NO125396B - - Google Patents
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- Publication number
- NO125396B NO125396B NO4523/68A NO452368A NO125396B NO 125396 B NO125396 B NO 125396B NO 4523/68 A NO4523/68 A NO 4523/68A NO 452368 A NO452368 A NO 452368A NO 125396 B NO125396 B NO 125396B
- Authority
- NO
- Norway
- Prior art keywords
- daunorubicin
- streptomyces griseus
- streptomyces
- antibiotic
- strain
- Prior art date
Links
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 31
- 229960000975 daunorubicin Drugs 0.000 claims description 31
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 30
- 241000187392 Streptomyces griseus Species 0.000 claims description 25
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 18
- 230000003115 biocidal effect Effects 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 6
- 241000187747 Streptomyces Species 0.000 claims description 4
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- 239000000049 pigment Substances 0.000 description 13
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- 239000000126 substance Substances 0.000 description 12
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000006877 oatmeal agar Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000015113 tomato pastes and purées Nutrition 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR128323 | 1967-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO125396B true NO125396B (fi) | 1972-09-04 |
Family
ID=8641737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO4523/68A NO125396B (fi) | 1967-11-15 | 1968-11-14 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3997661A (fi) |
| JP (1) | JPS5015880B1 (fi) |
| AT (1) | AT279045B (fi) |
| BE (1) | BE723951A (fi) |
| BR (1) | BR6803917D0 (fi) |
| CH (1) | CH489605A (fi) |
| DK (1) | DK120715B (fi) |
| FI (1) | FI45982C (fi) |
| FR (1) | FR1551195A (fi) |
| GB (1) | GB1203164A (fi) |
| IE (1) | IE32578B1 (fi) |
| IL (1) | IL31071A (fi) |
| NL (1) | NL6815861A (fi) |
| NO (1) | NO125396B (fi) |
| SE (1) | SE348756B (fi) |
| YU (1) | YU33806B (fi) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5921394A (ja) * | 1982-07-24 | 1984-02-03 | Sanraku Inc | ダウノマイシンの製造法 |
| US11260126B2 (en) * | 2015-08-21 | 2022-03-01 | University Of Otago | Acoustic driven drug delivery systems |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1533151A (fr) * | 1962-05-18 | 1968-07-19 | Rhone Poulenc Sa | Nouvel antibiotique et sa préparation |
-
1967
- 1967-11-15 FR FR128323A patent/FR1551195A/fr not_active Expired
-
1968
- 1968-10-25 FI FI683039A patent/FI45982C/fi active
- 1968-11-07 NL NL6815861A patent/NL6815861A/xx unknown
- 1968-11-12 BR BR203917/68A patent/BR6803917D0/pt unknown
- 1968-11-13 GB GB53918/68A patent/GB1203164A/en not_active Expired
- 1968-11-14 YU YU2659/68A patent/YU33806B/xx unknown
- 1968-11-14 DK DK554668AA patent/DK120715B/da unknown
- 1968-11-14 NO NO4523/68A patent/NO125396B/no unknown
- 1968-11-14 US US04/775,904 patent/US3997661A/en not_active Expired - Lifetime
- 1968-11-14 BE BE723951D patent/BE723951A/xx unknown
- 1968-11-14 SE SE15477/68A patent/SE348756B/xx unknown
- 1968-11-14 CH CH1703068A patent/CH489605A/fr not_active IP Right Cessation
- 1968-11-14 IL IL31071A patent/IL31071A/en unknown
- 1968-11-15 AT AT1114968A patent/AT279045B/de not_active IP Right Cessation
- 1968-11-15 IE IE1375/68A patent/IE32578B1/xx unknown
- 1968-11-15 JP JP43083299A patent/JPS5015880B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB1203164A (en) | 1970-08-26 |
| IL31071A (en) | 1972-09-28 |
| FI45982C (fi) | 1972-11-10 |
| YU33806B (en) | 1978-05-15 |
| SE348756B (fi) | 1972-09-11 |
| DK120715B (da) | 1971-07-05 |
| CH489605A (fr) | 1970-04-30 |
| DE1809187A1 (de) | 1969-11-06 |
| IL31071A0 (en) | 1969-01-29 |
| AT279045B (de) | 1970-02-25 |
| FR1551195A (fi) | 1968-12-27 |
| NL6815861A (fi) | 1969-05-19 |
| FI45982B (fi) | 1972-07-31 |
| IE32578B1 (en) | 1973-09-19 |
| IE32578L (en) | 1969-05-15 |
| BR6803917D0 (pt) | 1973-02-22 |
| BE723951A (fi) | 1969-05-14 |
| JPS5015880B1 (fi) | 1975-06-09 |
| US3997661A (en) | 1976-12-14 |
| DE1809187B2 (de) | 1976-08-05 |
| YU265968A (en) | 1977-10-31 |
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