MY143677A - Amide prodrug of gemcitabine, compositions and use thereof - Google Patents

Amide prodrug of gemcitabine, compositions and use thereof

Info

Publication number
MY143677A
MY143677A MYPI20055970A MYPI20055970A MY143677A MY 143677 A MY143677 A MY 143677A MY PI20055970 A MYPI20055970 A MY PI20055970A MY PI20055970 A MYPI20055970 A MY PI20055970A MY 143677 A MY143677 A MY 143677A
Authority
MY
Malaysia
Prior art keywords
compositions
gemcitabine
amide prodrug
amide
prodrug
Prior art date
Application number
MYPI20055970A
Other languages
English (en)
Inventor
David Michael Bender
David Michael Remick
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MY143677A publication Critical patent/MY143677A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
MYPI20055970A 2004-12-17 2005-12-16 Amide prodrug of gemcitabine, compositions and use thereof MY143677A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17

Publications (1)

Publication Number Publication Date
MY143677A true MY143677A (en) 2011-06-30

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20055970A MY143677A (en) 2004-12-17 2005-12-16 Amide prodrug of gemcitabine, compositions and use thereof

Country Status (31)

Country Link
US (1) US7691827B2 (cg-RX-API-DMAC7.html)
EP (1) EP1831237B1 (cg-RX-API-DMAC7.html)
JP (1) JP5022911B2 (cg-RX-API-DMAC7.html)
KR (1) KR100874052B1 (cg-RX-API-DMAC7.html)
CN (1) CN101080417B (cg-RX-API-DMAC7.html)
AR (1) AR055009A1 (cg-RX-API-DMAC7.html)
AT (1) ATE405573T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005316922B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0519117A2 (cg-RX-API-DMAC7.html)
CA (1) CA2589850C (cg-RX-API-DMAC7.html)
CY (1) CY1108447T1 (cg-RX-API-DMAC7.html)
DE (1) DE602005009255D1 (cg-RX-API-DMAC7.html)
DK (1) DK1831237T3 (cg-RX-API-DMAC7.html)
EA (1) EA011868B1 (cg-RX-API-DMAC7.html)
ES (1) ES2310860T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20080529T3 (cg-RX-API-DMAC7.html)
IL (1) IL183666A (cg-RX-API-DMAC7.html)
MA (1) MA29154B1 (cg-RX-API-DMAC7.html)
MX (1) MX2007007228A (cg-RX-API-DMAC7.html)
MY (1) MY143677A (cg-RX-API-DMAC7.html)
NO (1) NO20073368L (cg-RX-API-DMAC7.html)
NZ (1) NZ554732A (cg-RX-API-DMAC7.html)
PE (1) PE20060771A1 (cg-RX-API-DMAC7.html)
PL (1) PL1831237T3 (cg-RX-API-DMAC7.html)
PT (1) PT1831237E (cg-RX-API-DMAC7.html)
RS (1) RS50629B (cg-RX-API-DMAC7.html)
SI (1) SI1831237T1 (cg-RX-API-DMAC7.html)
TW (1) TWI326687B (cg-RX-API-DMAC7.html)
UA (1) UA86119C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006065525A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200705019B (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014909B1 (ru) * 2006-06-21 2011-02-28 Эли Лилли Энд Компани Кристаллические формы пролекарства на основе амида гемцитабина, композиции на их основе и их применение
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN104955458A (zh) 2012-11-07 2015-09-30 Z·索 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法
WO2014078295A1 (en) 2012-11-13 2014-05-22 BoYen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
EP3119795A4 (en) * 2014-03-03 2018-03-14 Nucorion Pharmaceuticals, Inc. Gemcitabine analogs
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
KR102708995B1 (ko) 2018-01-10 2024-09-23 누코리온 파마슈티컬스, 인코포레이티드. 포스포르(포스포론)아미다타세탈 및 포스프(온)아탈세탈 화합물
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
JP7598313B2 (ja) * 2018-04-26 2024-12-11 ナノメッド ホールディングス プロプライエタリー リミテッド ジェムシタビン両親媒性プロドラッグ
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
AU2019313484A1 (en) * 2018-08-03 2021-02-18 Cellix Bio Private Limited Compositions and methods for the treatment of cancer
KR20220035143A (ko) 2019-07-17 2022-03-21 누코리온 파마슈티컬스, 인코포레이티드. 사이클릭 디옥시리보뉴클레오티드 화합물
EP4143199B1 (en) 2020-04-21 2025-11-19 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
NZ336676A (en) * 1997-01-24 2000-01-28 Norsk Hydro As Gemcitabine esters or amides useful as anti-cancer and anti-viral agents
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
EP1567169A4 (en) * 2002-11-04 2009-10-21 Xenoport Inc GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
UA86119C2 (ru) 2009-03-25
ES2310860T3 (es) 2009-01-16
EA011868B1 (ru) 2009-06-30
TW200634023A (en) 2006-10-01
AU2005316922A1 (en) 2006-06-22
RS50629B (sr) 2010-06-30
KR20070086308A (ko) 2007-08-27
EP1831237A1 (en) 2007-09-12
DE602005009255D1 (de) 2008-10-02
BRPI0519117A2 (pt) 2008-12-23
SI1831237T1 (sl) 2009-02-28
EP1831237B1 (en) 2008-08-20
CN101080417A (zh) 2007-11-28
IL183666A0 (en) 2007-09-20
PE20060771A1 (es) 2006-09-23
AU2005316922B2 (en) 2011-08-25
ATE405573T1 (de) 2008-09-15
HRP20080529T3 (en) 2008-12-31
MA29154B1 (fr) 2008-01-02
KR100874052B1 (ko) 2008-12-12
PT1831237E (pt) 2008-09-22
TWI326687B (en) 2010-07-01
US20090156547A1 (en) 2009-06-18
ZA200705019B (en) 2008-10-29
MX2007007228A (es) 2007-08-14
DK1831237T3 (da) 2008-10-27
PL1831237T3 (pl) 2009-01-30
CA2589850C (en) 2012-05-01
JP2008524218A (ja) 2008-07-10
EA200701300A1 (ru) 2007-10-26
JP5022911B2 (ja) 2012-09-12
CA2589850A1 (en) 2006-06-22
NO20073368L (no) 2007-07-16
US7691827B2 (en) 2010-04-06
CY1108447T1 (el) 2014-04-09
WO2006065525A1 (en) 2006-06-22
AR055009A1 (es) 2007-08-01
NZ554732A (en) 2010-09-30
CN101080417B (zh) 2011-01-19
IL183666A (en) 2011-09-27
HK1109903A1 (en) 2008-06-27

Similar Documents

Publication Publication Date Title
MY143677A (en) Amide prodrug of gemcitabine, compositions and use thereof
ZA201002178B (en) 2'-fluoro-2'-deoxytetrahydrouridines as cytidine deaminase inhibitors
MY148253A (en) Azaadamantane derivatives and methods of use
PH12015500550A1 (en) Anti-notch1 nrr antibodies and methods using same
MX2007007189A (es) Prodrogas de compuestos de 2,4-pirimidindiamina y sus usos.
PT1984357E (pt) Compostos de 2,4-pirimidinadiamina para tratamento ou prevenção de doenças autoimunes
UA95975C2 (ru) N-метиламинометилизоиндольные соединения, композиции, содержащие их, и способы их применения
NO20081554L (no) Isoindollmidforbindelser og sammensetninger omfattende samme, og anvendelse derav
UA94833C2 (en) Substituted bicyclolactams
UA97502C2 (ru) Кристаллическая твердая основа разагилина
TW200640924A (en) VEGF-R2 inhibitors and methods
MX2007003175A (es) Medicamentos que contienen compuestos de carbonilo y su uso.
MX2009010174A (es) Derivados de aza-adamantano ester y carbamato y metodos de uso de los mismos.
TW200613308A (en) Cyclobutanetetracarboxylate compound and preparation method thereof
TW200744567A (en) Phenylethylamine analogs and their use for treating glaucoma
MX2009000198A (es) Formas cristalinas de profarmaco amida de gemcitabina, composiciones y usos del mismo.
EP1991248A4 (en) ANTIDEPRESSANT PRODRUGS
TW200745039A (en) Isotopically substituted pantoprazole
TW200800986A (en) Tetrahydroquinolines, synthesis thereof, and intermediates thereto
TW200738713A (en) Diazepinoquinolines, synthesis thereof, and intermediates thereto
MX2007011826A (es) Composiciones farmaceuticas de liberacion controlada de liotironina y metodos para elaborar y utilizar las mismas.
PL1845780T3 (pl) Zastosowanie pochodnych metylofenidatu
EP2069346A4 (en) ACETAMIDE AND CARBOXAMIDE AZAADAMANTANE DERIVATIVES AND METHODS OF USE
MY140858A (en) Ampa receptor potentiators
TW200603801A (en) Novel dialkoxy-imidazopyridines