NO169123B - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE CARBOCYCLIC 2 ', 3'-DIDEOXY-2', 3'-DIDEHYDROPURIN NUCLEOSIDE ANALOGS - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE CARBOCYCLIC 2 ', 3'-DIDEOXY-2', 3'-DIDEHYDROPURIN NUCLEOSIDE ANALOGS Download PDF

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Publication number
NO169123B
NO169123B NO890253A NO890253A NO169123B NO 169123 B NO169123 B NO 169123B NO 890253 A NO890253 A NO 890253A NO 890253 A NO890253 A NO 890253A NO 169123 B NO169123 B NO 169123B
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Prior art keywords
free
thread
mesh
net
pieces
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NO890253A
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Norwegian (no)
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NO890253D0 (en
NO169123C (en
NO890253L (en
Inventor
Robert Vince
Mei Hua
Peter Leslie Myers
Richard Storer
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Univ Minnesota
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Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Priority claimed from GB888821011A external-priority patent/GB8821011D0/en
Priority claimed from US07/278,652 external-priority patent/US4931559A/en
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of NO890253D0 publication Critical patent/NO890253D0/en
Publication of NO890253L publication Critical patent/NO890253L/en
Publication of NO169123B publication Critical patent/NO169123B/en
Publication of NO169123C publication Critical patent/NO169123C/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Description

Fremgangsmåte ved maskinell sammenskjøting av nettstykker. Procedure for mechanical joining of mesh pieces.

Ved fremstilling av slike fiskeredskaper som nøter, garn, trålposer og liknende blir det på spesialknytemaskiner fremstillet nettstykker som deretter skal skjøtes sammen side om side langs sidekantene for å oppnå den ønskete fulle bredde hos fiskeredska-pet. Særlig ved fremstilling av snurpenøter er slik sammenskjø-ting nødvendig, da en snurpenot består av et stort antall nettstykker lagt side om side. Ofte er enkelte nettstykker tilskåret med en spesiell form foråt noten skal oppføre seg på en bestemt ønsket måte under utsetting og mens den befinner seg i sjøen. Det er viktig at sammenskjøtingen skjer jevnt og at heller ikke skjøten danner noe svakt punkt i noten hvorfra en overbelastning kan bringe noten til å spjæres opp og rives istykker av fisketyngden. When manufacturing such fishing gear as nets, nets, trawl bags and the like, net pieces are produced on special tying machines which must then be joined together side by side along the side edges to achieve the desired full width of the fishing gear. Particularly in the production of twist nets, such joining is necessary, as a twist net consists of a large number of net pieces laid side by side. Often individual pieces of net are cut to a special shape so that the seine will behave in a certain desired way during release and while it is in the sea. It is important that the splicing takes place evenly and that the joint does not form a weak point in the seine from which an overload can cause the seine to split open and be torn to pieces by the weight of the fish.

Det er også viktig at de knuter som brukes, ikke glir selvom It is also important that the knots used do not slip

de skulle bli utsatt for skjev(diagonal)belastning. they were to be subjected to bias (diagonal) loading.

Alle disse hensyn fører til at slik sammenskjøting foregår All these considerations lead to such joining taking place

for hånd idag, idet det ikke har lykkes å konstruere noen maskin som kan foreta sammenskjøting og knyte knuter som tilfredsstiller de strenge krav som stilles til skjøten. by hand today, since it has not been possible to construct any machine that can perform splicing and tie knots that satisfy the strict requirements for the joint.

Formålet med den foreliggende oppfinnelse er å skaffe en maskinell fremgangsmåte for sammenføying av nettstykker med knuter som ikke vil gli eller løsne selvom de skulle bli utsatt for skjev (diagonal)belasting. Ytterligere et formål med oppfinnelsen er å skaffe en fremgangsmåte som lett lar seg gjennomføre maskinelt, The purpose of the present invention is to provide a mechanical method for joining net pieces with knots that will not slide or loosen even if they are subjected to bias (diagonal) loading. A further object of the invention is to provide a method which can easily be carried out by machine,

slik at sammenskjøtingen vil kunne foregå ved hjelp av en spesial-maskin. so that the jointing will be able to take place with the help of a special machine.

Oppfinnelsen vedrører således en fremgangsmåte ved maskinell sammenskjøting av nettstykker som langs sidekantene har frie masker som skal skjøtes sammen, og et kjennetegnende trekk ved frem-gangsmåten ifølge oppfinnelsen består i at en skjøtetråd eller den frie masketråd langs sidekanten på det tilstøtende nettstykke fø-res dobbeltlagt i løkke form inn i den øye formete frie maske, slås rundt denne og føres deretter mellom nettstykkemasken og den dobbeltlagte tråd så at den løkkeformete ende på denne tråd stikker ut fra knuten som en frittendende stump eller tamp. Ifølge en videreutvikling av oppfinnelsen innbindes en separat, kontinuerlig skjøtetråd vekselvis i endekant av maskene på de to nettstykker som skal skjøtes sammen. Man kan imidlertid som et alternativ la en kontinuerlig, fri masketråd langs sidekanten på det nevnte ene av de to tilstøtende nettstykker utformes med vesentlig større lengde enn vanlig, slik at de maskestaver som fremkommer etter knyttingen vil ha stort sett samme lengde som vanlige maskestaver i nettet. The invention thus relates to a method for mechanically joining mesh pieces that have free meshes along the side edges to be joined together, and a characteristic feature of the method according to the invention is that a joint thread or the free mesh thread along the side edge of the adjacent mesh piece is led in double layers in loop form into the eye-shaped free stitch, wrapped around this and then passed between the net piece stitch and the double-laid thread so that the loop-shaped end of this thread protrudes from the knot as a free-ended stub or tamp. According to a further development of the invention, a separate, continuous splicing wire is tied alternately into the end edge of the meshes of the two net pieces to be spliced together. However, as an alternative, a continuous, free mesh thread along the side edge of the aforementioned one of the two adjacent net pieces can be designed with a significantly greater length than usual, so that the mesh bars that appear after the knotting will have largely the same length as normal mesh bars in the net .

■Oppfinnelsen skal nå forklares nærmere i tilknytning til de medfølgende tegninger, hvor: Fig. 1 viser sammenskjøting av to nettstykker ifølge en før-ste utførelsesform for oppfinnelsen. Fig. 2 viser sammenskjøting av to nettstykker ifølge en an-nen utførelsesform for oppfinnelsen. ■The invention will now be explained in more detail in connection with the accompanying drawings, where: Fig. 1 shows the joining of two net pieces according to a first embodiment of the invention. Fig. 2 shows the joining of two net pieces according to another embodiment of the invention.

Under henvisning til fig. 1 har man et første nettstykke til høyre, oppbygget av maskestaver 1 og bundet sammen av knuter 2. Langs sidekanten har nettstykket frie masker 5- Til venstre har With reference to fig. 1 you have a first net piece on the right, made up of double crochets 1 and tied together by knots 2. Along the side edge the net piece has free stitches 5- On the left has

man et annet nettstykke med maskestaver 4 og knuter 5, samt frie masker 6 langs sidekantene. Disse sistnevnte frie masker 6 ligger another net piece with double crochets 4 and knots 5, as well as free stitches 6 along the side edges. These latter free stitches 6 lie

forskjøvet over en halv knuteavstand i forhold til det første nettstykkes frie masker 3- offset by half a knot distance in relation to the first net piece's free stitches 3-

En kontinuerlig tråd 7, som i dette utførelseseksempel er A continuous thread 7, which in this embodiment is

en separat tråd, er nederst dobbeltlagt til' dannelse av en løkke 8. Den er ferdig til å føres inn i den frie maske 3 på det høyre nettstykke. Ovenfor sees det hvorledes denne løkke 8 er ført inn i den øyeformete frie maske på det venstre nettstykke. Ovenfor dette igjen er løkken 8 ført under masken 3> idet et parti 9 ligger under nettmasken 3« Over dette igjen er den ytre del av skjø-tetrådløkken lagt over nettstykkemasken 6 med et parti 10, og ført inn under løkken 8, slik at en frittendende stump 11 stikker ut fra den knute som er dannet.. a separate thread, is doubled at the bottom to form a loop 8. It is ready to be fed into the free stitch 3 on the right net piece. Above, you can see how this loop 8 is inserted into the eye-shaped free stitch on the left net piece. Above this again, the loop 8 is passed under the mesh 3>, with a part 9 lying under the net mesh 3" Above this again, the outer part of the connecting thread loop is laid over the net piece mesh 6 with a part 10, and brought under the loop 8, so that a free-ended stump 11 protrudes from the knot that has been formed..

Den innbundete kontinuerlige tråd vil, som det sees, danne maskestaver 12 og 13 som forløper ut fra en knute 14. Det vil være lett å se, at dersom man trekker i enten maskestaven 12 eller 13» vil knuten bare trekke seg hardere til, og tråden vil ikke gli. The bound continuous thread will, as can be seen, form stitch bars 12 and 13 which extend from a knot 14. It will be easy to see that if you pull on either stitch bar 12 or 13", the knot will only tighten harder, and the thread will not slip.

Idet det nå henvises til fig. 2, vil det sees at man i dette tilfelle til høyre har et nettstykke med knuter 20 og frittendende masker 21, mens man til venstre har et tilsvarende nettstykke med knuter 22 og frie eller frittendende masker 23- Disse sistnevnte masker 23 blir innbundet i maskene 21 slik at en frittendende stump eller tamp 24 forløper ut fra den knute som er dannet, idet denne knute er fremstillet på samme måte som vist i fig. 1. Referring now to fig. 2, it will be seen that in this case on the right you have a net piece with knots 20 and free-ending stitches 21, while on the left you have a corresponding net piece with knots 22 and free or free-ending stitches 23 - These latter stitches 23 are tied into the stitches 21 so that a free-ended stub or tamp 24 extends from the knot that has been formed, this knot being made in the same way as shown in fig. 1.

I dette tilfelle er maskene 23 knyttet slik at de innehol-der et vesentlig lengre trådstykke enn ellers, men slik at de maskestaver 25, 26 som fremkommer etter knyttingen vil ha stort sett samme lengde som vanlige maskestaver i nettet. In this case, the stitches 23 are tied so that they contain a significantly longer piece of thread than otherwise, but so that the stitch bars 25, 26 which appear after the knotting will have largely the same length as normal stitch bars in the net.

Claims (3)

1. Fremgangsmåte ved maskinell sammenskjøting av nettstykker, som langs sidekantene har frie masker som skal skjøtes sammen, karakterisert ved at en skjøtetråd (7) eller den frie masketråd (25) langs sidekanten på det tilstøtende nettstykke føres dobbeltlagt i løkkeform (8) inn i den øyeformete frie maske (3> 6, 21), slås rundt denne og føres deretter mellom nettstykkemasken og den dobbeltlagte tråd så at den løkkeformete ende på denne tråd stikker ut fra knuten som en frittendende tamp (11, 24).1. Procedure for mechanical joining of mesh pieces, which along the side edges have free meshes to be joined together, characterized in that a joining thread (7) or the free mesh thread (25) along the side edge of the adjacent mesh piece is led in a double layer in the form of a loop (8) into the eye-shaped free stitch (3> 6, 21), is wrapped around this and then passed between the net piece stitch and the double-laid thread so that the loop-shaped end of this thread protrudes from the knot like a free-ended tampon (11, 24). 2. Fremgangsmåte i samsvar med krav 1, karakterisert ved at en separat, kontinuerlig skjøtetråd (7) innbindes vekselvis i endekant av maskene (3> 6) på de to nettstykker som skal skjøtes sammen.2. Method in accordance with claim 1, characterized in that a separate, continuous splicing wire (7) is tied alternately into the end edge of the meshes (3 > 6) on the two net pieces to be spliced together. 3. Fremgangsmåte i samsvar med krav 1, karakterisert ved at en kontinuerlig, fri masketråd (25) langs sidekanten på det nevnte ene av de to tilstøtende nettstykker utformes med vesentlig større lengde enn vanlig, slik at de maskestaver som fremkommer etter knyttingen vil ha stort sett samme lengde' som vanlige maskestaver i nettet.3. Method in accordance with claim 1, characterized in that a continuous, free mesh thread (25) along the side edge of the aforementioned one of the two adjacent net pieces is designed with a significantly greater length than usual, so that the mesh rods that appear after the knotting will have a large set the same length as regular stitches in the net.
NO890253A 1988-01-20 1989-01-19 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE CARBOCYCLIC 2 ', 3'-DIDEOXY-2', 3'-DIDEHYDROPURIN NUCLEOSIDE ANALOGS NO169123C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
GB888821011A GB8821011D0 (en) 1988-09-07 1988-09-07 Chemical compounds
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides

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NO890253D0 NO890253D0 (en) 1989-01-19
NO890253L NO890253L (en) 1989-07-21
NO169123B true NO169123B (en) 1992-02-03
NO169123C NO169123C (en) 1992-05-13

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NO890253A NO169123C (en) 1988-01-20 1989-01-19 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE CARBOCYCLIC 2 ', 3'-DIDEOXY-2', 3'-DIDEHYDROPURIN NUCLEOSIDE ANALOGS

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JP (1) JP2793825B2 (en)
KR (1) KR0127137B1 (en)
AT (1) AT397801B (en)
AU (2) AU626278B2 (en)
BE (1) BE1003815A4 (en)
CA (1) CA1339896C (en)
CH (1) CH679152A5 (en)
DE (1) DE3901502C2 (en)
DK (1) DK175131B1 (en)
ES (1) ES2010091A6 (en)
FI (1) FI93546C (en)
FR (1) FR2626002B1 (en)
GB (1) GB2217320B (en)
GR (1) GR890100033A (en)
HU (1) HU203755B (en)
IE (1) IE62275B1 (en)
IL (1) IL88999A (en)
IT (1) IT1229531B (en)
LU (1) LU87437A1 (en)
MY (1) MY103801A (en)
NL (1) NL8900122A (en)
NO (1) NO169123C (en)
NZ (1) NZ227663A (en)
OA (1) OA09031A (en)
PL (1) PL163814B1 (en)
PT (1) PT89482B (en)
RU (1) RU2114846C1 (en)
SE (1) SE505213C2 (en)
YU (1) YU47791B (en)

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GB8916480D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
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US6433170B1 (en) 1998-10-30 2002-08-13 Lonza Group Method for producing 4-[2',5'-diamino-6'-halopyrimidine-4'-yl)amino]- cyclopent-2-enylmethanols
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AU626278B2 (en) 1992-07-30
DK23489A (en) 1989-07-21
AU1018092A (en) 1992-03-12
KR890011902A (en) 1989-08-23
YU47791B (en) 1996-01-09
FR2626002A1 (en) 1989-07-21
HUT48887A (en) 1989-07-28
GB2217320A (en) 1989-10-25
PL163814B1 (en) 1994-05-31
GB2217320B (en) 1992-04-08
AT397801B (en) 1994-07-25
FI93546B (en) 1995-01-13
HU203755B (en) 1991-09-30
DE3901502C2 (en) 2002-06-13
CH679152A5 (en) 1991-12-31
KR0127137B1 (en) 1997-12-29
GB8901187D0 (en) 1989-03-15
MY103801A (en) 1993-09-30
AU637015B2 (en) 1993-05-13
PT89482A (en) 1989-10-04
NO890253D0 (en) 1989-01-19
IT8947546A0 (en) 1989-01-19
RU2114846C1 (en) 1998-07-10
IE62275B1 (en) 1995-01-25
SE505213C2 (en) 1997-07-14
IE890153L (en) 1989-07-20
GR890100033A (en) 1994-03-31
JPH02196788A (en) 1990-08-03
DE3901502A1 (en) 1989-07-27
IL88999A (en) 1994-12-29
JP2793825B2 (en) 1998-09-03
CA1339896C (en) 1998-06-02
NO169123C (en) 1992-05-13
SE8900192D0 (en) 1989-01-19
IT1229531B (en) 1991-09-04
DK23489D0 (en) 1989-01-19
PL277261A1 (en) 1989-09-18
FI890286A (en) 1989-07-21
DK175131B1 (en) 2004-06-14
FI93546C (en) 1995-04-25
BE1003815A4 (en) 1992-06-23
FI890286A0 (en) 1989-01-19
SE8900192L (en) 1989-07-21
ATA10689A (en) 1993-11-15
PT89482B (en) 1994-02-28
LU87437A1 (en) 1989-08-30
OA09031A (en) 1991-03-31
IL88999A0 (en) 1989-08-15
AU2867189A (en) 1989-07-20
YU12389A (en) 1991-10-31
NZ227663A (en) 1990-09-26
NO890253L (en) 1989-07-21
NL8900122A (en) 1989-08-16
ES2010091A6 (en) 1989-10-16
FR2626002B1 (en) 1994-01-28

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