MXPA06013299A - Medicamentos que contienen n-sulfamoil-n'-arilpiperazinas para la profilaxis o el tratamiento de la obesidad y estados relacionados. - Google Patents
Medicamentos que contienen n-sulfamoil-n'-arilpiperazinas para la profilaxis o el tratamiento de la obesidad y estados relacionados.Info
- Publication number
- MXPA06013299A MXPA06013299A MXPA06013299A MXPA06013299A MXPA06013299A MX PA06013299 A MXPA06013299 A MX PA06013299A MX PA06013299 A MXPA06013299 A MX PA06013299A MX PA06013299 A MXPA06013299 A MX PA06013299A MX PA06013299 A MXPA06013299 A MX PA06013299A
- Authority
- MX
- Mexico
- Prior art keywords
- phenyl
- alkoxy
- formula
- group
- alkyl
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title claims abstract description 27
- 235000020824 obesity Nutrition 0.000 title claims abstract description 26
- 238000011282 treatment Methods 0.000 title claims abstract description 23
- 238000011321 prophylaxis Methods 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 title claims description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 54
- 239000002253 acid Substances 0.000 claims abstract description 43
- 150000001875 compounds Chemical class 0.000 claims description 128
- -1 carboxy, hydroxy, hydroxycarbamoyl Chemical group 0.000 claims description 104
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 55
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 54
- 229910052736 halogen Inorganic materials 0.000 claims description 53
- 150000002367 halogens Chemical class 0.000 claims description 53
- 125000001424 substituent group Chemical group 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 42
- 239000003112 inhibitor Substances 0.000 claims description 42
- 125000003545 alkoxy group Chemical group 0.000 claims description 39
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 34
- 239000013543 active substance Substances 0.000 claims description 27
- 125000004432 carbon atom Chemical group C* 0.000 claims description 27
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 21
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 21
- 125000004076 pyridyl group Chemical group 0.000 claims description 21
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 19
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 19
- 241000124008 Mammalia Species 0.000 claims description 16
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 16
- 125000001624 naphthyl group Chemical group 0.000 claims description 15
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims description 14
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 14
- 239000002775 capsule Substances 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 125000004414 alkyl thio group Chemical group 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- PGOWYQPWIHCLJF-UHFFFAOYSA-N 4-phenylpiperazine-1-sulfonamide Chemical compound C1CN(S(=O)(=O)N)CCN1C1=CC=CC=C1 PGOWYQPWIHCLJF-UHFFFAOYSA-N 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 239000003826 tablet Substances 0.000 claims description 11
- 125000004605 1,2,3,4-tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 10
- 125000001041 indolyl group Chemical group 0.000 claims description 10
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 10
- 206010012601 diabetes mellitus Diseases 0.000 claims description 9
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims description 9
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 7
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- 239000012453 solvate Substances 0.000 claims description 7
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- 239000002585 base Substances 0.000 claims description 6
- 229910052740 iodine Inorganic materials 0.000 claims description 6
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 6
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 6
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 6
- 125000004306 triazinyl group Chemical group 0.000 claims description 6
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 5
- 201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
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- 229960002297 fenofibrate Drugs 0.000 claims description 5
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims description 5
- 208000011661 metabolic syndrome X Diseases 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 229960004586 rosiglitazone Drugs 0.000 claims description 5
- 229960002855 simvastatin Drugs 0.000 claims description 5
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 5
- LEZCTXCXZDXCHF-UHFFFAOYSA-N 4-(2-chlorophenyl)piperazine-1-sulfonamide Chemical compound C1CN(S(=O)(=O)N)CCN1C1=CC=CC=C1Cl LEZCTXCXZDXCHF-UHFFFAOYSA-N 0.000 claims description 4
- LAPKIZQFPQJCTN-UHFFFAOYSA-N 4-(2-methoxyphenyl)piperazine-1-sulfonamide Chemical compound COC1=CC=CC=C1N1CCN(S(N)(=O)=O)CC1 LAPKIZQFPQJCTN-UHFFFAOYSA-N 0.000 claims description 4
- WDDZIKQVLBYPLC-UHFFFAOYSA-N 4-(4-fluorophenyl)piperazine-1-sulfonamide Chemical compound C1CN(S(=O)(=O)N)CCN1C1=CC=C(F)C=C1 WDDZIKQVLBYPLC-UHFFFAOYSA-N 0.000 claims description 4
- NDJCYVRMNRZUMX-UHFFFAOYSA-N 4-[4-chloro-3-(trifluoromethyl)phenyl]piperazine-1-sulfonamide Chemical compound C1CN(S(=O)(=O)N)CCN1C1=CC=C(Cl)C(C(F)(F)F)=C1 NDJCYVRMNRZUMX-UHFFFAOYSA-N 0.000 claims description 4
- 229960000549 4-dimethylaminophenol Drugs 0.000 claims description 4
- XZYYLFYBBUIPOJ-UHFFFAOYSA-N 4-pyridin-4-ylpiperazine-1-sulfonamide Chemical compound C1CN(S(=O)(=O)N)CCN1C1=CC=NC=C1 XZYYLFYBBUIPOJ-UHFFFAOYSA-N 0.000 claims description 4
- VKXAFVHBIMGURJ-UHFFFAOYSA-N 4-pyrimidin-2-ylpiperazine-1-sulfonamide Chemical compound C1CN(S(=O)(=O)N)CCN1C1=NC=CC=N1 VKXAFVHBIMGURJ-UHFFFAOYSA-N 0.000 claims description 4
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 150000004283 biguanides Chemical class 0.000 claims description 4
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- 206010015037 epilepsy Diseases 0.000 claims description 4
- 239000013067 intermediate product Substances 0.000 claims description 4
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 4
- 229960003105 metformin Drugs 0.000 claims description 4
- 125000002950 monocyclic group Chemical group 0.000 claims description 4
- QAHVHSLSRLSVGS-UHFFFAOYSA-N sulfamoyl chloride Chemical compound NS(Cl)(=O)=O QAHVHSLSRLSVGS-UHFFFAOYSA-N 0.000 claims description 4
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- 125000001544 thienyl group Chemical group 0.000 claims description 4
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 3
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- 108010023302 HDL Cholesterol Proteins 0.000 claims description 3
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Quinoline Compounds (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57223604P | 2004-05-19 | 2004-05-19 | |
| EP04102210 | 2004-05-19 | ||
| PCT/EP2005/052281 WO2005110413A2 (en) | 2004-05-19 | 2005-05-18 | Medicaments containing n-sulfamoyl-n'-arylpiperazines for the prophylaxis or treatment of obesity and related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA06013299A true MXPA06013299A (es) | 2007-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| MXPA06013299A MXPA06013299A (es) | 2004-05-19 | 2005-05-18 | Medicamentos que contienen n-sulfamoil-n'-arilpiperazinas para la profilaxis o el tratamiento de la obesidad y estados relacionados. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1750712A2 (https=) |
| JP (1) | JP2007538054A (https=) |
| CN (1) | CN1997370B (https=) |
| AU (1) | AU2005244450B2 (https=) |
| BR (1) | BRPI0510137A (https=) |
| CA (1) | CA2567166A1 (https=) |
| IL (1) | IL178903A0 (https=) |
| MX (1) | MXPA06013299A (https=) |
| NO (1) | NO20065835L (https=) |
| RU (1) | RU2395503C2 (https=) |
| WO (1) | WO2005110413A2 (https=) |
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| EP1866298A2 (en) | 2005-03-31 | 2007-12-19 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| AU2007206997B2 (en) * | 2006-01-23 | 2011-11-24 | F. Hoffmann-La Roche Ag | Cyclohexyl sulfonamide derivatives having H3 receptor activity |
| PL2106260T3 (pl) * | 2007-01-25 | 2018-06-29 | NAIA Metabolic, Inc. | Środki uwrażliwiające na insulinę i sposoby leczenia |
| RU2539591C2 (ru) * | 2009-04-22 | 2015-01-20 | Аксикин Фармасьютикалз, Инк. | Антагонисты арилсульфонамида ccr3 |
| RU2445963C2 (ru) * | 2010-07-09 | 2012-03-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая противодиабетическая композиция |
| SG10201707409PA (en) | 2013-03-13 | 2017-10-30 | Forma Therapeutics Inc | Novel compounds and compositions for inhibition of fasn |
| GB201410817D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D | Therapeutic agents |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2748125A (en) * | 1954-04-26 | 1956-05-29 | American Cyanamid Co | 1-substituted-4-sulfamylpiperazine and method of preparing the same |
| FR2030116A1 (en) | 1969-01-02 | 1970-10-30 | Sandoz Sa | Herbicide compositions and prepn |
| US3709677A (en) * | 1969-06-25 | 1973-01-09 | Sandoz Ag | N-substituted sulfamoyl compounds useful as herbicides |
| SU1646258A3 (ru) * | 1989-02-08 | 1996-02-10 | Институт биохимии Литовской АН | 5-аминонафталин-1-сульфамиды в качестве детектируемых групп субстратов для флюоресцентного анализа пептидаз |
| DE4025387A1 (de) | 1990-08-10 | 1992-02-13 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien |
| US5728704A (en) * | 1992-09-28 | 1998-03-17 | Pfizer Inc. | Substituted pyridmidines for control of diabetic complications |
| WO1995009151A1 (en) * | 1993-09-28 | 1995-04-06 | Ciba-Geigy Ag | Acylated sulphonamides as insecticides and acaricides |
| ID22849A (id) * | 1997-01-23 | 1999-12-09 | Hoffmann La Roche | Penghambat-penghambat sulmafida-metaloprotease |
| DE10035227A1 (de) | 2000-07-20 | 2002-01-31 | Solvay Pharm Gmbh | Verfahren zum Auffinden von Verbindungen, welche zur Behandlung und/oder Prophylaxe von Fettleibigkeit geeignet sind |
| DE60326436D1 (en) * | 2002-03-13 | 2009-04-16 | Janssen Pharmaceutica Nv | Aminoderivate als histone-deacetylase-inhibitoren |
| DK1513516T3 (da) * | 2002-06-06 | 2009-10-19 | Boehringer Ingelheim Pharma | Substitueret 3-amino-thieno(2,3-b)-pyridin-2-carboxylsyreamid-forbindelser og fremgangsmåder til fremstilling og deres anvendelser |
| WO2005005382A2 (en) * | 2003-07-02 | 2005-01-20 | Cytokinetics, Inc. | Compounds, compositions and methods |
| KR101280095B1 (ko) | 2004-08-28 | 2013-09-09 | 아스트라제네카 아베 | 케모킨 수용체 조절제로서의 피리미딘 술폰아미드 유도체 |
-
2005
- 2005-05-18 BR BRPI0510137-9A patent/BRPI0510137A/pt not_active IP Right Cessation
- 2005-05-18 MX MXPA06013299A patent/MXPA06013299A/es not_active Application Discontinuation
- 2005-05-18 RU RU2006144812/04A patent/RU2395503C2/ru not_active IP Right Cessation
- 2005-05-18 CN CN2005800159695A patent/CN1997370B/zh not_active Expired - Fee Related
- 2005-05-18 JP JP2007517257A patent/JP2007538054A/ja active Pending
- 2005-05-18 EP EP05749492A patent/EP1750712A2/en not_active Withdrawn
- 2005-05-18 AU AU2005244450A patent/AU2005244450B2/en not_active Ceased
- 2005-05-18 WO PCT/EP2005/052281 patent/WO2005110413A2/en not_active Ceased
- 2005-05-18 CA CA002567166A patent/CA2567166A1/en not_active Abandoned
-
2006
- 2006-10-26 IL IL178903A patent/IL178903A0/en unknown
- 2006-12-18 NO NO20065835A patent/NO20065835L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006144812A (ru) | 2008-06-27 |
| IL178903A0 (en) | 2007-03-08 |
| AU2005244450A1 (en) | 2005-11-24 |
| JP2007538054A (ja) | 2007-12-27 |
| CN1997370A (zh) | 2007-07-11 |
| EP1750712A2 (en) | 2007-02-14 |
| WO2005110413A3 (en) | 2006-07-13 |
| AU2005244450B2 (en) | 2010-08-19 |
| CN1997370B (zh) | 2011-06-01 |
| NO20065835L (no) | 2007-02-16 |
| CA2567166A1 (en) | 2005-11-24 |
| WO2005110413A2 (en) | 2005-11-24 |
| BRPI0510137A (pt) | 2007-10-02 |
| RU2395503C2 (ru) | 2010-07-27 |
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