ES377421A1 - Procedure for the preparation of N-acil-indol-derivatives substituted in position 3. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of N-acil-indol-derivatives substituted in position 3. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES377421A1
ES377421A1 ES377421A ES377421A ES377421A1 ES 377421 A1 ES377421 A1 ES 377421A1 ES 377421 A ES377421 A ES 377421A ES 377421 A ES377421 A ES 377421A ES 377421 A1 ES377421 A1 ES 377421A1
Authority
ES
Spain
Prior art keywords
group
compounds
formula
translation
alcoholic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES377421A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES377421A1 publication Critical patent/ES377421A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cookers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of the 3-substituted N-acyl indole-derivatives of general formula I, (where R1 signifies hydrogen, halogen, an alcoholic group or alkoxy; R2 signifies an alcoholic group; R3 signifies hydrogen or an alcoholic group; R4 signifies hydrogen, an alkoxy, alcoholic or alkylamino group), characterized in that compounds of the general formula II are acylated (where R4 has the same meaning as indicated above and R represents hydrogen or an alcoholic group) or their salts, and below the compounds of formula III thus obtained (where R, R1 and R4 have the same meanings as indicated above) or their salts are reacted with compounds of formula IV (where R2 and R3 have the same meanings as indicated above) and from the compounds of formula Y (where R, R1, R2, R3 and R4 have the same meanings as indicated above) thus obtained, the group -NH-CO-R is eliminated and, in the case inthat in the compounds of formula I obtained R3 means an alcohol group, this alcohol group is replaced if desired by hydrogen by saponification. (Machine-translation by Google Translate, not legally binding)
ES377421A 1969-04-03 1970-03-12 Procedure for the preparation of N-acil-indol-derivatives substituted in position 3. (Machine-translation by Google Translate, not legally binding) Expired ES377421A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000877 HU162374B (en) 1969-04-03 1969-04-03

Publications (1)

Publication Number Publication Date
ES377421A1 true ES377421A1 (en) 1974-08-01

Family

ID=10994360

Family Applications (1)

Application Number Title Priority Date Filing Date
ES377421A Expired ES377421A1 (en) 1969-04-03 1970-03-12 Procedure for the preparation of N-acil-indol-derivatives substituted in position 3. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
JP (1) JPS517666B1 (en)
AT (1) AT293377B (en)
CH (1) CH555826A (en)
DE (1) DE2009474C2 (en)
ES (1) ES377421A1 (en)
FR (2) FR2042302A1 (en)
HU (1) HU162374B (en)
NO (1) NO136538C (en)
PL (1) PL97543B1 (en)
SE (1) SE380261B (en)
SU (1) SU543344A3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR23119A (en) * 1986-01-22 1989-04-03 Rohm & Haas ENSEKTISID N-SUELOSTITUEE N-ALKILHARBONIL-N 1-ACYL HYDRAZINES
CA1338289C (en) * 1986-01-22 1996-04-30 Raymond August Murphy Insecticidal n'-substituted-n-alkylcarbonyl- n'-acylhydrazines
CA1295618C (en) * 1986-02-28 1992-02-11 Adam Chi-Tung Hsu Insecticidal n'-substituted-n-acyl -n'-alkylcarbonylhydrazines
US5079332A (en) * 1989-04-17 1992-01-07 Georgia-Pacific Resins, Inc. Fast curing phenolic resin for making plywood
US5106697A (en) * 1989-04-17 1992-04-21 Georgia-Pacific Resins, Inc. Fast curing phenolic resin for making plywood

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT290523B (en) * 1962-01-05 1971-06-11 Merck & Co Inc Process for the production of new α- (3-indolyl) -carboxylic acids
AT262993B (en) * 1965-04-19 1968-07-10 Sumitomo Chemical Co Process for the preparation of some new aliphatic (3-indolyl) carboxylic acids or of functional derivatives thereof
GB1148908A (en) * 1965-04-19 1969-04-16 Sumitomo Chemical Co Indole derivatives and processes for making them
IL27173A (en) * 1966-01-12 1972-08-30 Sumitomo Chemical Co 1-carboxylic acyl-3-indolyl alkanoic acid derivatives and method for their preparation
FR1540725A (en) * 1966-10-13 1968-09-27 Merck & Co Inc Process for the preparation of indolyl-3-acetic acids
NL6804994A (en) * 1967-04-11 1968-10-14

Also Published As

Publication number Publication date
FR2120185A1 (en) 1972-08-11
FR2042302B1 (en) 1975-10-31
DE2009474A1 (en) 1970-11-05
SE380261B (en) 1975-11-03
SU543344A3 (en) 1977-01-15
NO136538B (en) 1977-06-13
PL97543B1 (en) 1978-03-30
CH555826A (en) 1974-11-15
HU162374B (en) 1973-02-28
JPS517666B1 (en) 1976-03-10
FR2042302A1 (en) 1971-02-12
AT293377B (en) 1971-10-11
NO136538C (en) 1977-09-21
DE2009474C2 (en) 1984-05-10
FR2120185B1 (en) 1975-10-10

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