MXPA06011017A - Moduladores canabinoides de tetrahidro-indazol. - Google Patents
Moduladores canabinoides de tetrahidro-indazol.Info
- Publication number
- MXPA06011017A MXPA06011017A MXPA06011017A MXPA06011017A MXPA06011017A MX PA06011017 A MXPA06011017 A MX PA06011017A MX PA06011017 A MXPA06011017 A MX PA06011017A MX PA06011017 A MXPA06011017 A MX PA06011017A MX PA06011017 A MXPA06011017 A MX PA06011017A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- phenyl
- hydroxy
- optionally substituted
- halogen
- Prior art date
Links
- 229930003827 cannabinoid Natural products 0.000 title abstract description 19
- 239000003557 cannabinoid Substances 0.000 title abstract description 19
- CSDFHCDNAZPVKH-UHFFFAOYSA-N 2,3,3a,7a-tetrahydro-1h-indazole Chemical compound C1=CC=CC2CNNC21 CSDFHCDNAZPVKH-UHFFFAOYSA-N 0.000 title abstract description 3
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- -1 C3-C12 cycloalkyl Chemical group 0.000 claims description 242
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
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Applications Claiming Priority (2)
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| US55589004P | 2004-03-24 | 2004-03-24 | |
| PCT/US2005/009819 WO2005095353A1 (en) | 2004-03-24 | 2005-03-23 | Tetrahydro-indazole cannabinoid modulators |
Publications (1)
| Publication Number | Publication Date |
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| MXPA06011017A true MXPA06011017A (es) | 2007-03-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| MXPA06011017A MXPA06011017A (es) | 2004-03-24 | 2005-03-23 | Moduladores canabinoides de tetrahidro-indazol. |
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| NO (1) | NO20064810L (enExample) |
| PL (1) | PL1735286T3 (enExample) |
| PT (1) | PT1735286E (enExample) |
| TW (1) | TW200602324A (enExample) |
| WO (1) | WO2005095353A1 (enExample) |
| ZA (1) | ZA200608808B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2875230A1 (fr) * | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| US7888381B2 (en) * | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
| CA2623803A1 (en) * | 2005-09-23 | 2007-03-29 | Janssen Pharmaceutica N.V. | Tetrahydro-cyclopentyl pyrazole cannabinoid modulators |
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US8378096B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| EP1931336A1 (en) * | 2005-09-23 | 2008-06-18 | Janssen Pharmaceutica, N.V. | Tetrahydro-indazolyl cannabinoid modulators |
| US8378117B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| CN101312726A (zh) * | 2005-09-23 | 2008-11-26 | 詹森药业有限公司 | 六氢-环庚三烯并吡唑大麻素调节剂 |
| US7851498B2 (en) * | 2005-09-23 | 2010-12-14 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US7795294B2 (en) | 2006-02-14 | 2010-09-14 | Janssen Pharmaceutica N.V. | Tetrahydro-2H-indazole pyrazole cannabinoid modulators |
| US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
| WO2007112402A1 (en) * | 2006-03-27 | 2007-10-04 | Janssen Pharmaceutica N.V. | Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators |
| WO2008054508A2 (en) * | 2006-04-13 | 2008-05-08 | Alza Corporation | Stable nanosized amorphous drug |
| US20080200501A1 (en) * | 2006-11-03 | 2008-08-21 | Glenmark Pharmaceuticals S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation |
| EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| EP2139327A4 (en) * | 2007-03-21 | 2011-06-15 | Janssen Pharmaceutica Nv | METHOD OF TREATING PAIN INDUCED BY A CB2 RECEPTOR |
| AU2008229264A1 (en) * | 2007-03-21 | 2008-09-25 | Janssen Pharmaceutica N.V. | Method for treating CB2 receptor mediated pain |
| UA100120C2 (en) | 2007-04-03 | 2012-11-26 | Анадис Фармасьютикалз, Инк. | 5,6-dihydro-1h-pyridin-2-one compounds |
| US8338623B2 (en) * | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
| BRPI0905681A2 (pt) * | 2008-01-08 | 2015-07-07 | Purdue Pharma Lp | "análogos da prolina como ligantes para receptores de canabinóide" |
| US20090215850A1 (en) * | 2008-02-27 | 2009-08-27 | Mingde Xia | Method for treating cb2 receptor mediated pain |
| MX2011002794A (es) * | 2008-09-25 | 2011-04-05 | Hoffmann La Roche | Indazol 2,3-sustituido o 4,5,6,7-tetrahidro-indazol como moduladores fxr contra dislipidemia y enfermedades relacionadas. |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10435375B2 (en) | 2015-05-05 | 2019-10-08 | Northwestern University | CXCR4 chemokine receptor modulators |
| US9682940B2 (en) | 2015-08-25 | 2017-06-20 | Janssen Pharmaceutica Nv | Indazole derivatives useful as CB-1 inverse agonists |
| CN105367498B (zh) * | 2015-11-11 | 2019-05-17 | 中国农业大学 | 吡唑并环-3-甲酰胺类似物及其制备和应用 |
| CN106397218A (zh) * | 2016-09-04 | 2017-02-15 | 王际菊 | S‑α‑环己基苯甲胺 |
| WO2020008317A1 (en) * | 2018-07-03 | 2020-01-09 | Janssen Pharmaceutica Nv | Acylsufonamide compounds useful as ep3 receptor antagonists |
| TWI768464B (zh) * | 2019-09-12 | 2022-06-21 | 大陸商四川海思科製藥有限公司 | 三環吡唑衍生物及其製備 |
| WO2021047581A1 (zh) * | 2019-09-12 | 2021-03-18 | 四川海思科制药有限公司 | 一种六氢化苯并吡唑衍生物及其制备 |
| JP7777548B2 (ja) * | 2020-06-11 | 2025-11-28 | 貝達薬業股▲ふん▼有限公司 | 二環化合物及びその使用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1052111B (it) * | 1972-02-29 | 1981-06-20 | Acraf | Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati |
| US3895025A (en) * | 1973-03-29 | 1975-07-15 | Du Pont | 2-Benzimidazolethiol preparation |
| WO1986007357A2 (en) * | 1985-06-14 | 1986-12-18 | Upjohn Co | Cyclopentapyrazole and tetrahydroindazole compounds |
| US4861777A (en) * | 1987-09-11 | 1989-08-29 | Mitsubishi Kasei Corporation | Pyrazole derivative and insecticidal and miticidal composition containing the derivative as active ingredient |
| JPH06306053A (ja) * | 1993-01-29 | 1994-11-01 | Sagami Chem Res Center | ３−アゾールカルボン酸誘導体の製造方法及びその中間体 |
| US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US6410533B1 (en) | 2000-02-10 | 2002-06-25 | Genzyme Corporation | Antibacterial compounds |
| US6653304B2 (en) | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| US7666867B2 (en) * | 2001-10-26 | 2010-02-23 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
| CA2480856A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Substituted aryl amides |
| US7145012B2 (en) * | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
-
2005
- 2005-03-23 MX MXPA06011017A patent/MXPA06011017A/es unknown
- 2005-03-23 WO PCT/US2005/009819 patent/WO2005095353A1/en not_active Ceased
- 2005-03-23 PL PL05732229T patent/PL1735286T3/pl unknown
- 2005-03-23 DK DK05732229.9T patent/DK1735286T3/da active
- 2005-03-23 EA EA200601760A patent/EA010887B1/ru not_active IP Right Cessation
- 2005-03-23 TW TW094108873A patent/TW200602324A/zh unknown
- 2005-03-23 CN CN2005800160828A patent/CN1956964B/zh not_active Expired - Fee Related
- 2005-03-23 CA CA2561305A patent/CA2561305C/en not_active Expired - Fee Related
- 2005-03-23 JP JP2007505172A patent/JP4825792B2/ja not_active Expired - Fee Related
- 2005-03-23 BR BRPI0509207-8A patent/BRPI0509207A/pt not_active IP Right Cessation
- 2005-03-23 AT AT05732229T patent/ATE540027T1/de active
- 2005-03-23 EP EP05732229A patent/EP1735286B1/en not_active Expired - Lifetime
- 2005-03-23 US US11/087,943 patent/US7452997B2/en not_active Expired - Fee Related
- 2005-03-23 ES ES05732229T patent/ES2378071T3/es not_active Expired - Lifetime
- 2005-03-23 PT PT05732229T patent/PT1735286E/pt unknown
- 2005-03-23 AU AU2005228868A patent/AU2005228868B2/en not_active Ceased
- 2005-03-28 AR ARP050101196A patent/AR048341A1/es not_active Application Discontinuation
-
2006
- 2006-09-22 EC EC2006006877A patent/ECSP066877A/es unknown
- 2006-09-25 IL IL178290A patent/IL178290A0/en unknown
- 2006-10-20 CR CR8701A patent/CR8701A/es unknown
- 2006-10-23 ZA ZA200608808A patent/ZA200608808B/en unknown
- 2006-10-23 NO NO20064810A patent/NO20064810L/no not_active Application Discontinuation
-
2008
- 2008-10-08 US US12/247,263 patent/US20090099143A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050228034A1 (en) | 2005-10-13 |
| CR8701A (es) | 2008-11-24 |
| CN1956964B (zh) | 2011-06-15 |
| JP4825792B2 (ja) | 2011-11-30 |
| NO20064810L (no) | 2006-12-22 |
| CA2561305A1 (en) | 2005-10-13 |
| TW200602324A (en) | 2006-01-16 |
| CA2561305C (en) | 2013-07-30 |
| ECSP066877A (es) | 2006-11-24 |
| IL178290A0 (en) | 2006-12-31 |
| AR048341A1 (es) | 2006-04-19 |
| PL1735286T3 (pl) | 2012-06-29 |
| EA010887B1 (ru) | 2008-12-30 |
| EP1735286B1 (en) | 2012-01-04 |
| CN1956964A (zh) | 2007-05-02 |
| ES2378071T3 (es) | 2012-04-04 |
| JP2007530577A (ja) | 2007-11-01 |
| ATE540027T1 (de) | 2012-01-15 |
| DK1735286T3 (da) | 2012-04-02 |
| BRPI0509207A (pt) | 2007-08-28 |
| US7452997B2 (en) | 2008-11-18 |
| EA200601760A1 (ru) | 2007-02-27 |
| AU2005228868A1 (en) | 2005-10-13 |
| WO2005095353A1 (en) | 2005-10-13 |
| PT1735286E (pt) | 2012-03-05 |
| AU2005228868B2 (en) | 2012-02-09 |
| EP1735286A1 (en) | 2006-12-27 |
| ZA200608808B (en) | 2008-06-25 |
| US20090099143A1 (en) | 2009-04-16 |
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