CN1956964B - 四氢-吲唑大麻素调节剂 - Google Patents
四氢-吲唑大麻素调节剂 Download PDFInfo
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- CN1956964B CN1956964B CN2005800160828A CN200580016082A CN1956964B CN 1956964 B CN1956964 B CN 1956964B CN 2005800160828 A CN2005800160828 A CN 2005800160828A CN 200580016082 A CN200580016082 A CN 200580016082A CN 1956964 B CN1956964 B CN 1956964B
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- compound
- aryl
- receptor
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- Expired - Fee Related
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- 0 CCOC(C(C1=CCC(C)C1)NC(C(C(CCCC1)=C1NC*1ccc(C)cc1)=N)=O)=O Chemical compound CCOC(C(C1=CCC(C)C1)NC(C(C(CCCC1)=C1NC*1ccc(C)cc1)=N)=O)=O 0.000 description 24
- KVOZXXSUSRZIKD-UHFFFAOYSA-N C=CCC1CCCCC1 Chemical compound C=CCC1CCCCC1 KVOZXXSUSRZIKD-UHFFFAOYSA-N 0.000 description 1
- HOQGGIFEGITFKG-UHFFFAOYSA-N CC(C)(C)OC(C(CC1)Cc2c1[n](C1CCCCC1)nc2C(CC1C(C2)C34C1CC3CC2C4)=O)=O Chemical compound CC(C)(C)OC(C(CC1)Cc2c1[n](C1CCCCC1)nc2C(CC1C(C2)C34C1CC3CC2C4)=O)=O HOQGGIFEGITFKG-UHFFFAOYSA-N 0.000 description 1
- UDJUXWGLSYKCBN-UHFFFAOYSA-N CC(C)(C)OC(NN=C1CCCCCCC1)=O Chemical compound CC(C)(C)OC(NN=C1CCCCCCC1)=O UDJUXWGLSYKCBN-UHFFFAOYSA-N 0.000 description 1
- OXJLOUANFUGVCS-UHFFFAOYSA-N CC(C)NCC1CCCCC1 Chemical compound CC(C)NCC1CCCCC1 OXJLOUANFUGVCS-UHFFFAOYSA-N 0.000 description 1
- NHLLAVQEYCIZMY-UHFFFAOYSA-N CC(C1)(C1C1CC2(C)CC1)C2NC(C(C(CCCC1)=C1NCc1ccc(C)cc1)=N)=O Chemical compound CC(C1)(C1C1CC2(C)CC1)C2NC(C(C(CCCC1)=C1NCc1ccc(C)cc1)=N)=O NHLLAVQEYCIZMY-UHFFFAOYSA-N 0.000 description 1
- QYULZPGQLTXEJM-YQYDADCPSA-N CC(C1CCC1)NC(C1=N[C@H](CC2CCCCC2)C2=C1CCCC2)=O Chemical compound CC(C1CCC1)NC(C1=N[C@H](CC2CCCCC2)C2=C1CCCC2)=O QYULZPGQLTXEJM-YQYDADCPSA-N 0.000 description 1
- PURBNBHBMYXFKR-UFAKBRAWSA-N CC([C@H]1CC[C@H](C)CC1)NC(C(C1=C(C)CCCC1)=[N]=CC1CCCCC1)=O Chemical compound CC([C@H]1CC[C@H](C)CC1)NC(C(C1=C(C)CCCC1)=[N]=CC1CCCCC1)=O PURBNBHBMYXFKR-UFAKBRAWSA-N 0.000 description 1
- ZCAHMGSNJZMVLD-UHFFFAOYSA-N CC(c1ccccc1)[n]1nc(C(NC2C(CCC3)CC3CC2C)=O)c2c1CCCC2 Chemical compound CC(c1ccccc1)[n]1nc(C(NC2C(CCC3)CC3CC2C)=O)c2c1CCCC2 ZCAHMGSNJZMVLD-UHFFFAOYSA-N 0.000 description 1
- ZFTUJGFXRVCAGD-UHFFFAOYSA-N CC(c1ccccc1)[n]1nc(C(NCC2CCCCC2)=O)c2c1CCCC2 Chemical compound CC(c1ccccc1)[n]1nc(C(NCC2CCCCC2)=O)c2c1CCCC2 ZFTUJGFXRVCAGD-UHFFFAOYSA-N 0.000 description 1
- CCXNWKNZTSJVHZ-UHFFFAOYSA-N CCC(CC(C)C1)=CC1(C)NC(c1n[n](C(C)c2ccccc2)c2c1CCCC2)=O Chemical compound CCC(CC(C)C1)=CC1(C)NC(c1n[n](C(C)c2ccccc2)c2c1CCCC2)=O CCXNWKNZTSJVHZ-UHFFFAOYSA-N 0.000 description 1
- WDUMWLBWDGWPSB-UHFFFAOYSA-O CCOC(C(C1CC2CC1)C2NC(C(C(CC(CC1)C(OCC)=O)=C1NC1CCCCC1)=[NH2+])=O)=O Chemical compound CCOC(C(C1CC2CC1)C2NC(C(C(CC(CC1)C(OCC)=O)=C1NC1CCCCC1)=[NH2+])=O)=O WDUMWLBWDGWPSB-UHFFFAOYSA-O 0.000 description 1
- SCLYRCPDKYRTQK-UHFFFAOYSA-N CCc1n[n](C2CCCCC2)c2c1CCCC2 Chemical compound CCc1n[n](C2CCCCC2)c2c1CCCC2 SCLYRCPDKYRTQK-UHFFFAOYSA-N 0.000 description 1
- HGXXZQSXQGDBDA-UHFFFAOYSA-N COc1ccc(C(CNC(c2n[n](C3CCCCC3)c3c2CCCC3)=O)O)cc1 Chemical compound COc1ccc(C(CNC(c2n[n](C3CCCCC3)c3c2CCCC3)=O)O)cc1 HGXXZQSXQGDBDA-UHFFFAOYSA-N 0.000 description 1
- XJZCXWLSFDUTRV-UHFFFAOYSA-N Cc(cc1C)ccc1NC(CCCC1)=C1C(C(NN1CCCCC1)=O)=N Chemical compound Cc(cc1C)ccc1NC(CCCC1)=C1C(C(NN1CCCCC1)=O)=N XJZCXWLSFDUTRV-UHFFFAOYSA-N 0.000 description 1
- IVSZLXZYQVIEFR-UHFFFAOYSA-N Cc1cc(C)ccc1 Chemical compound Cc1cc(C)ccc1 IVSZLXZYQVIEFR-UHFFFAOYSA-N 0.000 description 1
- NJKHWCCRAXNBAC-UHFFFAOYSA-N N=C(C(NC1CCCCCCC1)=O)C(CCCC1)=C1NC1CCCCC1 Chemical compound N=C(C(NC1CCCCCCC1)=O)C(CCCC1)=C1NC1CCCCC1 NJKHWCCRAXNBAC-UHFFFAOYSA-N 0.000 description 1
- KFCIJKHYHVSUMO-UHFFFAOYSA-O N=C(CCCC1)C1=C(C(NC1(C2)CC(C3)CC2C3C1)=O)[NH2+]c(cc1)c(CCl)cc1Cl Chemical compound N=C(CCCC1)C1=C(C(NC1(C2)CC(C3)CC2C3C1)=O)[NH2+]c(cc1)c(CCl)cc1Cl KFCIJKHYHVSUMO-UHFFFAOYSA-O 0.000 description 1
- KBGWLCCUUHMQBT-UHFFFAOYSA-N NNC1CCCCCCC1 Chemical compound NNC1CCCCCCC1 KBGWLCCUUHMQBT-UHFFFAOYSA-N 0.000 description 1
- CDEUZLIYDQOEKX-UHFFFAOYSA-N OC(C(CC1)Cc2c1[n](CC1C=CC=CC1)nc2C(NC1C2CC(C3)CC1CC3C2)=O)=O Chemical compound OC(C(CC1)Cc2c1[n](CC1C=CC=CC1)nc2C(NC1C2CC(C3)CC1CC3C2)=O)=O CDEUZLIYDQOEKX-UHFFFAOYSA-N 0.000 description 1
- SZIGRJXAMWRDAU-UHFFFAOYSA-N OC(CNC(c1n[n](C2CCCCC2)c2c1CCCC2)=O)c(cc1)ccc1Br Chemical compound OC(CNC(c1n[n](C2CCCCC2)c2c1CCCC2)=O)c(cc1)ccc1Br SZIGRJXAMWRDAU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A61P27/06—Antiglaucoma agents or miotics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55589004P | 2004-03-24 | 2004-03-24 | |
| US60/555,890 | 2004-03-24 | ||
| PCT/US2005/009819 WO2005095353A1 (en) | 2004-03-24 | 2005-03-23 | Tetrahydro-indazole cannabinoid modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1956964A CN1956964A (zh) | 2007-05-02 |
| CN1956964B true CN1956964B (zh) | 2011-06-15 |
Family
ID=34965110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800160828A Expired - Fee Related CN1956964B (zh) | 2004-03-24 | 2005-03-23 | 四氢-吲唑大麻素调节剂 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7452997B2 (enExample) |
| EP (1) | EP1735286B1 (enExample) |
| JP (1) | JP4825792B2 (enExample) |
| CN (1) | CN1956964B (enExample) |
| AR (1) | AR048341A1 (enExample) |
| AT (1) | ATE540027T1 (enExample) |
| AU (1) | AU2005228868B2 (enExample) |
| BR (1) | BRPI0509207A (enExample) |
| CA (1) | CA2561305C (enExample) |
| CR (1) | CR8701A (enExample) |
| DK (1) | DK1735286T3 (enExample) |
| EA (1) | EA010887B1 (enExample) |
| EC (1) | ECSP066877A (enExample) |
| ES (1) | ES2378071T3 (enExample) |
| IL (1) | IL178290A0 (enExample) |
| MX (1) | MXPA06011017A (enExample) |
| NO (1) | NO20064810L (enExample) |
| PL (1) | PL1735286T3 (enExample) |
| PT (1) | PT1735286E (enExample) |
| TW (1) | TW200602324A (enExample) |
| WO (1) | WO2005095353A1 (enExample) |
| ZA (1) | ZA200608808B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2875230A1 (fr) * | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| US7888381B2 (en) * | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
| CA2623803A1 (en) * | 2005-09-23 | 2007-03-29 | Janssen Pharmaceutica N.V. | Tetrahydro-cyclopentyl pyrazole cannabinoid modulators |
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US8378096B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| EP1931336A1 (en) * | 2005-09-23 | 2008-06-18 | Janssen Pharmaceutica, N.V. | Tetrahydro-indazolyl cannabinoid modulators |
| US8378117B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| CN101312726A (zh) * | 2005-09-23 | 2008-11-26 | 詹森药业有限公司 | 六氢-环庚三烯并吡唑大麻素调节剂 |
| US7851498B2 (en) * | 2005-09-23 | 2010-12-14 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US7795294B2 (en) | 2006-02-14 | 2010-09-14 | Janssen Pharmaceutica N.V. | Tetrahydro-2H-indazole pyrazole cannabinoid modulators |
| US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
| WO2007112402A1 (en) * | 2006-03-27 | 2007-10-04 | Janssen Pharmaceutica N.V. | Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators |
| WO2008054508A2 (en) * | 2006-04-13 | 2008-05-08 | Alza Corporation | Stable nanosized amorphous drug |
| US20080200501A1 (en) * | 2006-11-03 | 2008-08-21 | Glenmark Pharmaceuticals S.A. | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation |
| EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| EP2139327A4 (en) * | 2007-03-21 | 2011-06-15 | Janssen Pharmaceutica Nv | METHOD OF TREATING PAIN INDUCED BY A CB2 RECEPTOR |
| AU2008229264A1 (en) * | 2007-03-21 | 2008-09-25 | Janssen Pharmaceutica N.V. | Method for treating CB2 receptor mediated pain |
| UA100120C2 (en) | 2007-04-03 | 2012-11-26 | Анадис Фармасьютикалз, Инк. | 5,6-dihydro-1h-pyridin-2-one compounds |
| US8338623B2 (en) * | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
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| WO2020008317A1 (en) * | 2018-07-03 | 2020-01-09 | Janssen Pharmaceutica Nv | Acylsufonamide compounds useful as ep3 receptor antagonists |
| TWI768464B (zh) * | 2019-09-12 | 2022-06-21 | 大陸商四川海思科製藥有限公司 | 三環吡唑衍生物及其製備 |
| WO2021047581A1 (zh) * | 2019-09-12 | 2021-03-18 | 四川海思科制药有限公司 | 一种六氢化苯并吡唑衍生物及其制备 |
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- 2005-03-23 EA EA200601760A patent/EA010887B1/ru not_active IP Right Cessation
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- 2005-03-23 AT AT05732229T patent/ATE540027T1/de active
- 2005-03-23 EP EP05732229A patent/EP1735286B1/en not_active Expired - Lifetime
- 2005-03-23 US US11/087,943 patent/US7452997B2/en not_active Expired - Fee Related
- 2005-03-23 ES ES05732229T patent/ES2378071T3/es not_active Expired - Lifetime
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- 2005-03-23 AU AU2005228868A patent/AU2005228868B2/en not_active Ceased
- 2005-03-28 AR ARP050101196A patent/AR048341A1/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| US20050228034A1 (en) | 2005-10-13 |
| CR8701A (es) | 2008-11-24 |
| JP4825792B2 (ja) | 2011-11-30 |
| NO20064810L (no) | 2006-12-22 |
| CA2561305A1 (en) | 2005-10-13 |
| TW200602324A (en) | 2006-01-16 |
| CA2561305C (en) | 2013-07-30 |
| ECSP066877A (es) | 2006-11-24 |
| IL178290A0 (en) | 2006-12-31 |
| AR048341A1 (es) | 2006-04-19 |
| PL1735286T3 (pl) | 2012-06-29 |
| EA010887B1 (ru) | 2008-12-30 |
| EP1735286B1 (en) | 2012-01-04 |
| CN1956964A (zh) | 2007-05-02 |
| ES2378071T3 (es) | 2012-04-04 |
| JP2007530577A (ja) | 2007-11-01 |
| ATE540027T1 (de) | 2012-01-15 |
| DK1735286T3 (da) | 2012-04-02 |
| BRPI0509207A (pt) | 2007-08-28 |
| MXPA06011017A (es) | 2007-03-21 |
| US7452997B2 (en) | 2008-11-18 |
| EA200601760A1 (ru) | 2007-02-27 |
| AU2005228868A1 (en) | 2005-10-13 |
| WO2005095353A1 (en) | 2005-10-13 |
| PT1735286E (pt) | 2012-03-05 |
| AU2005228868B2 (en) | 2012-02-09 |
| EP1735286A1 (en) | 2006-12-27 |
| ZA200608808B (en) | 2008-06-25 |
| US20090099143A1 (en) | 2009-04-16 |
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