EP0189080A3 - (1,2,4-Oxadiazol-3-yl)-arylméthanones, procédé pour leur préparation et leur utilisation comme médicaments - Google Patents
(1,2,4-Oxadiazol-3-yl)-arylméthanones, procédé pour leur préparation et leur utilisation comme médicaments Download PDFInfo
- Publication number
- EP0189080A3 EP0189080A3 EP86100346A EP86100346A EP0189080A3 EP 0189080 A3 EP0189080 A3 EP 0189080A3 EP 86100346 A EP86100346 A EP 86100346A EP 86100346 A EP86100346 A EP 86100346A EP 0189080 A3 EP0189080 A3 EP 0189080A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- arylmethanones
- oxadiazol
- medicaments
- preparation
- loweralkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/693,509 US4562186A (en) | 1985-01-22 | 1985-01-22 | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
US693509 | 1985-01-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0189080A2 EP0189080A2 (fr) | 1986-07-30 |
EP0189080A3 true EP0189080A3 (fr) | 1987-07-15 |
Family
ID=24784962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP86100346A Withdrawn EP0189080A3 (fr) | 1985-01-22 | 1986-01-13 | (1,2,4-Oxadiazol-3-yl)-arylméthanones, procédé pour leur préparation et leur utilisation comme médicaments |
Country Status (8)
Country | Link |
---|---|
US (1) | US4562186A (fr) |
EP (1) | EP0189080A3 (fr) |
JP (1) | JPS61167674A (fr) |
DK (1) | DK30186A (fr) |
ES (2) | ES8705868A1 (fr) |
GR (1) | GR860142B (fr) |
IE (1) | IE860177L (fr) |
PT (1) | PT81880B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4562186A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
US7576220B2 (en) * | 2006-04-06 | 2009-08-18 | Rikkyo Gakuin | Method of producing 1,2,4-oxadiazole derivatives |
CN113195461A (zh) * | 2018-10-01 | 2021-07-30 | Pi工业有限公司 | 新型恶二唑类化合物 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB924608A (en) * | 1959-09-29 | 1963-04-24 | Francesco Angelini | Improvements in or relating to 1.2.4-oxadiazoles and processes for producing the same |
FR2053742A5 (en) * | 1969-07-16 | 1971-04-16 | Berlin Chemie Veb | Prepn of 3-acyl-1,2,4-oxadiazoles useful in syn - of medicaments, in plant protection and as inter |
US4160829A (en) * | 1972-12-22 | 1979-07-10 | Gist-Brocades N.V. | Antibacterial 1,2,4-oxadiazolylacetamido cephalosporins |
EP0091726A2 (fr) * | 1982-03-03 | 1983-10-19 | Sumitomo Chemical Company, Limited | 1,2,4-oxadiazoles 5-substitués, leur préparation et les compositions pharmaceutiques les contenant |
US4562186A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
US4562187A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE738276A (en) * | 1968-09-01 | 1970-02-16 | Prepn of 3-acyl-1,2,4-oxadiazoles useful in syn - of medicaments, in plant protection and as inter | |
GB1227978A (fr) * | 1968-09-13 | 1971-04-15 | ||
IL42363A0 (en) * | 1972-07-04 | 1973-07-30 | Lepetit Spa | 1,2,4-oxadiazole derivatives |
-
1985
- 1985-01-22 US US06/693,509 patent/US4562186A/en not_active Expired - Fee Related
-
1986
- 1986-01-13 EP EP86100346A patent/EP0189080A3/fr not_active Withdrawn
- 1986-01-20 GR GR860142A patent/GR860142B/el unknown
- 1986-01-20 ES ES551041A patent/ES8705868A1/es not_active Expired
- 1986-01-21 JP JP61009084A patent/JPS61167674A/ja active Pending
- 1986-01-21 DK DK30186A patent/DK30186A/da not_active Application Discontinuation
- 1986-01-21 PT PT81880A patent/PT81880B/pt unknown
- 1986-01-21 IE IE860177A patent/IE860177L/xx unknown
- 1986-09-01 ES ES557045A patent/ES8800917A1/es not_active Expired
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB924608A (en) * | 1959-09-29 | 1963-04-24 | Francesco Angelini | Improvements in or relating to 1.2.4-oxadiazoles and processes for producing the same |
FR2053742A5 (en) * | 1969-07-16 | 1971-04-16 | Berlin Chemie Veb | Prepn of 3-acyl-1,2,4-oxadiazoles useful in syn - of medicaments, in plant protection and as inter |
US4160829A (en) * | 1972-12-22 | 1979-07-10 | Gist-Brocades N.V. | Antibacterial 1,2,4-oxadiazolylacetamido cephalosporins |
EP0091726A2 (fr) * | 1982-03-03 | 1983-10-19 | Sumitomo Chemical Company, Limited | 1,2,4-oxadiazoles 5-substitués, leur préparation et les compositions pharmaceutiques les contenant |
US4562186A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
US4562187A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use |
Also Published As
Publication number | Publication date |
---|---|
JPS61167674A (ja) | 1986-07-29 |
ES551041A0 (es) | 1987-05-16 |
PT81880A (en) | 1986-02-01 |
DK30186D0 (da) | 1986-01-21 |
IE860177L (en) | 1986-07-22 |
EP0189080A2 (fr) | 1986-07-30 |
ES8705868A1 (es) | 1987-05-16 |
US4562186A (en) | 1985-12-31 |
ES8800917A1 (es) | 1987-12-01 |
PT81880B (en) | 1987-11-12 |
DK30186A (da) | 1986-07-23 |
GR860142B (en) | 1986-05-16 |
ES557045A0 (es) | 1987-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
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AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19870919 |
|
17Q | First examination report despatched |
Effective date: 19890222 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19900418 |
|
R18W | Application withdrawn (corrected) |
Effective date: 19900418 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: TEGELER, JOHN J. Inventor name: DIAMOND, CRAIG J. |