PE20060771A1 - Profarmaco de amida de gemcitabina y composiciones que lo contienen - Google Patents

Profarmaco de amida de gemcitabina y composiciones que lo contienen

Info

Publication number
PE20060771A1
PE20060771A1 PE2005001474A PE2005001474A PE20060771A1 PE 20060771 A1 PE20060771 A1 PE 20060771A1 PE 2005001474 A PE2005001474 A PE 2005001474A PE 2005001474 A PE2005001474 A PE 2005001474A PE 20060771 A1 PE20060771 A1 PE 20060771A1
Authority
PE
Peru
Prior art keywords
gemcitabin
propharmac
amide
compositions containing
drug
Prior art date
Application number
PE2005001474A
Other languages
English (en)
Spanish (es)
Inventor
David Michael Bender
David Michael Remick
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20060771A1 publication Critical patent/PE20060771A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
PE2005001474A 2004-12-17 2005-12-15 Profarmaco de amida de gemcitabina y composiciones que lo contienen PE20060771A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17

Publications (1)

Publication Number Publication Date
PE20060771A1 true PE20060771A1 (es) 2006-09-23

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001474A PE20060771A1 (es) 2004-12-17 2005-12-15 Profarmaco de amida de gemcitabina y composiciones que lo contienen

Country Status (31)

Country Link
US (1) US7691827B2 (cg-RX-API-DMAC7.html)
EP (1) EP1831237B1 (cg-RX-API-DMAC7.html)
JP (1) JP5022911B2 (cg-RX-API-DMAC7.html)
KR (1) KR100874052B1 (cg-RX-API-DMAC7.html)
CN (1) CN101080417B (cg-RX-API-DMAC7.html)
AR (1) AR055009A1 (cg-RX-API-DMAC7.html)
AT (1) ATE405573T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005316922B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0519117A2 (cg-RX-API-DMAC7.html)
CA (1) CA2589850C (cg-RX-API-DMAC7.html)
CY (1) CY1108447T1 (cg-RX-API-DMAC7.html)
DE (1) DE602005009255D1 (cg-RX-API-DMAC7.html)
DK (1) DK1831237T3 (cg-RX-API-DMAC7.html)
EA (1) EA011868B1 (cg-RX-API-DMAC7.html)
ES (1) ES2310860T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20080529T3 (cg-RX-API-DMAC7.html)
IL (1) IL183666A (cg-RX-API-DMAC7.html)
MA (1) MA29154B1 (cg-RX-API-DMAC7.html)
MX (1) MX2007007228A (cg-RX-API-DMAC7.html)
MY (1) MY143677A (cg-RX-API-DMAC7.html)
NO (1) NO20073368L (cg-RX-API-DMAC7.html)
NZ (1) NZ554732A (cg-RX-API-DMAC7.html)
PE (1) PE20060771A1 (cg-RX-API-DMAC7.html)
PL (1) PL1831237T3 (cg-RX-API-DMAC7.html)
PT (1) PT1831237E (cg-RX-API-DMAC7.html)
RS (1) RS50629B (cg-RX-API-DMAC7.html)
SI (1) SI1831237T1 (cg-RX-API-DMAC7.html)
TW (1) TWI326687B (cg-RX-API-DMAC7.html)
UA (1) UA86119C2 (cg-RX-API-DMAC7.html)
WO (1) WO2006065525A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200705019B (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014909B1 (ru) * 2006-06-21 2011-02-28 Эли Лилли Энд Компани Кристаллические формы пролекарства на основе амида гемцитабина, композиции на их основе и их применение
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN104955458A (zh) 2012-11-07 2015-09-30 Z·索 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法
WO2014078295A1 (en) 2012-11-13 2014-05-22 BoYen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
EP3119795A4 (en) * 2014-03-03 2018-03-14 Nucorion Pharmaceuticals, Inc. Gemcitabine analogs
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
KR102708995B1 (ko) 2018-01-10 2024-09-23 누코리온 파마슈티컬스, 인코포레이티드. 포스포르(포스포론)아미다타세탈 및 포스프(온)아탈세탈 화합물
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
JP7598313B2 (ja) * 2018-04-26 2024-12-11 ナノメッド ホールディングス プロプライエタリー リミテッド ジェムシタビン両親媒性プロドラッグ
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
AU2019313484A1 (en) * 2018-08-03 2021-02-18 Cellix Bio Private Limited Compositions and methods for the treatment of cancer
KR20220035143A (ko) 2019-07-17 2022-03-21 누코리온 파마슈티컬스, 인코포레이티드. 사이클릭 디옥시리보뉴클레오티드 화합물
EP4143199B1 (en) 2020-04-21 2025-11-19 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
NZ336676A (en) * 1997-01-24 2000-01-28 Norsk Hydro As Gemcitabine esters or amides useful as anti-cancer and anti-viral agents
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
EP1567169A4 (en) * 2002-11-04 2009-10-21 Xenoport Inc GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
UA86119C2 (ru) 2009-03-25
ES2310860T3 (es) 2009-01-16
EA011868B1 (ru) 2009-06-30
TW200634023A (en) 2006-10-01
AU2005316922A1 (en) 2006-06-22
RS50629B (sr) 2010-06-30
KR20070086308A (ko) 2007-08-27
EP1831237A1 (en) 2007-09-12
DE602005009255D1 (de) 2008-10-02
BRPI0519117A2 (pt) 2008-12-23
SI1831237T1 (sl) 2009-02-28
EP1831237B1 (en) 2008-08-20
CN101080417A (zh) 2007-11-28
IL183666A0 (en) 2007-09-20
AU2005316922B2 (en) 2011-08-25
ATE405573T1 (de) 2008-09-15
HRP20080529T3 (en) 2008-12-31
MA29154B1 (fr) 2008-01-02
KR100874052B1 (ko) 2008-12-12
PT1831237E (pt) 2008-09-22
TWI326687B (en) 2010-07-01
US20090156547A1 (en) 2009-06-18
ZA200705019B (en) 2008-10-29
MX2007007228A (es) 2007-08-14
DK1831237T3 (da) 2008-10-27
PL1831237T3 (pl) 2009-01-30
CA2589850C (en) 2012-05-01
JP2008524218A (ja) 2008-07-10
EA200701300A1 (ru) 2007-10-26
JP5022911B2 (ja) 2012-09-12
CA2589850A1 (en) 2006-06-22
NO20073368L (no) 2007-07-16
US7691827B2 (en) 2010-04-06
CY1108447T1 (el) 2014-04-09
MY143677A (en) 2011-06-30
WO2006065525A1 (en) 2006-06-22
AR055009A1 (es) 2007-08-01
NZ554732A (en) 2010-09-30
CN101080417B (zh) 2011-01-19
IL183666A (en) 2011-09-27
HK1109903A1 (en) 2008-06-27

Similar Documents

Publication Publication Date Title
PE20060771A1 (es) Profarmaco de amida de gemcitabina y composiciones que lo contienen
PH12022553603A1 (en) Triazine derivative having virus propagation inhibitory effect, and pharmaceutical composition containing same
TW200833370A (en) Pharmaceutical composition containing low substituted hydroxypropylcellulose
EE200300403A (et) N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
MA28921B1 (fr) Derive heterocyclique azote et medicament le contenant en tant que principe actif
MX2007010532A (es) Derivados de amida de acido 1-sulfonil-piperidina-3-carboxilico como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa para el tratamiento de diabetes mellitus tipo ii.
WO2003063864A3 (fr) Composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
EA200702498A1 (ru) N-(пиридин-2-ил)сульфонамидные производные
MX2011012627A (es) Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
CO5590918A2 (es) Formulaciones
TW200621737A (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
TW200517106A (en) Sustained release pharmaceutical compositions
EA201070588A1 (ru) Производные 1,2,3-триазола для применения в качестве ингибиторов стеароил-соа десатуразы
GEP20094605B (en) Pyrazole derivatives, compositions containing such compounds and methods of use thereof
MY151295A (en) Pyrimidyl indoline compound
IL174665A0 (en) Heterocyclic compounds which act as p-glycoprotein inhibitors and pharmaceutical compositions containing the same
UA97348C2 (en) HETEROCYCLIC NF-kB INHIBITORS
SG158863A1 (en) Intravenous formulations of pde-5 inhibitors
PL1843754T3 (pl) Nowa kompozycja farmaceutyczna zawierająca cyleksetyl kandesartanu jako lipofilową substancję krystaliczną
IL191670A0 (en) Compounds for the inhibition of apoptosis
WO2007009691A3 (en) Combination of substituted pyrazolines and anti -addictive agent
TW201129557A (en) Pharmaceutical composition for oral administration
TNSN08242A1 (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
ATE460934T1 (de) Pharmazeutische zubereitungen von ciprofloxacin

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed