NL9400530A - Stabiele waterige folinaatoplossing. - Google Patents

Stabiele waterige folinaatoplossing. Download PDF

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Publication number
NL9400530A
NL9400530A NL9400530A NL9400530A NL9400530A NL 9400530 A NL9400530 A NL 9400530A NL 9400530 A NL9400530 A NL 9400530A NL 9400530 A NL9400530 A NL 9400530A NL 9400530 A NL9400530 A NL 9400530A
Authority
NL
Netherlands
Prior art keywords
solution
folinate
stable aqueous
sodium
stable
Prior art date
Application number
NL9400530A
Other languages
English (en)
Dutch (nl)
Inventor
Alfred James Nijkerk
Johanna Maria Pieterne Vermeer
Original Assignee
Pharmachemie Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv
Priority to NL9400530A priority Critical patent/NL9400530A/nl
Priority to ES95913428T priority patent/ES2149354T3/es
Priority to SI9530430T priority patent/SI0755396T1/xx
Priority to CA002187186A priority patent/CA2187186C/en
Priority to AU20862/95A priority patent/AU684350B2/en
Priority to JP7525589A priority patent/JPH09510989A/ja
Priority to PT95913428T priority patent/PT755396E/pt
Priority to EP95913428A priority patent/EP0755396B1/de
Priority to DE69517806T priority patent/DE69517806T2/de
Priority to AT95913428T priority patent/ATE194346T1/de
Priority to DK95913428T priority patent/DK0755396T3/da
Priority to PCT/NL1995/000126 priority patent/WO1995026963A1/en
Priority to ZA952805A priority patent/ZA952805B/xx
Publication of NL9400530A publication Critical patent/NL9400530A/nl
Priority to FI963972A priority patent/FI120039B/fi
Priority to NO19964231A priority patent/NO314039B1/no
Priority to US08/726,803 priority patent/US6613767B1/en
Priority to GR20000401477T priority patent/GR3033863T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NL9400530A 1994-04-05 1994-04-05 Stabiele waterige folinaatoplossing. NL9400530A (nl)

Priority Applications (17)

Application Number Priority Date Filing Date Title
NL9400530A NL9400530A (nl) 1994-04-05 1994-04-05 Stabiele waterige folinaatoplossing.
EP95913428A EP0755396B1 (de) 1994-04-05 1995-04-04 Stabile wässrige folinatlösung
DK95913428T DK0755396T3 (da) 1994-04-05 1995-04-04 Stabil vandig folinatopløsning
CA002187186A CA2187186C (en) 1994-04-05 1995-04-04 Stable aqueous folinate solution
AU20862/95A AU684350B2 (en) 1994-04-05 1995-04-04 Stable aqueous folinate solution
JP7525589A JPH09510989A (ja) 1994-04-05 1995-04-04 安定なフォリン酸塩水溶液
PT95913428T PT755396E (pt) 1994-04-05 1995-04-04 Solucao aquosa estavel de folinato
ES95913428T ES2149354T3 (es) 1994-04-05 1995-04-04 Solucion acuosa, estable de folinato.
DE69517806T DE69517806T2 (de) 1994-04-05 1995-04-04 Stabile wässrige folinatlösung
AT95913428T ATE194346T1 (de) 1994-04-05 1995-04-04 Stabile wässrige folinatlösung
SI9530430T SI0755396T1 (en) 1994-04-05 1995-04-04 Stable aqueous folinate solution
PCT/NL1995/000126 WO1995026963A1 (en) 1994-04-05 1995-04-04 Stable aqueous folinate solution
ZA952805A ZA952805B (en) 1994-04-05 1995-04-05 Stable aqueous folinate solution
FI963972A FI120039B (fi) 1994-04-05 1996-10-03 Stabiili vesipitoinen folinaattiliuos
NO19964231A NO314039B1 (no) 1994-04-05 1996-10-04 Stabil vandig folinatopplösning
US08/726,803 US6613767B1 (en) 1994-04-05 1996-10-07 Stable aqueous folinate solution
GR20000401477T GR3033863T3 (en) 1994-04-05 2000-07-06 Stable aqueous folinate solution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9400530A NL9400530A (nl) 1994-04-05 1994-04-05 Stabiele waterige folinaatoplossing.
NL9400530 1994-04-05

Publications (1)

Publication Number Publication Date
NL9400530A true NL9400530A (nl) 1995-11-01

Family

ID=19864026

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9400530A NL9400530A (nl) 1994-04-05 1994-04-05 Stabiele waterige folinaatoplossing.

Country Status (15)

Country Link
US (1) US6613767B1 (de)
EP (1) EP0755396B1 (de)
JP (1) JPH09510989A (de)
AT (1) ATE194346T1 (de)
AU (1) AU684350B2 (de)
DE (1) DE69517806T2 (de)
DK (1) DK0755396T3 (de)
ES (1) ES2149354T3 (de)
FI (1) FI120039B (de)
GR (1) GR3033863T3 (de)
NL (1) NL9400530A (de)
NO (1) NO314039B1 (de)
PT (1) PT755396E (de)
WO (1) WO1995026963A1 (de)
ZA (1) ZA952805B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
CH697021A5 (de) * 2003-06-26 2008-03-31 Merck Eprova Ag Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat.
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CN102258463A (zh) * 2011-07-18 2011-11-30 重庆煜澍丰医药有限公司 一种稳定的亚叶酸钠注射液
ES2414557B1 (es) * 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
WO2014025807A1 (en) 2012-08-06 2014-02-13 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising l-leucovorin
US10059710B2 (en) 2016-02-17 2018-08-28 Merck & Cie Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
EP0401895A1 (de) * 1989-06-06 1990-12-12 Pharmachemie B.V. Bei Kühlschranktemperatur stabile wässrige Folinatlösung sowie Verfahren zu deren Herstellung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH673459A5 (de) 1987-05-15 1990-03-15 Eprova Ag
WO1990010460A1 (en) 1989-03-13 1990-09-20 Kenneth Naoyuki Matsumura Method for reducing side effects of a drug
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
CH687062A5 (de) 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
EP0401895A1 (de) * 1989-06-06 1990-12-12 Pharmachemie B.V. Bei Kühlschranktemperatur stabile wässrige Folinatlösung sowie Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
EP0755396A1 (de) 1997-01-29
JPH09510989A (ja) 1997-11-04
FI963972A0 (fi) 1996-10-03
PT755396E (pt) 2000-10-31
EP0755396B1 (de) 2000-07-05
FI963972A (fi) 1996-10-03
DE69517806T2 (de) 2001-11-08
NO314039B1 (no) 2003-01-20
GR3033863T3 (en) 2000-10-31
AU2086295A (en) 1995-10-23
ES2149354T3 (es) 2000-11-01
FI120039B (fi) 2009-06-15
DE69517806D1 (de) 2000-08-10
ZA952805B (en) 1995-12-19
NO964231D0 (no) 1996-10-04
ATE194346T1 (de) 2000-07-15
NO964231L (no) 1996-10-04
AU684350B2 (en) 1997-12-11
WO1995026963A1 (en) 1995-10-12
DK0755396T3 (da) 2000-11-13
US6613767B1 (en) 2003-09-02

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A1B A search report has been drawn up
BV The patent application has lapsed