DK283589A - 1-indolylalkyl-4-(substitueret pyridinyl)-piperaziner - Google Patents

1-indolylalkyl-4-(substitueret pyridinyl)-piperaziner Download PDF

Info

Publication number
DK283589A
DK283589A DK283589A DK283589A DK283589A DK 283589 A DK283589 A DK 283589A DK 283589 A DK283589 A DK 283589A DK 283589 A DK283589 A DK 283589A DK 283589 A DK283589 A DK 283589A
Authority
DK
Denmark
Prior art keywords
hydrogen
independently selected
indolylalkyl
piperazines
substituted pyridinyl
Prior art date
Application number
DK283589A
Other languages
Danish (da)
English (en)
Other versions
DK283589D0 (da
Inventor
David W Smith
Frank D Yocca
Joseph P Yevich
Ronald J Mattson
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK283589D0 publication Critical patent/DK283589D0/da
Publication of DK283589A publication Critical patent/DK283589A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01MPROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M6/00Primary cells; Manufacture thereof
    • H01M6/04Cells with aqueous electrolyte
    • H01M6/06Dry cells, i.e. cells wherein the electrolyte is rendered non-fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01MPROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M4/00Electrodes
    • H01M4/02Electrodes composed of, or comprising, active material
    • H01M4/62Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
    • H01M4/621Binders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK283589A 1988-06-10 1989-06-09 1-indolylalkyl-4-(substitueret pyridinyl)-piperaziner DK283589A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20484588A 1988-06-10 1988-06-10
US07/338,253 US4954502A (en) 1988-06-10 1989-04-14 1-indolyalkyl-4-(substituted-pyridinyl)piperazines

Publications (2)

Publication Number Publication Date
DK283589D0 DK283589D0 (da) 1989-06-09
DK283589A true DK283589A (da) 1989-12-11

Family

ID=26899839

Family Applications (1)

Application Number Title Priority Date Filing Date
DK283589A DK283589A (da) 1988-06-10 1989-06-09 1-indolylalkyl-4-(substitueret pyridinyl)-piperaziner

Country Status (17)

Country Link
US (1) US4954502A (ko)
EP (1) EP0345808B1 (ko)
JP (1) JP2786480B2 (ko)
KR (1) KR0128210B1 (ko)
AT (1) ATE116982T1 (ko)
AU (1) AU624147B2 (ko)
CA (1) CA1337421C (ko)
CY (1) CY1846A (ko)
DE (1) DE68920482T2 (ko)
DK (1) DK283589A (ko)
ES (1) ES2067500T3 (ko)
FI (1) FI95698C (ko)
HK (1) HK83295A (ko)
IE (1) IE66569B1 (ko)
NO (1) NO174296C (ko)
PT (1) PT90805B (ko)
SG (1) SG32583G (ko)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120843A (en) * 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
US4975445A (en) * 1989-12-06 1990-12-04 Warner-Lambert Company Substituted cyclohexenes as central nervous system agents
US5563142A (en) * 1989-12-28 1996-10-08 The Upjohn Company Diaromatic substituted compounds as anti-HIV-1 agents
AU654808B2 (en) * 1989-12-28 1994-11-24 Pharmacia & Upjohn Company Diaromatic substituted anti-aids compounds
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
US5270312A (en) * 1990-11-05 1993-12-14 Warner-Lambert Company Substituted piperazines as central nervous system agents
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5599930A (en) * 1991-07-03 1997-02-04 The Upjohn Company Substituted indoles as anti-AIDS pharmaceuticals
US5145973A (en) * 1991-09-30 1992-09-08 Union Carbide Chemicals & Plastics Technology Corporation Oxa-Bicyclic polyfunctional compounds and preparation thereof
US5206393A (en) * 1991-09-30 1993-04-27 Union Carbide Chemicals & Plastics Technology Corporation Oxa-bicyclic polyfunctional compounds and preparation thereof
US5314896A (en) * 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
CA2091204C (en) * 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
CA2152160A1 (en) * 1992-12-21 1994-07-07 Tomoyuki Ikemoto N-substituted indole derivative
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5391570A (en) * 1993-10-14 1995-02-21 Bristol-Myers Squibb Aminomethyl-benzodioxane and benzopyran serotonergic agents
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する1−アリールアルキル−4−(アルコキシピリジニル)−又は4−(アルコキシピリミジニル)ピペラジン誘導体
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
AU5343498A (en) * 1997-01-21 1998-08-07 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compounds and medicinal use thereof
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
EP1068199B1 (en) * 1998-04-08 2002-11-13 Wyeth N-aryloxyethyl-indoly-alkylamines for the treatment of depression
TW520367B (en) * 1998-04-29 2003-02-11 Wyeth Corp Indolyl derivatives as serotonergic agents
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
DK1147083T3 (da) * 1999-01-07 2004-08-16 Wyeth Corp Arylpiperazinyl-cyclohexylindolderivater til behandling af depression
US6313126B1 (en) * 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
AU771234B2 (en) * 1999-01-28 2004-03-18 Bristol-Myers Squibb Company Antidepressant heterocyclic compounds
US7265115B2 (en) 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
BR0015425A (pt) * 1999-11-08 2002-07-16 Wyeth Corp N-aril-( homopiperazinil )-ciclohexilaminas como transportadoras de 5-ht
CN1380883A (zh) 2000-03-31 2002-11-20 萨诺化学药物股份公司 雪花胺的新衍生物和类似物
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
CA2354606C (en) * 2000-08-03 2005-12-06 Pfizer Products Inc. Azabicycloalkane derivatives and therapeutic uses thereof
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
JP4387103B2 (ja) * 2000-11-20 2009-12-16 ビオヴィトルム・アクチボラゲット(プブリクト) セロトニン5ht−2レセプターのアゴニストまたはアンタゴニストとしてのピペラジニルピラジン化合物
US8013156B2 (en) 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use
NZ555491A (en) * 2005-01-03 2010-01-29 Univ Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
JP2009515834A (ja) * 2006-08-29 2009-04-16 テバ ファーマシューティカル インダストリーズ リミティド 5−フェニル−1−トリチル−1h−テトラゾールの合成のための方法
CN101970436A (zh) * 2008-03-14 2011-02-09 默克专利股份有限公司 用于治疗中枢神经系统功能障碍的氮杂吲哚化合物
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
EP3027607B1 (en) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CN104725363B (zh) * 2013-12-20 2019-03-01 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN104725359B (zh) * 2013-12-20 2017-05-03 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN106795143B (zh) * 2015-08-13 2019-05-24 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
ES2974248T3 (es) 2017-09-29 2024-06-26 Sunshine Lake Pharma Co Ltd Compuesto de pirimidin-piperazina sustituido y uso del mismo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (ko) * 1959-09-25 1900-01-01
US3468882A (en) 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
GB1189064A (en) * 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
US3472855A (en) * 1967-05-29 1969-10-14 Sterling Drug Inc 1-((benz(g)-indolyl)-lower-alkyl)-4-substituted-piperazines
US4302589A (en) * 1980-05-08 1981-11-24 American Cyanamid Company Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation

Also Published As

Publication number Publication date
ATE116982T1 (de) 1995-01-15
AU3628289A (en) 1989-12-14
KR910000708A (ko) 1991-01-30
NO892381D0 (no) 1989-06-09
NO174296C (no) 1994-04-13
DE68920482T2 (de) 1995-06-01
CY1846A (en) 1996-03-08
EP0345808A1 (en) 1989-12-13
SG32583G (en) 1995-09-01
PT90805A (pt) 1989-12-29
FI95698B (fi) 1995-11-30
US4954502A (en) 1990-09-04
JPH0285277A (ja) 1990-03-26
NO892381L (no) 1989-12-11
AU624147B2 (en) 1992-06-04
KR0128210B1 (ko) 1998-04-02
CA1337421C (en) 1995-10-24
FI95698C (fi) 1996-03-11
FI892787A0 (fi) 1989-06-07
DK283589D0 (da) 1989-06-09
IE891861L (en) 1989-12-10
EP0345808B1 (en) 1995-01-11
PT90805B (pt) 1994-10-31
ES2067500T3 (es) 1995-04-01
HK83295A (en) 1995-06-01
DE68920482D1 (de) 1995-02-23
JP2786480B2 (ja) 1998-08-13
NO174296B (no) 1994-01-03
FI892787A (fi) 1989-12-11
IE66569B1 (en) 1996-01-24

Similar Documents

Publication Publication Date Title
DK283589D0 (da) 1-indolylalkyl-4-(substitueret pyridinyl)-piperaziner
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
KR900003138A (ko) 복소환식 화합물
ES2045109T3 (es) 1-fenil-3-naftaleniloxipropanaminas.
DK249089D0 (da) Benzamid-forbindelser, der er nyttige som protease-inhibitorer
IL93443A0 (en) Trifluoromethylphenylazolyl-methyloxirane derivatives and fungicides containing these compounds
DE3772015D1 (de) Chinolinverbindung.
ATE86860T1 (de) Praeparat gegen ulcus.
GR3003776T3 (ko)
NO875357L (no) Kjemiske sammensetninger og deres bruk som brennstoffadditiver.
ATE84028T1 (de) Biologisch aktive verbindungen.
DE68905406D1 (de) Chinolin-verbindung.
DE3781986D1 (de) Substituierte chinoxaline.
DE3778088D1 (de) Substituierte pyrimidochinoxaline.
DE69112095D1 (de) 1-Phenoxycarbonyl-2-Pyrrolidon-Derivate und nootrope Wirkstoffe.

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment