FR2100907A1 - 1-phenyl-2-amino-3-cyclohexene-1-carboxylic acid derivs - - used as analgesics - Google Patents
1-phenyl-2-amino-3-cyclohexene-1-carboxylic acid derivs - - used as analgesicsInfo
- Publication number
- FR2100907A1 FR2100907A1 FR7125519A FR7125519A FR2100907A1 FR 2100907 A1 FR2100907 A1 FR 2100907A1 FR 7125519 A FR7125519 A FR 7125519A FR 7125519 A FR7125519 A FR 7125519A FR 2100907 A1 FR2100907 A1 FR 2100907A1
- Authority
- FR
- France
- Prior art keywords
- amino
- phenyl
- analgesics
- alkyl
- cpds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1-phenyl-2-amino-3-cyclohexane-1-carboyxlic acid derivs. - used as analgesics. Novel title cpds. of formula: (where R1 = lower alkyl, R2 = H, lower alkyl, benzyl or R1 and R2 together with the N atom form a 5 or 6 membered heterocyclic opt. contng. a further O or NH gp. (opt. alkyl substrd), R3 = H, lower alkyl, R4 = lower alkoxy, R5 = H, lower alkoxy or R4 and R5 together = methylenedioxy) and their acid addition salts are prepared by reaction of an alkyl -2-(substd phenyl)-acrylate with a 1-amino-buta-1,3-diene. The cpds. where R2 = H can be obtained by hydrolyenolysis of the cpds. where R2 = benzyl. The cis and trans isomers may be separated by fractional crystallisation of their salts.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1073970A CH529720A (en) | 1970-07-15 | 1970-07-15 | 1-phenyl-2-amino-3-cyclohexene-1-carboxylic acid derivs - - used as analgesics |
| CH461871 | 1971-03-30 | ||
| CH469671 | 1971-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2100907A1 true FR2100907A1 (en) | 1972-03-24 |
Family
ID=27174916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7125519A Withdrawn FR2100907A1 (en) | 1970-07-15 | 1971-07-12 | 1-phenyl-2-amino-3-cyclohexene-1-carboxylic acid derivs - - used as analgesics |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU3116671A (en) |
| BE (1) | BE769969A (en) |
| DE (1) | DE2134821A1 (en) |
| FR (1) | FR2100907A1 (en) |
| HU (1) | HU162862B (en) |
| NL (1) | NL7109303A (en) |
-
1971
- 1971-07-06 NL NL7109303A patent/NL7109303A/xx unknown
- 1971-07-12 FR FR7125519A patent/FR2100907A1/en not_active Withdrawn
- 1971-07-13 BE BE769969A patent/BE769969A/en unknown
- 1971-07-13 AU AU31166/71A patent/AU3116671A/en not_active Expired
- 1971-07-13 HU HUSA002221 patent/HU162862B/hu unknown
- 1971-07-13 DE DE19712134821 patent/DE2134821A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2134821A1 (en) | 1972-01-20 |
| NL7109303A (en) | 1972-01-18 |
| HU162862B (en) | 1973-04-28 |
| AU3116671A (en) | 1973-01-18 |
| BE769969A (en) | 1972-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |