NO135810B - - Google Patents
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- Publication number
- NO135810B NO135810B NO3062/73A NO306273A NO135810B NO 135810 B NO135810 B NO 135810B NO 3062/73 A NO3062/73 A NO 3062/73A NO 306273 A NO306273 A NO 306273A NO 135810 B NO135810 B NO 135810B
- Authority
- NO
- Norway
- Prior art keywords
- inhibitor
- dag
- experiments
- digluconate
- chlorhexidine
- Prior art date
Links
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 13
- 235000013024 sodium fluoride Nutrition 0.000 claims description 10
- 239000011775 sodium fluoride Substances 0.000 claims description 10
- 230000000845 anti-microbial effect Effects 0.000 claims description 8
- PTFSLTXIXFNFSI-UHFFFAOYSA-N 2-[bis(2-aminoethyl)amino]tetradecanoic acid Chemical compound CCCCCCCCCCCCC(C(O)=O)N(CCN)CCN PTFSLTXIXFNFSI-UHFFFAOYSA-N 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 3
- -1 fluorine ions Chemical class 0.000 claims description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 3
- 229960002799 stannous fluoride Drugs 0.000 claims description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 235000003270 potassium fluoride Nutrition 0.000 claims description 2
- 239000011698 potassium fluoride Substances 0.000 claims description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 2
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 description 35
- 238000002474 experimental method Methods 0.000 description 23
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 229960003260 chlorhexidine Drugs 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 210000003296 saliva Anatomy 0.000 description 8
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 7
- 208000002064 Dental Plaque Diseases 0.000 description 7
- 241000194032 Enterococcus faecalis Species 0.000 description 7
- 239000013543 active substance Substances 0.000 description 7
- 238000007792 addition Methods 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000002779 inactivation Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000008363 phosphate buffer Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 208000002925 dental caries Diseases 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 150000002222 fluorine compounds Chemical class 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 229940091249 fluoride supplement Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 244000005706 microflora Species 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- IYXRHLYQRUOCHU-UHFFFAOYSA-L [Sn](F)F.[Na] Chemical compound [Sn](F)F.[Na] IYXRHLYQRUOCHU-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000002508 compound effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000005548 dental material Substances 0.000 description 1
- 210000003074 dental pulp Anatomy 0.000 description 1
- 210000004262 dental pulp cavity Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940074371 monofluorophosphate Drugs 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7209953A SE374658B (sv) | 1972-07-31 | 1972-07-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO135810B true NO135810B (sv) | 1977-02-28 |
| NO135810C NO135810C (sv) | 1977-06-08 |
Family
ID=20277883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO3062/73A NO135810C (sv) | 1972-07-31 | 1973-07-30 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3932607A (sv) |
| JP (1) | JPS4950122A (sv) |
| CH (1) | CH583037A5 (sv) |
| DE (1) | DE2338031A1 (sv) |
| FI (1) | FI58425C (sv) |
| FR (1) | FR2194440B1 (sv) |
| GB (1) | GB1386920A (sv) |
| IT (1) | IT1048132B (sv) |
| NO (1) | NO135810C (sv) |
| SE (1) | SE374658B (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2410132A1 (de) * | 1973-03-06 | 1974-09-12 | Procter & Gamble | Mund- und/oder zahnpflegemittel |
| CA1159834A (en) * | 1979-04-26 | 1984-01-03 | Paul L. Warner, Jr. | Chlorhexidine salts and compositions of same |
| US4666896A (en) * | 1979-04-26 | 1987-05-19 | Bristol-Myers Company | Chlorhexidine salts and compositions of same |
| US4251507A (en) * | 1979-10-02 | 1981-02-17 | Dominion Pharmacal, Inc. | Process and composition for reducing dental plaque |
| DE3528209C2 (de) * | 1984-08-07 | 1993-10-28 | Fresenius Ag | Desinfektionsmittel |
| SE8503256L (sv) * | 1985-07-01 | 1987-01-02 | Dermaci Ab Ideon | Blandning av klorhexidin och tris buffert for anvendning i vagina, pa hud och pa andra slemhinnor med lagt ph |
| US5585391A (en) * | 1993-10-08 | 1996-12-17 | Fhj Scientific, Inc. | Hydroxyl ions as unique therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents and processes for preparing them |
| US5679711A (en) * | 1993-10-08 | 1997-10-21 | Fhj Scientific, Inc. | Hydroxyl ions as novel therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents |
| DE19813686A1 (de) * | 1998-03-27 | 1999-09-30 | Roeko Gmbh & Co | Antibakteriell wirksames Mittel zur Behandlung oder zum Füllen von Wurzelkanälen und Herstellungsverfahren |
| FI990529A (sv) * | 1999-03-11 | 2000-09-12 | Eva K Siren | Kompositioner och förfarande för desinfektion av tandrotkanaler |
| WO2010080936A2 (en) | 2009-01-07 | 2010-07-15 | Entrotech, Inc. | Chlorhexidine-containing antimicrobial laminates |
| KR101350442B1 (ko) * | 2011-10-12 | 2014-01-15 | 김동진 | 클로르헥시딘을 함유하는 안정한 수용성 살균방부제 조성물 |
| EP3131540B1 (en) | 2014-04-18 | 2023-11-22 | Entrotech, Inc. | Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH77A (de) * | 1889-01-09 | Christian Herren | Wurzelschneidmaschine | |
| AT264013B (de) * | 1965-02-04 | 1968-08-12 | Arcana Kommanditgesellschaft D | Verfahren zur Herstellung von biocide Stoffe enthaltenden Emulsionen bzw. Suspensionen |
-
1972
- 1972-07-31 SE SE7209953A patent/SE374658B/xx unknown
-
1973
- 1973-07-19 GB GB3456473A patent/GB1386920A/en not_active Expired
- 1973-07-26 DE DE19732338031 patent/DE2338031A1/de not_active Ceased
- 1973-07-26 US US05/382,815 patent/US3932607A/en not_active Expired - Lifetime
- 1973-07-30 CH CH1108773A patent/CH583037A5/xx not_active IP Right Cessation
- 1973-07-30 NO NO3062/73A patent/NO135810C/no unknown
- 1973-07-31 FI FI2402/73A patent/FI58425C/fi active
- 1973-07-31 FR FR7328006A patent/FR2194440B1/fr not_active Expired
- 1973-07-31 IT IT27338/73A patent/IT1048132B/it active
- 1973-07-31 JP JP48086276A patent/JPS4950122A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB1386920A (en) | 1975-03-12 |
| JPS4950122A (sv) | 1974-05-15 |
| US3932607A (en) | 1976-01-13 |
| FI58425C (fi) | 1981-02-10 |
| CH583037A5 (sv) | 1976-12-31 |
| FR2194440B1 (sv) | 1976-12-31 |
| IT1048132B (it) | 1980-11-20 |
| FR2194440A1 (sv) | 1974-03-01 |
| SE374658B (sv) | 1975-03-17 |
| FI58425B (fi) | 1980-10-31 |
| DE2338031A1 (de) | 1974-02-14 |
| NO135810C (sv) | 1977-06-08 |
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