NL7210549A - 4-Alkoxy or hydroxy-5-phenyl-3-thienylalkano-ic acids - antiphlogistics - Google Patents

4-Alkoxy or hydroxy-5-phenyl-3-thienylalkano-ic acids - antiphlogistics

Info

Publication number
NL7210549A
NL7210549A NL7210549A NL7210549A NL7210549A NL 7210549 A NL7210549 A NL 7210549A NL 7210549 A NL7210549 A NL 7210549A NL 7210549 A NL7210549 A NL 7210549A NL 7210549 A NL7210549 A NL 7210549A
Authority
NL
Netherlands
Prior art keywords
lower alkyl
alkoxy
alkyl
acids
single bond
Prior art date
Application number
NL7210549A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to NL7210549A priority Critical patent/NL7210549A/en
Publication of NL7210549A publication Critical patent/NL7210549A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New cpds. of formula (I): (where R1 is H or lower alkyl, and R2 is OH, alkoxy, cycloalkoxy, cycloalkylalkoxy or amino opt. mono- or di-substd. by lower alkyl, or R1 and R2 together form a single bond; R3 is H, Cl, lower alkyl or (when R1=H or R1+R2 is a single bond) also OH, or (when R1 = lower alkyl) also lower alkoxy; R4 is H, Cl, Br lower alkyl, or (when R1=H or R1+R2 is a single bond) also OH, or (when R1=lower alkyl) also lower alkoxy, or (when R3=H) also F or CF3; R5 is H or lower alkyl; R6 is H or Me), and their salts and/or optical isomers, are prepd. by (a) solvolysis of the corresp. nitrile; (b) hydrolysis of the esters to free acids; (c) esterification of the free acids; (d) reaction of (I; R5 = H) with an alkyl halide or sulphone to give (I; R5 = alkyl); (e) reaction of the free acids with NH3 or an amine to give (I; R2=NH2 or mono- or dialkylamino); (f) hydrolysis of (I; R1=alkyl) to (I; R1=OH); or (g) cyclisation of (I; R1=H, R2=OH) to the lactone.
NL7210549A 1972-08-01 1972-08-01 4-Alkoxy or hydroxy-5-phenyl-3-thienylalkano-ic acids - antiphlogistics NL7210549A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7210549A NL7210549A (en) 1972-08-01 1972-08-01 4-Alkoxy or hydroxy-5-phenyl-3-thienylalkano-ic acids - antiphlogistics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7210549A NL7210549A (en) 1972-08-01 1972-08-01 4-Alkoxy or hydroxy-5-phenyl-3-thienylalkano-ic acids - antiphlogistics

Publications (1)

Publication Number Publication Date
NL7210549A true NL7210549A (en) 1973-02-08

Family

ID=19816640

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7210549A NL7210549A (en) 1972-08-01 1972-08-01 4-Alkoxy or hydroxy-5-phenyl-3-thienylalkano-ic acids - antiphlogistics

Country Status (1)

Country Link
NL (1) NL7210549A (en)

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