NO167337B - Fremgangsmaate og utstyr for bestemmelse av en analytt valgt fra et antibiotikum i vancomycinklassen. - Google Patents
Fremgangsmaate og utstyr for bestemmelse av en analytt valgt fra et antibiotikum i vancomycinklassen. Download PDFInfo
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- NO167337B NO167337B NO853432A NO853432A NO167337B NO 167337 B NO167337 B NO 167337B NO 853432 A NO853432 A NO 853432A NO 853432 A NO853432 A NO 853432A NO 167337 B NO167337 B NO 167337B
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- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 9
- -1 chloroformate ester Chemical class 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 239000012024 dehydrating agents Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000007858 starting material Substances 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 238000007363 ring formation reaction Methods 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 108010056243 alanylalanine Proteins 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 13
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002585 base Substances 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WIHSDUPAYPXRSA-UHFFFAOYSA-N 3-(3,3-dimethyl-1-phenyl-2h-inden-1-yl)-n-methylpropan-1-amine Chemical compound C1C(C)(C)C2=CC=CC=C2C1(CCCNC)C1=CC=CC=C1 WIHSDUPAYPXRSA-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920000137 polyphosphoric acid Polymers 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
- AVGQTJUPLKNPQP-UHFFFAOYSA-N 1,1,1-trichloropropane Chemical compound CCC(Cl)(Cl)Cl AVGQTJUPLKNPQP-UHFFFAOYSA-N 0.000 description 1
- RRHNMFYHZDMVFN-UHFFFAOYSA-N 3-(3,3-dimethyl-1-phenyl-2h-inden-1-yl)-n,n-dimethylpropan-1-amine Chemical compound C1C(C)(C)C2=CC=CC=C2C1(CCCN(C)C)C1=CC=CC=C1 RRHNMFYHZDMVFN-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- BXKYFONHSSFLKR-UHFFFAOYSA-M [Cl-].[Mg+]CC(C)(C)C1=CC=CC=C1 Chemical compound [Cl-].[Mg+]CC(C)(C)C1=CC=CC=C1 BXKYFONHSSFLKR-UHFFFAOYSA-M 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000004103 aminoalkyl group Chemical group 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000000891 anti-reserpine Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 150000002468 indanes Chemical class 0.000 description 1
- 150000002469 indenes Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- NGPAITITALWALP-UHFFFAOYSA-M magnesium;n,n-dimethylpropan-1-amine;chloride Chemical compound [Mg+2].[Cl-].CN(C)CC[CH2-] NGPAITITALWALP-UHFFFAOYSA-M 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- KAQPNQMPHIRKJJ-UHFFFAOYSA-N n,n-dimethyl-2-(1-phenylinden-1-yl)ethanamine Chemical compound C1=CC2=CC=CC=C2C1(CCN(C)C)C1=CC=CC=C1 KAQPNQMPHIRKJJ-UHFFFAOYSA-N 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9446—Antibacterials
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Plant Substances (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Description
Fremgangsmåter for fremstilling av terapeutisk virksomme aminoalkylsubstituerte indaner..
Nærværende oppfinnelse vedrorer fremgangsmåter for fremstilling av terapeutisk virksomme forbindelser med den generelle formel I:
12
hvor R og R begge betegner alkylgrupper med
1-4 karbonatomer,
såvel som ikke-giftige syreaddisjonssalter derav..
Forbindelsene med formel I og deres syreaddisjonssalter er anvendelige som terapeutika bg er i besittelse av verdifulle farmakodynamiske egenskaper. Ved dyie forsok viser forbindelsene en meget utpreget potensierehde effekt på adrenalin bg noradrenalin og også en meget sterk anti-reserpin virkning.
De har dessuten relativt svak sedativ og anti-cholinergisk effekt. Disse effekter kombinert med en relativt lav giftighet gjor forbindelsene med formel I såvel som deres syreaddisjonssalter meget anvendelige ved behandling innen psykoterapien, særlig endogene depresjoner.
En omtale av de farmakologiske egenskaper for 3,3-dimetyl-l-(3'-metylaminopropyl)-1-fenylindan som fremstilles ifolge nærværende oppfinnelse, er gitt i Acta pharmacol. et toxicol. 1966, 24, 121-133. Det vises her spesielt til tabell 2, hvorav det fremgår at nevnte forbindelse ved forsok utfort med mus har utvist en reserpinantagonisme som er klart bedre enn de fra belgisk patent nr. 667.739 kjente indenderivater l-(2-metyl-aminoetyl)-1-fenylinden og 1-(2-dimetylaminoetyl)-1-fenylin-den.
3,3-dimetyl-l-(3'-metylaminopropyl)-l-fenylindan er foretruk-ket fordi den er den mest aktive av forbindelsene av formel
(I) • Ifolge fremgangsmåtene ifolge oppfinnelsen omsettes en for-' bindslse med formal II
1 2
hvor R og R er som foran definert,
med et sterkt dehydratiserends middel med evne til å forårsake ringdannelse, eller en forbindelse med formel
1 2
hvor R og R er som foran definert,
omsettes med en klormaursyreester med formel C1„C00R , hvor R betegner en lavere alkylgruppe aller en benzylgruppe, og den resulterende forbindelse med formel
hydrolyseres,
"hvoretter forbindelsen av formel (I) isoleres som det frie amin eller i form av et ikke-giftig syreaddisjons-salt.
Som dehydratiserende midler som kan forårsake ringslutning
kan nevnes polyfosforsyrer, fosforoksyhalogenider, slik som kloridet eller bromidet, fosforpentoksyd, konsentrert svovelsyre eller lignende, og det er spesielt fordelaktig å anvende polyfosforsyrer som dehydratiserende middel.
Utgangsforbindelsene med formel II som er hittil -ukjente kan hensiktsmessig fremstilles ved å omsette en forbindelse med den generelle formel:
med en Grignard-forbindelse haloMg.CH20CH2.CH2.NH.CH2 og hydrolysere og isolere på vanlig måte.
Syreaddisjonssaltene av de nye forbindelser med formel I er fortrinnsvis salter av farmakologisk aksepterbare ikke-giftige syrer, slik som mineralsyrene saltsyre, hydrogenbromid, fosfor-syre, svovelsyre og lignende, og organiske syrer slik som eddiksyre, vinsyre, maleinsyre, sitronsyre, metansulfonsyre og lignende.
Ds folgende eksempler illustrerer fremgangsmåtene ifolge oppfinnelsen, og fremstilling av forbindelsene av formel II.
EKSEMPEL 1
3,3-dimetyl-l-(3<1->metylaminopropyl)-1-fenylindan og dets hydroklorid 11 g 7- metylamino-2-matyl-2,4-difenyl-heptan-4-ol ble opplost under kraftig omroring i 50 g polyfosforsyre, som resulterte i betraktelig utvikling av varme. Reaksjonsblandingen fikk stå i en halv time, hvoretter finknust is ble tilsatt.
Blandingen ble gjort alkalisk med konsentrert vandig natrium-hydroksydopplosning og ekstrahert med ster. Eterlaget ble skilt fra, torket over vannfritt kaliumkarbonat, behandlet med aktivt kull, hvorpå hydrokloridet av 3,3-dimetyl-l-(31 - metylaminopropyl)-1-fenylindan ble felt ut ved tilsetning av en opplosning av tort hydrogenklorid i eter. Utbytte 7 g. Smeltepunkt etter omkrystallisasjon fra etanol/aceton 150-155°C.
Utgangsforbindelsen, 7-metylamino-2-mstyl-2,4-difenyl-heptan-4-ol ble fremstilt på folgende måte: 31 g f eayl-(l-f enyl-1, l-dimetyl-etyl)-keton (0,13 mol), fremstilt fra 1-fenyl-1,1-dimetyletyl-magnesiumklorid og benzonitril med påfolgende hydrolyse,ble tilsatt til et overskudd (ca. 0,25 mol) av 3-dimetylaminopropylmagnesiumklorid i tetrahydrofuran. Grignard-komplekset som oppnås ved reaksjonen ble hydrolysert
med fortynnet eddiksyre, og basen frigjores ved tilsetning av fortynnet vandig alkali inntil basisk reaksjon» Basen ble ekstrahert med eter, eteren torket over vannfritt kaliumkarbonat, og hydrokloridet av 7-dimetylamino-2-metyl-2,4-difenylheptan-4-ol ble felt ut ved tilsetning av en opplosning av tort hydrogenklorid i eter„ Etter omkrystallisasjon fra aceton smeltet hydrokloridet ved 177-178°C0 Utbytte 42 g„ Fra den frie base fremstilles på kjent måte ved demetylering med etylklorforrniat 17 g 7-metylamino-2-metyl-2,4-difenyl-heptan-4-ol som en gullig olje»
EKSEMPEL 2
3,3-dimetyl-l-(3<1->metylaminopropyl)-1-fenylindan og dets hydroklorid.
11 g av hydrokloridet av 3,3-dimetyl-l-(3'-dimetylaminopropyl)-1-fenylindan ble omdannet til den frie base ved opplosning i vann, tilsetning av natriumhydroksyd og ekstrahering av den frigjorte base med benzen og.torking av benzenopplosningen over vannfritt kaliumkarbonat0 Derpå ble 20 g tort etylklor-
formiat tilsatt og blandingen ble holdt ved 4o°C i en time. Benzenopplosningen ble deretter ekstrahert med vann, fortynnet
saltsyre og natrium-hydrogenkarbonatopplosning, torket og fordampet. Resten ble forsåpet med en blanding av 7 g kaliumhydroksyd, 7 ml vann og 50 ml dietylenglykol-mono-etyl-
eter under tilbakelop i 20 timer. Reaksjonsblandingen ble derpå fortynnet med vann, og basen ekstrahert med eterc Ved tilsetning av fortynnet saltsyre til eterfasen ble hydro-
kloridet av 3, 3-dimetyl-l-(3-metylaminopropyl)-1-fenyl-indan oppnådd som fargeldsa krystaller, som etter torking og omkry-
stallisasjon fra aceton smeltet ved 150-155°C. Utbytte 4 g.
Claims (2)
1. Fremgangsmåter for fremstilling av terapeutisk virksomme forbindelser med den generelle formel I
hvor R 1 og R" ? begge betegner alkylgrupper med 1-4 karbonatomer,
såvel som ikke-giftige syreaddisjonssalter derav, karakterisert ved at
en forbindelse med formel II 1 2 hvor R og R er som foran definert,
omsettes med et sterkt dehydratiserende middel med evne til å forårsake ringdannelse eller at
en forbindelse med formel 1 2
hvor R og R er som foran definert, omsettes med en klormaursyreester med formel C1.C00R , hvor R betegner en lavere alkylgruppe eller en benzylgruppe, og den resulterende forbindelse med formel hydrolyseres, hvoretter forbindelsen av ,formel (I) isoleres som det fris amin eller i form av et ikke-giftig syreaddisjons-salt.
2. Fremgangsmåteretter krav 1, karakterisert ved at det som utgangsmaterialer anvendes forbindelser 1 2 nvor R og R er metylgrupper.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848427436A GB8427436D0 (en) | 1984-10-30 | 1984-10-30 | Receptor assay |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO853432L NO853432L (no) | 1986-05-02 |
| NO167337B true NO167337B (no) | 1991-07-15 |
| NO167337C NO167337C (no) | 1991-10-23 |
Family
ID=10568983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO853432A NO167337C (no) | 1984-10-30 | 1985-08-30 | Fremgangsmaate og utstyr for bestemmelse av en analytt valgt fra et antibiotikum i vancomycinklassen. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0184615B1 (no) |
| JP (1) | JPS61108966A (no) |
| KR (1) | KR860003346A (no) |
| CN (1) | CN85106820A (no) |
| AT (1) | ATE45042T1 (no) |
| AU (1) | AU588825B2 (no) |
| CA (1) | CA1250211A (no) |
| DE (1) | DE3571880D1 (no) |
| DK (1) | DK161916C (no) |
| ES (1) | ES8703933A1 (no) |
| FI (1) | FI81207C (no) |
| GB (1) | GB8427436D0 (no) |
| GR (1) | GR851923B (no) |
| HU (1) | HU194408B (no) |
| IL (1) | IL76186A0 (no) |
| NO (1) | NO167337C (no) |
| NZ (1) | NZ213124A (no) |
| PT (1) | PT81034B (no) |
| ZA (1) | ZA856104B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8522388D0 (en) * | 1985-09-10 | 1985-10-16 | Lepetit Spa | Receptor-antibody sandwich assay |
| EP2490029A1 (en) * | 2011-02-16 | 2012-08-22 | Université Catholique De Louvain | Vancomycin analysis |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230685A (en) * | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
| US4425438A (en) * | 1981-03-13 | 1984-01-10 | Bauman David S | Assay method and device |
| JPS587279A (ja) * | 1981-07-03 | 1983-01-17 | 松下電工株式会社 | 電気かみそりの内刃 |
| US4390343A (en) * | 1981-07-06 | 1983-06-28 | Miles Laboratories, Inc. | Multilayer analytical element having an impermeable radiation diffusing and blocking layer |
| US4606855A (en) * | 1982-07-26 | 1986-08-19 | Mex Research Associates C/O Leon Reimer | Monoclonal antibody to digoxin |
| DE3485839T2 (de) * | 1983-03-17 | 1993-03-04 | Biowhittaker Inc | Fluorometrische pruefung des gesamten ige niveaus und reagens dafuer. |
| GB8311136D0 (en) * | 1983-04-25 | 1983-06-02 | Lepetit Spa | Immobilised oligopeptides |
| US4667024A (en) * | 1983-07-13 | 1987-05-19 | Smithkline Beckman Corporation | Process for the preparation of purified vancomycin class antibiotics |
| GB8423227D0 (en) * | 1984-09-14 | 1984-10-17 | Unilever Plc | Materials for specific binding assays |
-
1984
- 1984-10-30 GB GB848427436A patent/GB8427436D0/en active Pending
-
1985
- 1985-08-06 DK DK356685A patent/DK161916C/da not_active IP Right Cessation
- 1985-08-06 GR GR851923A patent/GR851923B/el unknown
- 1985-08-12 CN CN198585106820A patent/CN85106820A/zh active Pending
- 1985-08-13 ZA ZA856104A patent/ZA856104B/xx unknown
- 1985-08-16 NZ NZ213124A patent/NZ213124A/xx unknown
- 1985-08-19 CA CA000489000A patent/CA1250211A/en not_active Expired
- 1985-08-23 DE DE8585110627T patent/DE3571880D1/de not_active Expired
- 1985-08-23 AT AT85110627T patent/ATE45042T1/de not_active IP Right Cessation
- 1985-08-23 EP EP85110627A patent/EP0184615B1/en not_active Expired
- 1985-08-26 IL IL76186A patent/IL76186A0/xx not_active IP Right Cessation
- 1985-08-27 PT PT81034A patent/PT81034B/pt not_active IP Right Cessation
- 1985-08-28 JP JP60187532A patent/JPS61108966A/ja active Pending
- 1985-08-29 HU HU853293A patent/HU194408B/hu not_active IP Right Cessation
- 1985-08-30 FI FI853350A patent/FI81207C/fi not_active IP Right Cessation
- 1985-08-30 NO NO853432A patent/NO167337C/no unknown
- 1985-08-30 KR KR1019850006301A patent/KR860003346A/ko not_active Application Discontinuation
- 1985-08-30 ES ES546591A patent/ES8703933A1/es not_active Expired
- 1985-08-30 AU AU46905/85A patent/AU588825B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE3571880D1 (en) | 1989-08-31 |
| CN85106820A (zh) | 1987-02-11 |
| NO167337C (no) | 1991-10-23 |
| ATE45042T1 (de) | 1989-08-15 |
| PT81034A (en) | 1985-09-01 |
| KR860003346A (ko) | 1986-05-23 |
| NZ213124A (en) | 1989-03-29 |
| NO853432L (no) | 1986-05-02 |
| HU194408B (en) | 1988-01-28 |
| EP0184615A1 (en) | 1986-06-18 |
| ES546591A0 (es) | 1987-03-01 |
| DK161916B (da) | 1991-08-26 |
| JPS61108966A (ja) | 1986-05-27 |
| ES8703933A1 (es) | 1987-03-01 |
| FI81207B (fi) | 1990-05-31 |
| DK356685D0 (da) | 1985-08-06 |
| GR851923B (no) | 1985-12-06 |
| DK356685A (da) | 1986-05-01 |
| FI853350A0 (fi) | 1985-08-30 |
| CA1250211A (en) | 1989-02-21 |
| FI81207C (fi) | 1990-09-10 |
| PT81034B (pt) | 1987-09-18 |
| GB8427436D0 (en) | 1984-12-05 |
| EP0184615B1 (en) | 1989-07-26 |
| AU4690585A (en) | 1986-05-08 |
| FI853350L (fi) | 1986-05-01 |
| DK161916C (da) | 1992-03-16 |
| ZA856104B (en) | 1986-06-25 |
| HUT38439A (en) | 1986-05-28 |
| IL76186A0 (en) | 1985-12-31 |
| AU588825B2 (en) | 1989-09-28 |
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