NL7907800A - Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten. - Google Patents

Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten. Download PDF

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Publication number
NL7907800A
NL7907800A NL7907800A NL7907800A NL7907800A NL 7907800 A NL7907800 A NL 7907800A NL 7907800 A NL7907800 A NL 7907800A NL 7907800 A NL7907800 A NL 7907800A NL 7907800 A NL7907800 A NL 7907800A
Authority
NL
Netherlands
Prior art keywords
methyl
hydroxy
compound
formula
hydrogen
Prior art date
Application number
NL7907800A
Other languages
English (en)
Dutch (nl)
Original Assignee
Acf Chemiefarma Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv
Priority to NL7907800A priority Critical patent/NL7907800A/nl
Priority to AT80106213T priority patent/ATE8990T1/de
Priority to DE8080106213T priority patent/DE3068961D1/de
Priority to EP80106213A priority patent/EP0028717B1/en
Priority to DK435380A priority patent/DK435380A/da
Priority to FI803237A priority patent/FI67373C/fi
Priority to IL61324A priority patent/IL61324A/xx
Priority to NZ195329A priority patent/NZ195329A/en
Priority to CA000362879A priority patent/CA1155840A/en
Priority to AU63540/80A priority patent/AU539310B2/en
Priority to IE2188/80A priority patent/IE50667B1/en
Priority to JP14887180A priority patent/JPS5686164A/ja
Priority to ES496167A priority patent/ES8106894A1/es
Priority to PT71949A priority patent/PT71949B/pt
Priority to ZA00806528A priority patent/ZA806528B/xx
Publication of NL7907800A publication Critical patent/NL7907800A/nl
Priority to US06/282,799 priority patent/US4425353A/en
Priority to US06/283,084 priority patent/US4406904A/en
Priority to FI833268A priority patent/FI68225C/fi
Priority to FI833269A priority patent/FI68226C/fi
Priority to FI833267A priority patent/FI68224C/fi
Priority to MY184/87A priority patent/MY8700184A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL7907800A 1979-10-23 1979-10-23 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten. NL7907800A (nl)

Priority Applications (21)

Application Number Priority Date Filing Date Title
NL7907800A NL7907800A (nl) 1979-10-23 1979-10-23 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.
AT80106213T ATE8990T1 (de) 1979-10-23 1980-10-13 6,7-benzomorphan-derivate, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische zusammensetzungen und ihre verwendung als pharmazeutika.
DE8080106213T DE3068961D1 (en) 1979-10-23 1980-10-13 6,7-benzomorphan derivatives, processes for their production, pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
EP80106213A EP0028717B1 (en) 1979-10-23 1980-10-13 6,7-benzomorphan derivatives, processes for their production, pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
DK435380A DK435380A (da) 1979-10-23 1980-10-14 Fremgangsmaade til fremstilling af benzomorphanderivater
FI803237A FI67373C (fi) 1979-10-23 1980-10-14 Foerfarande foer framstaellning av 6,7-bensomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av det luten isrande hormonet
AU63540/80A AU539310B2 (en) 1979-10-23 1980-10-21 Benzomorphan derivatives
NZ195329A NZ195329A (en) 1979-10-23 1980-10-21 6,7-benzomorphan derivatives and pharmaceutical compositions
CA000362879A CA1155840A (en) 1979-10-23 1980-10-21 6,7-benzomorphan derivatives, processes for their production, pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
IL61324A IL61324A (en) 1979-10-23 1980-10-21 5-oxy-6,7-benzomorphan derivatives,their production and pharmaceutical compositions containing them
PT71949A PT71949B (en) 1979-10-23 1980-10-22 Process for the preparation of new derivatives of 6,7-benzomor-phan having pharmaceutical effect
JP14887180A JPS5686164A (en) 1979-10-23 1980-10-22 6*77benzomorphan derivatives* their manufacture and medicine containing them
ES496167A ES8106894A1 (es) 1979-10-23 1980-10-22 Perfeccionamientos en o relacionados con compuestos organi- cos
IE2188/80A IE50667B1 (en) 1979-10-23 1980-10-22 6-7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
ZA00806528A ZA806528B (en) 1979-10-23 1980-10-23 6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
US06/282,799 US4425353A (en) 1979-10-23 1981-07-13 Analgesic 5-oxygenated-6,7-benzomorphan derivatives
US06/283,084 US4406904A (en) 1979-10-23 1981-07-13 Method of inhibiting luteinizing hormone secretion with 6,7-benzomorphan derivatives
FI833268A FI68225C (fi) 1979-10-23 1983-09-13 Foerfarande foer framstaellning av 6,7-benzomorfanderivat vilka aer anvaendbara som analgetiska medel antagonister foer nakotiska medel och inhibitorer foer sekretion av luteinise rigshormon
FI833269A FI68226C (fi) 1979-10-23 1983-09-13 Foerfarande foer framstaellning av 6,7-benzomorfanderivat vilka aer anvaendbara som analgetiska aemnen antagonister foer narkotiska medel och inhibitorer foer sekretion av luteiniseringshormon
FI833267A FI68224C (fi) 1979-10-23 1983-09-13 Foerfarande foer framstaellning av 6,7-benzomorfanderivat vilka aer anvaendbara som analgetiska aemnen antagonister foer narkotiska medel och inhibitorer foer sekretion av luteiniseringshormon
MY184/87A MY8700184A (en) 1979-10-23 1987-12-30 6 7-benzomorphan derivatives processes for their production pharmaceutical compositions containing said derivatives and their use as pharmaceuticals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL7907800 1979-10-23
NL7907800A NL7907800A (nl) 1979-10-23 1979-10-23 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Publications (1)

Publication Number Publication Date
NL7907800A true NL7907800A (nl) 1981-04-27

Family

ID=19834064

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7907800A NL7907800A (nl) 1979-10-23 1979-10-23 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Country Status (17)

Country Link
US (2) US4406904A (fi)
EP (1) EP0028717B1 (fi)
JP (1) JPS5686164A (fi)
AT (1) ATE8990T1 (fi)
AU (1) AU539310B2 (fi)
CA (1) CA1155840A (fi)
DE (1) DE3068961D1 (fi)
DK (1) DK435380A (fi)
ES (1) ES8106894A1 (fi)
FI (1) FI67373C (fi)
IE (1) IE50667B1 (fi)
IL (1) IL61324A (fi)
MY (1) MY8700184A (fi)
NL (1) NL7907800A (fi)
NZ (1) NZ195329A (fi)
PT (1) PT71949B (fi)
ZA (1) ZA806528B (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579950A (en) * 1982-08-20 1986-04-01 Hoechst-Roussel Pharmaceuticals Inc. Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine] compounds
JPH01102077A (ja) * 1987-09-24 1989-04-19 Hoechst Roussel Pharmaceut Inc ２，６‐メタノピロロ‐３‐ベンズアゾジン類
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
AU9621598A (en) 1997-10-20 1999-05-10 Novo Nordisk A/S Luteinising hormone antagonists useful for treatment of estrogen deficiencies, or as a contraceptive
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
AU3885901A (en) 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders
US6495694B2 (en) * 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
EP2858976B1 (en) 2012-05-11 2018-03-14 Purdue Pharma LP Benzomorphan compounds as opioid receptors modulators
US10138207B2 (en) 2012-11-09 2018-11-27 Purdue Pharma, L.P. Benzomorphan analogs and the use thereof
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
EP3139921A4 (en) 2014-05-06 2018-02-14 Purdue Pharma L.P. Benzomorphan analogs and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050227A (fi) 1963-11-07
US4087532A (en) 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
DE2716687A1 (de) 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
US4202897A (en) * 1977-07-25 1980-05-13 Sandoz, Inc. Prolactin secretion inhibitors
IT8049377A0 (it) 1979-08-03 1980-07-30 Sandoz Ag Medicamento a base di composti triciclici per inibire la secrezione dell'ormone luteinizzante(caso 1005224)

Also Published As

Publication number Publication date
MY8700184A (en) 1987-12-31
ES496167A0 (es) 1981-09-16
ZA806528B (en) 1982-06-30
NZ195329A (en) 1984-05-31
IL61324A0 (en) 1980-12-31
DK435380A (da) 1981-04-24
PT71949A (en) 1981-08-19
FI67373C (fi) 1985-03-11
IL61324A (en) 1985-03-31
FI803237L (fi) 1981-04-24
PT71949B (en) 1981-12-17
EP0028717B1 (en) 1984-08-15
AU539310B2 (en) 1984-09-20
JPS5686164A (en) 1981-07-13
EP0028717A1 (en) 1981-05-20
IE802188L (en) 1981-04-23
CA1155840A (en) 1983-10-25
ES8106894A1 (es) 1981-09-16
US4425353A (en) 1984-01-10
US4406904A (en) 1983-09-27
ATE8990T1 (de) 1984-09-15
DE3068961D1 (en) 1984-09-20
IE50667B1 (en) 1986-06-11
FI67373B (fi) 1984-11-30
AU6354080A (en) 1981-04-30

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed