NO169493C - Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater

Info

Publication number
NO169493C
NO169493C NO860190A NO860190A NO169493C NO 169493 C NO169493 C NO 169493C NO 860190 A NO860190 A NO 860190A NO 860190 A NO860190 A NO 860190A NO 169493 C NO169493 C NO 169493C
Authority
NO
Norway
Prior art keywords
peptid
derivatives
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO860190A
Other languages
English (en)
Norwegian (no)
Other versions
NO860190L (no
NO169493B (no
Inventor
Scott Haven Bergeson
Philip Duke Edwards
John Anthony Schwartz
Andrew Shaw
Mark Morris Stein
Diane Amy Trainor
Richard Alan Wildonger
Donald John Wolanin
Original Assignee
Ici America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858501523A external-priority patent/GB8501523D0/en
Priority claimed from GB858501524A external-priority patent/GB8501524D0/en
Priority claimed from GB858501522A external-priority patent/GB8501522D0/en
Application filed by Ici America Inc filed Critical Ici America Inc
Publication of NO860190L publication Critical patent/NO860190L/no
Publication of NO169493B publication Critical patent/NO169493B/no
Publication of NO169493C publication Critical patent/NO169493C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/02—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO860190A 1985-01-22 1986-01-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater NO169493C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858501523A GB8501523D0 (en) 1985-01-22 1985-01-22 Tripeptide derivatives
GB858501524A GB8501524D0 (en) 1985-01-22 1985-01-22 Tetrapeptide derivatives
GB858501522A GB8501522D0 (en) 1985-01-22 1985-01-22 Dipeptide derivatives

Publications (3)

Publication Number Publication Date
NO860190L NO860190L (no) 1986-07-23
NO169493B NO169493B (no) 1992-03-23
NO169493C true NO169493C (no) 1992-07-01

Family

ID=27262565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO860190A NO169493C (no) 1985-01-22 1986-01-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater

Country Status (25)

Country Link
US (2) US4910190A (ja)
EP (1) EP0189305B1 (ja)
JP (2) JPH0759591B2 (ja)
KR (1) KR910002689B1 (ja)
CN (1) CN1027640C (ja)
AU (1) AU594658B2 (ja)
CA (1) CA1341023C (ja)
CZ (1) CZ278063B6 (ja)
DE (1) DE3686172T2 (ja)
DK (1) DK172736B1 (ja)
ES (3) ES8706169A1 (ja)
FI (1) FI84171C (ja)
GB (1) GB8600263D0 (ja)
GR (1) GR860169B (ja)
HK (1) HK18097A (ja)
HU (1) HU206370B (ja)
IE (1) IE58957B1 (ja)
IL (1) IL77680A (ja)
NO (1) NO169493C (ja)
PH (1) PH26575A (ja)
PL (1) PL150268B1 (ja)
PT (1) PT81887B (ja)
SK (1) SK278095B6 (ja)
UA (1) UA39093C2 (ja)
ZW (1) ZW1486A1 (ja)

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US5182263A (en) * 1988-04-25 1993-01-26 Hoffmann-La Roche Inc. Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
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US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
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GB9014132D0 (en) * 1990-06-25 1990-08-15 Ici Plc Agent for therapy
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US5521179A (en) * 1991-04-18 1996-05-28 Zeneca Limited Heterocyclic amides
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
US5340801A (en) * 1991-05-08 1994-08-23 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having cholecystokinin and gastrin antagonistic properties
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GB9113164D0 (en) * 1991-06-18 1991-08-07 Ici Plc Pharmaceutical agent
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GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
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US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
JPH07505877A (ja) * 1992-04-16 1995-06-29 ゼネカ・リミテッド α−アミノボロン酸ペプチド及びエラスターゼ阻害剤としてのそれらの使用
US5486529A (en) * 1992-04-16 1996-01-23 Zeneca Limited Certain pyridyl ketones for treating diseases involving leukocyte elastase
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9214053D0 (en) * 1992-07-02 1992-08-12 Ici Plc Heterocyclic amides
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
WO1995033763A1 (en) * 1994-06-02 1995-12-14 Hoechst Marion Roussel, Inc. Novel elastase inhibitors
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US6693072B2 (en) * 1994-06-02 2004-02-17 Aventis Pharmaceuticals Inc. Elastase inhibitors
MX9606034A (es) * 1994-06-02 1998-05-31 Merrell Pharma Inc Derivados enolicos acilados como profarmacos de inhibidores de elastasa.
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US6423688B1 (en) * 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
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US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
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US6583139B1 (en) * 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
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US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
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US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
CH672792A5 (ja) * 1985-02-19 1989-12-29 Sandoz Ag
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
ES2052560T3 (es) * 1986-06-05 1994-07-16 Ici America Inc Compuestos difluorcetonicos.

Also Published As

Publication number Publication date
EP0189305B1 (en) 1992-07-29
US4910190A (en) 1990-03-20
US5726158A (en) 1998-03-10
ES557048A0 (es) 1987-08-01
KR910002689B1 (ko) 1991-05-03
CN1027640C (zh) 1995-02-15
CN86101066A (zh) 1986-11-05
FI84171C (fi) 1991-10-25
JPH0680039B2 (ja) 1994-10-12
HUT39464A (en) 1986-09-29
EP0189305A2 (en) 1986-07-30
UA39093C2 (uk) 2001-06-15
HU206370B (en) 1992-10-28
JPH05246984A (ja) 1993-09-24
CS39586A3 (en) 1992-01-15
AU594658B2 (en) 1990-03-15
DE3686172D1 (de) 1992-09-03
KR860005835A (ko) 1986-08-13
FI860281A0 (fi) 1986-01-21
DK30886D0 (da) 1986-01-21
ZW1486A1 (en) 1987-09-30
FI860281A (fi) 1986-07-23
PH26575A (en) 1992-08-19
CA1341023C (en) 2000-06-13
DK30886A (da) 1986-07-23
IL77680A (en) 1990-12-23
JPS61218518A (ja) 1986-09-29
AU5262386A (en) 1986-07-31
IE58957B1 (en) 1993-12-01
FI84171B (fi) 1991-07-15
ES8706169A1 (es) 1987-05-16
PT81887A (en) 1986-02-01
JPH0759591B2 (ja) 1995-06-28
ES8707551A1 (es) 1987-08-01
ES557363A0 (es) 1988-07-01
ES8802526A1 (es) 1988-07-01
GR860169B (en) 1986-05-15
PL150268B1 (en) 1990-05-31
CZ278063B6 (en) 1993-08-11
SK278095B6 (en) 1995-12-06
PT81887B (pt) 1988-05-27
GB8600263D0 (en) 1986-02-12
DE3686172T2 (de) 1993-01-14
HK18097A (en) 1997-02-13
NO860190L (no) 1986-07-23
IE860180L (en) 1986-07-22
PL257573A1 (en) 1987-03-23
EP0189305A3 (en) 1988-10-05
ES551113A0 (es) 1987-05-16
DK172736B1 (da) 1999-06-21
NO169493B (no) 1992-03-23

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