ES8705868A1 - Un procedimiento para preparar (1,2,4-oxadiazol-3-il)-arilmetanonas - Google Patents
Un procedimiento para preparar (1,2,4-oxadiazol-3-il)-arilmetanonasInfo
- Publication number
- ES8705868A1 ES8705868A1 ES551041A ES551041A ES8705868A1 ES 8705868 A1 ES8705868 A1 ES 8705868A1 ES 551041 A ES551041 A ES 551041A ES 551041 A ES551041 A ES 551041A ES 8705868 A1 ES8705868 A1 ES 8705868A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- arylmethanones
- oxadiazol
- medicaments
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1,2,4-Oxadiazol-3-YL Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR (1,2,4-OXIADAZOL-3-IL)-ARILMETANONAS. CONSISTE EN TRATAR A UN COMPUESTO DE FORMULA (II) CON UN MALONITRILO DE FORMULA (CH2CCN)2, EN XILENO O TOLUENO, A UNA TEMPERATURA ENTRE 100 Y 150JC, PARA OBTENER (1,2,4-OXADIAZOL-3-IL)-ARILMETANONAS DE FORMULA (I), SUS ANTIPODAS OPTICAS Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLE. SIENDO: R, -CN Y X, H, HAL O ALQUILO INFERIOR. SE UTILIZAN COMO AGENTES ANTIHIPERTENSORES, ANALGESICOS Y ANTIINFLAMATORIOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/693,509 US4562186A (en) | 1985-01-22 | 1985-01-22 | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8705868A1 true ES8705868A1 (es) | 1987-05-16 |
| ES551041A0 ES551041A0 (es) | 1987-05-16 |
Family
ID=24784962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551041A Expired ES8705868A1 (es) | 1985-01-22 | 1986-01-20 | Un procedimiento para preparar (1,2,4-oxadiazol-3-il)-arilmetanonas |
| ES557045A Expired ES8800917A1 (es) | 1985-01-22 | 1986-09-01 | Un procedimiento para preparar (1,2,4-oxadiazol-3-il)-arilmetanonas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557045A Expired ES8800917A1 (es) | 1985-01-22 | 1986-09-01 | Un procedimiento para preparar (1,2,4-oxadiazol-3-il)-arilmetanonas |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4562186A (es) |
| EP (1) | EP0189080A3 (es) |
| JP (1) | JPS61167674A (es) |
| DK (1) | DK30186A (es) |
| ES (2) | ES8705868A1 (es) |
| GR (1) | GR860142B (es) |
| IE (1) | IE860177L (es) |
| PT (1) | PT81880B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562186A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
| US7576220B2 (en) * | 2006-04-06 | 2009-08-18 | Rikkyo Gakuin | Method of producing 1,2,4-oxadiazole derivatives |
| CA3112924A1 (en) * | 2018-10-01 | 2020-04-09 | Pi Industries Ltd | Oxadiazoles as fungicides |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL120029C (es) * | 1959-09-29 | |||
| BE738276A (en) * | 1968-09-01 | 1970-02-16 | Prepn of 3-acyl-1,2,4-oxadiazoles useful in syn - of medicaments, in plant protection and as inter | |
| GB1227978A (es) * | 1968-09-13 | 1971-04-15 | ||
| FR2053742A5 (en) * | 1969-07-16 | 1971-04-16 | Berlin Chemie Veb | Prepn of 3-acyl-1,2,4-oxadiazoles useful in syn - of medicaments, in plant protection and as inter |
| IL42363A0 (en) * | 1972-07-04 | 1973-07-30 | Lepetit Spa | 1,2,4-oxadiazole derivatives |
| US4160829A (en) * | 1972-12-22 | 1979-07-10 | Gist-Brocades N.V. | Antibacterial 1,2,4-oxadiazolylacetamido cephalosporins |
| JPS58150576A (ja) * | 1982-03-03 | 1983-09-07 | Sumitomo Chem Co Ltd | 新規な１，２，４−オキサジアゾ−ル誘導体 |
| US4562186A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use |
| US4562187A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use |
-
1985
- 1985-01-22 US US06/693,509 patent/US4562186A/en not_active Expired - Fee Related
-
1986
- 1986-01-13 EP EP86100346A patent/EP0189080A3/en not_active Withdrawn
- 1986-01-20 ES ES551041A patent/ES8705868A1/es not_active Expired
- 1986-01-20 GR GR860142A patent/GR860142B/el unknown
- 1986-01-21 DK DK30186A patent/DK30186A/da not_active Application Discontinuation
- 1986-01-21 IE IE860177A patent/IE860177L/xx unknown
- 1986-01-21 JP JP61009084A patent/JPS61167674A/ja active Pending
- 1986-01-21 PT PT81880A patent/PT81880B/pt unknown
- 1986-09-01 ES ES557045A patent/ES8800917A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES557045A0 (es) | 1987-12-01 |
| EP0189080A2 (en) | 1986-07-30 |
| IE860177L (en) | 1986-07-22 |
| PT81880A (en) | 1986-02-01 |
| DK30186D0 (da) | 1986-01-21 |
| EP0189080A3 (en) | 1987-07-15 |
| GR860142B (en) | 1986-05-16 |
| US4562186A (en) | 1985-12-31 |
| JPS61167674A (ja) | 1986-07-29 |
| DK30186A (da) | 1986-07-23 |
| ES8800917A1 (es) | 1987-12-01 |
| PT81880B (en) | 1987-11-12 |
| ES551041A0 (es) | 1987-05-16 |
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