MXPA05009953A - Anticuerpo anti-cd4 humanizado con propiedades inmunosupresoras. - Google Patents

Anticuerpo anti-cd4 humanizado con propiedades inmunosupresoras.

Info

Publication number
MXPA05009953A
MXPA05009953A MXPA05009953A MXPA05009953A MXPA05009953A MX PA05009953 A MXPA05009953 A MX PA05009953A MX PA05009953 A MXPA05009953 A MX PA05009953A MX PA05009953 A MXPA05009953 A MX PA05009953A MX PA05009953 A MXPA05009953 A MX PA05009953A
Authority
MX
Mexico
Prior art keywords
antibody
humanized anti
immunosuppressive properties
immunosuppressive
properties
Prior art date
Application number
MXPA05009953A
Other languages
English (en)
Inventor
John Wijdenes
Original Assignee
Biotest Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Ag filed Critical Biotest Ag
Publication of MXPA05009953A publication Critical patent/MXPA05009953A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Abstract

La invencion se refiere a un anticuerpo humanizado derivado de un anticuerpo B-F5 anti-CD4 monoclonal de raton. El anticuerpo es capaz de activar a las celulas T reguladoras CD25+CD4+ y es util para preparar las composiciones inmunosupresoras.
MXPA05009953A 2003-03-21 2004-03-19 Anticuerpo anti-cd4 humanizado con propiedades inmunosupresoras. MXPA05009953A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03290725 2003-03-21
EP03290942A EP1460088A1 (en) 2003-03-21 2003-04-16 Humanized anti-CD4 antibody with immunosuppressive properties
PCT/EP2004/002888 WO2004083247A1 (en) 2003-03-21 2004-03-19 Humanized anti-cd4 antibody with immunosuppressive properties

Publications (1)

Publication Number Publication Date
MXPA05009953A true MXPA05009953A (es) 2006-03-09

Family

ID=32826809

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009953A MXPA05009953A (es) 2003-03-21 2004-03-19 Anticuerpo anti-cd4 humanizado con propiedades inmunosupresoras.

Country Status (21)

Country Link
US (6) US7452981B2 (es)
EP (4) EP1460088A1 (es)
JP (1) JP4491454B2 (es)
KR (2) KR20130042654A (es)
AT (2) ATE520716T1 (es)
AU (1) AU2004222089B2 (es)
CA (1) CA2519620C (es)
CY (2) CY1109390T1 (es)
DE (1) DE602004021702D1 (es)
DK (2) DK1654286T3 (es)
ES (1) ES2327523T3 (es)
HK (2) HK1132278A1 (es)
IL (2) IL169657A (es)
MX (1) MXPA05009953A (es)
NZ (1) NZ541523A (es)
PL (2) PL2070948T3 (es)
PT (2) PT1654286E (es)
RU (1) RU2375375C2 (es)
SG (1) SG159392A1 (es)
SI (2) SI1654286T1 (es)
WO (1) WO2004083247A1 (es)

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Also Published As

Publication number Publication date
HK1088337A1 (en) 2006-11-03
SG159392A1 (en) 2010-03-30
SI1654286T1 (sl) 2009-12-31
EP2070948B1 (en) 2011-08-17
US8440806B2 (en) 2013-05-14
ATE434626T1 (de) 2009-07-15
DE602004021702D1 (de) 2009-08-06
CY1109390T1 (el) 2014-07-02
NZ541523A (en) 2007-07-27
AU2004222089A1 (en) 2004-09-30
AU2004222089B2 (en) 2010-12-02
IL212949A (en) 2016-06-30
SI2070948T1 (sl) 2011-12-30
US8685651B2 (en) 2014-04-01
HK1132278A1 (en) 2010-02-19
DK1654286T3 (da) 2009-08-31
ES2327523T3 (es) 2009-10-30
US20090208497A1 (en) 2009-08-20
EP1654286A1 (en) 2006-05-10
US8586715B2 (en) 2013-11-19
JP4491454B2 (ja) 2010-06-30
CY1112044T1 (el) 2015-11-04
KR101276596B1 (ko) 2013-06-21
US20090208496A1 (en) 2009-08-20
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EP2332991A3 (en) 2012-12-19
US8673304B2 (en) 2014-03-18
RU2005132389A (ru) 2006-06-27
PL1654286T3 (pl) 2009-12-31
WO2004083247A1 (en) 2004-09-30
US20090104190A1 (en) 2009-04-23
KR20050111748A (ko) 2005-11-28
CA2519620C (en) 2015-02-03
US20060051346A1 (en) 2006-03-09
ATE520716T1 (de) 2011-09-15
US20140220008A1 (en) 2014-08-07
PT2070948E (pt) 2011-09-05
KR20130042654A (ko) 2013-04-26
PT1654286E (pt) 2009-08-28
JP2007525156A (ja) 2007-09-06
RU2375375C2 (ru) 2009-12-10
EP2070948A1 (en) 2009-06-17
EP1654286B1 (en) 2009-06-24
PL2070948T3 (pl) 2012-03-30
EP1460088A1 (en) 2004-09-22
US9758581B2 (en) 2017-09-12
DK2070948T3 (da) 2011-09-12
US7452981B2 (en) 2008-11-18
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