NO166869B - Fremgangsmaate for dannelse av et forbedret, hydrofilt belegg paa en polymeroverflate og anvendelse av fremgangsmaaten. - Google Patents
Fremgangsmaate for dannelse av et forbedret, hydrofilt belegg paa en polymeroverflate og anvendelse av fremgangsmaaten. Download PDFInfo
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- NO166869B NO166869B NO863872A NO863872A NO166869B NO 166869 B NO166869 B NO 166869B NO 863872 A NO863872 A NO 863872A NO 863872 A NO863872 A NO 863872A NO 166869 B NO166869 B NO 166869B
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- solution
- osmolality
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- hydrophilic
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- 229920000642 polymer Polymers 0.000 title claims abstract description 22
- 238000000576 coating method Methods 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000011248 coating agent Substances 0.000 title claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000002344 surface layer Substances 0.000 claims abstract description 19
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 17
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims abstract description 15
- 239000011780 sodium chloride Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 9
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 8
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 5
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 4
- 239000001110 calcium chloride Substances 0.000 claims abstract description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 4
- 239000008103 glucose Substances 0.000 claims abstract description 4
- 239000001103 potassium chloride Substances 0.000 claims abstract description 4
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 4
- 239000004323 potassium nitrate Substances 0.000 claims abstract description 4
- 235000010333 potassium nitrate Nutrition 0.000 claims abstract description 4
- 239000001509 sodium citrate Substances 0.000 claims abstract description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 3
- 239000000600 sorbitol Substances 0.000 claims abstract description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 230000002485 urinary effect Effects 0.000 claims description 3
- 150000002016 disaccharides Chemical class 0.000 claims description 2
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 230000005660 hydrophilic surface Effects 0.000 abstract description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 235000007715 potassium iodide Nutrition 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012973 diazabicyclooctane Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Laminated Bodies (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
- Physical Water Treatments (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Vehicle Body Suspensions (AREA)
Description
Foreliggende oppfinnelse vedrører en fremgangsmåte for belegging av et hydrofilt polymeroverflatelag med en osmo-lalitetsforøkende forbindelse for dannelse av en mer stabil hydrofil overflate, samt medisinske gjenstander som er belagt med nevnte forbedrede hydrofile belegg, samt anvendelse av f remgangsmåten.
Et hydrofilt belegg har en mye lavere friksjonskoeffisient i våt tilstand enn i tørr tilstand. Således har dannelsen av hydrofile belegg på substrater mange anvendelser, men er spesielt ønskelig i mange biomedisinske anvendelser. Slike biomedisinske anvendelser er f.eks. sårdreneringer, katetere, kirurgiske verktøy og andre medisinske instrumenter som skal innføres i kroppshulrom fordi instrumentet gir et godt hånd-grep i tørr tilstand mens det samtidig blir meget glatt når det kommer i kontakt med vannbaserte væsker, og kan således lett innføres uten å forårsake vanskeligheter for pasienten. Videre, en gjenstand som har et hydrofilt overflatebelegg, er ønskelig for å minimalisere trombose, krystalldannelse, vevstrauma, vevsadhesjon til medisinske instrumenter og frem-mede kroppsreaksjoner. I tidligere kjente metoder har overflater blitt gjort hydrofile ved slike metoder som høyenergi-bestråling i in situ polymerisasjonsprosesser, ved podning, ved dannelse av interpolymer-nettverk eller ved direkte kjemisk binding, f.eks. med isocyanater eller silaner. Slike polymeroverflater for medisinsk bruk er beskrevet f.eks. i GB1.600.963, US 4.373.009, US 4.459.317, WO 83/03977 og EP patent 93.093. Omfattende studier viser imidlertid at det hydrofile belegget kan tørke ut og således gjøre gjenstanden utilstrekkelig hydrofil.
Formålet med foreliggende oppfinnelse er å fremstille et forbedret hydrofilt belegg på et allerede hydrofilt polymer-overf latelag på et substrat. Dette formål har overraskende blitt oppnådd ved påføring av en oppløsning av en osmo-lalitetsforøkende forbindelse på et ikke-reaktivt hydrofilt polymeroverflatelag og deretter fordamping av oppløsnings-mlddelet 1 oppløsningen.
Under eksperimentering med hydrofile polymerbelegg på forskjellige substrater fant man at når en gjenstand belagt med et hydrofilt polymeroverflatelag dyppes i vann, vil den bli godt fuktet, men det er en stor risiko for at polymeroverflaten taper sitt vann når den kommer i kontakt med en slimhinne eller lignende. Dette avhenger av forskjellen i det osmotiske potensial mellom den hydrofile overflaten og slimhinnen. Slimhinnen har et høyere osmotisk potensial, dvs. en høyere saltkonsentrasjon enn den hydrofile overflaten, hvilket resulterer i at vannet går fra det hydrofile overflatelaget til slimhinnen slik at forskjellen i salt-konsentrasjonen vil bli oppveiet.
I foreliggende sammenheng er det overraskende funnet mulig ytterligere å redusere den lave friksjonen til den hydrofile overflaten og samtidig å forøke osmolaliteten til den hydrofile overflaten ved påføring av et belegg av en osmolalitetsforøkende forbindelse på det hydrofile polymer-overf latelaget .
Ifølge foreliggende oppfinnelse er det således tilveiebragt en fremgangsmåte for dannelse av et forbedret, hydrofilt belegg for å bibeholde glattheten i lengre tid på et substrat, hvorved
(a) et ikke-reaktivt overflatelag av hydrofil polymer
påføres på substratet,
(b) det på det ikke-reaktive overflatelag av hydrofil polymer påføres en oppløsning omfattende et opp-løsningsmiddel eventuelt inneholdende en polymer, fortrinnsvis den samme polymeren som i polymer-overf latelaget , og
(c) oppløsningsmiddelet inndampes,
og denne fremgangsmåten er kjennetegnet ved at oppløsningen omfattende et oppløsningsmiddel også omfatter over 296 (vekt pr. volum) av en osmolalitetsforøkende forbindelse valgt fra gruppen bestående av mono- og disakkarider, sukkeralkoholer, og ikke-toksiske organiske og uorganiske salter, forutsatt at den osmolalitetsforøkende forbindelsen ikke er et trihalogenid slik som KI3 (KI/I2).
Eksempler på de osmolalitetsforøkende forbindelser er glukose, sorbitol, natriumklorid, natriumcitrat, natriumbenzoat, kalsiumklorid, kaliumklorid, kaliumiodid, kaliumnitrat. Den osmolalitetsforøkende forbindelsen må være ikke-tokslsk. Fremgangsmåten er funnet å være spesielt nyttig for natriumklorid. Den osmolalitetsforøkende forbindelsen kan blandes med en polymer og oppløses i vann eller en lavere alkohol, fortrinnsvis i vann, til en egnet viskositet. Nevnte oppløsning påføres på det hydrofile polymeroverflatelaget ved dypping, spraying eller lignende, og deretter for-dampes oppløsningsmiddelet ved lufttørking eller ved tørking med forhøyet temperatur. Den tilsatte polymer bør være godt forenlig med polymeren i polymeroverflatelaget, fortrinnsvis den samme polymeren. Polymeren er ikke et nødvendig additiv til oppløsningen, men den forøker viskositeten, og ved dette kan mottagelsen av den osmolalitetsforøkende forbindelsen reguleres. Videre har polymeren en smørende egenskap og en kontrollert frigjøringseffekt.
Foreliggende fremgangsmåte kan benyttes for belegging av mange forskjellige typer av velkjente hydrofile polymer-overf later, hvor den hydrofile polymeren er valgt fra polyvinylforbindelser, polysakkarider, polyuretaner, polyakrylater eller kopolymerer av vinylforbindelser og akrylater eller anhydrider. Spesielt kan nevnes polyetylenoksyd, poly-vinylpyrrolidon, heparin, dekstran, xantan, polyvinylalkohol, hydroksypropylcellulose, metylcellulose, kopolymer av vinyl-pyrrolidon og hydroksyetylmetylakrylat eller kopolymer av polymetylvinyleter og maleinsyreanhydrid. Den foretrukne hydrofile polymeren er polyvlnylpyrrolldon. Polymeroverflatelaget må være gjort ikke-reaktlvt, f.eks. ved herding.
Substratene kan være et hvilket som helst polymermateriale som det er velkjent å benytte og til hvilket nevnte hydrofile polymerer fester seg slik som polyuretaner, lateksgummier, andre gummier, polyvinylklorid, andre vinylpolymerer, poly-estere og polyakrylater.
Den hydrofile overflaten inneholder en vesentlig mengde av delvis fritt bevegbare polymerkjeder. Det har således blitt vist at noen belegg kan kompleks-binde en vesentlig mengde av elementært jod, som tilfellet f.eks. er med fritt polyvlnylpyrrolldon og jod når en hydrofil overflate av polyvlnylpyrrolldon behandles med en KI/l2~oppløsning. PVP-belagte katetere behandlet med en Kl/^-oppløsning har en mindre glatt overflate enn den tilsvarende ubehandlede overflate, og slike Kl3~behandlede katetere tørker hurtigere.
Ifølge oppfinnelsen anvendes foreliggende fremgangsmåte for belegging av katetere, og spesielt for belegging av urinkatetere.
Eksempel.
Et trimerisert heksametylendiisocyanat av biuret-typen (betegnet Desmodur L 2291; Bayer AG) ble oppløst i metylen-, klorid til en konsentrasjon på b% (vekt/volum). ET PVC-urinkateter ble dyppet i denne oppløsning i 30 sek. Kateteret ble deretter tørket ved 70°C i 60 sek. hvoretter det ble dyppet i 5 sek. i en oppløsning inneholdende inneholdende 33 g polyvlnylpyrrolldon (K25; midlere molekylvekt 25.000) pr. 100 ml metylenklorid. Denne oppløsning inneholdt også 0,33 g trietylendiamin (DABCO®) pr. 100 ml oppløsning. Kateteret fikk deretter tørke ved omgivelsestemperatur i 60 sek., deretter ble det herdet i 40 min. ved 70°C, avkjølt til omgivelsestemperatur og ble deretter skyld i vann. Et slikt kateter ble dyppet i en oppløsning inneholdende 20% (vekt/- volum) natriumklorid og 5$ polyvlnylpyrrolldon (PVP)
(vekt/volum) oppløst i vann i 1 time ved 20°C. Kateteret fikk deretter tørke ved 70°C i 8 timer. Kateteret har en meget glatt og adherende overflate i fuktig tilstand.
Forsøk
En rekke katetere i overensstemmelse med eksemplene ble dyppet i forskjellige oppløsninger omfattende osmolalitets-forøkende forbindelser i 10 min. , og ble deretter anbragt i vann i 30 sek. ved 23°C og en relativ fuktighet på 4996 og deretter tørket ved romtemperatur. Glattheten ble notert 1 min., 2 min., osv., etter allerede påbegynt tørking. Glatthetsverdien ble notert på en relativ skala, hvor 8 betyr en meget glatt overflate, og 0 betyr en tørr overflate.
Dette forsøk ble gjentatt med en rekke tilsvarende PVP-belagte katetere, men uten belegget av osmolalitetsforøkende forbindelse.
Keltrol® er en xantangummi; Kelco Co.
Resultat
Tabell 1 viser at kateterene som har et belegg av en ikke-toksisk osmolalitetsforøkende forbindelse, bibeholder deres glatthet i lengre tid enn de tilsvarende ubehandlede overflater, dvs. de belagte katerene tørkes langsommere. De osmolalitetsforøkende forbindelsene hindrer den hydrofile polymeroverflaten i å uttørke.
Kateteret som er påført en osmolalitetforøkende forbindelse slik som natriumklorid ifølge foreliggende oppfinnelse, tørker således langsommere enn tilsvarende ubehandlede katetere. Det natriumkloridbehandlede kateteret beholder sin glatthet i en meget lengre tidsperiode, hvilket er meget ønskelig.
Medisinske forsøk viser at kateterene som er påført et belegg av eh osmolalitetsforøkende forbindelse slik natriumklorid, er overlegne både ved innføringen og ved fjerningen av kateteret i urinrøret.
Claims (8)
1. Fremgangsmåte for dannelse av et forbedret, hydrofilt belegg for å bibeholde glattheten i lengre tid på et substrat, hvorved: (a) et ikke-reaktivt overflatelag av hydrofil polymer påføres på substratet, (b) det på det ikke-reaktive overflatelag av hydrofil polymer påføres en oppløsning omfattende et opp-løsningsmiddel eventuelt inneholdende en polymer, fortrinnsvis den samme polymeren som i polymer-overf latelaget, og (c) oppløsningsmiddelet inndampes, karakterisert ved at
oppløsningen omfattende et oppløsningsmiddel også omfatter over 2% (vekt pr. volum) av en osmolalitetsforøkende forbindelse valgt fra gruppen bestående av mono- og disakkarider, sukkeralkoholer, og ikke-toksiske organiske og uorganiske salter, forutsatt at den osmolalitetsforøkende forbindelsen ikke er et trihalogenid slik som KI3 (KI/I2).
2. Fremgangsmåte ifølge krav 1, karakterisert ved at den osmolalitetsforøkende forbindelsen i oppløsningen velges fra gruppen bestående av glukose, sorbitol, natriumklorid, natriumcitrat, natriumbenzoat, kalsiumklorid, kaliumklorid, kaliumiodid, eller kaliumnitrat.
3. Fremgangsmåte ifølge krav 2, karakterisert ved at forbindelsen i oppløsningen velges fra gruppen bestående av glukose, natriumklorid, natriumcitrat, natriumbenzoat, kalsiumklorid, kaliumklorid, kaliumiodid eller kaliumnitrat.
4. Fremgangsmåte ifølge krav 1-3, karakterisert ved at oppløsningen inneholder fra 4 til 40% (vekt/volum) av natriumklorid.
5. Fremgangsmåte ifølge krav 1, karakterisert ved at polymeroverflatelaget er herdet.
6. Fremgangsmåte ifølge krav 1, karakterisert ved at polymeroverflatelaget påføres polyvlnylpyrrolldon,' og at det foretas behandling med en oppløsning som inneholder ' 20% (vekt/volum) av natriumklorid.
7. Anvendelse av fremgangsmåten ifølge krav 1, for belegging av katetere.
8. Anvendelse av fremgangsmåten ifølge krav 7, for belegging av urinkatetere.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO904205A NO176236C (no) | 1985-09-30 | 1990-09-27 | Medisinsk gjenstand belagt med hydrofile belegg |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8504501A SE8504501D0 (sv) | 1985-09-30 | 1985-09-30 | Method of forming an improved hydrophilic coating on a polymer surface |
Publications (4)
Publication Number | Publication Date |
---|---|
NO863872D0 NO863872D0 (no) | 1986-09-29 |
NO863872L NO863872L (no) | 1987-03-31 |
NO166869B true NO166869B (no) | 1991-06-03 |
NO166869C NO166869C (no) | 1991-09-11 |
Family
ID=20361558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO863872A NO166869C (no) | 1985-09-30 | 1986-09-29 | Fremgangsmaate for dannelse av et forbedret, hydrofilt belegg paa en polymeroverflate og anvendelse av fremgangsmaaten. |
Country Status (14)
Country | Link |
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US (1) | US4906237A (no) |
EP (1) | EP0217771B1 (no) |
JP (1) | JPH0691898B2 (no) |
AT (1) | ATE70075T1 (no) |
AU (1) | AU591703B2 (no) |
CA (1) | CA1292649C (no) |
DE (2) | DE217771T1 (no) |
DK (1) | DK169552B1 (no) |
ES (1) | ES2002009A6 (no) |
FI (1) | FI86070C (no) |
HK (1) | HK12995A (no) |
IE (1) | IE58507B1 (no) |
NO (1) | NO166869C (no) |
SE (1) | SE8504501D0 (no) |
Families Citing this family (194)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4798597A (en) * | 1987-04-29 | 1989-01-17 | Sherwood Medical Co | Flexible composite intubation tube |
KR900701332A (ko) * | 1988-08-09 | 1990-12-01 | 마에다 카쓰노스케 | 이활성의료재료 및 그 제조방법 |
US5091205A (en) * | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
ES2043289T3 (es) | 1989-09-25 | 1993-12-16 | Schneider Usa Inc | La extrusion de capas multiples como procedimiento para hacer balones de angioplastia. |
US5478320A (en) * | 1989-11-29 | 1995-12-26 | Cordis Corporation | Puncture resistant balloon catheter and method of manufacturing |
US5290306A (en) * | 1989-11-29 | 1994-03-01 | Cordis Corporation | Puncture resistant balloon catheter |
US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
US5441739A (en) * | 1990-06-22 | 1995-08-15 | The Regents Of The University Of California | Reduced and controlled surface binding of biologically active molecules |
US5295978A (en) * | 1990-12-28 | 1994-03-22 | Union Carbide Chemicals & Plastics Technology Corporation | Biocompatible hydrophilic complexes and process for preparation and use |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
CA2068584C (en) * | 1991-06-18 | 1997-04-22 | Paul H. Burmeister | Intravascular guide wire and method for manufacture thereof |
US5443907A (en) * | 1991-06-18 | 1995-08-22 | Scimed Life Systems, Inc. | Coating for medical insertion guides |
US5284157A (en) * | 1991-07-26 | 1994-02-08 | Ortho Pharmaceutical Corporation | Elastomeric film products with improved chemical resistance |
US5242428A (en) * | 1991-10-04 | 1993-09-07 | Aubrey Palestrant | Apparatus for wetting hydrophilic-coated guide wires and catheters |
WO1993011751A1 (en) * | 1991-12-18 | 1993-06-24 | Scimed Life Systems, Inc. | Lubricous polymer network |
DK172393B1 (da) * | 1992-06-10 | 1998-05-18 | Maersk Medical As | Fremgangsmåde til fremstilling af en genstand med friktionsnedsættende overfladebelægning, belægningsmateriale til anvendelse ved fremstilling af en sådan genstand samt anvendelse af en osmolalitetsforøgende forbindelse i opslæmmet eller emulgeret form i belægningsmaterialet |
DK7193B (da) * | 1993-01-21 | 1994-07-22 | Coloplast As | Fremgangsmåde til fremstilling af en hydrofil belægning på en overflade og medicinsk artikel fremstillet ved fremgangsmåden |
US6387080B1 (en) * | 1993-01-21 | 2002-05-14 | Colorplast A/S | Method of forming a hydrophilic surface coating on a medical device and a medical device prepared according to this method |
US5531715A (en) * | 1993-05-12 | 1996-07-02 | Target Therapeutics, Inc. | Lubricious catheters |
US5531716A (en) * | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
JP3577082B2 (ja) | 1993-10-01 | 2004-10-13 | ボストン・サイエンティフィック・コーポレーション | 熱可塑性エラストマーから成る医療装置用バルーン |
US6896842B1 (en) * | 1993-10-01 | 2005-05-24 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
US5718694A (en) * | 1993-11-09 | 1998-02-17 | The Board Of Regents Of The University Of Nebraska | Inhibition of adherence of microorganisms to biomaterial surfaces by treatment with carbohydrates |
US5505713A (en) * | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
US5545150A (en) * | 1994-05-06 | 1996-08-13 | Endoscopic Concepts, Inc. | Trocar |
CN1056117C (zh) * | 1994-08-30 | 2000-09-06 | 中国康复研究中心 | 高含水弹性体成型物的制备方法 |
US5558900A (en) * | 1994-09-22 | 1996-09-24 | Fan; You-Ling | One-step thromboresistant, lubricious coating |
SE9404486D0 (sv) * | 1994-12-22 | 1994-12-22 | Astra Ab | Catheter |
US5576072A (en) * | 1995-02-01 | 1996-11-19 | Schneider (Usa), Inc. | Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel |
DE69625799T2 (de) * | 1995-02-01 | 2003-10-23 | Schneider Usa Inc | Verfahren zur hydrophilisierung von hydrophoben polymeren |
US6017577A (en) * | 1995-02-01 | 2000-01-25 | Schneider (Usa) Inc. | Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices |
US5662960A (en) * | 1995-02-01 | 1997-09-02 | Schneider (Usa) Inc. | Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel |
US5919570A (en) * | 1995-02-01 | 1999-07-06 | Schneider Inc. | Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices |
DE69602729T3 (de) * | 1995-03-29 | 2007-10-31 | Coloplast A/S | Applikator und verfahren zur verwendung beim nichtverunreinigenden einführen eines medizinischen katheters |
US5731087A (en) * | 1995-06-07 | 1998-03-24 | Union Carbide Chemicals & Plastics Technology Corporation | Lubricious coatings containing polymers with vinyl and carboxylic acid moieties |
US5620738A (en) * | 1995-06-07 | 1997-04-15 | Union Carbide Chemicals & Plastics Technology Corporation | Non-reactive lubicious coating process |
SE9600276D0 (sv) * | 1996-01-25 | 1996-01-25 | Astra Ab | A wetting device for wetting a hydrophilic catheter and a urine collection bag incorporating said device |
SE9602529D0 (sv) * | 1996-06-26 | 1996-06-26 | Astra Ab | Medical device |
US6083230A (en) | 1997-07-30 | 2000-07-04 | Allergan | Method for making IOL insertion apparatus |
US6368356B1 (en) | 1996-07-11 | 2002-04-09 | Scimed Life Systems, Inc. | Medical devices comprising hydrogel polymers having improved mechanical properties |
US6060534A (en) | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
US5830217A (en) | 1996-08-09 | 1998-11-03 | Thomas J. Fogarty | Soluble fixation device and method for stent delivery catheters |
DK172941B1 (da) | 1996-09-18 | 1999-10-11 | Coloplast As | Urinkateterindretning |
US5800412A (en) * | 1996-10-10 | 1998-09-01 | Sts Biopolymers, Inc. | Hydrophilic coatings with hydrating agents |
WO1998019729A1 (en) * | 1996-11-01 | 1998-05-14 | Coloplast A/S | A urinary catheter assembly with a ready-to-use catheter |
US5997517A (en) * | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
ATE204594T1 (de) * | 1997-06-20 | 2001-09-15 | Coloplast As | Hydrophile beschichtung und verfahren zu ihrer herstellung |
US6110483A (en) * | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
SE9704712D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Medical device |
US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
US6338727B1 (en) * | 1998-08-13 | 2002-01-15 | Alsius Corporation | Indwelling heat exchange catheter and method of using same |
USD426635S (en) * | 1998-08-18 | 2000-06-13 | Genicon, Lc | Combination trocar, cannula, and valve |
US6986868B2 (en) | 1998-11-20 | 2006-01-17 | Coloplast A/S | Method for sterilizing a medical device having a hydrophilic coating |
WO2000030696A1 (en) * | 1998-11-20 | 2000-06-02 | Coloplast A/S | A method for sterilising a medical device having a hydrophilic coating |
SE9900465D0 (sv) * | 1999-02-12 | 1999-02-12 | Astra Ab | Storage package |
SE9903613D0 (sv) | 1999-10-06 | 1999-10-06 | Astra Ab | Rectal insertion device |
US7153319B1 (en) | 2000-01-26 | 2006-12-26 | Genico, Inc. | Trocar system having shielded trocar |
USD449887S1 (en) | 2000-01-26 | 2001-10-30 | Genicon Lc | Combined obturator, cannula and valve assembly |
USD443360S1 (en) | 2000-03-22 | 2001-06-05 | Dexterity Surgical Inc. | Distal end of obturator for a trocar |
US20020120333A1 (en) * | 2001-01-31 | 2002-08-29 | Keogh James R. | Method for coating medical device surfaces |
US6913765B2 (en) | 2001-03-21 | 2005-07-05 | Scimed Life Systems, Inc. | Controlling resorption of bioresorbable medical implant material |
US20050008839A1 (en) * | 2002-01-30 | 2005-01-13 | Cramer Ronald Dean | Method for hydrophilizing materials using hydrophilic polymeric materials with discrete charges |
DE10244847A1 (de) * | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
WO2004075944A2 (en) * | 2003-02-26 | 2004-09-10 | Coloplast A/S | A medical device having a coating comprising hydrogen peroxide and package therefore |
US20040220534A1 (en) * | 2003-04-29 | 2004-11-04 | Martens Paul W. | Medical device with antimicrobial layer |
WO2005014055A2 (en) | 2003-08-08 | 2005-02-17 | Hollister Incorporated | Vapor hydration in a hydrophilic catheter package |
WO2005033198A1 (en) * | 2003-10-07 | 2005-04-14 | Coloplast A/S | A composition useful as an adhesive and use of such a composition |
SE0303525D0 (sv) | 2003-12-22 | 2003-12-22 | Astra Tech Ab | Catheter assembly with osmolality-increasing |
US7842382B2 (en) * | 2004-03-11 | 2010-11-30 | Knauf Insulation Gmbh | Binder compositions and associated methods |
WO2005104845A1 (en) * | 2004-04-30 | 2005-11-10 | Coloplast A/S | A hydrophilic coating of a water-swellable hydrophilic matrix and an anti-microbial polymer |
US8566231B2 (en) * | 2004-06-17 | 2013-10-22 | Visa International Service Association | Method and system for providing buyer bank payable discounting aggregation services |
WO2006044302A1 (en) * | 2004-10-13 | 2006-04-27 | Knauf Insulation Gmbh | Polyester binding compositions |
US8864730B2 (en) | 2005-04-12 | 2014-10-21 | Rochester Medical Corporation | Silicone rubber male external catheter with absorbent and adhesive |
US8747882B2 (en) * | 2005-04-21 | 2014-06-10 | Astra Tech Ab | Catheter assembly with bactericidal effect |
DE602006012039D1 (de) | 2005-05-02 | 2010-03-18 | Coloplast As | Verfahren zur sterilisierung einer medizinischen vorrichtung mit hydrophiler beschichtung |
US7951182B2 (en) | 2005-07-14 | 2011-05-31 | Zoll Circulation, Inc. | System and method for leak detection in external cooling pad |
DK1745807T3 (da) | 2005-07-18 | 2012-11-26 | Dentsply Ih Ab | Urinvejskateter |
CN111138867B (zh) * | 2005-07-26 | 2022-06-21 | 可耐福保温材料有限公司 | 粘结剂和由其制备的材料 |
US20070078413A1 (en) * | 2005-08-25 | 2007-04-05 | Stenzel Eric B | Medical device having a lubricant |
US8328792B2 (en) | 2005-10-27 | 2012-12-11 | C. R. Bard, Inc. | Enhanced pre-wetted intermittent catheter with lubricious coating |
WO2007080387A2 (en) * | 2006-01-09 | 2007-07-19 | Polybiomed Limited | Hydrophilic coating method for medical devices |
AU2007209856B2 (en) | 2006-02-01 | 2013-06-13 | Hollister Incorporated | Methods of applying a hydrophilic coating to a substrate, and substrates having a hydrophilic coating |
ES2426272T3 (es) | 2006-06-08 | 2013-10-22 | Hollister Incorporated | Envase para producto de catéter |
EP2450493A3 (en) | 2007-01-25 | 2015-07-29 | Knauf Insulation SPRL | Mineral fibre board |
US20100084598A1 (en) * | 2007-01-25 | 2010-04-08 | Roger Jackson | Mineral fibre insulation |
EP2108006B8 (en) | 2007-01-25 | 2020-11-11 | Knauf Insulation GmbH | Binders and materials made therewith |
PL2126179T3 (pl) * | 2007-01-25 | 2015-02-27 | Knauf Insulation | Produkt będący izolacją z włókna mineralnego, wolny od formaldehydu |
CN101720341B (zh) | 2007-01-25 | 2013-06-12 | 克瑙夫绝缘私人有限公司 | 复合木板 |
US8552140B2 (en) | 2007-04-13 | 2013-10-08 | Knauf Insulation Gmbh | Composite maillard-resole binders |
CA2692489A1 (en) * | 2007-07-05 | 2009-01-08 | Knauf Insulation Gmbh | Hydroxymonocarboxylic acid-based maillard binder |
GB0715100D0 (en) | 2007-08-03 | 2007-09-12 | Knauf Insulation Ltd | Binders |
DK2060296T3 (en) | 2007-11-19 | 2016-12-05 | Hollister Inc | Damphydratiseret catheter assembly and method for production thereof |
MX2010007325A (es) * | 2008-01-04 | 2012-12-06 | Bard Inc C R | Cateter de foley de poliisopreno sintetico. |
ES2373930T3 (es) | 2008-04-17 | 2012-02-10 | Astra Tech Ab | Dispositivo médico mejorado con revestimiento hidrofílico. |
AU2009267626A1 (en) | 2008-06-16 | 2010-01-14 | Coloplast A/S | Buffered swelling media for radiation sterilized hydrophilic coatings |
JP2011526814A (ja) * | 2008-06-30 | 2011-10-20 | シー.アール.バード,インコーポレイテッド | ポリウレタン/ポリイソプレンブレンドカテーテル |
GB0816365D0 (en) * | 2008-09-08 | 2008-10-15 | Univ Belfast | Polymeric material |
EP2177238B1 (en) | 2008-10-14 | 2016-11-09 | Dentsply IH AB | Medical device with controllably releasable antibacterial agent |
DK2198897T3 (en) | 2008-12-19 | 2016-11-14 | Dentsply Ih Ab | PROCESS FOR THE PREPARATION OF A medical device having a crosslinked hydrophilic coating |
JP5766127B2 (ja) * | 2009-02-20 | 2015-08-19 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | エステル結合したポリ(エステル−ブロック−アミド)上における粒子発生を低減する親水性コーティング |
US10149961B2 (en) | 2009-07-29 | 2018-12-11 | C. R. Bard, Inc. | Catheter having improved drainage and/or a retractable sleeve and method of using the same |
WO2011015946A2 (en) | 2009-08-07 | 2011-02-10 | Knauf Insulation | Molasses binder |
US9821139B2 (en) | 2009-08-13 | 2017-11-21 | C. R. Bard, Inc. | Catheter having internal hydrating fluid storage and/or catheter package using the same and method of making and/or using the same |
DK2644224T3 (en) | 2009-09-04 | 2019-03-04 | Dentsply Ih Ab | Catheter assembly with re-sealable opening |
EP2292294B1 (en) | 2009-09-04 | 2017-08-23 | Dentsply IH AB | Catheter with customizable connector |
US8287890B2 (en) * | 2009-12-15 | 2012-10-16 | C.R. Bard, Inc. | Hydrophilic coating |
ES2391441T3 (es) | 2009-12-18 | 2012-11-26 | Dentsply Ih Ab | Dispositivo médico para uso durante un tiempo breve con agente antibacteriano liberable rápidamente |
EP2335745B1 (de) * | 2009-12-21 | 2017-11-22 | Biotronik VI Patent AG | Implantat mit Beschichtung |
WO2011079129A1 (en) | 2009-12-23 | 2011-06-30 | C. R. Bard, Inc. | Catheter assembly/package utilizing a hydrating/hydrogel sleeve and method of making and using the same |
WO2011109393A1 (en) | 2010-03-04 | 2011-09-09 | C.R. Bard, Inc. | Catheter assembly/package utilizing a hydrating/hydrogel sleeve and a foil outer layer and method of making and using the same |
US10369327B2 (en) * | 2010-04-28 | 2019-08-06 | Clph, Llc | Catheters with lubricious linings and methods for making and using them |
US9493603B2 (en) | 2010-05-07 | 2016-11-15 | Knauf Insulation Sprl | Carbohydrate binders and materials made therewith |
JP6223823B2 (ja) | 2010-05-07 | 2017-11-01 | ナフ インサレーション エセペーアールエル | 炭水化物ポリアミン結合剤およびそれを用いて作製される材料 |
CA2801546C (en) | 2010-06-07 | 2018-07-10 | Knauf Insulation | Fiber products having temperature control additives |
US9453196B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Cell carrier, methods of making and use |
US9518249B2 (en) | 2010-12-16 | 2016-12-13 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
US9453197B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Methods of making cell carrier |
US9926523B2 (en) | 2010-12-16 | 2018-03-27 | General Electric Company | Cell carriers and methods for culturing cells |
US9534206B2 (en) | 2010-12-16 | 2017-01-03 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
EP2468346B1 (en) | 2010-12-22 | 2020-11-04 | Dentsply IH AB | Catheter assembly and a method and system for producing such an assembly |
HUE025515T2 (en) | 2010-12-22 | 2016-05-30 | Dentsply Ih Ab | Urine drainage catheter |
US10099032B2 (en) | 2010-12-30 | 2018-10-16 | Dentsply Ih Ab | Catheter with integrated insertion aid |
EP2471569B1 (en) | 2010-12-30 | 2018-10-03 | Dentsply IH AB | Catheter with integrated insertion aid |
US9707375B2 (en) | 2011-03-14 | 2017-07-18 | Rochester Medical Corporation, a subsidiary of C. R. Bard, Inc. | Catheter grip and method |
US20140186635A1 (en) | 2011-05-07 | 2014-07-03 | Knauf Insulation | Liquid high solids binder composition |
US9283110B2 (en) | 2011-09-20 | 2016-03-15 | Zoll Circulation, Inc. | Patient temperature control catheter with outer sleeve cooled by inner sleeve |
US8888832B2 (en) | 2011-09-28 | 2014-11-18 | Zoll Circulation, Inc. | System and method for doubled use of patient temperature control catheter |
US10045881B2 (en) | 2011-09-28 | 2018-08-14 | Zoll Circulation, Inc. | Patient temperature control catheter with helical heat exchange paths |
US9314370B2 (en) | 2011-09-28 | 2016-04-19 | Zoll Circulation, Inc. | Self-centering patient temperature control catheter |
US9259348B2 (en) | 2011-09-28 | 2016-02-16 | Zoll Circulation, Inc. | Transatrial patient temperature control catheter |
DK2609956T3 (da) | 2011-12-27 | 2019-06-03 | Dentsply Ih Ab | Midlertidigt foldbart kateteraggregat og dertil hørende fremgangsmåde |
USD775522S1 (en) | 2011-12-27 | 2017-01-03 | Dentsply Ih Ab | Catheter package |
DK2609955T3 (da) | 2011-12-27 | 2020-08-17 | Dentsply Ih Ab | Katetersamling med genlukkelig åbning |
EP2636421B1 (en) | 2012-03-05 | 2017-08-23 | Dentsply IH AB | Catheter with partially slitted insertion aid |
GB201206193D0 (en) | 2012-04-05 | 2012-05-23 | Knauf Insulation Ltd | Binders and associated products |
GB201214734D0 (en) | 2012-08-17 | 2012-10-03 | Knauf Insulation Ltd | Wood board and process for its production |
US9717625B2 (en) | 2012-09-28 | 2017-08-01 | Zoll Circulation, Inc. | Intravascular heat exchange catheter with non-round coiled coolant path |
US9241827B2 (en) | 2012-09-28 | 2016-01-26 | Zoll Circulation, Inc. | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
US9801756B2 (en) | 2012-09-28 | 2017-10-31 | Zoll Circulation, Inc. | Intravascular heat exchange catheter and system with RFID coupling |
US9433528B2 (en) | 2012-09-28 | 2016-09-06 | Zoll Circulation, Inc. | Intravascular heat exchange catheter with rib cage-like coolant path |
US9872969B2 (en) | 2012-11-20 | 2018-01-23 | Rochester Medical Corporation, a subsidiary of C.R. Bard, Inc. | Catheter in bag without additional packaging |
US10092728B2 (en) | 2012-11-20 | 2018-10-09 | Rochester Medical Corporation, a subsidiary of C.R. Bard, Inc. | Sheath for securing urinary catheter |
EP2928936B1 (en) | 2012-12-05 | 2022-04-13 | Knauf Insulation SPRL | Binder |
US8785679B2 (en) | 2012-12-10 | 2014-07-22 | Empire Technology Development Llc | Hydrophilic biocidal coatings |
EP2745868A1 (en) | 2012-12-21 | 2014-06-25 | Dentsply IH AB | Medical device and method of producing thereof having a tubular substrate and at least partly surface treated access openings |
US8998882B2 (en) | 2013-03-13 | 2015-04-07 | C. R. Bard, Inc. | Enhanced pre-wetted intermittent catheter with lubricious coating |
US9474644B2 (en) | 2014-02-07 | 2016-10-25 | Zoll Circulation, Inc. | Heat exchange system for patient temperature control with multiple coolant chambers for multiple heat exchange modalities |
EP3102587B1 (en) | 2014-02-07 | 2018-07-04 | Knauf Insulation, LLC | Uncured articles with improved shelf-life |
US11033424B2 (en) | 2014-02-14 | 2021-06-15 | Zoll Circulation, Inc. | Fluid cassette with tensioned polymeric membranes for patient heat exchange system |
US10500088B2 (en) | 2014-02-14 | 2019-12-10 | Zoll Circulation, Inc. | Patient heat exchange system with two and only two fluid loops |
US10792185B2 (en) | 2014-02-14 | 2020-10-06 | Zoll Circulation, Inc. | Fluid cassette with polymeric membranes and integral inlet and outlet tubes for patient heat exchange system |
GB201408909D0 (en) | 2014-05-20 | 2014-07-02 | Knauf Insulation Ltd | Binders |
MX2017002457A (es) | 2014-08-26 | 2017-05-19 | Bard Inc C R | Cateter urinario. |
US9784263B2 (en) | 2014-11-06 | 2017-10-10 | Zoll Circulation, Inc. | Heat exchange system for patient temperature control with easy loading high performance peristaltic pump |
US11359620B2 (en) | 2015-04-01 | 2022-06-14 | Zoll Circulation, Inc. | Heat exchange system for patient temperature control with easy loading high performance peristaltic pump |
CA2967015C (en) | 2014-11-07 | 2023-02-28 | C.R. Bard, Inc. | Connection system for tunneled catheters |
SI3040097T1 (sl) | 2014-12-29 | 2020-11-30 | Dentsply Ih Ab | Urinarni kateter z mehko konico |
US11213423B2 (en) | 2015-03-31 | 2022-01-04 | Zoll Circulation, Inc. | Proximal mounting of temperature sensor in intravascular temperature management catheter |
US10537465B2 (en) | 2015-03-31 | 2020-01-21 | Zoll Circulation, Inc. | Cold plate design in heat exchanger for intravascular temperature management catheter and/or heat exchange pad |
US10022265B2 (en) | 2015-04-01 | 2018-07-17 | Zoll Circulation, Inc. | Working fluid cassette with hinged plenum or enclosure for interfacing heat exchanger with intravascular temperature management catheter |
DK3283136T3 (da) | 2015-04-16 | 2021-06-28 | Hollister Inc | Hydrofile belægninger og fremgangsmåder til dannelse heraf |
EP3313494B1 (en) | 2015-06-26 | 2019-05-01 | Coloplast A/S | A urinary catheter assembly |
GB201517867D0 (en) | 2015-10-09 | 2015-11-25 | Knauf Insulation Ltd | Wood particle boards |
GB201610063D0 (en) | 2016-06-09 | 2016-07-27 | Knauf Insulation Ltd | Binders |
RU2748012C2 (ru) | 2016-09-27 | 2021-05-18 | Колопласт А/С | Гидратированный катетер с рукавом |
GB201701569D0 (en) | 2017-01-31 | 2017-03-15 | Knauf Insulation Ltd | Improved binder compositions and uses thereof |
US11337851B2 (en) | 2017-02-02 | 2022-05-24 | Zoll Circulation, Inc. | Devices, systems and methods for endovascular temperature control |
US11185440B2 (en) | 2017-02-02 | 2021-11-30 | Zoll Circulation, Inc. | Devices, systems and methods for endovascular temperature control |
US11116657B2 (en) | 2017-02-02 | 2021-09-14 | Zoll Circulation, Inc. | Devices, systems and methods for endovascular temperature control |
BR112019017727B1 (pt) * | 2017-02-24 | 2022-12-06 | Qvanteq Ag | Implante para inserção em um lúmen corporal, método para a fabricação do mesmo e conjunto de implante |
EP3421071B1 (en) | 2017-06-30 | 2023-09-20 | Wellspect AB | Steam sterilized catheter assembly and method of producing thereof |
WO2019040801A1 (en) | 2017-08-23 | 2019-02-28 | C.R. Bard, Inc. | CATHETER ASSEMBLIES AND ASSOCIATED METHODS |
MX2020002752A (es) | 2017-09-19 | 2020-07-20 | Bard Inc C R | Dispositivo puente de cateter urinario, sistemas y metodos de estos. |
WO2019074791A1 (en) | 2017-10-13 | 2019-04-18 | Colorado State University Research Foundation | HYDROPHILIC, BUT SLIPPERY SOLID SURFACES |
JP7003619B2 (ja) * | 2017-12-14 | 2022-01-20 | ニプロ株式会社 | 医療機器および医療機器の製造方法 |
GB201804907D0 (en) | 2018-03-27 | 2018-05-09 | Knauf Insulation Ltd | Composite products |
GB201804908D0 (en) | 2018-03-27 | 2018-05-09 | Knauf Insulation Ltd | Binder compositions and uses thereof |
DK3793626T3 (da) | 2018-05-17 | 2023-03-13 | Hollister Inc | Fremgangsmåder til fremstilling af hydrofile kateterenheder med muffe |
EP4245349A3 (en) | 2018-05-24 | 2023-11-15 | Wellspect AB | Urinary catheter assembly with attachable handle |
USD910836S1 (en) | 2018-05-24 | 2021-02-16 | Dentsply Ih Ab | Urinary catheter assembly |
DK180417B1 (en) | 2018-07-20 | 2021-04-22 | Coloplast As | INTERMITTING URINCATHER FITTING |
US20210338897A1 (en) * | 2018-08-24 | 2021-11-04 | Qvanteq Ag | Vascular device and method for manufacturing a vascular device |
EP3897480A1 (en) | 2018-12-20 | 2021-10-27 | Coloplast A/S | Urine collecting bag |
EP3701994A1 (en) | 2019-02-27 | 2020-09-02 | Dentsply IH AB | Urinary catheter assembly with integrated handle |
EP3701993A1 (en) | 2019-02-27 | 2020-09-02 | Dentsply IH AB | Urinary catheter assembly with integrated pivotable handle |
WO2020187493A1 (en) * | 2019-03-19 | 2020-09-24 | Qvanteq Ag | Medical device and process of preparing a medical device |
EP3711808A1 (en) | 2019-03-21 | 2020-09-23 | Dentsply IH AB | Urinary catheter assembly |
EP3711806A1 (en) | 2019-03-21 | 2020-09-23 | Dentsply IH AB | Urinary catheter assembly |
EP3711807A1 (en) | 2019-03-21 | 2020-09-23 | Dentsply IH AB | Urinary catheter assembly |
EP3932438A1 (en) | 2020-07-02 | 2022-01-05 | Dentsply IH AB | Hydrophilic medical device assembly |
EP3991773A1 (en) | 2020-10-27 | 2022-05-04 | Dentsply IH AB | Urinary catheter assembly |
EP4049689A1 (en) | 2021-02-25 | 2022-08-31 | Dentsply IH AB | Medical device with substrate comprising natural fibers |
EP4062952B1 (en) | 2021-03-23 | 2024-01-31 | Wellspect AB | Reusable hydrophilic urinary catheter assembly |
EP4302811A1 (en) | 2022-07-08 | 2024-01-10 | Wellspect AB | Urinary catheter assembly and introducer device for use in such an assembly |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL92465C (no) * | 1955-12-27 | |||
CS154977B1 (no) * | 1971-10-08 | 1974-04-30 | ||
US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
US3886947A (en) * | 1973-04-13 | 1975-06-03 | Meadox Medicals Inc | Non-thrombogenic catheter |
DE2456807C3 (de) * | 1974-11-30 | 1981-04-09 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Polymerisaten des Vinylpyrrolidons |
US4094967A (en) * | 1976-10-22 | 1978-06-13 | Allor Foundation | Iodine-polyvinylpyrrolidone solid product and method of preparation |
US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US4119094A (en) * | 1977-08-08 | 1978-10-10 | Biosearch Medical Products Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US4143423A (en) * | 1977-10-25 | 1979-03-13 | Sternlieb Jack J | Surgical lubricants |
US4318947A (en) * | 1979-12-26 | 1982-03-09 | The Kendall Company | Polymer coating and curing process for catheters |
US4373009A (en) * | 1981-05-18 | 1983-02-08 | International Silicone Corporation | Method of forming a hydrophilic coating on a substrate |
US4515593A (en) * | 1981-12-31 | 1985-05-07 | C. R. Bard, Inc. | Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same |
SE430695B (sv) * | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | Forfarande for framstellning av en hydrofil beleggning samt enligt forfarandet framstellda medicinska artiklar |
US4526579A (en) * | 1983-06-17 | 1985-07-02 | Pfizer Inc. | Method for graft copolymerization to natural rubber articles |
US4657544A (en) * | 1984-04-18 | 1987-04-14 | Cordis Corporation | Cardiovascular graft and method of forming same |
AU4198785A (en) * | 1984-05-07 | 1985-11-14 | Lloyd A. Ferreira | Conductive material and biomedical electrode |
US4589873A (en) * | 1984-05-29 | 1986-05-20 | Becton, Dickinson And Company | Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby |
US4677143A (en) * | 1984-10-01 | 1987-06-30 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
-
1985
- 1985-09-30 SE SE8504501A patent/SE8504501D0/xx unknown
-
1986
- 1986-09-09 AU AU62464/86A patent/AU591703B2/en not_active Expired
- 1986-09-16 IE IE247386A patent/IE58507B1/en not_active IP Right Cessation
- 1986-09-19 AT AT86850317T patent/ATE70075T1/de not_active IP Right Cessation
- 1986-09-19 DE DE198686850317T patent/DE217771T1/de active Pending
- 1986-09-19 EP EP86850317A patent/EP0217771B1/en not_active Expired - Lifetime
- 1986-09-19 DE DE8686850317T patent/DE3682742D1/de not_active Expired - Lifetime
- 1986-09-23 DK DK453286A patent/DK169552B1/da not_active IP Right Cessation
- 1986-09-29 NO NO863872A patent/NO166869C/no unknown
- 1986-09-29 FI FI863922A patent/FI86070C/fi not_active IP Right Cessation
- 1986-09-29 ES ES8602258A patent/ES2002009A6/es not_active Expired
- 1986-09-29 CA CA000519255A patent/CA1292649C/en not_active Expired - Lifetime
- 1986-09-29 JP JP61228531A patent/JPH0691898B2/ja not_active Expired - Lifetime
-
1988
- 1988-08-24 US US07/232,139 patent/US4906237A/en not_active Expired - Lifetime
-
1995
- 1995-01-26 HK HK12995A patent/HK12995A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK453286D0 (da) | 1986-09-23 |
DK169552B1 (da) | 1994-11-28 |
DE217771T1 (de) | 1987-10-15 |
NO863872D0 (no) | 1986-09-29 |
FI863922A0 (fi) | 1986-09-29 |
IE58507B1 (en) | 1993-10-06 |
AU591703B2 (en) | 1989-12-14 |
HK12995A (en) | 1995-02-03 |
DK453286A (da) | 1987-03-31 |
US4906237A (en) | 1990-03-06 |
AU6246486A (en) | 1987-04-02 |
EP0217771B1 (en) | 1991-12-04 |
FI863922A (fi) | 1987-03-31 |
NO863872L (no) | 1987-03-31 |
IE862473L (en) | 1987-03-30 |
ATE70075T1 (de) | 1991-12-15 |
NO166869C (no) | 1991-09-11 |
ES2002009A6 (es) | 1988-07-01 |
EP0217771A1 (en) | 1987-04-08 |
JPS6282968A (ja) | 1987-04-16 |
FI86070C (fi) | 1992-07-10 |
FI86070B (fi) | 1992-03-31 |
CA1292649C (en) | 1991-12-03 |
DE3682742D1 (de) | 1992-01-16 |
JPH0691898B2 (ja) | 1994-11-16 |
SE8504501D0 (sv) | 1985-09-30 |
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