FR2042302A1 - Therapeutic indole derivs. prodn. - Google Patents

Therapeutic indole derivs. prodn.

Info

Publication number
FR2042302A1
FR2042302A1 FR7012110A FR7012110A FR2042302A1 FR 2042302 A1 FR2042302 A1 FR 2042302A1 FR 7012110 A FR7012110 A FR 7012110A FR 7012110 A FR7012110 A FR 7012110A FR 2042302 A1 FR2042302 A1 FR 2042302A1
Authority
FR
France
Prior art keywords
alkyl
group
prodn
therapeutic
coor3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7012110A
Other languages
French (fr)
Other versions
FR2042302B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2042302A1 publication Critical patent/FR2042302A1/en
Application granted granted Critical
Publication of FR2042302B1 publication Critical patent/FR2042302B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cookers (AREA)

Abstract

Indole derivs. having anti-inflammatory, anti-fever and analgetic properties, of fomula (in which R1 is H, halogen, alkyl or alkoxy group; R2 is an alkyl; R3 is H or an alkyl; and R4 is H, an alkoxy, alkyl or alkylamino group) are produced by benzoylating a phenylhydrazide of a carboxylic acid to obtain a compound of formula R4C6H4-N(R1C6H4CO)NHCOR (II) (in which R is H or an alkyl) and then reacting the product with R2-CO-CH2CH2-COOR3 to produce a compound of the formula from which the group -NH-COR is subsequently eliminated. Opt. the ester group -COOR3 can be saponified. Compounds of formulae (II) and (III) are claimed as novel.
FR7012110A 1969-04-03 1970-04-03 Therapeutic indole derivs. prodn. Granted FR2042302A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000877 HU162374B (en) 1969-04-03 1969-04-03

Publications (2)

Publication Number Publication Date
FR2042302A1 true FR2042302A1 (en) 1971-02-12
FR2042302B1 FR2042302B1 (en) 1975-10-31

Family

ID=10994360

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7012110A Granted FR2042302A1 (en) 1969-04-03 1970-04-03 Therapeutic indole derivs. prodn.
FR7200673A Expired FR2120185B1 (en) 1969-04-03 1972-01-10

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7200673A Expired FR2120185B1 (en) 1969-04-03 1972-01-10

Country Status (11)

Country Link
JP (1) JPS517666B1 (en)
AT (1) AT293377B (en)
CH (1) CH555826A (en)
DE (1) DE2009474C2 (en)
ES (1) ES377421A1 (en)
FR (2) FR2042302A1 (en)
HU (1) HU162374B (en)
NO (1) NO136538C (en)
PL (1) PL97543B1 (en)
SE (1) SE380261B (en)
SU (1) SU543344A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232075A1 (en) * 1986-01-22 1987-08-12 Rohm And Haas Company Insecticidal N'-substituted-N-alkylcarbonyl-N'-acyl hydrazines
TR23119A (en) * 1986-01-22 1989-04-03 Rohm & Haas ENSEKTISID N-SUELOSTITUEE N-ALKILHARBONIL-N 1-ACYL HYDRAZINES

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295618C (en) * 1986-02-28 1992-02-11 Adam Chi-Tung Hsu Insecticidal n'-substituted-n-acyl -n'-alkylcarbonylhydrazines
US5079332A (en) * 1989-04-17 1992-01-07 Georgia-Pacific Resins, Inc. Fast curing phenolic resin for making plywood
US5106697A (en) * 1989-04-17 1992-04-21 Georgia-Pacific Resins, Inc. Fast curing phenolic resin for making plywood

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1540725A (en) * 1966-10-13 1968-09-27 Merck & Co Inc Process for the preparation of indolyl-3-acetic acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT290523B (en) * 1962-01-05 1971-06-11 Merck & Co Inc Process for the production of new α- (3-indolyl) -carboxylic acids
GB1148909A (en) * 1965-04-19 1969-04-16 Sumitomo Chemical Co Process for production of novel phenylhydrazone and phenylhydrazine derivatives
AT262993B (en) * 1965-04-19 1968-07-10 Sumitomo Chemical Co Process for the preparation of some new aliphatic (3-indolyl) carboxylic acids or of functional derivatives thereof
IL27173A (en) * 1966-01-12 1972-08-30 Sumitomo Chemical Co 1-carboxylic acyl-3-indolyl alkanoic acid derivatives and method for their preparation
BR6898229D0 (en) * 1967-04-11 1973-04-17 Sumitomo Chemical Co PROCESS FOR THE PRODUCTION OF 1-CAIL-3-INDOLYL-ALIFATIC ACID DERIVATIVES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1540725A (en) * 1966-10-13 1968-09-27 Merck & Co Inc Process for the preparation of indolyl-3-acetic acids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232075A1 (en) * 1986-01-22 1987-08-12 Rohm And Haas Company Insecticidal N'-substituted-N-alkylcarbonyl-N'-acyl hydrazines
TR23119A (en) * 1986-01-22 1989-04-03 Rohm & Haas ENSEKTISID N-SUELOSTITUEE N-ALKILHARBONIL-N 1-ACYL HYDRAZINES

Also Published As

Publication number Publication date
FR2120185A1 (en) 1972-08-11
SU543344A3 (en) 1977-01-15
FR2042302B1 (en) 1975-10-31
NO136538C (en) 1977-09-21
HU162374B (en) 1973-02-28
NO136538B (en) 1977-06-13
ES377421A1 (en) 1974-08-01
PL97543B1 (en) 1978-03-30
DE2009474C2 (en) 1984-05-10
CH555826A (en) 1974-11-15
JPS517666B1 (en) 1976-03-10
AT293377B (en) 1971-10-11
FR2120185B1 (en) 1975-10-10
DE2009474A1 (en) 1970-11-05
SE380261B (en) 1975-11-03

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse