NL8005336A - E-5-(2-halogeenvinyl)-2'-deoxycytidinen. - Google Patents

E-5-(2-halogeenvinyl)-2'-deoxycytidinen. Download PDF

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Publication number
NL8005336A
NL8005336A NL8005336A NL8005336A NL8005336A NL 8005336 A NL8005336 A NL 8005336A NL 8005336 A NL8005336 A NL 8005336A NL 8005336 A NL8005336 A NL 8005336A NL 8005336 A NL8005336 A NL 8005336A
Authority
NL
Netherlands
Prior art keywords
deoxycytidine
vinyl
halo
compounds
virus
Prior art date
Application number
NL8005336A
Other languages
English (en)
Dutch (nl)
Original Assignee
Univ Birmingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Birmingham filed Critical Univ Birmingham
Publication of NL8005336A publication Critical patent/NL8005336A/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NL8005336A 1979-10-03 1980-09-24 E-5-(2-halogeenvinyl)-2'-deoxycytidinen. NL8005336A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7934248A GB2060604B (en) 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines
GB7934248 1979-10-03

Publications (1)

Publication Number Publication Date
NL8005336A true NL8005336A (nl) 1981-04-07

Family

ID=10508255

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8005336A NL8005336A (nl) 1979-10-03 1980-09-24 E-5-(2-halogeenvinyl)-2'-deoxycytidinen.

Country Status (11)

Country Link
US (1) US4382925A (fr)
JP (1) JPS5695198A (fr)
BE (1) BE885415A (fr)
CA (1) CA1173438A (fr)
CH (1) CH647245A5 (fr)
DE (1) DE3036131A1 (fr)
FR (1) FR2466472A1 (fr)
GB (1) GB2060604B (fr)
IT (1) IT1209758B (fr)
NL (1) NL8005336A (fr)
SE (1) SE445740B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
EP0080305A1 (fr) * 1981-11-19 1983-06-01 Beecham Group Plc 2'-Déoxyuridines à activité antivirale, leur préparation et emploi
EP0082668A1 (fr) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogénovinyl)-2'-déoxyuridines, leurs méthodes de préparation, compositions pharmaceutiques les contenant et leur emploi dans le traitement d'infections virales
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
FR2531962B1 (fr) * 1982-08-17 1986-11-14 Sandoz Sa Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
CA1257595A (fr) * 1982-09-17 1989-07-18 Glaxo Group Ltd Derives de 5-halogenovinyl-2'-desoxyuridine
HU198393B (en) * 1984-03-06 1989-10-30 Sloan Kettering Inst Cancer Process for production of medical composition suitable for treatment of hepatitis containing as active substance derivatives of piramidin-nucleoside
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
EP0428623A4 (en) * 1988-08-10 1993-12-08 Stephen Leslie Sacks Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
DK1284720T3 (da) 2000-03-29 2007-01-15 Univ Georgetown L-FMAU til behandling af hepatitis delta-virusinfektion
WO2003053360A2 (fr) * 2001-12-20 2003-07-03 Pharmassett Ltd. Traitement du virus d'epstein-barr, infection a l'herpesvirus lie au sarcome de kaposi et proliferation cellulaire anormale associee
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
US4024143A (en) * 1976-03-11 1977-05-17 Pcr, Inc. Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides

Also Published As

Publication number Publication date
FR2466472A1 (fr) 1981-04-10
JPS5695198A (en) 1981-08-01
JPS637199B2 (fr) 1988-02-15
GB2060604A (en) 1981-05-07
IT8009551A0 (it) 1980-10-02
DE3036131C2 (fr) 1989-07-06
DE3036131A1 (de) 1981-04-16
FR2466472B1 (fr) 1983-12-23
SE8006669L (sv) 1981-04-04
US4382925A (en) 1983-05-10
SE445740B (sv) 1986-07-14
GB2060604B (en) 1983-11-23
CH647245A5 (de) 1985-01-15
BE885415A (nl) 1981-03-26
CA1173438A (fr) 1984-08-28
IT1209758B (it) 1989-08-30

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed