTOS DE FORMULA: DONDE DR1,R2,X Y "AR" SON COMO ESTAN DEFINIDOS EN LA DEMANDA 1; ASI COMO LAS SALES ACIDAS FARMACEUTICAMENTE ACEPTABLES Y LOS ISONUEROS ESTEREOS DE LO MISMO. LOS COMPUESTOS TIENEN ACTIVIDAD ESTEROMINA CENTRAL CON PREFERENCIA PARA LOS RECEPTORES DE SEROTONINA S-HT1A, QUE SON INDICADOS EN EL TRATAMIENTO DE DESORDENES DEL CNS, INCLUYENDO ANSIEDAD, DEPRESION Y AGRESIVIDAD, O EN ENFERMEDADES RELACIONADAS CON LOS SISTEMAS CARDIOBASCULAR, GASTROINTESTINAL Y RENAL. TAMBIEN SE DESCRIBEN METODOS DE PREPARACION DE DICHOS COMPUESTOS, Y COMPOSICIONES FARMACEUTICAS CONTENIENDOLOS.
ES89313371T 1988-12-28 1989-12-20 Derivados de piperazinilo. Expired - Lifetime ES2062050T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888830312A GB8830312D0 (en) 1988-12-28 1988-12-28 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2062050T3 true ES2062050T3 (es) 1994-12-16

Family

ID=10649223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89313371T Expired - Lifetime ES2062050T3 (es) 1988-12-28 1989-12-20 Derivados de piperazinilo.

Country Status (17)

Country Link
US (1) US5002948A (es)
EP (1) EP0376607B1 (es)
JP (1) JP2895121B2 (es)
AT (1) ATE102184T1 (es)
AU (1) AU637991B2 (es)
CA (1) CA2006356C (es)
DE (1) DE68913487T2 (es)
DK (1) DK169266B1 (es)
ES (1) ES2062050T3 (es)
FI (1) FI93005C (es)
GB (1) GB8830312D0 (es)
IE (1) IE62668B1 (es)
IL (1) IL92990A (es)
NO (1) NO174772C (es)
NZ (1) NZ231855A (es)
PT (1) PT92728B (es)
ZA (1) ZA899960B (es)

Families Citing this family (82)

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DE3923045A1 (de) * 1989-07-13 1991-01-17 Merck Patent Gmbh Indolderivate
EP0465254B1 (en) * 1990-07-06 1996-11-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused thiophene compounds and uses thereof
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DE4127849A1 (de) * 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
ES2050623B1 (es) * 1992-11-06 1994-12-16 Merck Patent Gmbh Derivados de 1,4-benzodioxano.
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
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DE19512639A1 (de) 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
AR013206A1 (es) * 1997-07-25 2000-12-13 Lundbeck & Co As H Derivados indol y 2,3-dihidroindol, composiciones farmaceuticas que contienen estos compuestos y el uso de dichos compuestos para la preparacion de un medicamento para el tratamiento de desordenes sensibles a la inhibicion de la reabsorcion de serotonina y antagonismo de receptores 5-ht1a.
DE69819173T2 (de) * 1997-07-25 2004-04-15 H. Lundbeck A/S Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung
ATE223379T1 (de) * 1998-04-08 2002-09-15 Wyeth Corp N-aryloxyethylaminderivate zur behandlung der depression
AR022303A1 (es) 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
SK287018B6 (sk) * 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
HUP0203645A3 (en) * 1999-12-30 2004-01-28 Lundbeck & Co As H Phenylpiperazinyl derivatives, pharmaceutical compositions containing them and their use
AR027134A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de indol.
EP1246816B1 (en) * 1999-12-30 2004-03-17 H. Lundbeck A/S Substituted phenyl-piperazine derivatives, their preparation and use
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US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
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US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
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US8742100B2 (en) 2009-07-30 2014-06-03 National University Of Singapore Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
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CN102993186B (zh) * 2012-12-20 2015-11-18 北京海步国际医药科技发展有限公司 一种新型的哌嗪衍生物
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Also Published As

Publication number Publication date
IE62668B1 (en) 1995-02-22
PT92728B (pt) 1995-12-29
DK645689D0 (da) 1989-12-19
AU637991B2 (en) 1993-06-17
DK169266B1 (da) 1994-09-26
EP0376607B1 (en) 1994-03-02
IL92990A0 (en) 1990-09-17
FI896300A0 (fi) 1989-12-28
NO174772B (no) 1994-03-28
NO895281D0 (no) 1989-12-27
NO174772C (no) 1994-07-06
EP0376607A1 (en) 1990-07-04
CA2006356C (en) 1999-09-14
CA2006356A1 (en) 1990-06-28
JPH02225460A (ja) 1990-09-07
GB8830312D0 (en) 1989-02-22
JP2895121B2 (ja) 1999-05-24
DK645689A (da) 1990-06-29
NZ231855A (en) 1992-02-25
DE68913487T2 (de) 1994-08-04
IE893976L (en) 1990-06-13
PT92728A (pt) 1990-06-29
FI93005B (fi) 1994-10-31
FI93005C (fi) 1995-02-10
ZA899960B (en) 1990-11-28
DE68913487D1 (de) 1994-04-07
ATE102184T1 (de) 1994-03-15
NO895281L (no) 1990-06-29
AU4719889A (en) 1990-07-05
US5002948A (en) 1991-03-26
IL92990A (en) 1995-01-24

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