NO171788C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive fosfinsyrederivater - Google Patents
Analogifremgangsmaate ved fremstilling av terapeutisk aktive fosfinsyrederivaterInfo
- Publication number
- NO171788C NO171788C NO875214A NO875214A NO171788C NO 171788 C NO171788 C NO 171788C NO 875214 A NO875214 A NO 875214A NO 875214 A NO875214 A NO 875214A NO 171788 C NO171788 C NO 171788C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- acid derivatives
- phosphinic acid
- therapeutic active
- analogy procedure
- Prior art date
Links
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868629876A GB8629876D0 (en) | 1986-12-15 | 1986-12-15 | Phosphinic acid derivatives |
| GB878722245A GB8722245D0 (en) | 1986-12-15 | 1987-09-22 | Phosphinic acid derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO875214D0 NO875214D0 (no) | 1987-12-14 |
| NO875214L NO875214L (no) | 1988-06-16 |
| NO171788B NO171788B (no) | 1993-01-25 |
| NO171788C true NO171788C (no) | 1993-05-05 |
Family
ID=26291694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO875214A NO171788C (no) | 1986-12-15 | 1987-12-14 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive fosfinsyrederivater |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US4885283A (cs) |
| EP (1) | EP0276436B1 (cs) |
| CN (1) | CN1017337B (cs) |
| AU (1) | AU606901B2 (cs) |
| CA (1) | CA1326737C (cs) |
| CS (1) | CS272231B2 (cs) |
| DE (1) | DE3786250T2 (cs) |
| DK (1) | DK641687A (cs) |
| ES (1) | ES2056810T3 (cs) |
| FI (1) | FI89059C (cs) |
| HU (1) | HU203109B (cs) |
| IE (1) | IE62334B1 (cs) |
| IL (1) | IL84766A (cs) |
| MC (1) | MC1881A1 (cs) |
| NO (1) | NO171788C (cs) |
| NZ (1) | NZ222824A (cs) |
| PH (1) | PH25030A (cs) |
| PT (1) | PT86366B (cs) |
| ZW (1) | ZW23187A1 (cs) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0347840B1 (en) * | 1988-06-23 | 1995-12-27 | Banyu Pharmaceutical Co., Ltd. | Phosphinic acid derivates |
| US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
| US5239078A (en) * | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
| US5114953A (en) * | 1990-11-21 | 1992-05-19 | University Of Florida | Treatment for tissue ulceration |
| US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
| US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| CA2058797A1 (en) * | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| FR2676059B1 (fr) * | 1991-05-02 | 1993-07-23 | Commissariat Energie Atomique | Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes. |
| EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
| AU3475393A (en) * | 1992-01-15 | 1993-08-03 | Merck & Co., Inc. | Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents |
| US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
| US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
| AU5825094A (en) * | 1993-11-19 | 1995-06-06 | Astra Aktiebolag | Novel dipeptide derivatives |
| GB9405076D0 (en) * | 1994-03-16 | 1994-04-27 | Inst Of Ophtalmology | A medical use of matrix metalloproteinase inhibitors |
| US5476847A (en) * | 1994-06-29 | 1995-12-19 | Schering Corporation | Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors |
| US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| US5831004A (en) | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| US6011021A (en) * | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| FR2730235A1 (fr) * | 1995-02-06 | 1996-08-09 | Commissariat Energie Atomique | Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15 |
| KR19990072009A (ko) * | 1995-08-12 | 1999-09-27 | 게리 이. 프리드만 | 메탈로프로티나제 방해제, 그를 포함하는 약제 조성물 및 약제로서의 용도, 그리고 그의 제조방법 및 제조에 유용한 중간체 |
| US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
| ATE225343T1 (de) * | 1995-12-20 | 2002-10-15 | Hoffmann La Roche | Matrix-metalloprotease inhibitoren |
| US5795877A (en) * | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5863536A (en) * | 1996-12-31 | 1999-01-26 | Guilford Pharmaceuticals Inc. | Phosphoramidate derivatives |
| US5672592A (en) * | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| US6054444A (en) | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
| US5902817A (en) * | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
| US6025345A (en) * | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US6025344A (en) * | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
| US6071965A (en) * | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
| US5977090A (en) * | 1996-09-27 | 1999-11-02 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors |
| TR199802638T2 (xx) | 1996-06-17 | 1999-03-22 | Guilford Pharmaceuticals, Inc. | Kanser tedavisinde naaladase inhibit�rleri kullan�m�. |
| US6384022B1 (en) | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
| US6046180A (en) * | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
| ES2175415T3 (es) * | 1996-07-18 | 2002-11-16 | Pfizer | Inhibidores de metaloproteasas matriciales basados en fosfinato. |
| US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
| US5962521A (en) | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US5981209A (en) * | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
| US6028216A (en) * | 1997-12-31 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives |
| US6121252A (en) * | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
| US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| US6265609B1 (en) | 1998-07-06 | 2001-07-24 | Guilford Pharmaceuticals Inc. | Thio-substituted pentanedioic acid derivatives |
| US6395718B1 (en) * | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
| JP4503836B2 (ja) | 1998-07-06 | 2010-07-14 | エイザイ インコーポレイテッド | 医薬化合物及び組成物として有用なＮＡＡＬＡＤａｓｅ阻害剤 |
| NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| AU1618000A (en) * | 1998-11-12 | 2000-05-29 | Du Pont Pharmaceuticals Company | Use of radioligands to screen inhibitors of amyloid-beta peptide production |
| US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| GB9922577D0 (en) * | 1999-09-23 | 1999-11-24 | Center For Clinical & Basic Re | Substituted phosphinate based peptide derivatives |
| US6696456B1 (en) | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
| KR20030005229A (ko) * | 2000-03-21 | 2003-01-17 | 더 프록터 앤드 갬블 캄파니 | 메탈로프로테아제 저해제를 함유하는 탄소환식 측쇄 |
| CA2401728A1 (en) * | 2000-03-21 | 2001-09-27 | The Procter & Gamble Company | Difluorobutyric acid metalloprotease inhibitors |
| PL365444A1 (en) | 2000-03-21 | 2005-01-10 | The Procter & Gamble Company | Heterocyclic side chain containing, n-substituted metalloprotease inhibitors |
| BR0106717A (pt) | 2000-06-01 | 2002-04-16 | Bristol Myers Squibb Pharma Co | Compostos, composição farmacêutica e usos dos compostos de lactama inovadora |
| US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| AU2003233154A1 (en) | 2002-06-10 | 2003-12-22 | Pfizer Inc. | Metabolites of prinomastat and their sythesis |
| CA2938919C (en) * | 2014-02-28 | 2020-12-29 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4226610A (en) * | 1978-04-15 | 1980-10-07 | Meiji Selka Kaisha, Ltd. | Herbicidal compounds, preparation thereof and herbicides containing the same |
| JPS60163899A (ja) * | 1984-02-03 | 1985-08-26 | Sankyo Co Ltd | レニン阻害ペプチド類 |
| US4661473A (en) * | 1984-03-27 | 1987-04-28 | Merck & Co., Inc. | Renin inhibitors containing peptide isosteres |
| EP0210545A3 (en) * | 1985-07-24 | 1988-07-20 | Merck & Co. Inc. | Phosphorous containing enzyme inhibitors |
| EP0209848A3 (en) * | 1985-07-24 | 1988-07-27 | Merck & Co. Inc. | Enzyme inhibitors |
-
1987
- 1987-11-30 ZW ZW231/87A patent/ZW23187A1/xx unknown
- 1987-12-01 US US07/126,643 patent/US4885283A/en not_active Expired - Fee Related
- 1987-12-03 AU AU82176/87A patent/AU606901B2/en not_active Ceased
- 1987-12-07 CA CA000553634A patent/CA1326737C/en not_active Expired - Fee Related
- 1987-12-07 DK DK641687A patent/DK641687A/da not_active Application Discontinuation
- 1987-12-07 NZ NZ222824A patent/NZ222824A/xx unknown
- 1987-12-09 IL IL8476687A patent/IL84766A/en not_active IP Right Cessation
- 1987-12-09 CS CS879002A patent/CS272231B2/cs unknown
- 1987-12-10 ES ES87118328T patent/ES2056810T3/es not_active Expired - Lifetime
- 1987-12-10 MC MC871933A patent/MC1881A1/xx unknown
- 1987-12-10 EP EP87118328A patent/EP0276436B1/en not_active Expired - Lifetime
- 1987-12-10 DE DE87118328T patent/DE3786250T2/de not_active Expired - Fee Related
- 1987-12-11 HU HU875593A patent/HU203109B/hu not_active IP Right Cessation
- 1987-12-14 NO NO875214A patent/NO171788C/no unknown
- 1987-12-14 CN CN87101164.6A patent/CN1017337B/zh not_active Expired
- 1987-12-14 PH PH36216A patent/PH25030A/en unknown
- 1987-12-14 IE IE338387A patent/IE62334B1/en not_active IP Right Cessation
- 1987-12-14 FI FI875484A patent/FI89059C/fi not_active IP Right Cessation
- 1987-12-15 PT PT86366A patent/PT86366B/pt not_active IP Right Cessation
-
1989
- 1989-09-22 US US07/410,779 patent/US5006651A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI89059B (fi) | 1993-04-30 |
| CS900287A2 (en) | 1990-03-14 |
| FI875484A7 (fi) | 1988-06-16 |
| NZ222824A (en) | 1990-08-28 |
| CN87101164A (zh) | 1988-06-29 |
| EP0276436B1 (en) | 1993-06-16 |
| DE3786250T2 (de) | 1993-10-07 |
| AU8217687A (en) | 1988-06-16 |
| AU606901B2 (en) | 1991-02-21 |
| NO875214L (no) | 1988-06-16 |
| HU203109B (en) | 1991-05-28 |
| CS272231B2 (en) | 1991-01-15 |
| DK641687A (da) | 1988-06-16 |
| IE62334B1 (en) | 1995-01-25 |
| CA1326737C (en) | 1994-02-01 |
| CN1017337B (zh) | 1992-07-08 |
| PH25030A (en) | 1991-01-28 |
| DK641687D0 (da) | 1987-12-07 |
| US4885283A (en) | 1989-12-05 |
| DE3786250D1 (en) | 1993-07-22 |
| NO171788B (no) | 1993-01-25 |
| ZW23187A1 (en) | 1988-06-29 |
| IL84766A (en) | 1994-02-27 |
| MC1881A1 (fr) | 1989-01-24 |
| US5006651A (en) | 1991-04-09 |
| HUT46699A (en) | 1988-11-28 |
| EP0276436A1 (en) | 1988-08-03 |
| IL84766A0 (en) | 1988-05-31 |
| FI89059C (fi) | 1993-08-10 |
| NO875214D0 (no) | 1987-12-14 |
| ES2056810T3 (es) | 1994-10-16 |
| PT86366B (pt) | 1990-11-20 |
| FI875484A0 (fi) | 1987-12-14 |
| IE873383L (en) | 1988-06-15 |
| PT86366A (en) | 1988-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO171788C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive fosfinsyrederivater | |
| NO170480C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive fenoksyeddiksyre-derivater | |
| NO168770C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater | |
| NO172045C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydropyridinoksimer | |
| NO168174C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive triazolforbindelser | |
| NO171506C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive adenosin-derivater | |
| NO170629C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater | |
| NO800858L (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 4-amino-3-kinolincarboxylsyrederivater | |
| NO864425L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocyklyl-oksoftalazinyl-eddiksyre-derivater | |
| NO172343C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive askorbinsyrederivater | |
| NO167916C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tiolaktam-n-eddiksyrederivater | |
| NO167026C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater | |
| NO169438C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrazolforbindelser | |
| NO167510C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenylkinolincarboxylsyrer | |
| NO168355C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater | |
| NO170976C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylbuten-syrederivater | |
| NO168299C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater | |
| NO172489C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive imidazolderivater | |
| NO162619C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive l-aminosyre-derivater | |
| NO170021C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 3-propenylcefem-derivater | |
| NO168041C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive retinsyreestere av erytromycin. | |
| NO170582C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-alkylenfenyl-heterocykliske forbindelser | |
| NO169069C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-alkoksy-2-aminopropylaminderivater | |
| NO169007C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive uridinderivater | |
| NO169648C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater |