NL7212931A - - Google Patents

Info

Publication number
NL7212931A
NL7212931A NL7212931A NL7212931A NL7212931A NL 7212931 A NL7212931 A NL 7212931A NL 7212931 A NL7212931 A NL 7212931A NL 7212931 A NL7212931 A NL 7212931A NL 7212931 A NL7212931 A NL 7212931A
Authority
NL
Netherlands
Application number
NL7212931A
Other versions
NL146793B (nl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712149070 external-priority patent/DE2149070C3/de
Application filed filed Critical
Publication of NL7212931A publication Critical patent/NL7212931A/xx
Publication of NL146793B publication Critical patent/NL146793B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL727212931A 1971-10-01 1972-09-25 Werkwijze voor het bereiden van een geneesmiddel met lipide-verlagende werking, het volgens die werkwijze verkregen gevormde geneesmiddel en een werkwijze voor het bereiden van een fenoxyalkaancarbonzuurderivaat, geschikt voor de toepassing in het geneesmiddel. NL146793B (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19712149070 DE2149070C3 (de) 1971-10-01 1971-10-01 Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel
DE2230383A DE2230383C3 (de) 1971-10-01 1972-06-22 Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben

Publications (2)

Publication Number Publication Date
NL7212931A true NL7212931A (show.php) 1973-04-03
NL146793B NL146793B (nl) 1975-08-15

Family

ID=25761810

Family Applications (1)

Application Number Title Priority Date Filing Date
NL727212931A NL146793B (nl) 1971-10-01 1972-09-25 Werkwijze voor het bereiden van een geneesmiddel met lipide-verlagende werking, het volgens die werkwijze verkregen gevormde geneesmiddel en een werkwijze voor het bereiden van een fenoxyalkaancarbonzuurderivaat, geschikt voor de toepassing in het geneesmiddel.

Country Status (18)

Country Link
US (1) US3781328A (show.php)
JP (1) JPS5112618B2 (show.php)
AR (1) AR193131A1 (show.php)
AT (1) AT319209B (show.php)
BE (1) BE857160Q (show.php)
CA (1) CA1010892A (show.php)
CH (1) CH576427A5 (show.php)
DE (1) DE2230383C3 (show.php)
ES (1) ES407208A1 (show.php)
FI (1) FI55493C (show.php)
FR (1) FR2154739B1 (show.php)
GB (1) GB1359264A (show.php)
HK (1) HK41877A (show.php)
HU (1) HU164572B (show.php)
KE (1) KE2755A (show.php)
NL (1) NL146793B (show.php)
SE (1) SE393800B (show.php)
YU (1) YU36291B (show.php)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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US3864366A (en) * 1971-12-29 1975-02-04 Eastman Kodak Co Novel acylamidophenol photographic couplers
GB1484413A (en) * 1974-04-18 1977-09-01 Kissei Pharmaceutical Aromatic amidocarboxylic acid derivatives
DE2500157C2 (de) * 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
US4042711A (en) * 1975-01-09 1977-08-16 Boehringer Ingelheim Gmbh Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their use as antihyperlipidemics
AT341512B (de) * 1975-01-09 1978-02-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen biphenylathern
DE2517229A1 (de) * 1975-04-18 1976-10-28 Boehringer Mannheim Gmbh Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung
DE2532420A1 (de) * 1975-07-19 1977-02-03 Boehringer Mannheim Gmbh Phenylessigsaeure-derivate und verfahren zu ihrer herstellung
DE2541342A1 (de) * 1975-09-17 1977-03-31 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben
DE2546996C2 (de) * 1975-10-21 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim Phenoxyalkylcarbonsäure-Derivate, Verfahren zur Herstellung derselben sowie Arzneimittel, die diese Verbindungen als Wirkstoff enthalten
US4214094A (en) * 1977-03-30 1980-07-22 Fujisawa Pharmaceutical Co., Ltd. Substituted-phenyl substituted-alkyl ethers and the preparation thereof
JPS5649906B2 (en) * 1978-05-12 1981-11-25 Boehringer Mannheim Gmbh Manufacture of alphaa*44*44chlorobenzoylaminoo ethyl**phenoxy**isoethylacetic acid
JPS56145261A (en) * 1980-04-10 1981-11-11 Kaken Pharmaceut Co Ltd Novel oxyacetic acid derivative, its preparation, and lowering agent of lipid in blood comprising it as active ingredient
US4281190A (en) * 1980-08-14 1981-07-28 Morton-Norwich Products, Inc. Process for preparing N-[2-(p-hydroxyphenyl)-ethyl]-p-chlorobenzamide
JPS57140754A (en) * 1981-02-24 1982-08-31 Kureha Chem Ind Co Ltd Dihydroxybenzoic acid derivative and physiologically active preparation containing the same
US4927955A (en) * 1987-08-12 1990-05-22 Sanofi Process for the O-alkylation of N-(hydroxy)aralkylphenylethanolamines
IL102707A (en) * 1992-08-02 1996-11-14 Cherkez Stephen Processes for the preparation of tyramine derivatives
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
CA2356240C (en) 1998-12-23 2008-04-01 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
PL348503A1 (en) * 1998-12-23 2002-05-20 Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
CZ20012340A3 (cs) * 1998-12-23 2001-11-14 G. D. Searle Llc Kombinace inhibitorů transportu kyčelní ľlučové kyseliny a proteinových inhibitorů cholesteryl-esterového přenosu pro kardiovaskulární indikace
HUP0104745A3 (en) * 1998-12-23 2003-01-28 G D Searle Llc Chicago Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
US6489366B1 (en) * 1998-12-23 2002-12-03 G. D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
IL143947A0 (en) * 1998-12-23 2002-04-21 Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
AU779264B2 (en) * 1998-12-23 2005-01-13 G.D. Searle Llc Combinations for cardiovascular indications
EP1246792B1 (en) * 2000-01-13 2014-08-13 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU2001240115A1 (en) 2000-03-10 2001-09-24 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
US20020061888A1 (en) * 2000-03-10 2002-05-23 Keller Bradley T. Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
CA2434033A1 (en) * 2001-01-26 2002-08-01 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
AU2002243557B2 (en) * 2001-01-26 2006-01-05 Merck Sharp & Dohme Corp. The use of substituted azetidinone compounds for the treatment of sitosterolemia
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
TW200840563A (en) * 2001-01-26 2008-10-16 Schering Corp Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
ATE362757T1 (de) * 2001-01-26 2007-06-15 Schering Corp Kombinationen eines hemmers der sterolabsorption und eines kardiovaskulären wirkstoffes zur behandlung von kardiovaskulären indikationen
DK1413331T3 (da) * 2001-01-26 2007-12-10 Schering Corp Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivatoren fenofibrat og sterolabsorptionsinhibitoren ezetimib til vaskulære indikationer
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US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
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US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
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JP2005521653A (ja) 2002-01-17 2005-07-21 ファルマシア コーポレイション 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1080503A (en) * 1965-07-02 1967-08-23 Smith & Nephew Substituted acetic acids and a process for their preparation

Also Published As

Publication number Publication date
JPS5112618B2 (show.php) 1976-04-21
GB1359264A (en) 1974-07-10
NL146793B (nl) 1975-08-15
DE2230383B2 (de) 1980-10-09
HU164572B (show.php) 1974-03-28
DE2230383A1 (de) 1974-01-17
US3781328A (en) 1973-12-25
CH576427A5 (show.php) 1976-06-15
SE393800B (sv) 1977-05-23
FR2154739B1 (show.php) 1975-10-31
FI55493C (fi) 1979-08-10
FR2154739A1 (show.php) 1973-05-11
AR193131A1 (es) 1973-03-30
BE857160Q (fr) 1978-01-26
DE2230383C3 (de) 1981-12-03
KE2755A (en) 1977-10-14
HK41877A (en) 1977-08-19
FI55493B (fi) 1979-04-30
ES407208A1 (es) 1975-11-01
CA1010892A (en) 1977-05-24
AU4723372A (en) 1973-08-23
AT319209B (de) 1974-12-10
YU245572A (en) 1980-10-31
JPS4840741A (show.php) 1973-06-15
YU36291B (en) 1982-06-18

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Legal Events

Date Code Title Description
NL80 Information provided on patent owner name for an already discontinued patent

Owner name: BOEHRINGER

V4 Discontinued because of reaching the maximum lifetime of a patent