NL1006266C2 - Werkwijze voor de bereiding van ampicilline. - Google Patents

Werkwijze voor de bereiding van ampicilline. Download PDF

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Publication number
NL1006266C2
NL1006266C2 NL1006266A NL1006266A NL1006266C2 NL 1006266 C2 NL1006266 C2 NL 1006266C2 NL 1006266 A NL1006266 A NL 1006266A NL 1006266 A NL1006266 A NL 1006266A NL 1006266 C2 NL1006266 C2 NL 1006266C2
Authority
NL
Netherlands
Prior art keywords
apa
ampicillin
concentration
reaction mixture
phenylglycine
Prior art date
Application number
NL1006266A
Other languages
English (en)
Dutch (nl)
Inventor
Wilhelmus Hubertus Jos Boesten
Harold Monro Moody
Original Assignee
Chemferm Vof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL1006266A priority Critical patent/NL1006266C2/nl
Application filed by Chemferm Vof filed Critical Chemferm Vof
Priority to BR9810020-3A priority patent/BR9810020A/pt
Priority to AU76777/98A priority patent/AU7677798A/en
Priority to CN98807876A priority patent/CN1115417C/zh
Priority to AT98924672T priority patent/ATE319849T1/de
Priority to ES98924672T priority patent/ES2258298T3/es
Priority to PCT/NL1998/000295 priority patent/WO1998056946A1/en
Priority to KR10-1999-7011645A priority patent/KR100508290B1/ko
Priority to EP98924672A priority patent/EP0988393B1/de
Priority to TR2000/00201T priority patent/TR200000201T2/xx
Priority to IN1224MA1998 priority patent/IN186863B/en
Application granted granted Critical
Publication of NL1006266C2 publication Critical patent/NL1006266C2/nl
Priority to US09/457,765 priority patent/US7029885B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
NL1006266A 1997-06-10 1997-06-10 Werkwijze voor de bereiding van ampicilline. NL1006266C2 (nl)

Priority Applications (12)

Application Number Priority Date Filing Date Title
NL1006266A NL1006266C2 (nl) 1997-06-10 1997-06-10 Werkwijze voor de bereiding van ampicilline.
AU76777/98A AU7677798A (en) 1997-06-10 1998-05-25 Process for the preparation of ampicillin
CN98807876A CN1115417C (zh) 1997-06-10 1998-05-25 用于制备氨苄青霉素的方法
AT98924672T ATE319849T1 (de) 1997-06-10 1998-05-25 Verfahren zur herstellung vom ampicillin
BR9810020-3A BR9810020A (pt) 1997-06-10 1998-05-25 Processo para a preparação de ampicilina
ES98924672T ES2258298T3 (es) 1997-06-10 1998-05-25 Proceso para la preparacion de ampicilina.
PCT/NL1998/000295 WO1998056946A1 (en) 1997-06-10 1998-05-25 Process for the preparation of ampicillin
KR10-1999-7011645A KR100508290B1 (ko) 1997-06-10 1998-05-25 암피실린의 제조방법
EP98924672A EP0988393B1 (de) 1997-06-10 1998-05-25 Verfahren zur herstellung vom ampicillin
TR2000/00201T TR200000201T2 (tr) 1997-06-10 1998-05-25 Ampisilinin hazırlanması için proses
IN1224MA1998 IN186863B (de) 1997-06-10 1998-06-05
US09/457,765 US7029885B2 (en) 1997-06-10 1999-12-10 Process for the preparation of ampicillin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1006266A NL1006266C2 (nl) 1997-06-10 1997-06-10 Werkwijze voor de bereiding van ampicilline.
NL1006266 1997-06-10

Publications (1)

Publication Number Publication Date
NL1006266C2 true NL1006266C2 (nl) 1998-12-14

Family

ID=19765126

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1006266A NL1006266C2 (nl) 1997-06-10 1997-06-10 Werkwijze voor de bereiding van ampicilline.

Country Status (12)

Country Link
US (1) US7029885B2 (de)
EP (1) EP0988393B1 (de)
KR (1) KR100508290B1 (de)
CN (1) CN1115417C (de)
AT (1) ATE319849T1 (de)
AU (1) AU7677798A (de)
BR (1) BR9810020A (de)
ES (1) ES2258298T3 (de)
IN (1) IN186863B (de)
NL (1) NL1006266C2 (de)
TR (1) TR200000201T2 (de)
WO (1) WO1998056946A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538045B1 (en) * 1999-12-23 2003-03-25 Dsm N.V. Optical fiber coating compositions containing secondary or tertiary amino silicone-containing additive
EP2723882B1 (de) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von 3 '-thiosubstituierten cephalosporinen unter verwendung einer penicillin-g-acylase
CN103635586A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 结晶头孢氧哌唑中间体、其制备方法及其制药用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2188608A5 (en) * 1972-06-14 1974-01-18 Aries Robert Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
EP0473008A2 (de) * 1990-08-28 1992-03-04 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Verbessertes Verfahren zur Herstellung von Penicillinen und Cephalosporinen
WO1995003420A1 (en) * 1993-07-19 1995-02-02 Dsm N.V. Process for the enzymatic preparation of a beta-lactam derivative
WO1996002663A1 (en) * 1994-07-18 1996-02-01 Gist-Brocades B.V. PROCESS FOR PREPARATION OF β-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1007077C2 (nl) 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007076C2 (nl) 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007302C2 (nl) 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2188608A5 (en) * 1972-06-14 1974-01-18 Aries Robert Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
EP0473008A2 (de) * 1990-08-28 1992-03-04 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Verbessertes Verfahren zur Herstellung von Penicillinen und Cephalosporinen
WO1995003420A1 (en) * 1993-07-19 1995-02-02 Dsm N.V. Process for the enzymatic preparation of a beta-lactam derivative
WO1996002663A1 (en) * 1994-07-18 1996-02-01 Gist-Brocades B.V. PROCESS FOR PREPARATION OF β-LACTAMS AT CONSTANTLY HIGH CONCENTRATION OF REACTANTS
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin

Also Published As

Publication number Publication date
EP0988393B1 (de) 2006-03-08
WO1998056946A1 (en) 1998-12-17
IN186863B (de) 2001-11-24
CN1115417C (zh) 2003-07-23
AU7677798A (en) 1998-12-30
US7029885B2 (en) 2006-04-18
EP0988393A1 (de) 2000-03-29
TR200000201T2 (tr) 2000-06-21
BR9810020A (pt) 2000-09-19
CN1265706A (zh) 2000-09-06
ATE319849T1 (de) 2006-03-15
US20020009769A1 (en) 2002-01-24
KR100508290B1 (ko) 2005-08-17
ES2258298T3 (es) 2006-08-16
KR20010013635A (ko) 2001-02-26

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