ES2010091A6 - Dideoxydidehydrocarbocyclic nucleosides - Google Patents
Dideoxydidehydrocarbocyclic nucleosidesInfo
- Publication number
- ES2010091A6 ES2010091A6 ES8900184A ES8900184A ES2010091A6 ES 2010091 A6 ES2010091 A6 ES 2010091A6 ES 8900184 A ES8900184 A ES 8900184A ES 8900184 A ES8900184 A ES 8900184A ES 2010091 A6 ES2010091 A6 ES 2010091A6
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- dideoxydidehydrocarbocyclic
- nucleosides
- nrr
- antiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Compounds of the formula < IMAGE > in which X = H, NRR<1>, SR, OR or halogen Z = H, OR<1> or NRR<1> R, R<1> and R<2> are H, C1-4-alkyl or aryl and pharmaceutically acceptable derivatives thereof are described. The use of the compounds as antiviral and antitumour agents is likewise described as well as pharmaceutical formulations and methods for the preparation of the compounds and their intermediates.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/146,252 US4916224A (en) | 1988-01-20 | 1988-01-20 | Dideoxycarbocyclic nucleosides |
GB888821011A GB8821011D0 (en) | 1988-09-07 | 1988-09-07 | Chemical compounds |
US07/278,652 US4931559A (en) | 1988-01-20 | 1988-12-05 | Optically-active isomers of dideoxycarbocyclic nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2010091A6 true ES2010091A6 (en) | 1989-10-16 |
Family
ID=27264063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8900184A Expired ES2010091A6 (en) | 1988-01-20 | 1989-01-19 | Dideoxydidehydrocarbocyclic nucleosides |
Country Status (29)
Country | Link |
---|---|
JP (1) | JP2793825B2 (en) |
KR (1) | KR0127137B1 (en) |
AT (1) | AT397801B (en) |
AU (2) | AU626278B2 (en) |
BE (1) | BE1003815A4 (en) |
CA (1) | CA1339896C (en) |
CH (1) | CH679152A5 (en) |
DE (1) | DE3901502C2 (en) |
DK (1) | DK175131B1 (en) |
ES (1) | ES2010091A6 (en) |
FI (1) | FI93546C (en) |
FR (1) | FR2626002B1 (en) |
GB (1) | GB2217320B (en) |
GR (1) | GR890100033A (en) |
HU (1) | HU203755B (en) |
IE (1) | IE62275B1 (en) |
IL (1) | IL88999A (en) |
IT (1) | IT1229531B (en) |
LU (1) | LU87437A1 (en) |
MY (1) | MY103801A (en) |
NL (1) | NL8900122A (en) |
NO (1) | NO169123C (en) |
NZ (1) | NZ227663A (en) |
OA (1) | OA09031A (en) |
PL (1) | PL163814B1 (en) |
PT (1) | PT89482B (en) |
RU (1) | RU2114846C1 (en) |
SE (1) | SE505213C2 (en) |
YU (1) | YU47791B (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1215339B (en) * | 1987-01-14 | 1990-02-08 | Co Pharma Corp Srl | PROCEDURE FOR THE PREPARATION OF 9- (HYDROXIALCHIL) -IPOXANTINE |
US5631370A (en) | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
US4939252A (en) * | 1989-04-20 | 1990-07-03 | Hoffmann-La Roche Inc. | Novel intermediates for the preparation of Carbovir |
JP3164361B2 (en) * | 1989-06-27 | 2001-05-08 | ザ ウエルカム ファウンデーション リミテッド | Therapeutic nucleoside |
GB8916479D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
GB8916477D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
GB8916478D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
GB8916480D0 (en) * | 1989-07-19 | 1989-09-06 | Glaxo Group Ltd | Chemical process |
MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
US5126452A (en) * | 1990-04-06 | 1992-06-30 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
US5241069A (en) * | 1990-04-06 | 1993-08-31 | Glaxo Inc. | Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives |
US5057630A (en) * | 1990-04-06 | 1991-10-15 | Glaxo Inc. | Synthesis of cyclopentene derivatives |
US5144034A (en) * | 1990-04-06 | 1992-09-01 | Glaxo Inc. | Process for the synthesis of cyclopentene derivatives of purines |
GB9108376D0 (en) * | 1991-04-19 | 1991-06-05 | Enzymatix Ltd | Cyclopentenes |
CN1137274A (en) * | 1993-11-12 | 1996-12-04 | 默里尔药物公司 | 6-oxo-nucleosides useful as immunosuppressants |
GB9721780D0 (en) | 1997-10-14 | 1997-12-10 | Glaxo Group Ltd | Process for the synthesis of chloropurine intermediates |
DE59905679D1 (en) | 1998-10-30 | 2003-06-26 | Lonza Ag | METHOD FOR PRODUCING 4 - [(2 ', 5'-DIAMINO-6'-HALOGENPYRIMIDIN-4'-YL) AMINO] -CYCLOPENT-2-ENYLMETHANOLS |
AU1158000A (en) * | 1998-10-30 | 2000-05-22 | Lonza A.G. | Method for producing 4- ((2',5'- diamino-6'- halopyrimidine- 4'-YL)amino)- cyclopent- 2-enylmethanols |
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
GB9903091D0 (en) * | 1999-02-12 | 1999-03-31 | Glaxo Group Ltd | Therapeutic nucleoside compound |
AR039540A1 (en) | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | MICROBICIDE COMPOUNDS WITH PIRIMIDINE OR TRIAZINE CONTENT |
JP7104154B2 (en) | 2018-07-27 | 2022-07-20 | 富士フイルム株式会社 | Cyclopentenylpurine derivative or salt thereof |
WO2021191417A1 (en) | 2020-03-27 | 2021-09-30 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of synucleinopathies |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268672A (en) * | 1977-02-09 | 1981-05-19 | The Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine nucleosides and method of preparation |
US4742064A (en) * | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
JPS62177234A (en) * | 1986-01-30 | 1987-08-04 | Mitsubishi Heavy Ind Ltd | Production device of carbon fiber by centrifugal spinning |
IN164556B (en) * | 1986-03-06 | 1989-04-08 | Takeda Chemical Industries Ltd | |
NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
-
1989
- 1989-01-19 CH CH172/89A patent/CH679152A5/de not_active IP Right Cessation
- 1989-01-19 RU RU92004364A patent/RU2114846C1/en active
- 1989-01-19 NZ NZ227663A patent/NZ227663A/en unknown
- 1989-01-19 OA OA59510A patent/OA09031A/en unknown
- 1989-01-19 GR GR890100033A patent/GR890100033A/en not_active IP Right Cessation
- 1989-01-19 BE BE8900061A patent/BE1003815A4/en active
- 1989-01-19 LU LU87437A patent/LU87437A1/en unknown
- 1989-01-19 AT AT0010689A patent/AT397801B/en not_active IP Right Cessation
- 1989-01-19 DK DK198900234A patent/DK175131B1/en not_active IP Right Cessation
- 1989-01-19 ES ES8900184A patent/ES2010091A6/en not_active Expired
- 1989-01-19 IT IT8947546A patent/IT1229531B/en active
- 1989-01-19 KR KR1019890000551A patent/KR0127137B1/en not_active IP Right Cessation
- 1989-01-19 DE DE3901502A patent/DE3901502C2/en not_active Expired - Lifetime
- 1989-01-19 PT PT89482A patent/PT89482B/en not_active IP Right Cessation
- 1989-01-19 SE SE8900192A patent/SE505213C2/en not_active IP Right Cessation
- 1989-01-19 IL IL8899989A patent/IL88999A/en unknown
- 1989-01-19 IE IE15389A patent/IE62275B1/en not_active IP Right Cessation
- 1989-01-19 NL NL8900122A patent/NL8900122A/en not_active Application Discontinuation
- 1989-01-19 MY MYPI89000064A patent/MY103801A/en unknown
- 1989-01-19 FI FI890286A patent/FI93546C/en not_active IP Right Cessation
- 1989-01-19 CA CA000588614A patent/CA1339896C/en not_active Expired - Lifetime
- 1989-01-19 YU YU12389A patent/YU47791B/en unknown
- 1989-01-19 FR FR8900592A patent/FR2626002B1/en not_active Expired - Lifetime
- 1989-01-19 NO NO890253A patent/NO169123C/en not_active IP Right Cessation
- 1989-01-19 HU HU89210A patent/HU203755B/en unknown
- 1989-01-19 JP JP1008744A patent/JP2793825B2/en not_active Expired - Lifetime
- 1989-01-19 GB GB8901187A patent/GB2217320B/en not_active Expired - Lifetime
- 1989-01-19 PL PL89277261A patent/PL163814B1/en unknown
- 1989-01-20 AU AU28671/89A patent/AU626278B2/en not_active Expired
-
1992
- 1992-01-13 AU AU10180/92A patent/AU637015B2/en not_active Expired
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20090120 |