NL9300058A - 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan. - Google Patents
1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan. Download PDFInfo
- Publication number
- NL9300058A NL9300058A NL9300058A NL9300058A NL9300058A NL 9300058 A NL9300058 A NL 9300058A NL 9300058 A NL9300058 A NL 9300058A NL 9300058 A NL9300058 A NL 9300058A NL 9300058 A NL9300058 A NL 9300058A
- Authority
- NL
- Netherlands
- Prior art keywords
- alkyl
- anhydrohexitol
- group
- nucleoside analogues
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92201803 | 1992-06-18 | ||
EP92201803 | 1992-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
NL9300058A true NL9300058A (nl) | 1994-01-17 |
Family
ID=8210706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL9300058A NL9300058A (nl) | 1992-06-18 | 1993-01-12 | 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5607922A (de) |
EP (1) | EP0646125B1 (de) |
JP (1) | JPH08501071A (de) |
AT (1) | ATE166655T1 (de) |
AU (1) | AU671129B2 (de) |
CA (1) | CA2138415A1 (de) |
DE (1) | DE69318836T2 (de) |
DK (1) | DK0646125T3 (de) |
ES (1) | ES2117134T3 (de) |
GR (1) | GR3027651T3 (de) |
NL (1) | NL9300058A (de) |
WO (1) | WO1993025565A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06263793A (ja) * | 1993-03-04 | 1994-09-20 | Asahi Breweries Ltd | ピラノース型ヌクレオシド誘導体 |
CN1158618A (zh) * | 1994-08-17 | 1997-09-03 | 雷加Vzw基金会 | 核酸序列专一性结合寡聚体及其在反义方法中的用途 |
HUT77436A (hu) * | 1994-10-05 | 1998-04-28 | Darwin Discovery Limited | Purin- és guaninszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására |
AU1874397A (en) * | 1996-02-16 | 1997-09-02 | Stichting Rega Vzw | Hexitol containing oligonucleotides and their use in antisense strategies |
US20040266706A1 (en) * | 2002-11-05 | 2004-12-30 | Muthiah Manoharan | Cross-linked oligomeric compounds and their use in gene modulation |
US20040203024A1 (en) * | 1996-06-06 | 2004-10-14 | Baker Brenda F. | Modified oligonucleotides for use in RNA interference |
US20040171028A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Phosphorous-linked oligomeric compounds and their use in gene modulation |
US20040171032A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Non-phosphorous-linked oligomeric compounds and their use in gene modulation |
US20040171030A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation |
US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US20050042647A1 (en) * | 1996-06-06 | 2005-02-24 | Baker Brenda F. | Phosphorous-linked oligomeric compounds and their use in gene modulation |
US7812149B2 (en) * | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
WO2005121370A2 (en) * | 2004-06-03 | 2005-12-22 | Isis Pharmaceuticals, Inc. | Oligomeric compounds that facilitate risc loading |
US20040161844A1 (en) * | 1996-06-06 | 2004-08-19 | Baker Brenda F. | Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation |
US20050118605A9 (en) * | 1996-06-06 | 2005-06-02 | Baker Brenda F. | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation |
US20040161777A1 (en) * | 1996-06-06 | 2004-08-19 | Baker Brenda F. | Modified oligonucleotides for use in RNA interference |
US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US20050053976A1 (en) * | 1996-06-06 | 2005-03-10 | Baker Brenda F. | Chimeric oligomeric compounds and their use in gene modulation |
DE60011787T2 (de) * | 1999-09-10 | 2005-07-14 | Stichting Rega V.Z.W. | Carbocyclische nukleoside und verfahren zu deren herstellung |
US7138531B2 (en) * | 2001-10-15 | 2006-11-21 | Kemin Pharma B.V.B.A. | Preparation and use of carbohydrate-based bicyclic ring structures with antimicrobial and cytostatic activity |
US9150605B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
AU2003291753B2 (en) * | 2002-11-05 | 2010-07-08 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
AU2003287502B2 (en) * | 2002-11-05 | 2010-12-09 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
US9150606B2 (en) * | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
US7560231B2 (en) | 2002-12-20 | 2009-07-14 | Roche Molecular Systems, Inc. | Mannitol and glucitol derivatives |
CA2463719A1 (en) * | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
EP1636342A4 (de) * | 2003-06-20 | 2008-10-08 | Isis Pharmaceuticals Inc | Oligomere verbindungen zur verwendung bei der modulation von genen |
US8569474B2 (en) * | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
US8394947B2 (en) * | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
US7884086B2 (en) * | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
AU2007211080B9 (en) | 2006-01-27 | 2012-05-03 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
AU2007257094B2 (en) * | 2006-05-05 | 2012-10-25 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of SGLT2 |
US7666854B2 (en) * | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
US7547684B2 (en) * | 2006-05-11 | 2009-06-16 | Isis Pharmaceuticals, Inc. | 5′-modified bicyclic nucleic acid analogs |
AU2008286771B2 (en) | 2007-08-15 | 2013-08-15 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
WO2009100320A2 (en) * | 2008-02-07 | 2009-08-13 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexitol nucleic acid analogs |
US20120021515A1 (en) | 2009-02-06 | 2012-01-26 | Swayze Eric E | Oligomeric compounds and methods |
WO2010090969A1 (en) | 2009-02-06 | 2010-08-12 | Isis Pharmaceuticals, Inc. | Tetrahydropyran nucleic acid analogs |
US8496917B2 (en) * | 2009-11-13 | 2013-07-30 | Sytheon Ltd | Compositions and methods for improving skin appearance |
US8993738B2 (en) | 2010-04-28 | 2015-03-31 | Isis Pharmaceuticals, Inc. | Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom |
JP6129844B2 (ja) | 2011-09-14 | 2017-05-17 | ラナ セラピューティクス インコーポレイテッド | 多量体オリゴヌクレオチド化合物 |
DK3137476T3 (da) | 2014-04-28 | 2019-11-18 | Ionis Pharmaceuticals Inc | Linker-modificerede oligomerforbindelser |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK167377B1 (da) * | 1985-09-17 | 1993-10-25 | Wellcome Found | 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion |
US4997926A (en) * | 1987-11-18 | 1991-03-05 | Scripps Clinic And Research Foundation | Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy |
SE8802687D0 (sv) * | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
-
1993
- 1993-01-12 NL NL9300058A patent/NL9300058A/nl not_active Application Discontinuation
- 1993-06-18 CA CA002138415A patent/CA2138415A1/en not_active Abandoned
- 1993-06-18 WO PCT/BE1993/000036 patent/WO1993025565A1/en active IP Right Grant
- 1993-06-18 EP EP93912478A patent/EP0646125B1/de not_active Expired - Lifetime
- 1993-06-18 DE DE69318836T patent/DE69318836T2/de not_active Expired - Fee Related
- 1993-06-18 JP JP6500978A patent/JPH08501071A/ja active Pending
- 1993-06-18 AU AU43013/93A patent/AU671129B2/en not_active Ceased
- 1993-06-18 DK DK93912478T patent/DK0646125T3/da active
- 1993-06-18 AT AT93912478T patent/ATE166655T1/de not_active IP Right Cessation
- 1993-06-18 ES ES93912478T patent/ES2117134T3/es not_active Expired - Lifetime
- 1993-12-17 US US08/170,117 patent/US5607922A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/482,823 patent/US5668113A/en not_active Expired - Fee Related
-
1998
- 1998-08-14 GR GR980401826T patent/GR3027651T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0646125T3 (da) | 1999-03-22 |
AU4301393A (en) | 1994-01-04 |
US5668113A (en) | 1997-09-16 |
EP0646125B1 (de) | 1998-05-27 |
EP0646125A1 (de) | 1995-04-05 |
DE69318836T2 (de) | 1999-01-28 |
US5607922A (en) | 1997-03-04 |
ATE166655T1 (de) | 1998-06-15 |
JPH08501071A (ja) | 1996-02-06 |
GR3027651T3 (en) | 1998-11-30 |
WO1993025565A1 (en) | 1993-12-23 |
CA2138415A1 (en) | 1993-12-23 |
AU671129B2 (en) | 1996-08-15 |
DE69318836D1 (de) | 1998-07-02 |
ES2117134T3 (es) | 1998-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1B | A search report has been drawn up | ||
BV | The patent application has lapsed |