MXPA05007652A - Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados. - Google Patents

Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados.

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Publication number
MXPA05007652A
MXPA05007652A MXPA05007652A MXPA05007652A MXPA05007652A MX PA05007652 A MXPA05007652 A MX PA05007652A MX PA05007652 A MXPA05007652 A MX PA05007652A MX PA05007652 A MXPA05007652 A MX PA05007652A MX PA05007652 A MXPA05007652 A MX PA05007652A
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Mexico
Prior art keywords
immunostimulatory
oligonucleotides
oligonucleotide
modulation
based compounds
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Application number
MXPA05007652A
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English (en)
Inventor
Ekambar Kandimalla
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Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of MXPA05007652A publication Critical patent/MXPA05007652A/es

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    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N15/09—Recombinant DNA-technology
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    • C12N2310/00—Structure or type of the nucleic acid
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Abstract

La invencion se refiere al uso terapeutico de oligonucleotidos como agentes inmunoestimulantes en aplicaciones de inmunoterapia; mas particularmente, la invencion provee inmunomeros y un oligonucleotido inmunoestimulante para uso en metodos para generar una respuesta inmune o para tratar un paciente que necesita de inmunoestimulacion; los inmunomeros y un oligonucleotido inmunoestimulante de la invencion preferiblemente comprenden purinas novedosas; los inmunomeros de conformidad con la invencion comprenden adicionalmente al menos dos oligonucleotidos enlazados en sus extremos 3', enlaces internucleosido o nucleobase funcionalizada o azucar aun enlazador no nucleotidico, al menos uno de los oligonucleotidos siendo un oligonucleotido inmunomodulador y que tiene un extremo 5' accessible.
MXPA05007652A 2003-01-16 2004-01-14 Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados. MXPA05007652A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44058703P 2003-01-16 2003-01-16
PCT/US2004/000828 WO2004064782A2 (en) 2003-01-16 2004-01-14 Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

Publications (1)

Publication Number Publication Date
MXPA05007652A true MXPA05007652A (es) 2006-02-22

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MXPA05007652A MXPA05007652A (es) 2003-01-16 2004-01-14 Modulacion de propiedades inmunoestimulantes de compuestos basados en oligonucleotido mediante la utilizacion de dinucleotidos inmunoestimulantes modificados.

Country Status (8)

Country Link
US (6) US7851453B2 (es)
EP (1) EP1601789A4 (es)
JP (2) JP4726630B2 (es)
KR (1) KR101123489B1 (es)
AU (2) AU2004206820B2 (es)
CA (1) CA2512484A1 (es)
MX (1) MXPA05007652A (es)
WO (1) WO2004064782A2 (es)

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