NL2016404B1 - Double tubular structures. - Google Patents

Double tubular structures. Download PDF

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Publication number
NL2016404B1
NL2016404B1 NL2016404A NL2016404A NL2016404B1 NL 2016404 B1 NL2016404 B1 NL 2016404B1 NL 2016404 A NL2016404 A NL 2016404A NL 2016404 A NL2016404 A NL 2016404A NL 2016404 B1 NL2016404 B1 NL 2016404B1
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NL
Netherlands
Prior art keywords
cells
microfluidic channel
epithelial
channel network
mesenchymal
Prior art date
Application number
NL2016404A
Other languages
English (en)
Dutch (nl)
Other versions
NL2016404A (en
Inventor
Vulto Paul
Małgorzata Kurek Dorota
Johannes Trietsch Sebastiaan
Theodorus Joore Adrianus
Leonore Lanz Henriëtte
Original Assignee
Mimetas B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL2016404A priority Critical patent/NL2016404B1/en
Application filed by Mimetas B V filed Critical Mimetas B V
Priority to AU2017231580A priority patent/AU2017231580B2/en
Priority to CA3017100A priority patent/CA3017100A1/en
Priority to KR1020187029134A priority patent/KR102403435B1/ko
Priority to PCT/NL2017/050145 priority patent/WO2017155399A1/en
Priority to US16/083,372 priority patent/US20190076842A1/en
Priority to RU2018132008A priority patent/RU2756404C1/ru
Priority to JP2018547340A priority patent/JP7117245B2/ja
Priority to EP17715816.9A priority patent/EP3426769B1/en
Priority to CN201780028395.8A priority patent/CN109072184A/zh
Priority to BR112018068303A priority patent/BR112018068303A2/pt
Publication of NL2016404A publication Critical patent/NL2016404A/en
Application granted granted Critical
Publication of NL2016404B1 publication Critical patent/NL2016404B1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M31/00—Means for providing, directing, scattering or concentrating light
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1392—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/23—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the gastro-intestinal tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NL2016404A 2016-03-09 2016-03-09 Double tubular structures. NL2016404B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NL2016404A NL2016404B1 (en) 2016-03-09 2016-03-09 Double tubular structures.
CA3017100A CA3017100A1 (en) 2016-03-09 2017-03-09 Double tubular structures
KR1020187029134A KR102403435B1 (ko) 2016-03-09 2017-03-09 이중 관형 구조
PCT/NL2017/050145 WO2017155399A1 (en) 2016-03-09 2017-03-09 Double tubular structures
AU2017231580A AU2017231580B2 (en) 2016-03-09 2017-03-09 Double tubular structures
US16/083,372 US20190076842A1 (en) 2016-03-09 2017-03-09 Double tubular structures
RU2018132008A RU2756404C1 (ru) 2016-03-09 2017-03-09 Двойные трубчатые структуры
JP2018547340A JP7117245B2 (ja) 2016-03-09 2017-03-09 二重管状構造体
EP17715816.9A EP3426769B1 (en) 2016-03-09 2017-03-09 Double tubular structures
CN201780028395.8A CN109072184A (zh) 2016-03-09 2017-03-09 双管状结构
BR112018068303A BR112018068303A2 (pt) 2016-03-09 2017-03-09 método de cultivo e/ou monitoramento de células epiteliais usando um sistema de cultura celular microfluida, uso das células no sistema de cultura celular microfluida, composição ou sistema e sistema de cultura celular microfluida

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2016404A NL2016404B1 (en) 2016-03-09 2016-03-09 Double tubular structures.

Publications (2)

Publication Number Publication Date
NL2016404A NL2016404A (en) 2017-09-19
NL2016404B1 true NL2016404B1 (en) 2017-09-26

Family

ID=55967375

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2016404A NL2016404B1 (en) 2016-03-09 2016-03-09 Double tubular structures.

Country Status (11)

Country Link
US (1) US20190076842A1 (https=)
EP (1) EP3426769B1 (https=)
JP (1) JP7117245B2 (https=)
KR (1) KR102403435B1 (https=)
CN (1) CN109072184A (https=)
AU (1) AU2017231580B2 (https=)
BR (1) BR112018068303A2 (https=)
CA (1) CA3017100A1 (https=)
NL (1) NL2016404B1 (https=)
RU (1) RU2756404C1 (https=)
WO (1) WO2017155399A1 (https=)

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CA3076664C (en) * 2017-09-21 2023-10-10 EMULATE, Inc. Physiology and pathophysiology of human gut: intestine-on-chip
NL2020518B1 (en) 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
US20210341462A1 (en) 2018-10-05 2021-11-04 The Trustees Of The University Of Pennsylvania Artificial human pulmonary airway and methods of preparation
CN109926112A (zh) * 2019-04-10 2019-06-25 中南大学 三维微结构聚合物微流控芯片的叠层制造方法
NL2024202B1 (en) * 2019-11-08 2021-07-20 Mimetas B V Microfluidic cell culture system
US12480079B2 (en) 2021-04-23 2025-11-25 Massachusetts Institute Of Technology Fluidic platforms for perfusable vascularized tissues with infiltrates
EP4358982A4 (en) * 2021-06-25 2025-05-14 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Primordial germ cells
CN115301301B (zh) * 2022-07-29 2026-01-13 江苏艾玮得生物科技有限公司 微流控芯片
WO2024072511A1 (en) * 2022-09-30 2024-04-04 Xellar, Inc. Microfluidic devices containing hydrogels, and techniques for making and using
PL443644A1 (pl) * 2023-01-31 2024-08-05 Politechnika Warszawska System mikroprzepływowy do wielonarządowej hodowli komórkowej i jego zastosowanie
WO2025232822A1 (en) * 2024-05-09 2025-11-13 Anivance Ai Corporation Chip, microfluidic cell culture device including the same, and method for cell culture using the same

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US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US9157060B2 (en) * 2005-06-09 2015-10-13 The United States Of America, As Represented By The Secretary Of The Navy Micro blood vessels and tissue ducts
EP1937326B1 (en) * 2005-10-21 2018-09-12 CellResearch Corporation Pte Ltd Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom
US20110129850A1 (en) 2006-12-22 2011-06-02 UCLA Office of Intellectual Property Microfluidic platform for cell culture and assay
EP2222837A2 (en) * 2007-02-09 2010-09-01 The General Hospital Corporation Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof
WO2009154466A1 (en) * 2008-06-20 2009-12-23 Universiteit Twente Self-assembling tissue modules
EP2213364A1 (en) 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
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Also Published As

Publication number Publication date
KR20180131569A (ko) 2018-12-10
EP3426769B1 (en) 2024-09-25
EP3426769A1 (en) 2019-01-16
US20190076842A1 (en) 2019-03-14
JP2019507602A (ja) 2019-03-22
WO2017155399A1 (en) 2017-09-14
CN109072184A (zh) 2018-12-21
EP3426769C0 (en) 2024-09-25
BR112018068303A2 (pt) 2019-03-06
AU2017231580A1 (en) 2018-09-27
KR102403435B1 (ko) 2022-05-30
NL2016404A (en) 2017-09-19
JP7117245B2 (ja) 2022-08-12
CA3017100A1 (en) 2017-09-14
AU2017231580B2 (en) 2023-03-30
RU2756404C1 (ru) 2021-09-30

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