NO134605B - - Google Patents
Download PDFInfo
- Publication number
- NO134605B NO134605B NO740780A NO740780A NO134605B NO 134605 B NO134605 B NO 134605B NO 740780 A NO740780 A NO 740780A NO 740780 A NO740780 A NO 740780A NO 134605 B NO134605 B NO 134605B
- Authority
- NO
- Norway
- Prior art keywords
- chalcomycin
- medium
- culture
- liters
- fermentation
- Prior art date
Links
- KLGADJPDTCIJLO-LJUCOGSUSA-N Chalcomycin Chemical compound O[C@@H]1[C@@H](OC)C[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)/C=C/C(=O)O[C@H](C)[C@@H](CO[C@H]2[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O2)OC)[C@H]2O[C@@H]2/C=C/C(=O)[C@@](C)(O)C[C@@H]1C KLGADJPDTCIJLO-LJUCOGSUSA-N 0.000 claims description 87
- IJESDYFOSZHYNR-UHFFFAOYSA-N chalcomycin Natural products COC1CC(C)OC(OC2CCC(C)(O)C(=O)C=CC3OC3C(COC4OC(C)C(O)C(OC)C4OC)C(C)OC(=O)C=CC2)C1O IJESDYFOSZHYNR-UHFFFAOYSA-N 0.000 claims description 86
- 239000000203 mixture Substances 0.000 claims description 34
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 32
- 235000015097 nutrients Nutrition 0.000 claims description 19
- 241000186992 Streptomyces bikiniensis Species 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 230000003115 biocidal effect Effects 0.000 claims description 15
- 229910052799 carbon Inorganic materials 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 230000000844 anti-bacterial effect Effects 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 69
- 239000002609 medium Substances 0.000 description 53
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 39
- 238000000855 fermentation Methods 0.000 description 38
- 230000004151 fermentation Effects 0.000 description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 36
- 239000000047 product Substances 0.000 description 27
- 239000000243 solution Substances 0.000 description 26
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 25
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 18
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 16
- 229920001817 Agar Polymers 0.000 description 15
- 239000008272 agar Substances 0.000 description 15
- 239000000725 suspension Substances 0.000 description 15
- 239000000284 extract Substances 0.000 description 14
- 238000005273 aeration Methods 0.000 description 13
- 239000002518 antifoaming agent Substances 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 13
- 239000001963 growth medium Substances 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 12
- 238000003756 stirring Methods 0.000 description 12
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 10
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 9
- 238000004587 chromatography analysis Methods 0.000 description 9
- 238000011534 incubation Methods 0.000 description 9
- 239000001301 oxygen Substances 0.000 description 9
- 229910052760 oxygen Inorganic materials 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 8
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 8
- 238000004452 microanalysis Methods 0.000 description 8
- 239000005909 Kieselgur Substances 0.000 description 7
- 241000191938 Micrococcus luteus Species 0.000 description 7
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 7
- 239000012531 culture fluid Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 238000000862 absorption spectrum Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- 239000010935 stainless steel Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 240000008042 Zea mays Species 0.000 description 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 5
- 235000005822 corn Nutrition 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000012136 culture method Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- HHURSJAUVYNJBT-UHFFFAOYSA-M sodium;heptadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCOS([O-])(=O)=O HHURSJAUVYNJBT-UHFFFAOYSA-M 0.000 description 4
- 241000894007 species Species 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- 241001446247 uncultured actinomycete Species 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000005903 acid hydrolysis reaction Methods 0.000 description 3
- 238000005904 alkaline hydrolysis reaction Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 230000005789 organism growth Effects 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000187747 Streptomyces Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229940072049 amyl acetate Drugs 0.000 description 2
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000002026 chloroform extract Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 238000012364 cultivation method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000002024 ethyl acetate extract Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- UQZSVIGPZAULMV-DKWTVANSSA-N (2s)-2,4-diamino-4-oxobutanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OC(=O)[C@@H](N)CC(N)=O UQZSVIGPZAULMV-DKWTVANSSA-N 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 241000203809 Actinomycetales Species 0.000 description 1
- 241000589155 Agrobacterium tumefaciens Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 1
- 108010028690 Fish Proteins Proteins 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 239000005905 Hydrolysed protein Substances 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 241000364057 Peoria Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000192023 Sarcina Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- OZKXLOZHHUHGNV-UHFFFAOYSA-N Viomycin Natural products NCCCC(N)CC(=O)NC1CNC(=O)C(=CNC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC1=O)C2CC(O)NC(=N)N2 OZKXLOZHHUHGNV-UHFFFAOYSA-N 0.000 description 1
- 108010015940 Viomycin Proteins 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- DLRVVLDZNNYCBX-ZZFZYMBESA-N beta-melibiose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 DLRVVLDZNNYCBX-ZZFZYMBESA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000012499 inoculation medium Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229910001959 inorganic nitrate Inorganic materials 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000005453 ketone based solvent Substances 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 229940066779 peptones Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000001974 tryptic soy broth Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
- 229950001272 viomycin Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B2017/4216—Operations on uterus, e.g. endometrium
- A61B2017/4225—Cervix uteri
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Surgical Instruments (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US338697A US3900033A (en) | 1973-03-07 | 1973-03-07 | Dilator for cervical canal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO134605B true NO134605B (nl) | 1976-08-09 |
| NO134605C NO134605C (nl) | 1976-11-17 |
Family
ID=23325781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO740780A NO134605C (nl) | 1973-03-07 | 1974-03-06 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US3900033A (nl) |
| JP (1) | JPS49126196A (nl) |
| AR (1) | AR197859A1 (nl) |
| BE (1) | BE812023A (nl) |
| BR (1) | BR7401695D0 (nl) |
| CH (1) | CH562603A5 (nl) |
| DE (1) | DE2410933A1 (nl) |
| FR (1) | FR2220284B1 (nl) |
| GB (1) | GB1457811A (nl) |
| IE (1) | IE39335B1 (nl) |
| IL (1) | IL44363A (nl) |
| IN (1) | IN139926B (nl) |
| NL (1) | NL7402762A (nl) |
| NO (1) | NO134605C (nl) |
| PH (1) | PH10674A (nl) |
| SE (1) | SE401319B (nl) |
| SU (1) | SU535885A3 (nl) |
| ZA (1) | ZA741466B (nl) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3900033A (en) * | 1973-03-07 | 1975-08-19 | Ortho Pharma Corp | Dilator for cervical canal |
| JPS51133194U (nl) * | 1975-02-21 | 1976-10-27 | ||
| NZ180784A (en) * | 1975-05-21 | 1978-06-20 | Ortho Pharma Corp | Body canal dilating device |
| JPS5545353Y2 (nl) * | 1976-03-02 | 1980-10-24 | ||
| IT1088048B (it) * | 1977-11-29 | 1985-06-04 | Magnasco Dante | Divaricatore per applicazioni in campo medico |
| US4327709A (en) * | 1978-03-06 | 1982-05-04 | Datascope Corp. | Apparatus and method for the percutaneous introduction of intra-aortic balloons into the human body |
| US4261339A (en) * | 1978-03-06 | 1981-04-14 | Datascope Corp. | Balloon catheter with rotatable support |
| DE2813215C3 (de) * | 1978-03-25 | 1982-01-28 | Rolf 3500 Kassel Thomas | Mit Luftdruck aufblasbarer flexibler Formkörper zur Anpassung an auszudehnende menschliche und tierische Höhlungen |
| US4270541A (en) * | 1979-05-14 | 1981-06-02 | Fuji Latex Co., Ltd. | Instrument for induction of labor |
| US4338943A (en) * | 1979-05-14 | 1982-07-13 | Fuji Latex Co., Ltd. | Instrument for induction of labor |
| NL7907774A (nl) * | 1979-10-22 | 1981-04-24 | Arnoldus Theodorus Maria Van D | Gewapende cervixdilatatie en weerstandsmeting-ballon. |
| US4237893A (en) * | 1979-11-28 | 1980-12-09 | Alza Corporation | Cervical dilator |
| EP0151583A1 (en) * | 1983-06-24 | 1985-08-21 | Project U | Improved endometrial cytologic sampling apparatus and method |
| US4552557A (en) * | 1983-10-21 | 1985-11-12 | Avvari Rangaswamy | Inflatable uterine hemostat |
| US4669478A (en) * | 1985-03-21 | 1987-06-02 | Robertson Jack R | Device for diagnosing and relieving female incontinence |
| US5312430A (en) * | 1986-12-09 | 1994-05-17 | Rosenbluth Robert F | Balloon dilation catheter |
| US5527336A (en) * | 1986-12-09 | 1996-06-18 | Boston Scientific Corporation | Flow obstruction treatment method |
| US4762127A (en) * | 1987-04-15 | 1988-08-09 | The Montefiore Hospital Association Of Western Pennsylvania | Apparatus and method for enlarging the ends of a vessel prior to anastomosis |
| US5133732A (en) | 1987-10-19 | 1992-07-28 | Medtronic, Inc. | Intravascular stent |
| US4949718B1 (en) * | 1988-09-09 | 1998-11-10 | Gynelab Products | Intrauterine cauterizing apparatus |
| US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
| US5065772A (en) * | 1989-10-13 | 1991-11-19 | Inamed Corporation | Inflatable cerivical pessary |
| ES2020435A6 (es) * | 1990-02-15 | 1991-08-01 | Frontela Carreras Luis | Procedimiento y dispositivo para la exploracion y medida del himen. |
| US5549559A (en) | 1990-03-22 | 1996-08-27 | Argomed Ltd. | Thermal treatment apparatus |
| US5571153A (en) * | 1991-09-20 | 1996-11-05 | Wallst+E,Acu E+Ee N; Hans I. | Device for hyperthermia treatment |
| US5382261A (en) * | 1992-09-01 | 1995-01-17 | Expandable Grafts Partnership | Method and apparatus for occluding vessels |
| US6849063B1 (en) | 1994-03-11 | 2005-02-01 | Wit Ip Corporation | Thermal treatment apparatus |
| US5545122A (en) * | 1994-10-12 | 1996-08-13 | Spruill; Theresa | Inflatable speculum |
| US6187346B1 (en) | 1995-06-07 | 2001-02-13 | Ablation Products, Inc. | Intrauterine chemical cauterizing method and composition |
| WO1996040171A1 (en) | 1995-06-07 | 1996-12-19 | Neuwirth Robert S | Intrauterine chemical necrosing method and composition |
| GB9519851D0 (en) * | 1995-09-29 | 1995-11-29 | Rocket Medical Plc | Device |
| US5891457A (en) * | 1997-05-12 | 1999-04-06 | Neuwirth; Robert S. | Intrauterine chemical necrosing method, composition, and apparatus |
| US6893430B2 (en) * | 1998-02-04 | 2005-05-17 | Wit Ip Corporation | Urethral catheter and guide |
| US6673008B1 (en) | 1998-04-28 | 2004-01-06 | Ronald J. Thompson | Fallopian tube and method of in vitro fertilization and embryo development |
| US20020058674A1 (en) | 1999-01-08 | 2002-05-16 | Hedenstrom John C. | Systems and methods for treating a mucosal surface |
| US6695859B1 (en) * | 1999-04-05 | 2004-02-24 | Coalescent Surgical, Inc. | Apparatus and methods for anastomosis |
| US6716252B2 (en) | 2000-06-30 | 2004-04-06 | Wit Ip Corporation | Prostatic stent with localized tissue engaging anchoring means and methods for inhibiting obstruction of the prostatic urethra |
| AUPR790901A0 (en) * | 2001-09-25 | 2001-10-18 | Mccloskey, Jenny Colleen | Inactivation of papillomavirus |
| IL149687A0 (en) * | 2002-05-15 | 2002-11-10 | Alexander Condrea | Cervical dilator |
| US20040127931A1 (en) * | 2002-08-09 | 2004-07-01 | Geoffrey Kincaid | Cervical dilator |
| AU2003295853A1 (en) * | 2002-11-21 | 2004-06-18 | Timothy B. Hibler | Cervical medical device, system and method |
| US20050165427A1 (en) * | 2004-01-22 | 2005-07-28 | Jahns Scott E. | Vessel sealing devices |
| WO2005084745A1 (en) * | 2004-03-08 | 2005-09-15 | Medilator | Catheter and method for dilating a body passageway |
| US7947207B2 (en) | 2005-04-12 | 2011-05-24 | Abbott Cardiovascular Systems Inc. | Method for retaining a vascular stent on a catheter |
| NZ540710A (en) * | 2005-06-10 | 2008-07-31 | Insitu Systems Ltd | Surgical apparatus for enabling establishment of a pneumoperitoneum and for uterus manipulation during a vaginal hysterectomy procedure |
| US20070276314A1 (en) * | 2006-05-26 | 2007-11-29 | Becker Bruce B | Nasolacrimal duct probing, intubating and irrigating device |
| US20100010530A1 (en) * | 2006-07-14 | 2010-01-14 | Ams Research Corporation | Balloon Dilation for Implantable Prosthesis |
| ITVI20070180A1 (it) | 2007-06-21 | 2008-12-22 | Slavica Slatinac | Dilatatore uterino di tipo monouso |
| US8123773B1 (en) * | 2008-09-10 | 2012-02-28 | Utah Medical Products Inc. | Postpartum hemorrhage balloon tamponade catheter |
| US8097014B2 (en) * | 2008-09-30 | 2012-01-17 | William D. Borkon | Variable rigidity vaginal dilator and use thereof |
| JP2012505050A (ja) | 2008-10-10 | 2012-03-01 | インターバルブ， インコーポレイテッド | 弁形成術用カテーテルおよび方法 |
| CN105079950A (zh) * | 2015-09-21 | 2015-11-25 | 北京优尼康通医疗科技有限公司 | 一种新型前列腺扩裂导管 |
| JP7323257B2 (ja) | 2017-12-05 | 2023-08-08 | ジェニー コリーン マクロスキー， | 体管および隣接する表面を治療するためのデバイス |
| US20230293204A1 (en) * | 2021-08-18 | 2023-09-21 | Celestial Life Sciences, Llc | Cervical dilator |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1282881A (en) * | 1917-07-07 | 1918-10-29 | John T Landis | Pneumatic dilator. |
| US1735519A (en) * | 1926-07-17 | 1929-11-12 | Arlyn T Vance | Physician's dilator |
| US1690995A (en) * | 1927-12-28 | 1928-11-06 | Monte Lloyd Corp | Anorectal dilator |
| GB328598A (en) * | 1929-01-28 | 1930-04-28 | Electro Thermal Company | Improvements in dilators |
| US2499045A (en) * | 1948-08-16 | 1950-02-28 | Walker Frank Ray | Rectal dilator and medicator |
| US2494393A (en) * | 1949-02-05 | 1950-01-10 | Otis F Lamson | Removable appliance for use as an artificial dam in cases of rectal incontinence |
| US2667875A (en) * | 1951-03-30 | 1954-02-02 | American Cystoscope Makers Inc | Inflatable retention catheter |
| US3046988A (en) * | 1958-12-01 | 1962-07-31 | Davol Rubber Co | Esophageal nasogastric tube |
| US3095871A (en) * | 1960-01-26 | 1963-07-02 | Edward C Mann | Method for determining the condition of the uterine isthmus |
| US3480017A (en) * | 1966-04-27 | 1969-11-25 | Wallace B Shute | Cervical dilator |
| US3460017A (en) * | 1967-01-16 | 1969-08-05 | Reliance Electric & Eng Co | Solid state trigger for scr |
| US3585983A (en) * | 1968-03-05 | 1971-06-22 | Adrian Kantrowitz | Cardiac assisting pump |
| US3626949A (en) * | 1969-01-23 | 1971-12-14 | Wallace B Shute | Cervical dilator |
| US3848602A (en) * | 1972-04-19 | 1974-11-19 | Gutnick Morton | Abortion facilitating device and process |
| US3799170A (en) * | 1972-05-31 | 1974-03-26 | M Walsh | Therapeutic dilator, disposable or reusable |
| US3900033A (en) * | 1973-03-07 | 1975-08-19 | Ortho Pharma Corp | Dilator for cervical canal |
| US3882852A (en) * | 1974-01-11 | 1975-05-13 | Manfred Sinnreich | Surgical dilators having insufflating means |
-
1973
- 1973-03-07 US US338697A patent/US3900033A/en not_active Expired - Lifetime
-
1974
- 1974-02-28 IN IN424/CAL/74A patent/IN139926B/en unknown
- 1974-02-28 NL NL7402762A patent/NL7402762A/xx not_active Application Discontinuation
- 1974-03-01 GB GB932474A patent/GB1457811A/en not_active Expired
- 1974-03-04 PH PH15571A patent/PH10674A/en unknown
- 1974-03-05 SE SE7402917A patent/SE401319B/xx not_active IP Right Cessation
- 1974-03-06 IE IE467/74A patent/IE39335B1/xx unknown
- 1974-03-06 ZA ZA00741466A patent/ZA741466B/xx unknown
- 1974-03-06 SU SU2009220A patent/SU535885A3/ru active
- 1974-03-06 NO NO740780A patent/NO134605C/no unknown
- 1974-03-06 CH CH315774A patent/CH562603A5/xx not_active IP Right Cessation
- 1974-03-06 IL IL44363A patent/IL44363A/en unknown
- 1974-03-06 FR FR7407632A patent/FR2220284B1/fr not_active Expired
- 1974-03-07 AR AR252686A patent/AR197859A1/es active
- 1974-03-07 DE DE2410933A patent/DE2410933A1/de active Pending
- 1974-03-07 BE BE141775A patent/BE812023A/xx unknown
- 1974-03-07 JP JP49025817A patent/JPS49126196A/ja active Pending
- 1974-03-07 BR BR1695/74A patent/BR7401695D0/pt unknown
-
1975
- 1975-05-21 US US05/579,631 patent/US4137922A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AR197859A1 (es) | 1974-05-10 |
| NL7402762A (nl) | 1974-09-10 |
| IL44363A (en) | 1976-09-30 |
| JPS49126196A (nl) | 1974-12-03 |
| US3900033A (en) | 1975-08-19 |
| FR2220284A1 (nl) | 1974-10-04 |
| US4137922A (en) | 1979-02-06 |
| FR2220284B1 (nl) | 1977-09-23 |
| SU535885A3 (ru) | 1976-11-15 |
| BE812023A (fr) | 1974-09-09 |
| GB1457811A (en) | 1976-12-08 |
| PH10674A (en) | 1977-08-05 |
| IE39335L (en) | 1974-09-07 |
| DE2410933A1 (de) | 1974-09-12 |
| IL44363A0 (en) | 1974-06-30 |
| NO134605C (nl) | 1976-11-17 |
| IE39335B1 (en) | 1978-09-13 |
| IN139926B (nl) | 1976-08-21 |
| CH562603A5 (nl) | 1975-06-13 |
| AU6621174A (en) | 1975-09-04 |
| ZA741466B (en) | 1975-10-29 |
| SE401319B (sv) | 1978-05-02 |
| BR7401695D0 (pt) | 1974-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO134605B (nl) | ||
| US2653899A (en) | Erythromycin, its salts, and method of preparation | |
| SU695565A3 (ru) | Способ получени клавулановой кислоты и ее солей | |
| NO118145B (nl) | ||
| NO115429B (nl) | ||
| DK158739B (da) | Svovlholdige antibiotiske og cytotoxiske forbindelser, betegnet cl-1577d og cl-1577e, fremgangsmaade til fremstilling af disse, samt farmaceutiske praeparater indeholdende forbindelserne | |
| US3065137A (en) | Chalcomycin and its fermentative production | |
| US3616208A (en) | Fermentation process for 9-(beta-d-arabinofuranosyl)adenine | |
| JPH05504469A (ja) | Ａ８３５４３回収方法 | |
| JPS6220984B2 (nl) | ||
| US3076746A (en) | New antibiotics azalomycin b and f and a process for the production thereof | |
| NO123091B (nl) | ||
| NO127316B (nl) | ||
| US4335108A (en) | Paulomycin A and B and preparation thereof | |
| US2996435A (en) | Process for producing azaserine | |
| US3023204A (en) | Viridogrisein, and its fermentative production with griseoviridin | |
| US3094461A (en) | Antimicrobial agent m-259 and method of preparation | |
| US4296101A (en) | Antibiotic kristenin | |
| US3647776A (en) | 1-hydroxy- and acetyloxy-3-(1-hexenylazoxy)-2-butanone | |
| US3043830A (en) | Actinobolin and its fermentative production | |
| JP3796540B2 (ja) | 黄色色素の製造方法 | |
| NO760873L (nl) | ||
| US2965547A (en) | Process for the production of l-6-diazo-5-oxonorleucine | |
| US3956067A (en) | Antibiotic X-372A | |
| JPS6015318B2 (ja) | 新抗生物質ｓｆ−１９４２物質，その製造法およびそれを含有する抗ガン剤 |