NO174296C - Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner - Google Patents
Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperazinerInfo
- Publication number
- NO174296C NO174296C NO892381A NO892381A NO174296C NO 174296 C NO174296 C NO 174296C NO 892381 A NO892381 A NO 892381A NO 892381 A NO892381 A NO 892381A NO 174296 C NO174296 C NO 174296C
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- indolylalkyl
- piperazines
- pyridinyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M4/00—Electrodes
- H01M4/02—Electrodes composed of, or comprising, active material
- H01M4/62—Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
- H01M4/621—Binders
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M6/00—Primary cells; Manufacture thereof
- H01M6/04—Cells with aqueous electrolyte
- H01M6/06—Dry cells, i.e. cells wherein the electrolyte is rendered non-fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Manufacturing & Machinery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20484588A | 1988-06-10 | 1988-06-10 | |
| US07/338,253 US4954502A (en) | 1988-06-10 | 1989-04-14 | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO892381D0 NO892381D0 (no) | 1989-06-09 |
| NO892381L NO892381L (no) | 1989-12-11 |
| NO174296B NO174296B (no) | 1994-01-03 |
| NO174296C true NO174296C (no) | 1994-04-13 |
Family
ID=26899839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO892381A NO174296C (no) | 1988-06-10 | 1989-06-09 | Analogifremgangsmåte til fremstilling av terapeutisk aktive 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4954502A (ko) |
| EP (1) | EP0345808B1 (ko) |
| JP (1) | JP2786480B2 (ko) |
| KR (1) | KR0128210B1 (ko) |
| AT (1) | ATE116982T1 (ko) |
| AU (1) | AU624147B2 (ko) |
| CA (1) | CA1337421C (ko) |
| CY (1) | CY1846A (ko) |
| DE (1) | DE68920482T2 (ko) |
| DK (1) | DK283589A (ko) |
| ES (1) | ES2067500T3 (ko) |
| FI (1) | FI95698C (ko) |
| HK (1) | HK83295A (ko) |
| IE (1) | IE66569B1 (ko) |
| NO (1) | NO174296C (ko) |
| PT (1) | PT90805B (ko) |
| SG (1) | SG32583G (ko) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120843A (en) * | 1987-04-27 | 1992-06-09 | Upjohn | Pharmaceutically active amines |
| US4975445A (en) * | 1989-12-06 | 1990-12-04 | Warner-Lambert Company | Substituted cyclohexenes as central nervous system agents |
| US5563142A (en) * | 1989-12-28 | 1996-10-08 | The Upjohn Company | Diaromatic substituted compounds as anti-HIV-1 agents |
| AU654808B2 (en) * | 1989-12-28 | 1994-11-24 | Pharmacia & Upjohn Company | Diaromatic substituted anti-aids compounds |
| US5077293A (en) * | 1990-06-29 | 1991-12-31 | Bristol-Myers Squibb Co. | 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines |
| CA2043709C (en) * | 1990-06-29 | 2002-01-22 | David W. Smith | Antimigraine alkoxypyrimidine derivatives |
| US5270312A (en) * | 1990-11-05 | 1993-12-14 | Warner-Lambert Company | Substituted piperazines as central nervous system agents |
| US5124332A (en) * | 1991-01-28 | 1992-06-23 | Warner-Lambert Company | Substituted indoles as central nervous system agents |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5599930A (en) * | 1991-07-03 | 1997-02-04 | The Upjohn Company | Substituted indoles as anti-AIDS pharmaceuticals |
| US5145973A (en) * | 1991-09-30 | 1992-09-08 | Union Carbide Chemicals & Plastics Technology Corporation | Oxa-Bicyclic polyfunctional compounds and preparation thereof |
| US5206393A (en) * | 1991-09-30 | 1993-04-27 | Union Carbide Chemicals & Plastics Technology Corporation | Oxa-bicyclic polyfunctional compounds and preparation thereof |
| US5314896A (en) * | 1991-11-20 | 1994-05-24 | Warner-Lambert Company | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
| CA2152160A1 (en) * | 1992-12-21 | 1994-07-07 | Tomoyuki Ikemoto | N-substituted indole derivative |
| CA2130078A1 (en) * | 1993-09-16 | 1995-03-17 | Jonas A. Gylys | Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines |
| US5391570A (en) * | 1993-10-14 | 1995-02-21 | Bristol-Myers Squibb | Aminomethyl-benzodioxane and benzopyran serotonergic agents |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| US5468767A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives |
| GB9423682D0 (en) * | 1994-11-23 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
| US5618816A (en) * | 1995-03-02 | 1997-04-08 | Bristol-Myers Squibb Company | Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines |
| JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体 |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| AU5343498A (en) * | 1997-01-21 | 1998-08-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Thiophene compounds and medicinal use thereof |
| US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
| EP1068199B1 (en) * | 1998-04-08 | 2002-11-13 | Wyeth | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
| TW520367B (en) * | 1998-04-29 | 2003-02-11 | Wyeth Corp | Indolyl derivatives as serotonergic agents |
| FR2786769B1 (fr) * | 1998-12-04 | 2002-10-25 | Synthelabo | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique |
| DK1147083T3 (da) * | 1999-01-07 | 2004-08-16 | Wyeth Corp | Arylpiperazinyl-cyclohexylindolderivater til behandling af depression |
| US6313126B1 (en) * | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| AU771234B2 (en) * | 1999-01-28 | 2004-03-18 | Bristol-Myers Squibb Company | Antidepressant heterocyclic compounds |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| BR0015425A (pt) * | 1999-11-08 | 2002-07-16 | Wyeth Corp | N-aril-( homopiperazinil )-ciclohexilaminas como transportadoras de 5-ht |
| CN1380883A (zh) | 2000-03-31 | 2002-11-20 | 萨诺化学药物股份公司 | 雪花胺的新衍生物和类似物 |
| US6809105B2 (en) | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
| CA2354606C (en) * | 2000-08-03 | 2005-12-06 | Pfizer Products Inc. | Azabicycloalkane derivatives and therapeutic uses thereof |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| JP4387103B2 (ja) * | 2000-11-20 | 2009-12-16 | ビオヴィトルム・アクチボラゲット（プブリクト） | セロトニン５ｈｔ−２レセプターのアゴニストまたはアンタゴニストとしてのピペラジニルピラジン化合物 |
| US8013156B2 (en) | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| NZ555491A (en) * | 2005-01-03 | 2010-01-29 | Univ Siena | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
| JP2009515834A (ja) * | 2006-08-29 | 2009-04-16 | テバ ファーマシューティカル インダストリーズ リミティド | ５−フェニル−１−トリチル−１ｈ−テトラゾールの合成のための方法 |
| CN101970436A (zh) * | 2008-03-14 | 2011-02-09 | 默克专利股份有限公司 | 用于治疗中枢神经系统功能障碍的氮杂吲哚化合物 |
| CN104163813B (zh) * | 2013-05-16 | 2017-02-01 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| EP3027607B1 (en) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| CN104725363B (zh) * | 2013-12-20 | 2019-03-01 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| CN104725359B (zh) * | 2013-12-20 | 2017-05-03 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| CN106795143B (zh) * | 2015-08-13 | 2019-05-24 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| ES2974248T3 (es) | 2017-09-29 | 2024-06-26 | Sunshine Lake Pharma Co Ltd | Compuesto de pirimidin-piperazina sustituido y uso del mismo |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB944443A (ko) * | 1959-09-25 | 1900-01-01 | ||
| US3468882A (en) | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
| GB1189064A (en) * | 1967-05-01 | 1970-04-22 | Sterling Drug Inc | Indole Derivatives |
| US3472855A (en) * | 1967-05-29 | 1969-10-14 | Sterling Drug Inc | 1-((benz(g)-indolyl)-lower-alkyl)-4-substituted-piperazines |
| US4302589A (en) * | 1980-05-08 | 1981-11-24 | American Cyanamid Company | Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation |
-
1989
- 1989-04-14 US US07/338,253 patent/US4954502A/en not_active Expired - Lifetime
- 1989-05-30 CA CA000601179A patent/CA1337421C/en not_active Expired - Lifetime
- 1989-06-07 FI FI892787A patent/FI95698C/fi active IP Right Grant
- 1989-06-09 NO NO892381A patent/NO174296C/no not_active IP Right Cessation
- 1989-06-09 JP JP1148200A patent/JP2786480B2/ja not_active Expired - Lifetime
- 1989-06-09 PT PT90805A patent/PT90805B/pt not_active IP Right Cessation
- 1989-06-09 ES ES89110485T patent/ES2067500T3/es not_active Expired - Lifetime
- 1989-06-09 EP EP89110485A patent/EP0345808B1/en not_active Expired - Lifetime
- 1989-06-09 DK DK283589A patent/DK283589A/da not_active Application Discontinuation
- 1989-06-09 DE DE68920482T patent/DE68920482T2/de not_active Expired - Lifetime
- 1989-06-09 AT AT89110485T patent/ATE116982T1/de not_active IP Right Cessation
- 1989-06-09 AU AU36282/89A patent/AU624147B2/en not_active Expired
- 1989-06-09 SG SG1995907465A patent/SG32583G/en unknown
- 1989-06-10 KR KR1019890008025A patent/KR0128210B1/ko not_active IP Right Cessation
- 1989-06-12 IE IE186189A patent/IE66569B1/en not_active IP Right Cessation
-
1995
- 1995-05-25 HK HK83295A patent/HK83295A/xx not_active IP Right Cessation
-
1996
- 1996-03-08 CY CY184696A patent/CY1846A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE116982T1 (de) | 1995-01-15 |
| AU3628289A (en) | 1989-12-14 |
| KR910000708A (ko) | 1991-01-30 |
| NO892381D0 (no) | 1989-06-09 |
| DE68920482T2 (de) | 1995-06-01 |
| CY1846A (en) | 1996-03-08 |
| EP0345808A1 (en) | 1989-12-13 |
| SG32583G (en) | 1995-09-01 |
| DK283589A (da) | 1989-12-11 |
| PT90805A (pt) | 1989-12-29 |
| FI95698B (fi) | 1995-11-30 |
| US4954502A (en) | 1990-09-04 |
| JPH0285277A (ja) | 1990-03-26 |
| NO892381L (no) | 1989-12-11 |
| AU624147B2 (en) | 1992-06-04 |
| KR0128210B1 (ko) | 1998-04-02 |
| CA1337421C (en) | 1995-10-24 |
| FI95698C (fi) | 1996-03-11 |
| FI892787A0 (fi) | 1989-06-07 |
| DK283589D0 (da) | 1989-06-09 |
| IE891861L (en) | 1989-12-10 |
| EP0345808B1 (en) | 1995-01-11 |
| PT90805B (pt) | 1994-10-31 |
| ES2067500T3 (es) | 1995-04-01 |
| HK83295A (en) | 1995-06-01 |
| DE68920482D1 (de) | 1995-02-23 |
| JP2786480B2 (ja) | 1998-08-13 |
| NO174296B (no) | 1994-01-03 |
| FI892787A (fi) | 1989-12-11 |
| IE66569B1 (en) | 1996-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |