NL2026426B1 - Fluorine-containing graphene quantum dots, preparation method and application thereof as photosensitiser for photodanamic therapy - Google Patents
Fluorine-containing graphene quantum dots, preparation method and application thereof as photosensitiser for photodanamic therapy Download PDFInfo
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- NL2026426B1 NL2026426B1 NL2026426A NL2026426A NL2026426B1 NL 2026426 B1 NL2026426 B1 NL 2026426B1 NL 2026426 A NL2026426 A NL 2026426A NL 2026426 A NL2026426 A NL 2026426A NL 2026426 B1 NL2026426 B1 NL 2026426B1
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- Prior art keywords
- fluorine
- quantum dots
- containing graphene
- graphene quantum
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- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 98
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 98
- 239000011737 fluorine Substances 0.000 title claims abstract description 98
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000002560 therapeutic procedure Methods 0.000 title description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 58
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 33
- 238000002428 photodynamic therapy Methods 0.000 claims abstract description 27
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- 239000002096 quantum dot Substances 0.000 claims abstract description 14
- 238000006862 quantum yield reaction Methods 0.000 claims abstract description 14
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 8
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 4
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- YAXWOADCWUUUNX-UHFFFAOYSA-N 1,2,2,3-tetramethylpiperidine Chemical compound CC1CCCN(C)C1(C)C YAXWOADCWUUUNX-UHFFFAOYSA-N 0.000 description 3
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- DNUYOWCKBJFOGS-UHFFFAOYSA-N 2-[[10-(2,2-dicarboxyethyl)anthracen-9-yl]methyl]propanedioic acid Chemical compound C1=CC=C2C(CC(C(=O)O)C(O)=O)=C(C=CC=C3)C3=C(CC(C(O)=O)C(O)=O)C2=C1 DNUYOWCKBJFOGS-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/65—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/15—Nano-sized carbon materials
- C01B32/182—Graphene
- C01B32/184—Preparation
- C01B32/19—Preparation by exfoliation
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/15—Nano-sized carbon materials
- C01B32/182—Graphene
- C01B32/198—Graphene oxide
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- Nanotechnology (AREA)
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- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910854472.6A CN111518552B (zh) | 2019-09-10 | 2019-09-10 | 含氟石墨烯量子点与制备及其作为光动力治疗光敏剂的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL2026426A NL2026426A (en) | 2021-05-12 |
| NL2026426B1 true NL2026426B1 (en) | 2021-09-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| NL2026426A NL2026426B1 (en) | 2019-09-10 | 2020-09-08 | Fluorine-containing graphene quantum dots, preparation method and application thereof as photosensitiser for photodanamic therapy |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN111518552B (zh) |
| NL (1) | NL2026426B1 (zh) |
| WO (1) | WO2021046966A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114479843B (zh) * | 2021-12-20 | 2023-06-30 | 华南农业大学 | 一种具有光动力治疗和杀菌功能的新型荧光纳米材料的制备方法和应用 |
| CN115403831B (zh) * | 2022-09-13 | 2023-10-24 | 中国科学院深圳先进技术研究院 | 一种改性氟化石墨烯量子点、光敏复合材料及其应用 |
| CN116041176B (zh) * | 2023-02-21 | 2024-06-25 | 武汉科技大学 | 分子级亲水型石墨烯量子点及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8865932B2 (en) * | 2010-12-22 | 2014-10-21 | Ocean's King Lighting Science & Technology Co., Ltd. | Fluorinated graphene oxide and preparation method thereof |
| CN102660270A (zh) * | 2012-05-03 | 2012-09-12 | 吉林大学 | 溶剂热法制备荧光石墨烯量子点的方法 |
| CN104944403B (zh) * | 2014-03-24 | 2017-04-26 | 中国科学院兰州化学物理研究所 | 一种水溶性双色氟化石墨烯量子点的制备方法 |
| CN105460920B (zh) * | 2014-09-05 | 2018-02-27 | 中国科学院兰州化学物理研究所 | 水溶性的氟含量可控的氟化石墨烯量子点的制备方法 |
| CN105271200B (zh) * | 2015-11-06 | 2017-11-28 | 昆明物理研究所 | 氟掺杂石墨烯量子点及其制备方法 |
| CN105567229B (zh) * | 2016-01-29 | 2018-01-30 | 天津大学 | 氟掺杂荧光碳量子点制备的方法 |
| CN105565310A (zh) * | 2016-03-02 | 2016-05-11 | 桂林理工大学 | 一种具有优异光学性能的氟掺杂石墨烯量子点的制备方法 |
| CN106477565B (zh) * | 2016-10-24 | 2019-05-14 | 国家纳米科学中心 | 一种氟化石墨烯量子点、及其制备方法和用途 |
| CN109486483B (zh) * | 2017-09-11 | 2021-11-23 | 天津大学 | 氟氮双元素掺杂荧光碳量子点及其制备方法 |
| CN108423655B (zh) * | 2018-03-29 | 2020-02-21 | 中国科学院福建物质结构研究所 | 一种氟氧化石墨烯的制备方法 |
| CN108545729A (zh) * | 2018-04-24 | 2018-09-18 | 常州烯思新材料科技有限公司 | 高效石墨烯量子点的制备方法 |
| CN108706579B (zh) * | 2018-07-23 | 2020-11-10 | 广西师范大学 | 一种制备氟掺杂石墨烯量子点的方法 |
-
2019
- 2019-09-10 CN CN201910854472.6A patent/CN111518552B/zh active Active
- 2019-10-17 WO PCT/CN2019/111622 patent/WO2021046966A1/zh active Application Filing
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- 2020-09-08 NL NL2026426A patent/NL2026426B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL2026426A (en) | 2021-05-12 |
| CN111518552A (zh) | 2020-08-11 |
| WO2021046966A1 (zh) | 2021-03-18 |
| CN111518552B (zh) | 2021-08-10 |
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