NO166869B - Fremgangsmaate for dannelse av et forbedret, hydrofilt belegg paa en polymeroverflate og anvendelse av fremgangsmaaten. - Google Patents
Fremgangsmaate for dannelse av et forbedret, hydrofilt belegg paa en polymeroverflate og anvendelse av fremgangsmaaten. Download PDFInfo
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- NO166869B NO166869B NO863872A NO863872A NO166869B NO 166869 B NO166869 B NO 166869B NO 863872 A NO863872 A NO 863872A NO 863872 A NO863872 A NO 863872A NO 166869 B NO166869 B NO 166869B
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- solution
- osmolality
- polymer
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- hydrophilic
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- 229920000642 polymer Polymers 0.000 title claims abstract description 22
- 238000000576 coating method Methods 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000011248 coating agent Substances 0.000 title claims abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 22
- 239000002344 surface layer Substances 0.000 claims abstract description 19
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 17
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims abstract description 15
- 239000011780 sodium chloride Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 9
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 8
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 5
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 4
- 239000001110 calcium chloride Substances 0.000 claims abstract description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 4
- 239000008103 glucose Substances 0.000 claims abstract description 4
- 239000001103 potassium chloride Substances 0.000 claims abstract description 4
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 4
- 239000004323 potassium nitrate Substances 0.000 claims abstract description 4
- 235000010333 potassium nitrate Nutrition 0.000 claims abstract description 4
- 239000001509 sodium citrate Substances 0.000 claims abstract description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 3
- 239000000600 sorbitol Substances 0.000 claims abstract description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 230000002485 urinary effect Effects 0.000 claims description 3
- 150000002016 disaccharides Chemical class 0.000 claims description 2
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 230000005660 hydrophilic surface Effects 0.000 abstract description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 235000007715 potassium iodide Nutrition 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012973 diazabicyclooctane Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Physical Water Treatments (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Vehicle Body Suspensions (AREA)
- Laminated Bodies (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
Description
Foreliggende oppfinnelse vedrører en fremgangsmåte for belegging av et hydrofilt polymeroverflatelag med en osmo-lalitetsforøkende forbindelse for dannelse av en mer stabil hydrofil overflate, samt medisinske gjenstander som er belagt med nevnte forbedrede hydrofile belegg, samt anvendelse av f remgangsmåten.
Et hydrofilt belegg har en mye lavere friksjonskoeffisient i våt tilstand enn i tørr tilstand. Således har dannelsen av hydrofile belegg på substrater mange anvendelser, men er spesielt ønskelig i mange biomedisinske anvendelser. Slike biomedisinske anvendelser er f.eks. sårdreneringer, katetere, kirurgiske verktøy og andre medisinske instrumenter som skal innføres i kroppshulrom fordi instrumentet gir et godt hånd-grep i tørr tilstand mens det samtidig blir meget glatt når det kommer i kontakt med vannbaserte væsker, og kan således lett innføres uten å forårsake vanskeligheter for pasienten. Videre, en gjenstand som har et hydrofilt overflatebelegg, er ønskelig for å minimalisere trombose, krystalldannelse, vevstrauma, vevsadhesjon til medisinske instrumenter og frem-mede kroppsreaksjoner. I tidligere kjente metoder har overflater blitt gjort hydrofile ved slike metoder som høyenergi-bestråling i in situ polymerisasjonsprosesser, ved podning, ved dannelse av interpolymer-nettverk eller ved direkte kjemisk binding, f.eks. med isocyanater eller silaner. Slike polymeroverflater for medisinsk bruk er beskrevet f.eks. i GB1.600.963, US 4.373.009, US 4.459.317, WO 83/03977 og EP patent 93.093. Omfattende studier viser imidlertid at det hydrofile belegget kan tørke ut og således gjøre gjenstanden utilstrekkelig hydrofil.
Formålet med foreliggende oppfinnelse er å fremstille et forbedret hydrofilt belegg på et allerede hydrofilt polymer-overf latelag på et substrat. Dette formål har overraskende blitt oppnådd ved påføring av en oppløsning av en osmo-lalitetsforøkende forbindelse på et ikke-reaktivt hydrofilt polymeroverflatelag og deretter fordamping av oppløsnings-mlddelet 1 oppløsningen.
Under eksperimentering med hydrofile polymerbelegg på forskjellige substrater fant man at når en gjenstand belagt med et hydrofilt polymeroverflatelag dyppes i vann, vil den bli godt fuktet, men det er en stor risiko for at polymeroverflaten taper sitt vann når den kommer i kontakt med en slimhinne eller lignende. Dette avhenger av forskjellen i det osmotiske potensial mellom den hydrofile overflaten og slimhinnen. Slimhinnen har et høyere osmotisk potensial, dvs. en høyere saltkonsentrasjon enn den hydrofile overflaten, hvilket resulterer i at vannet går fra det hydrofile overflatelaget til slimhinnen slik at forskjellen i salt-konsentrasjonen vil bli oppveiet.
I foreliggende sammenheng er det overraskende funnet mulig ytterligere å redusere den lave friksjonen til den hydrofile overflaten og samtidig å forøke osmolaliteten til den hydrofile overflaten ved påføring av et belegg av en osmolalitetsforøkende forbindelse på det hydrofile polymer-overf latelaget .
Ifølge foreliggende oppfinnelse er det således tilveiebragt en fremgangsmåte for dannelse av et forbedret, hydrofilt belegg for å bibeholde glattheten i lengre tid på et substrat, hvorved
(a) et ikke-reaktivt overflatelag av hydrofil polymer
påføres på substratet,
(b) det på det ikke-reaktive overflatelag av hydrofil polymer påføres en oppløsning omfattende et opp-løsningsmiddel eventuelt inneholdende en polymer, fortrinnsvis den samme polymeren som i polymer-overf latelaget , og
(c) oppløsningsmiddelet inndampes,
og denne fremgangsmåten er kjennetegnet ved at oppløsningen omfattende et oppløsningsmiddel også omfatter over 296 (vekt pr. volum) av en osmolalitetsforøkende forbindelse valgt fra gruppen bestående av mono- og disakkarider, sukkeralkoholer, og ikke-toksiske organiske og uorganiske salter, forutsatt at den osmolalitetsforøkende forbindelsen ikke er et trihalogenid slik som KI3 (KI/I2).
Eksempler på de osmolalitetsforøkende forbindelser er glukose, sorbitol, natriumklorid, natriumcitrat, natriumbenzoat, kalsiumklorid, kaliumklorid, kaliumiodid, kaliumnitrat. Den osmolalitetsforøkende forbindelsen må være ikke-tokslsk. Fremgangsmåten er funnet å være spesielt nyttig for natriumklorid. Den osmolalitetsforøkende forbindelsen kan blandes med en polymer og oppløses i vann eller en lavere alkohol, fortrinnsvis i vann, til en egnet viskositet. Nevnte oppløsning påføres på det hydrofile polymeroverflatelaget ved dypping, spraying eller lignende, og deretter for-dampes oppløsningsmiddelet ved lufttørking eller ved tørking med forhøyet temperatur. Den tilsatte polymer bør være godt forenlig med polymeren i polymeroverflatelaget, fortrinnsvis den samme polymeren. Polymeren er ikke et nødvendig additiv til oppløsningen, men den forøker viskositeten, og ved dette kan mottagelsen av den osmolalitetsforøkende forbindelsen reguleres. Videre har polymeren en smørende egenskap og en kontrollert frigjøringseffekt.
Foreliggende fremgangsmåte kan benyttes for belegging av mange forskjellige typer av velkjente hydrofile polymer-overf later, hvor den hydrofile polymeren er valgt fra polyvinylforbindelser, polysakkarider, polyuretaner, polyakrylater eller kopolymerer av vinylforbindelser og akrylater eller anhydrider. Spesielt kan nevnes polyetylenoksyd, poly-vinylpyrrolidon, heparin, dekstran, xantan, polyvinylalkohol, hydroksypropylcellulose, metylcellulose, kopolymer av vinyl-pyrrolidon og hydroksyetylmetylakrylat eller kopolymer av polymetylvinyleter og maleinsyreanhydrid. Den foretrukne hydrofile polymeren er polyvlnylpyrrolldon. Polymeroverflatelaget må være gjort ikke-reaktlvt, f.eks. ved herding.
Substratene kan være et hvilket som helst polymermateriale som det er velkjent å benytte og til hvilket nevnte hydrofile polymerer fester seg slik som polyuretaner, lateksgummier, andre gummier, polyvinylklorid, andre vinylpolymerer, poly-estere og polyakrylater.
Den hydrofile overflaten inneholder en vesentlig mengde av delvis fritt bevegbare polymerkjeder. Det har således blitt vist at noen belegg kan kompleks-binde en vesentlig mengde av elementært jod, som tilfellet f.eks. er med fritt polyvlnylpyrrolldon og jod når en hydrofil overflate av polyvlnylpyrrolldon behandles med en KI/l2~oppløsning. PVP-belagte katetere behandlet med en Kl/^-oppløsning har en mindre glatt overflate enn den tilsvarende ubehandlede overflate, og slike Kl3~behandlede katetere tørker hurtigere.
Ifølge oppfinnelsen anvendes foreliggende fremgangsmåte for belegging av katetere, og spesielt for belegging av urinkatetere.
Eksempel.
Et trimerisert heksametylendiisocyanat av biuret-typen (betegnet Desmodur L 2291; Bayer AG) ble oppløst i metylen-, klorid til en konsentrasjon på b% (vekt/volum). ET PVC-urinkateter ble dyppet i denne oppløsning i 30 sek. Kateteret ble deretter tørket ved 70°C i 60 sek. hvoretter det ble dyppet i 5 sek. i en oppløsning inneholdende inneholdende 33 g polyvlnylpyrrolldon (K25; midlere molekylvekt 25.000) pr. 100 ml metylenklorid. Denne oppløsning inneholdt også 0,33 g trietylendiamin (DABCO®) pr. 100 ml oppløsning. Kateteret fikk deretter tørke ved omgivelsestemperatur i 60 sek., deretter ble det herdet i 40 min. ved 70°C, avkjølt til omgivelsestemperatur og ble deretter skyld i vann. Et slikt kateter ble dyppet i en oppløsning inneholdende 20% (vekt/- volum) natriumklorid og 5$ polyvlnylpyrrolldon (PVP)
(vekt/volum) oppløst i vann i 1 time ved 20°C. Kateteret fikk deretter tørke ved 70°C i 8 timer. Kateteret har en meget glatt og adherende overflate i fuktig tilstand.
Forsøk
En rekke katetere i overensstemmelse med eksemplene ble dyppet i forskjellige oppløsninger omfattende osmolalitets-forøkende forbindelser i 10 min. , og ble deretter anbragt i vann i 30 sek. ved 23°C og en relativ fuktighet på 4996 og deretter tørket ved romtemperatur. Glattheten ble notert 1 min., 2 min., osv., etter allerede påbegynt tørking. Glatthetsverdien ble notert på en relativ skala, hvor 8 betyr en meget glatt overflate, og 0 betyr en tørr overflate.
Dette forsøk ble gjentatt med en rekke tilsvarende PVP-belagte katetere, men uten belegget av osmolalitetsforøkende forbindelse.
Keltrol® er en xantangummi; Kelco Co.
Resultat
Tabell 1 viser at kateterene som har et belegg av en ikke-toksisk osmolalitetsforøkende forbindelse, bibeholder deres glatthet i lengre tid enn de tilsvarende ubehandlede overflater, dvs. de belagte katerene tørkes langsommere. De osmolalitetsforøkende forbindelsene hindrer den hydrofile polymeroverflaten i å uttørke.
Kateteret som er påført en osmolalitetforøkende forbindelse slik som natriumklorid ifølge foreliggende oppfinnelse, tørker således langsommere enn tilsvarende ubehandlede katetere. Det natriumkloridbehandlede kateteret beholder sin glatthet i en meget lengre tidsperiode, hvilket er meget ønskelig.
Medisinske forsøk viser at kateterene som er påført et belegg av eh osmolalitetsforøkende forbindelse slik natriumklorid, er overlegne både ved innføringen og ved fjerningen av kateteret i urinrøret.
Claims (8)
1. Fremgangsmåte for dannelse av et forbedret, hydrofilt belegg for å bibeholde glattheten i lengre tid på et substrat, hvorved: (a) et ikke-reaktivt overflatelag av hydrofil polymer påføres på substratet, (b) det på det ikke-reaktive overflatelag av hydrofil polymer påføres en oppløsning omfattende et opp-løsningsmiddel eventuelt inneholdende en polymer, fortrinnsvis den samme polymeren som i polymer-overf latelaget, og (c) oppløsningsmiddelet inndampes, karakterisert ved at
oppløsningen omfattende et oppløsningsmiddel også omfatter over 2% (vekt pr. volum) av en osmolalitetsforøkende forbindelse valgt fra gruppen bestående av mono- og disakkarider, sukkeralkoholer, og ikke-toksiske organiske og uorganiske salter, forutsatt at den osmolalitetsforøkende forbindelsen ikke er et trihalogenid slik som KI3 (KI/I2).
2. Fremgangsmåte ifølge krav 1, karakterisert ved at den osmolalitetsforøkende forbindelsen i oppløsningen velges fra gruppen bestående av glukose, sorbitol, natriumklorid, natriumcitrat, natriumbenzoat, kalsiumklorid, kaliumklorid, kaliumiodid, eller kaliumnitrat.
3. Fremgangsmåte ifølge krav 2, karakterisert ved at forbindelsen i oppløsningen velges fra gruppen bestående av glukose, natriumklorid, natriumcitrat, natriumbenzoat, kalsiumklorid, kaliumklorid, kaliumiodid eller kaliumnitrat.
4. Fremgangsmåte ifølge krav 1-3, karakterisert ved at oppløsningen inneholder fra 4 til 40% (vekt/volum) av natriumklorid.
5. Fremgangsmåte ifølge krav 1, karakterisert ved at polymeroverflatelaget er herdet.
6. Fremgangsmåte ifølge krav 1, karakterisert ved at polymeroverflatelaget påføres polyvlnylpyrrolldon,' og at det foretas behandling med en oppløsning som inneholder ' 20% (vekt/volum) av natriumklorid.
7. Anvendelse av fremgangsmåten ifølge krav 1, for belegging av katetere.
8. Anvendelse av fremgangsmåten ifølge krav 7, for belegging av urinkatetere.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO904205A NO176236C (no) | 1985-09-30 | 1990-09-27 | Medisinsk gjenstand belagt med hydrofile belegg |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8504501A SE8504501D0 (sv) | 1985-09-30 | 1985-09-30 | Method of forming an improved hydrophilic coating on a polymer surface |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO863872D0 NO863872D0 (no) | 1986-09-29 |
| NO863872L NO863872L (no) | 1987-03-31 |
| NO166869B true NO166869B (no) | 1991-06-03 |
| NO166869C NO166869C (no) | 1991-09-11 |
Family
ID=20361558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO863872A NO166869C (no) | 1985-09-30 | 1986-09-29 | Fremgangsmaate for dannelse av et forbedret, hydrofilt belegg paa en polymeroverflate og anvendelse av fremgangsmaaten. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4906237A (no) |
| EP (1) | EP0217771B1 (no) |
| JP (1) | JPH0691898B2 (no) |
| AT (1) | ATE70075T1 (no) |
| AU (1) | AU591703B2 (no) |
| CA (1) | CA1292649C (no) |
| DE (2) | DE3682742D1 (no) |
| DK (1) | DK169552B1 (no) |
| ES (1) | ES2002009A6 (no) |
| FI (1) | FI86070C (no) |
| HK (1) | HK12995A (no) |
| IE (1) | IE58507B1 (no) |
| NO (1) | NO166869C (no) |
| SE (1) | SE8504501D0 (no) |
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-
1985
- 1985-09-30 SE SE8504501A patent/SE8504501D0/xx unknown
-
1986
- 1986-09-09 AU AU62464/86A patent/AU591703B2/en not_active Expired
- 1986-09-16 IE IE247386A patent/IE58507B1/en not_active IP Right Cessation
- 1986-09-19 DE DE8686850317T patent/DE3682742D1/de not_active Expired - Lifetime
- 1986-09-19 AT AT86850317T patent/ATE70075T1/de not_active IP Right Cessation
- 1986-09-19 EP EP86850317A patent/EP0217771B1/en not_active Expired - Lifetime
- 1986-09-19 DE DE198686850317T patent/DE217771T1/de active Pending
- 1986-09-23 DK DK453286A patent/DK169552B1/da not_active IP Right Cessation
- 1986-09-29 CA CA000519255A patent/CA1292649C/en not_active Expired - Lifetime
- 1986-09-29 ES ES8602258A patent/ES2002009A6/es not_active Expired
- 1986-09-29 NO NO863872A patent/NO166869C/no unknown
- 1986-09-29 FI FI863922A patent/FI86070C/fi not_active IP Right Cessation
- 1986-09-29 JP JP61228531A patent/JPH0691898B2/ja not_active Expired - Lifetime
-
1988
- 1988-08-24 US US07/232,139 patent/US4906237A/en not_active Expired - Lifetime
-
1995
- 1995-01-26 HK HK12995A patent/HK12995A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1292649C (en) | 1991-12-03 |
| JPS6282968A (ja) | 1987-04-16 |
| DK169552B1 (da) | 1994-11-28 |
| AU6246486A (en) | 1987-04-02 |
| JPH0691898B2 (ja) | 1994-11-16 |
| FI863922A (fi) | 1987-03-31 |
| ATE70075T1 (de) | 1991-12-15 |
| FI86070C (fi) | 1992-07-10 |
| NO863872D0 (no) | 1986-09-29 |
| IE58507B1 (en) | 1993-10-06 |
| US4906237A (en) | 1990-03-06 |
| NO166869C (no) | 1991-09-11 |
| SE8504501D0 (sv) | 1985-09-30 |
| EP0217771B1 (en) | 1991-12-04 |
| DE3682742D1 (de) | 1992-01-16 |
| EP0217771A1 (en) | 1987-04-08 |
| DE217771T1 (de) | 1987-10-15 |
| FI86070B (fi) | 1992-03-31 |
| AU591703B2 (en) | 1989-12-14 |
| DK453286D0 (da) | 1986-09-23 |
| HK12995A (en) | 1995-02-03 |
| NO863872L (no) | 1987-03-31 |
| ES2002009A6 (es) | 1988-07-01 |
| IE862473L (en) | 1987-03-30 |
| DK453286A (da) | 1987-03-31 |
| FI863922A0 (fi) | 1986-09-29 |
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