MY8700624A - Novel imidazol (1,2-a) pyridines and pyrazines processes for their preparation and pharmaceutical compositions containing them - Google Patents
Novel imidazol (1,2-a) pyridines and pyrazines processes for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- MY8700624A MY8700624A MY624/87A MY8700624A MY8700624A MY 8700624 A MY8700624 A MY 8700624A MY 624/87 A MY624/87 A MY 624/87A MY 8700624 A MY8700624 A MY 8700624A MY 8700624 A MY8700624 A MY 8700624A
- Authority
- MY
- Malaysia
- Prior art keywords
- pyrazines
- pyridines
- processes
- preparation
- pharmaceutical compositions
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003216 pyrazines Chemical class 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27757681A | 1981-06-26 | 1981-06-26 | |
US06/356,052 US4507294A (en) | 1982-03-08 | 1982-03-08 | Imidazo[1,2-a]pyrazines |
Publications (1)
Publication Number | Publication Date |
---|---|
MY8700624A true MY8700624A (en) | 1987-12-31 |
Family
ID=26958574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MY624/87A MY8700624A (en) | 1981-06-26 | 1987-12-30 | Novel imidazol (1,2-a) pyridines and pyrazines processes for their preparation and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (1) | US4450164A (ko) |
EP (1) | EP0068378B1 (ko) |
KR (1) | KR880001718B1 (ko) |
AU (1) | AU556062B2 (ko) |
DE (1) | DE3269604D1 (ko) |
DK (1) | DK284482A (ko) |
ES (1) | ES8307806A1 (ko) |
FI (1) | FI73433C (ko) |
GR (1) | GR74924B (ko) |
HU (1) | HU189595B (ko) |
IE (1) | IE53324B1 (ko) |
IL (1) | IL66141A0 (ko) |
MA (1) | MA19513A1 (ko) |
MY (1) | MY8700624A (ko) |
NO (1) | NO159724C (ko) |
NZ (1) | NZ201066A (ko) |
OA (1) | OA07130A (ko) |
PT (1) | PT75115B (ko) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8305245D0 (en) * | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
US4507481A (en) * | 1983-07-29 | 1985-03-26 | Pennwalt Corporation | Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines |
US4578387A (en) * | 1984-03-05 | 1986-03-25 | Eli Lilly And Company | Inotropic agents |
GB8415540D0 (en) * | 1984-06-18 | 1984-07-25 | Fujisawa Pharmaceutical Co | Imidazoisoquinoline compounds |
JPS61218589A (ja) * | 1985-03-26 | 1986-09-29 | Eisai Co Ltd | 5―(6―イミダゾ〔1,2―a〕ピリジニル)ピリジン誘導体 |
DE3516458A1 (de) * | 1985-05-08 | 1986-11-13 | W. Schlafhorst & Co, 4050 Mönchengladbach | Angetriebener fadenspeicher |
US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
US4596872A (en) * | 1985-06-05 | 1986-06-24 | Schering A.G. | Imidazo[1,2-a]pyridines, and process for their preparation |
EP0228006A1 (en) * | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
US4727145A (en) * | 1986-09-22 | 1988-02-23 | Ortho Pharmaceutical Corporation | 2- Or 3- aryl substituted imidazo [1,2-a]pyridines |
US4791117A (en) * | 1986-09-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers |
EP0266890A1 (en) * | 1986-10-07 | 1988-05-11 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them |
US4831041A (en) * | 1986-11-26 | 1989-05-16 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
IL86269A0 (en) * | 1987-05-08 | 1988-11-15 | Byk Gulden Lomberg Chem Fab | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
AT390438B (de) * | 1987-10-08 | 1990-05-10 | Yamanouchi Pharma Co Ltd | Neue imidazo(1,2-a)pyridinderivate und deren herstellung und diese enthaltende pharmazeutische zubereitungen |
SE8704248D0 (sv) * | 1987-10-30 | 1987-10-30 | Haessle Ab | Medical use |
US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
KR910011852A (ko) * | 1989-12-04 | 1991-08-07 | 폴 디. 매튜카이티스 | 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물 |
IE904346A1 (en) * | 1989-12-04 | 1991-06-05 | Searle & Co | IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5041442A (en) * | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
US5482947A (en) * | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
US5475027A (en) * | 1990-11-19 | 1995-12-12 | G.D. Searle & Co. | Retroviral protease inhibitors |
US5475013A (en) * | 1990-11-19 | 1995-12-12 | Monsanto Company | Retroviral protease inhibitors |
US5614522A (en) * | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
ATE199545T1 (de) * | 1992-05-21 | 2001-03-15 | Monsanto Co | Inhibitoren retroviraler proteasen |
US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
KR100296461B1 (ko) * | 1992-08-25 | 2001-11-14 | 죤 에이치. 뷰센 | 레트로바이러스프로테아제저해제로서유용한n-(알카노일아미노-2-히드록시프로필)-술폰아미드 |
US6046190A (en) * | 1992-08-25 | 2000-04-04 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6022994A (en) | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
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US5760076A (en) * | 1992-08-25 | 1998-06-02 | G.D Searle & Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
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US6337398B1 (en) * | 1992-10-30 | 2002-01-08 | G.D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
DE69331421T2 (de) | 1992-10-30 | 2002-08-01 | G.D. SEARLE & CO., CHICAGO | N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler Proteasen |
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US5578606A (en) * | 1992-10-30 | 1996-11-26 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US5756498A (en) * | 1992-10-30 | 1998-05-26 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
US5602119A (en) * | 1993-10-29 | 1997-02-11 | Vazquez; Michael L. | Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
EP0773946B1 (de) * | 1994-07-28 | 2002-03-27 | Byk Gulden Lomberg Chemische Fabrik GmbH | Imidazopyridin-azolidinone |
US5831117A (en) * | 1995-01-20 | 1998-11-03 | G. D. Searle & Co. | Method of preparing retroviral protease inhibitor intermediates |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6140505A (en) * | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US7339078B2 (en) * | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
DE69625183T2 (de) * | 1995-03-10 | 2003-10-09 | G.D. Searle & Co., Chicago | Heterocyclocarbonyl-aminosäure-hydroxyethylamino-sulfonamid inhibitoren retroviraler proteasen |
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US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
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US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
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SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
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SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
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KR20020038804A (ko) | 1999-10-08 | 2002-05-23 | 파퀘스, 파우쓰-베르구스 | 6원 환이 치환되어 있는 2환식 이미다조-3-일-아민 유도체 |
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DE19948437A1 (de) * | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Am Sechsring substituierte, bicyclische Imidazo-3-aminderivate |
DE19948434A1 (de) * | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
DE10019714A1 (de) | 2000-04-20 | 2002-01-10 | Gruenenthal Gmbh | Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen |
CA2311483A1 (en) * | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
SE0003186D0 (sv) * | 2000-09-07 | 2000-09-07 | Astrazeneca Ab | New process |
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DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
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US20040082605A1 (en) * | 2001-03-08 | 2004-04-29 | Arne Eek | Use |
DE10117184A1 (de) * | 2001-04-05 | 2002-10-17 | Gruenenthal Gmbh | Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen |
DE10117183A1 (de) * | 2001-04-05 | 2002-10-10 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel |
SE0102808D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
DE10145457A1 (de) | 2001-09-14 | 2003-04-03 | Basf Ag | Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
US7470791B2 (en) | 2003-03-10 | 2008-12-30 | Nycomed Gmbh | Process for the preparation of roflumilast |
SE0301904D0 (sv) * | 2003-06-26 | 2003-06-26 | Astrazeneca Ab | Novel imidazopyridine compound II with therapeutic effect |
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JP4898683B2 (ja) | 2004-09-03 | 2012-03-21 | ユーハン・コーポレイション | ピロロ[2,3−c]ピリジン誘導体及びその製造方法 |
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FI20086158A0 (fi) | 2008-12-03 | 2008-12-03 | Mikael Dahlstroem | Imidatsopyridiinijohdannaiset |
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US3701780A (en) * | 1970-09-18 | 1972-10-31 | Merck & Co Inc | Imidazo(1,2-a)pyridines |
US4044015A (en) * | 1975-09-03 | 1977-08-23 | Pfizer Inc. | Imidazopyridinium compounds as hypoglycemic agents |
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US4092321A (en) * | 1977-06-16 | 1978-05-30 | Merck & Co., Inc. | Process for the preparation of imidazo [1,2-a] pyridines |
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ZA81219B (en) * | 1980-01-23 | 1982-01-27 | Schering Corp | Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them |
-
1982
- 1982-06-21 DE DE8282105411T patent/DE3269604D1/de not_active Expired
- 1982-06-21 EP EP82105411A patent/EP0068378B1/en not_active Expired
- 1982-06-24 FI FI822266A patent/FI73433C/fi not_active IP Right Cessation
- 1982-06-24 GR GR68556A patent/GR74924B/el unknown
- 1982-06-24 PT PT75115A patent/PT75115B/pt not_active IP Right Cessation
- 1982-06-24 OA OA57720A patent/OA07130A/xx unknown
- 1982-06-24 MA MA19720A patent/MA19513A1/fr unknown
- 1982-06-24 NO NO822128A patent/NO159724C/no unknown
- 1982-06-24 DK DK284482A patent/DK284482A/da not_active Application Discontinuation
- 1982-06-24 IE IE1515/82A patent/IE53324B1/en not_active IP Right Cessation
- 1982-06-24 AU AU85178/82A patent/AU556062B2/en not_active Ceased
- 1982-06-24 NZ NZ201066A patent/NZ201066A/en unknown
- 1982-06-25 IL IL66141A patent/IL66141A0/xx not_active IP Right Cessation
- 1982-06-25 HU HU822071A patent/HU189595B/hu not_active IP Right Cessation
- 1982-06-25 ES ES513431A patent/ES8307806A1/es not_active Expired
- 1982-06-25 KR KR8202835A patent/KR880001718B1/ko active
- 1982-12-20 US US06/450,885 patent/US4450164A/en not_active Expired - Lifetime
-
1987
- 1987-12-30 MY MY624/87A patent/MY8700624A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI822266L (fi) | 1982-12-27 |
KR840000546A (ko) | 1984-02-25 |
EP0068378A1 (en) | 1983-01-05 |
FI73433C (fi) | 1987-10-09 |
ES513431A0 (es) | 1983-08-01 |
PT75115A (en) | 1982-07-01 |
PT75115B (en) | 1985-06-28 |
NZ201066A (en) | 1985-08-16 |
DK284482A (da) | 1982-12-27 |
NO822128L (no) | 1982-12-27 |
FI73433B (fi) | 1987-06-30 |
EP0068378B1 (en) | 1986-03-05 |
US4450164A (en) | 1984-05-22 |
OA07130A (fr) | 1984-03-31 |
DE3269604D1 (en) | 1986-04-10 |
IL66141A0 (en) | 1982-09-30 |
KR880001718B1 (ko) | 1988-09-08 |
HU189595B (en) | 1986-07-28 |
AU556062B2 (en) | 1986-10-23 |
GR74924B (ko) | 1984-07-12 |
IE821515L (en) | 1982-12-26 |
AU8517882A (en) | 1983-01-06 |
ES8307806A1 (es) | 1983-08-01 |
NO159724B (no) | 1988-10-24 |
MA19513A1 (fr) | 1982-12-31 |
IE53324B1 (en) | 1988-10-12 |
NO159724C (no) | 1989-02-01 |
FI822266A0 (fi) | 1982-06-24 |
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