NO130322B - - Google Patents
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- Publication number
- NO130322B NO130322B NO04595/69A NO459569A NO130322B NO 130322 B NO130322 B NO 130322B NO 04595/69 A NO04595/69 A NO 04595/69A NO 459569 A NO459569 A NO 459569A NO 130322 B NO130322 B NO 130322B
- Authority
- NO
- Norway
- Prior art keywords
- culture
- strain
- fibrinolysokinase
- nutrient solution
- streptomyces
- Prior art date
Links
- 238000000034 method Methods 0.000 claims description 10
- 241000187392 Streptomyces griseus Species 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 241000958262 Streptomyces californicus Species 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 102000035195 Peptidases Human genes 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 241000187747 Streptomyces Species 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 235000013312 flour Nutrition 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 239000013049 sediment Substances 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241000186986 Streptomyces anulatus Species 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000186361 Actinobacteria <class> Species 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/816—Enzyme separation or purification by solubility
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1810277A DE1810277C3 (de) | 1968-11-22 | 1968-11-22 | Verfahren zur Gewinnung einer Fibrinolysokinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO130322B true NO130322B (fr) | 1974-08-12 |
Family
ID=5713985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO04595/69A NO130322B (fr) | 1968-11-22 | 1969-11-20 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3660239A (fr) |
| JP (1) | JPS5011470B1 (fr) |
| AT (1) | AT286912B (fr) |
| BE (1) | BE742043A (fr) |
| BR (1) | BR6914390D0 (fr) |
| CA (1) | CA920963A (fr) |
| CH (1) | CH532121A (fr) |
| DE (1) | DE1810277C3 (fr) |
| ES (1) | ES373763A1 (fr) |
| FI (1) | FI46622C (fr) |
| FR (1) | FR2023938B1 (fr) |
| GB (1) | GB1240257A (fr) |
| IL (1) | IL33273A (fr) |
| NL (1) | NL6917593A (fr) |
| NO (1) | NO130322B (fr) |
| SE (1) | SE376256B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5362240U (fr) * | 1976-10-29 | 1978-05-26 | ||
| JPS5764924U (fr) * | 1980-10-06 | 1982-04-17 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3140984A (en) * | 1961-11-30 | 1964-07-14 | Univ Alberta | Production of high activity fibrinolytic agents |
| GB1133579A (en) * | 1966-03-09 | 1968-11-13 | Shionogi & Co | Process for preparing proteases and enzymatic composition prepared thereby |
| US3444045A (en) * | 1966-09-20 | 1969-05-13 | American Cyanamid Co | Process for purifying streptokinase |
| US3477913A (en) * | 1967-10-31 | 1969-11-11 | Century Lab Inc | Method of production of urokinase |
-
1968
- 1968-11-22 DE DE1810277A patent/DE1810277C3/de not_active Expired
-
1969
- 1969-10-27 CH CH1605469A patent/CH532121A/de not_active IP Right Cessation
- 1969-10-29 IL IL33273A patent/IL33273A/xx unknown
- 1969-11-06 AT AT1042569A patent/AT286912B/de not_active IP Right Cessation
- 1969-11-14 CA CA067471A patent/CA920963A/en not_active Expired
- 1969-11-18 US US877818A patent/US3660239A/en not_active Expired - Lifetime
- 1969-11-19 FI FI693336A patent/FI46622C/fi active
- 1969-11-20 JP JP44092591A patent/JPS5011470B1/ja active Pending
- 1969-11-20 NO NO04595/69A patent/NO130322B/no unknown
- 1969-11-21 BE BE742043D patent/BE742043A/xx unknown
- 1969-11-21 FR FR6940246A patent/FR2023938B1/fr not_active Expired
- 1969-11-21 BR BR214390/69A patent/BR6914390D0/pt unknown
- 1969-11-21 ES ES373763A patent/ES373763A1/es not_active Expired
- 1969-11-21 NL NL6917593A patent/NL6917593A/xx not_active Application Discontinuation
- 1969-11-21 GB GB57146/69A patent/GB1240257A/en not_active Expired
- 1969-11-24 SE SE6916125A patent/SE376256B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5011470B1 (fr) | 1975-05-01 |
| ES373763A1 (es) | 1972-05-16 |
| SE376256B (fr) | 1975-05-12 |
| BR6914390D0 (pt) | 1973-04-19 |
| FI46622B (fr) | 1973-01-31 |
| CA920963A (en) | 1973-02-13 |
| BE742043A (fr) | 1970-05-21 |
| IL33273A (en) | 1974-03-14 |
| DE1810277B2 (de) | 1978-03-09 |
| GB1240257A (en) | 1971-07-21 |
| DE1810277A1 (de) | 1970-06-11 |
| FR2023938A1 (fr) | 1970-08-21 |
| NL6917593A (fr) | 1970-05-26 |
| AT286912B (de) | 1970-12-28 |
| CH532121A (de) | 1972-12-31 |
| IL33273A0 (en) | 1969-12-31 |
| FI46622C (fi) | 1973-05-08 |
| FR2023938B1 (fr) | 1973-12-21 |
| US3660239A (en) | 1972-05-02 |
| DE1810277C3 (de) | 1978-11-02 |
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