NL8003385A - (3-alkylamino-2-hydroxypropoxy)-furan-2-carbonzuur- aniliden en werkwijzen voor het bereiden en toepassen van deze verbindingen. - Google Patents
(3-alkylamino-2-hydroxypropoxy)-furan-2-carbonzuur- aniliden en werkwijzen voor het bereiden en toepassen van deze verbindingen. Download PDFInfo
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- NL8003385A NL8003385A NL8003385A NL8003385A NL8003385A NL 8003385 A NL8003385 A NL 8003385A NL 8003385 A NL8003385 A NL 8003385A NL 8003385 A NL8003385 A NL 8003385A NL 8003385 A NL8003385 A NL 8003385A
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- 150000001875 compounds Chemical class 0.000 title claims description 55
- 238000000034 method Methods 0.000 title claims description 16
- 150000003931 anilides Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 15
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- XHVDWCKBZSFUDE-UHFFFAOYSA-N n-phenylfuran-2-carboxamide Chemical class C=1C=COC=1C(=O)NC1=CC=CC=C1 XHVDWCKBZSFUDE-UHFFFAOYSA-N 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
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- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
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- 125000003118 aryl group Chemical group 0.000 claims 1
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- 230000007306 turnover Effects 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 54
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
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- 150000007513 acids Chemical class 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
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- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical class OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 description 1
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- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/70—Nitro radicals
- C07D307/71—Nitro radicals attached in position 5
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2923817 | 1979-06-12 | ||
| DE2923817A DE2923817C2 (de) | 1979-06-12 | 1979-06-12 | (3-Alkylamino-2-hydroxyproposy)-furan-2-carbonsäureanilide und deren physiologisch verträgliche Säureadditionssalze und Verfahren zu deren Herstellung sowie Arzneimittel mit einem Gehalt dieser Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8003385A true NL8003385A (nl) | 1980-12-16 |
Family
ID=6073081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8003385A NL8003385A (nl) | 1979-06-12 | 1980-06-11 | (3-alkylamino-2-hydroxypropoxy)-furan-2-carbonzuur- aniliden en werkwijzen voor het bereiden en toepassen van deze verbindingen. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4269855A (de) |
| JP (1) | JPS562977A (de) |
| AT (1) | AT376428B (de) |
| AU (1) | AU535945B2 (de) |
| BE (1) | BE883766A (de) |
| CA (1) | CA1146953A (de) |
| CH (1) | CH643250A5 (de) |
| DE (1) | DE2923817C2 (de) |
| FR (1) | FR2458548A1 (de) |
| GB (1) | GB2051796B (de) |
| IT (1) | IT1131822B (de) |
| NL (1) | NL8003385A (de) |
| SE (1) | SE448377B (de) |
| ZA (1) | ZA803466B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2510573B1 (fr) * | 1981-07-29 | 1985-07-26 | Carpibem | (2-substitue 4-(thienyl acetamido) phenoxy) hydroxy propylamines, leur preparation, leur utilisation en therapeutique, et nouveaux intermediaires |
| IE56108B1 (en) * | 1982-07-16 | 1991-04-24 | Carpibem | 1-(2-carbalkoxy-4-(thienylcarboxamido)phenoxy)-3-amino 2-propanols,their preparation and applications thereof in therapeutics |
| FR2530245A1 (fr) * | 1982-07-16 | 1984-01-20 | Carpibem | Nouveaux 1-(2-carbalkoxy 4-(thienyl-alkylamido)phenoxy) 3-amino 2-propanols, leur preparation et leurs applications en therapeutique |
| FR2555179B1 (fr) * | 1983-11-21 | 1986-11-21 | Carpibem | Nouveaux (carbethoxy-2 furyl- ou benzofuryl-carboxamido-4 phenoxy)-1 amino-3 propanols-2 : leurs preparations et leurs applications en therapeutique |
| US6300368B1 (en) * | 1998-06-30 | 2001-10-09 | Mitsui Chemicals, Inc. | Anilide derivatives and antiarrhythmic agents containing the same |
| CN108358811B (zh) * | 2017-03-17 | 2019-09-03 | 上海柏翱纳吉医药科技有限公司 | 苯乙酮类化合物、其制备方法及其在调血脂方面的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1543689A (fr) * | 1966-11-03 | 1968-10-25 | Ici Ltd | Procédé de fabrication de nouvelles alcanolamines et de leurs dérivés |
| US3959481A (en) * | 1969-02-13 | 1976-05-25 | Uniroyal | Method of protecting plants from fungal diseases using furan-3-carboxamide derivatives |
| JPS5749552B2 (de) * | 1972-06-07 | 1982-10-22 | ||
| GB1531718A (en) * | 1974-11-20 | 1978-11-08 | Pharmacia As | Phenylethanolamines |
| DE2800504A1 (de) * | 1978-01-05 | 1979-07-12 | Consortium Elektrochem Ind | Verfahren zur herstellung von furancarbonsaeureanilid |
-
1979
- 1979-06-12 DE DE2923817A patent/DE2923817C2/de not_active Expired
-
1980
- 1980-04-14 CH CH285380A patent/CH643250A5/de not_active IP Right Cessation
- 1980-04-16 CA CA000350002A patent/CA1146953A/en not_active Expired
- 1980-05-29 GB GB8017550A patent/GB2051796B/en not_active Expired
- 1980-06-03 US US06/155,953 patent/US4269855A/en not_active Expired - Lifetime
- 1980-06-10 FR FR8012839A patent/FR2458548A1/fr active Granted
- 1980-06-11 SE SE8004351A patent/SE448377B/sv not_active IP Right Cessation
- 1980-06-11 BE BE0/200995A patent/BE883766A/fr not_active IP Right Cessation
- 1980-06-11 NL NL8003385A patent/NL8003385A/nl not_active Application Discontinuation
- 1980-06-11 IT IT22724/80A patent/IT1131822B/it active
- 1980-06-11 AU AU59212/80A patent/AU535945B2/en not_active Ceased
- 1980-06-11 ZA ZA00803466A patent/ZA803466B/xx unknown
- 1980-06-11 JP JP7790780A patent/JPS562977A/ja active Pending
- 1980-06-11 AT AT0307580A patent/AT376428B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1146953A (en) | 1983-05-24 |
| AU535945B2 (en) | 1984-04-12 |
| SE8004351L (sv) | 1980-12-13 |
| FR2458548A1 (fr) | 1981-01-02 |
| IT8022724A0 (it) | 1980-06-11 |
| GB2051796A (en) | 1981-01-21 |
| US4269855A (en) | 1981-05-26 |
| ATA307580A (de) | 1984-04-15 |
| CH643250A5 (de) | 1984-05-30 |
| GB2051796B (en) | 1983-04-27 |
| DE2923817C2 (de) | 1981-07-09 |
| FR2458548B1 (de) | 1983-08-05 |
| ZA803466B (en) | 1981-06-24 |
| BE883766A (fr) | 1980-10-01 |
| AU5921280A (en) | 1980-12-18 |
| SE448377B (sv) | 1987-02-16 |
| JPS562977A (en) | 1981-01-13 |
| DE2923817B1 (de) | 1980-08-14 |
| IT1131822B (it) | 1986-06-25 |
| AT376428B (de) | 1984-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |