NO167734B - Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte aminderivater. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte aminderivater. Download PDFInfo
- Publication number
- NO167734B NO167734B NO880511A NO880511A NO167734B NO 167734 B NO167734 B NO 167734B NO 880511 A NO880511 A NO 880511A NO 880511 A NO880511 A NO 880511A NO 167734 B NO167734 B NO 167734B
- Authority
- NO
- Norway
- Prior art keywords
- denotes
- cross
- preparation
- atom
- hydrocarbon residue
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- 238000003466 welding Methods 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- 229910000617 Mangalloy Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
Substituerte aminoderivater representert ved formelen:. hvor Rog Rhver betegner en acyklisk hydrokarbonrest eller en allcyklisk hydrokarbonrest; Rog Rhver betegner hydrogen eller en hydrokarbonrest eventuelt Inneholdende hetero-atom(er); A betegner en karbonkjede som har to eller flere karbonatomer eventuelt inneholdende eterbinding eller sulfidbinding, som kan være substituert og som per se kan danne en ring; Xog X. hver betegner oksygenatom eller svovelatom; og Y betegner amlnogruppe eller en organisk rest bundet gjennom nitrogenatomet, som kan danne en ring ved kombinasjon med et karbonatom som utgjør A; og deres salter har anti-arytmisk aktivitet og er nyttige for hindring og behandling av en rekke forskjellige arytmier.Det er også beskrevet fremgangsmåter for fremstilling av de ovenfor omtalte substituerte aminoderivatene.
Description
Kryss-spiss.
Inntil nylig er kryss-spisser av stbpestål blitt utfort med en rullebane som ved hver av sine ender avsluttes med en jern-baneskinneprofil, spesielt av Vignol -typen. Disse ender kan være tilkoblet på vanlig måte, f.eks. ved hjelp av lasker, til Vignol-skinnene der disse lbper sammen med kryss-spissen.
Denne måte å avslutte kryss-spissens rullebaner på, byr
på fremstillingsvanskeligheter og medfbrer et stort antall sprekk-dannelser under drift. Dette bevirker igjen at materialet kon-stant må overvåkes for å påse at boltene hele tiden er godt til-dratt.
Por å unngå disse ulemper er i fransk patent nr, \ 431 034 beskrevet kryss-spisser hvor rullebanene avsluttes med en ror-formig del med en stottesåle under og utenfor rullebanenes ender, hvorpå de for tilkobling avsette Vignol-skinner og forbindelses-klemmer anordnes for å holde disse på linje. Vignol-skinnene sveises til stbttesålen og til forbindelsesklemmene, og deres ender butter mot rullebanenes ender som er slik utformet at hjul-ene til de skinnegående kjoretoyer som passerer kryss-spissen får samme stbtte- og styringsunderlag som ved bruk av Vignol-skinner.
Denne lbsning kan imidlertid forbedres, og ved foreliggende oppfinnelse er det unbdvendig å anvende forbindelsesklemmene.
Ved foreliggende oppfinnelse tilveiebringes derfor,en kryss-spiss av 8tbpestål hvis rullebaner avsluttes med en rbrformig del hvor hver av kryss-spissens ender omfatter en stottesåle, og opp-finnelsen er særpreget ved at den rbrformige del er avskåret slik at det fåes et rom under den bvrige rbrformige del og over stbttesålen, og ved at stbttesålen er forsynt med stbtteflater og styreflater som muliggjbr anbringelse av koblingsstykker fullstendig på linje med rullebanenes rbrformige ender mellom disse og Vignol-skinnene og sammensveising av koblingsstykkene til disse.
Koblingsstykkene kan være utfort som beskrevet i fransk patent nr. 1 432 640.
Tegningen viser et eksempel på en av kryss-spissens to ender ifblge foreliggende oppfinnelse.
Fig. 1 viser et horisontalt snitt,
fig. 2 et vertikalsnitt langs linjen II - II på fig. 1, og fig. 3, 4 og 5 tverrsnitt langs henholdsvis linjene III-
III, IV - IV og V - V på fig. 1.
Kryss-spissen 1 omfatter en stottesåle 2 med stbtteflater
3 og styreflater 4 som bare i meget liten grad stikker opp over stbttesålens 2 ovre overflate. Kryss-spissens rullebaner 5 avsluttes av rbrformige deler 6 begrenset ved sine ender av en vertikal del 7 hvis utvendige profil tilsvarer profilen til en rbrformig jernbaneskinnes overflate, og de rbrformige deler 6
er avskåret slik at det fåes et fritt rom 8 mellom de rbrformige avskårede deler 6 og stbttesålen 2.
Ved forlengelsen av hver av rullebanene 5 a og 5 b kan to koblingsstykker 90- og 9b av stbpestål være anbragt og festet, hvor-ved koblingsstykkene har en rbrformig del 10 mot kryss-spissen og et Vignol-skinneprofil 11 mot skinnene,og koblingsstykkene er anbragt over en lengde tilstrekkelig til at de kan fastsveises. An-bringelsen av koblingsstykkene 9a og 9b avstedkommes ved hjelp av styreflater 4 og deres hoyde bestemmes ved hjelp av stbtteflåtene 3 og flatene 3a og ved hjelp av tverrplasserte strekkanordninger utenfor kryss-spissen.
Koblingsstykkene sveises ved 12 til kryss-spissen med mangan-stål ved rullebanenes ender 6 og ved 13 til styreflatene 4.
Claims (1)
- Kryss-spiss av stopestål hvis rullebaner avsluttes av en rbrformig del og hvor hver av kryss-spissens ender omfatter en stottesåle, karakterisert ved at den rbrformige del (6) er avskåret slik at det fåes et rom (8) under den bvrige rbrformige del og over stbttesålen (2), og ved at stbttesålen (2) er forsynt med stbtteflater (3) og styreflater (4) som muliggjbr anbringesle og fastsveising av koblingsstykker (9a og 9b) fullstendig på linje med rullebanenes (5a og 5b) rbrformige ender mellom kryss-spissens rbrformige del.(6) og Vignol-skinnene.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2681687 | 1987-02-06 | ||
| JP32251087 | 1987-12-18 | ||
| JP62331568A JPH0761992B2 (ja) | 1987-02-06 | 1987-12-25 | 置換アミン誘導体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO880511D0 NO880511D0 (no) | 1988-02-05 |
| NO880511L NO880511L (no) | 1988-08-08 |
| NO167734B true NO167734B (no) | 1991-08-26 |
| NO167734C NO167734C (no) | 1991-12-04 |
Family
ID=27285549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO880511A NO167734C (no) | 1987-02-06 | 1988-02-05 | Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte aminderivater. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4987130A (no) |
| EP (1) | EP0278621B1 (no) |
| JP (1) | JPH0761992B2 (no) |
| AU (1) | AU607180B2 (no) |
| CA (1) | CA1327969C (no) |
| DE (1) | DE3863191D1 (no) |
| DK (1) | DK45188A (no) |
| ES (1) | ES2029879T3 (no) |
| FI (1) | FI89907C (no) |
| GR (1) | GR3002298T3 (no) |
| HU (1) | HU201907B (no) |
| IL (1) | IL85183A0 (no) |
| NO (1) | NO167734C (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075099A (en) * | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5244915A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | Amico acid derivatives cyclized at the c-terminal |
| EP0474411A1 (en) * | 1990-09-03 | 1992-03-11 | Takeda Chemical Industries, Ltd. | Production of diethanolamine derivatives and their intermediates |
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| EP1137628A1 (en) * | 1998-12-09 | 2001-10-04 | La Jolla Pharmaceutical Company | Molecular scaffolds acting as templates comprising carbamate linkages |
| US6472533B1 (en) | 1999-04-08 | 2002-10-29 | The Texas A & M University System | Ligands for chiral catalysis |
| GB9907895D0 (en) * | 1999-04-08 | 1999-06-02 | Texas A & M Univ Sys | Novel ligands for chiral catalysis |
| CA2414076A1 (en) * | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| JP4882146B2 (ja) * | 2000-11-09 | 2012-02-22 | Ｊｎｃ株式会社 | イミド化合物、これを含有する樹脂組成物、液晶配向膜、液晶組成物および液晶表示素子 |
| CN113773229B (zh) * | 2021-09-03 | 2022-10-25 | 西安交通大学 | α,β-不饱和氨基酸衍生物及其DL-硒-甲基硒代氨基酸衍生物、合成方法和应用 |
| WO2024158042A1 (ja) * | 2023-01-27 | 2024-08-02 | 富士フイルム株式会社 | 化合物またはその塩、脂質組成物、医薬組成物および送達キャリア |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE949947C (de) * | 1953-03-04 | 1956-09-27 | Hoechst Ag | Verfahren zur Herstellung von basischen Bis-N-phenylurethanen |
| CH361567A (fr) * | 1959-06-11 | 1962-04-30 | Carter Prod Inc | Procédé de préparation de dicarbamates |
| US3285960A (en) * | 1964-01-14 | 1966-11-15 | Cutter Lab | 4, 4-diphenylcyclohexylamine derivatives |
| CH496675A (fr) * | 1968-10-29 | 1970-09-30 | Lepetit Spa | Procédé de préparation de dérivés d'acide carbamique |
| GB1369247A (en) * | 1970-08-07 | 1974-10-02 | Pfizer | Amines the preparation thereof and their use in pharmaceutical compositions |
| NZ215753A (en) * | 1985-04-16 | 1989-10-27 | Hoffmann La Roche | Phenethanolamine derivatives and pharmaceutical compositions |
-
1987
- 1987-12-25 JP JP62331568A patent/JPH0761992B2/ja not_active Expired - Fee Related
-
1988
- 1988-01-25 IL IL85183A patent/IL85183A0/xx unknown
- 1988-01-26 EP EP19880300596 patent/EP0278621B1/en not_active Expired - Lifetime
- 1988-01-26 DE DE8888300596T patent/DE3863191D1/de not_active Expired - Fee Related
- 1988-01-26 ES ES198888300596T patent/ES2029879T3/es not_active Expired - Lifetime
- 1988-01-29 DK DK045188A patent/DK45188A/da not_active Application Discontinuation
- 1988-02-03 CA CA000558088A patent/CA1327969C/en not_active Expired - Fee Related
- 1988-02-05 FI FI880525A patent/FI89907C/fi not_active IP Right Cessation
- 1988-02-05 NO NO880511A patent/NO167734C/no unknown
- 1988-02-05 AU AU11360/88A patent/AU607180B2/en not_active Ceased
- 1988-02-05 HU HU88544A patent/HU201907B/hu unknown
-
1989
- 1989-12-22 US US07/453,346 patent/US4987130A/en not_active Expired - Fee Related
-
1991
- 1991-07-11 GR GR91400995T patent/GR3002298T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL85183A0 (en) | 1988-07-31 |
| DK45188A (da) | 1988-08-07 |
| HU201907B (en) | 1991-01-28 |
| GR3002298T3 (en) | 1992-12-30 |
| EP0278621A1 (en) | 1988-08-17 |
| DK45188D0 (da) | 1988-01-29 |
| AU607180B2 (en) | 1991-02-28 |
| CA1327969C (en) | 1994-03-22 |
| JPH0761992B2 (ja) | 1995-07-05 |
| AU1136088A (en) | 1988-08-11 |
| HUT45968A (en) | 1988-09-28 |
| JPH0222259A (ja) | 1990-01-25 |
| NO880511L (no) | 1988-08-08 |
| FI89907B (fi) | 1993-08-31 |
| FI89907C (fi) | 1993-12-10 |
| FI880525A0 (fi) | 1988-02-05 |
| US4987130A (en) | 1991-01-22 |
| EP0278621B1 (en) | 1991-06-12 |
| FI880525A (fi) | 1988-08-07 |
| DE3863191D1 (de) | 1991-07-18 |
| NO167734C (no) | 1991-12-04 |
| NO880511D0 (no) | 1988-02-05 |
| ES2029879T3 (es) | 1992-10-01 |
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