MXPA05007382A - Tratamiento de cancer con 2-desoxiglucosa. - Google Patents
Tratamiento de cancer con 2-desoxiglucosa.Info
- Publication number
- MXPA05007382A MXPA05007382A MXPA05007382A MXPA05007382A MXPA05007382A MX PA05007382 A MXPA05007382 A MX PA05007382A MX PA05007382 A MXPA05007382 A MX PA05007382A MX PA05007382 A MXPA05007382 A MX PA05007382A MX PA05007382 A MXPA05007382 A MX PA05007382A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- administered
- dose
- administration
- days
- Prior art date
Links
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Landscapes
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| PCT/US2004/000530 WO2004062604A2 (en) | 2003-01-10 | 2004-01-09 | Treatment of cancer with 2-deoxyglucose |
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Cited By (1)
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| US7795227B2 (en) | 2004-06-17 | 2010-09-14 | Wisconsin Alumni Research Foundation | Compounds and methods for treating seizure disorders |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563522B2 (en) | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
| US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| EP1205493A1 (en) * | 2000-11-14 | 2002-05-15 | ATOFINA Research | Polymerisation catalyst systems and their preparation |
| US7666459B2 (en) * | 2001-09-12 | 2010-02-23 | The Procter & Gamble Company | Pet food compositions |
| US7547673B2 (en) * | 2001-09-13 | 2009-06-16 | The Johns Hopkins University | Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production |
| WO2004064734A2 (en) * | 2003-01-17 | 2004-08-05 | Threshold Pharmaceuticals, Inc. | Combination therapies for the treatment of cancer |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US7510710B2 (en) * | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
| CN1917885A (zh) * | 2004-02-06 | 2007-02-21 | 施瑞修德制药公司 | 抗癌疗法 |
| US20090252834A1 (en) * | 2004-05-10 | 2009-10-08 | Michael Griffin Hayek | Compositions comprising glucose anti-metabolites |
| EP1789107B1 (en) * | 2004-08-30 | 2009-05-27 | Interstitial Therapeutics | Medical stent provided with inhibitors of atp synthesis |
| US7740875B2 (en) * | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US20060078580A1 (en) * | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| JP2008519031A (ja) * | 2004-11-02 | 2008-06-05 | コンフォーマ・セラピューティクス・コーポレイション | 慢性リンパ球性白血病を治療する方法および組成物 |
| CA2598239C (en) * | 2005-02-18 | 2019-10-29 | Abraxis Bioscience, Inc. | Nanoparticulate formulations of taxanes and carrier proteins for use in combination chemotherapy |
| US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US7208611B2 (en) | 2005-02-23 | 2007-04-24 | Xenoport, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
| EP1924327A2 (en) | 2005-04-15 | 2008-05-28 | Biomac Privatinstitut für medizinische und Zahnmedizinische Forschung, Entwicklung und Diagnostik GmbH | Substances and pharmaceutical compositions for the inhibition of glyoxalases and their use to combat cancer |
| WO2006130188A1 (en) | 2005-05-31 | 2006-12-07 | The Iams Company | Feline probiotic bifidobacteria |
| DK1880001T3 (da) | 2005-05-31 | 2011-09-12 | Iams Company | Feline probiotiske lactobacilli |
| US20060287253A1 (en) * | 2005-06-17 | 2006-12-21 | Kriegler Steven M | Compounds and methods for treating seizure disorders |
| WO2006137595A1 (ja) * | 2005-06-24 | 2006-12-28 | Takeda Pharmaceutical Company Limited | Ｈｅｒ２発現癌の予防・治療薬 |
| US20070032383A1 (en) * | 2005-07-27 | 2007-02-08 | Newell M K | Systems, methods, and compositions for modifying the metabolism of plants and of euucaryotic microbes |
| WO2007035755A2 (en) * | 2005-09-19 | 2007-03-29 | Duke University | Methods of treating hematological malignancies |
| US8278349B2 (en) | 2005-11-28 | 2012-10-02 | Ramot At Tel-Aviv University Ltd. | Cancer treatment using FTS and 2-deoxyglucose |
| WO2007067516A2 (en) * | 2005-12-06 | 2007-06-14 | Duke University | Multiple myeloma |
| US7754693B2 (en) * | 2006-02-16 | 2010-07-13 | Young Hee Ko | Composition and method for the efficacious and safe administration of halopyruvate for the treatment of cancer |
| US8324175B2 (en) | 2006-02-16 | 2012-12-04 | Young Hee Ko | Compositions and methods for the treatment of cancer |
| US8242167B2 (en) * | 2006-02-24 | 2012-08-14 | University Of Miami | Mannose derivatives for killing tumor cells |
| WO2007101148A2 (en) * | 2006-02-24 | 2007-09-07 | Board Of Regents, The University Of Texas System | Hexose compounds to treat cancer |
| US9149489B2 (en) * | 2006-04-27 | 2015-10-06 | Board Of Regents, University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| WO2009108926A1 (en) * | 2008-02-29 | 2009-09-03 | Board Of Regents, The University Of Texas System | Inhibitors of glycolysis useful in the treatment of brain tumors |
| RU2398578C2 (ru) * | 2006-05-03 | 2010-09-10 | И.К.А., А.С. | Фармацевтическая композиция, содержащая производное таксана, которая предназначена для приготовления инфузионного раствора, способ его приготовления и использование |
| KR101556988B1 (ko) | 2006-11-20 | 2015-10-02 | 고쿠리츠다이가쿠호우징 카가와다이가쿠 | 데옥시케토헥소스 아이소머라제 및 그것을 이용한 데옥시케토헥소스 및 그 유도체의 제조 방법 |
| EP2114413B1 (en) * | 2006-12-18 | 2014-10-22 | The Johns Hopkins University | Therapeutics for treating cancer using 3-bromopyruvate |
| CN101711158A (zh) | 2007-02-01 | 2010-05-19 | 爱默思公司 | 使用葡萄糖抗代谢物、鳄梨或鳄梨提取物减轻哺乳动物炎症和应激反应的方法 |
| US8865646B2 (en) * | 2007-03-28 | 2014-10-21 | University Of South California | Dietary compositions and methods for protection against chemotherapy, radiotherapy, oxidative stress, and aging |
| WO2008119077A1 (en) * | 2007-03-28 | 2008-10-02 | University Of Southern California | Induction of differential stress resistance and uses thereof |
| RU2349271C2 (ru) * | 2007-03-29 | 2009-03-20 | ФГУ Ростовский научно-исследовательский онкологический институт Росздрава | Способ лечения рака прямой кишки |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| WO2008124691A1 (en) * | 2007-04-05 | 2008-10-16 | Threshold Pharmaceuticals, Inc. | Glufosfamide combination therapy |
| US20110091574A1 (en) * | 2008-02-15 | 2011-04-21 | Catholic Healthcare West | Treatment of adenocarcinoma expressing lkb1 with mtor inhibitor in combination with cox2 inhibitor |
| CA2716321A1 (en) | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
| PL2282773T3 (pl) | 2008-05-02 | 2014-08-29 | Seattle Genetics Inc | Sposoby i kompozycje do wytwarzania przeciwciał i pochodnych przeciwciał o obniżonej fukozylacji rdzeniowej |
| US20110183926A1 (en) * | 2008-05-23 | 2011-07-28 | University Of Miami | Treatment using continuous low dose application of sugar analogs |
| TW200950777A (en) * | 2008-05-27 | 2009-12-16 | Oncolytics Biotech Inc | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| ES2628180T3 (es) * | 2008-07-11 | 2017-08-02 | Board Of Regents, The University Of Texas System | Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa |
| CA2730773A1 (en) * | 2008-07-14 | 2010-01-21 | Martha Karen Newell | Methods and products for treating proliferative diseases |
| WO2010019396A1 (en) * | 2008-08-13 | 2010-02-18 | Threshold Pharmaceuticals, Inc. | Administration of glufosfamide for the treatment of cancer |
| PL2331092T3 (pl) * | 2008-08-21 | 2014-08-29 | Univ Johns Hopkins | Sposoby i kompozycje do podawania 3-halopirogronianiu i związków pochodnych w leczeniu nowotworu |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| DK2391363T3 (en) * | 2009-01-29 | 2017-01-16 | Young Hee Ko | COMPOSITIONS AND PROCEDURES FOR TREATING CANCER |
| CN108524505A (zh) | 2009-03-13 | 2018-09-14 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| PT2448582T (pt) | 2009-06-29 | 2017-07-10 | Agios Pharmaceuticals Inc | Compostos e composições terapêuticas |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| US8450090B2 (en) | 2009-10-06 | 2013-05-28 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for promoting fatty acid production in plants |
| EP3561077B1 (en) | 2009-10-21 | 2022-12-21 | Les Laboratoires Servier | Methods for cell-proliferation-related disorders |
| ES2812537T3 (es) | 2009-10-21 | 2021-03-17 | Agios Pharmaceuticals Inc | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| PT3095458T (pt) | 2009-10-22 | 2018-11-09 | Propanc Pty Ltd | Composição farmacêutica para tratar cancro compreendendo tripsinogénio e quimiotripsinogénio |
| CN102115483B (zh) | 2009-12-30 | 2014-12-17 | 苏州天人合生物技术有限公司 | 卤代双去氧糖衍生物及其制备方法与应用 |
| GB2478556A (en) * | 2010-03-09 | 2011-09-14 | Myrovlytis Technology Ventures Ltd | A composition for use in the treatment of Birt-Hogg-Dubô sydrome |
| MX2012011155A (es) | 2010-03-29 | 2012-12-05 | Abraxis Bioscience Llc | Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos. |
| ES2600912T3 (es) | 2010-03-29 | 2017-02-13 | Abraxis Bioscience, Llc | Métodos para tratar el cáncer |
| WO2011153010A1 (en) | 2010-06-04 | 2011-12-08 | Abraxis Biosciences, Llc | Methods of treatment of pancreatic cancer |
| EP2608796B1 (en) | 2010-08-05 | 2018-11-21 | Seattle Genetics, Inc. | Inhibition of protein fucosylation in vivo using fucose analogs |
| CN112755029A (zh) | 2010-10-13 | 2021-05-07 | 穆斯塔法·比尔金·阿里·贾姆戈兹 | 治疗癌症/抑制转移 |
| WO2012049439A1 (en) * | 2010-10-13 | 2012-04-19 | Imperial Innovations Limited | Treatment of cancer/inhibition of metastasis |
| JP2014505058A (ja) * | 2011-01-11 | 2014-02-27 | ザ・ユニバーシティ・オブ・テキサス・エム・ディー・アンダーソン・キャンサー | 増殖性および炎症性皮膚疾患の治療用単糖ベース化合物 |
| WO2012123774A1 (en) * | 2011-03-11 | 2012-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Glycolytic inhibitor with cytotoxic agent for use in the treatment of a cancer |
| US20120238511A1 (en) * | 2011-03-14 | 2012-09-20 | University Of Southern California | 2-deoxy-d-glucose formulations for prevention or treatment of neurodegenerative diseases |
| CN108451955B (zh) | 2011-05-03 | 2022-02-01 | 安吉奥斯医药品有限公司 | 用于治疗的丙酮酸激酶活化剂 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| US20130196349A1 (en) * | 2011-08-02 | 2013-08-01 | Realbio Technology, Inc. | In Vitro Tumor Metastasis Model |
| KR101900478B1 (ko) * | 2011-08-04 | 2018-09-20 | 한올바이오파마주식회사 | 암의 재발 또는 전이의 억제용 약제학적 조성물 |
| ES2675760T3 (es) | 2012-01-06 | 2018-07-12 | Agios Pharmaceuticals, Inc. | Compuestos terapéuticamente activos y métodos de uso de los mismos |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| US20160015725A1 (en) * | 2012-02-14 | 2016-01-21 | The Wistar Institute Of Anatomy And Biology | Methods of controlling tumor bioenergetics networks |
| AU2013202693B2 (en) * | 2012-04-16 | 2015-01-22 | Baxalta GmbH | Combination Therapy of Anti-MIF Antibodies and Chemotherapeutics |
| MX363385B (es) | 2012-08-23 | 2019-03-20 | Seattle Genetics Inc | Métodos para el tratamiento de enfermedad de células falciformes y otras condiciones inflamatorias. |
| CN104822373B (zh) | 2012-10-15 | 2018-08-28 | 安吉奥斯医药品有限公司 | 治疗性化合物和组合物 |
| WO2014072967A1 (en) * | 2012-11-12 | 2014-05-15 | Urifer Ltd | Drug combination comprising a glycolysis inhibitor and a tyrosine kinase inhibitor |
| KR101419816B1 (ko) * | 2013-01-30 | 2014-07-17 | (주)제욱 | 상승적 치료 효과를 갖는 비소세포폐암의 예방 또는 치료용 조성물 |
| EP3939595A1 (en) | 2013-04-05 | 2022-01-19 | Board of Regents, The University of Texas System | Esters of 2-deoxy-monosaccharides with anti proliferative activity |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| AU2014287121B2 (en) | 2013-07-11 | 2018-11-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CN106102725A (zh) | 2014-01-14 | 2016-11-09 | 约翰斯·霍普金斯大学 | 包封选择性atp抑制剂的环糊精组合物及其应用 |
| EA036325B1 (ru) | 2014-03-14 | 2020-10-27 | Аджиос Фармасьютикалз, Инк. | Фармацевтическая композиция на основе твердой дисперсии ингибитора idh1 |
| WO2016065353A1 (en) * | 2014-10-24 | 2016-04-28 | University Of Miami | Combination therapy with fenofibrate and 2-deoxyglucose or 2-deoxymannose |
| SMT202300344T1 (it) | 2015-06-11 | 2023-11-13 | Agios Pharmaceuticals Inc | Metodi di utilizzo degli attivatori della piruvato chinasi |
| UA123401C2 (uk) | 2015-10-15 | 2021-03-31 | Аджиос Фармасьютікалз, Інк. | Комбінована терапія для лікування злоякісних пухлин |
| ES2897959T3 (es) | 2015-10-15 | 2022-03-03 | Servier Lab | Terapia de combinación para tratar neoplasias malignas |
| EP3370712B1 (en) | 2015-11-06 | 2025-02-19 | The Johns Hopkins University | 3-bromopyruvate for treating liver fibrosis |
| US12419938B2 (en) | 2015-11-12 | 2025-09-23 | Propanc Pty Ltd | Proenzyme composition |
| JP7058604B2 (ja) | 2016-01-29 | 2022-04-22 | プロパンク・ピーティーワイ・リミテッド | 癌治療 |
| WO2017173360A2 (en) * | 2016-03-31 | 2017-10-05 | Stcube, Inc. | Combination treatments directed toward programmed death ligand-1 (pd-l1) positive cancers |
| US20200138840A1 (en) | 2017-06-28 | 2020-05-07 | Kawasaki Gakuen Educational Foundation | Pharmaceutical composition and tumor immunoactivity promoter |
| IL272173B2 (en) | 2017-07-21 | 2025-06-01 | Buck Inst Res Aging | S-enantiomers of beta-hydroxybutyrate and butanediol and methods for using same |
| WO2019147503A1 (en) | 2018-01-25 | 2019-08-01 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
| US11013733B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) |
| US11576906B2 (en) | 2018-05-16 | 2023-02-14 | Forma Therapeutics, Inc. | Inhibiting mutant IDH-1 |
| US10532047B2 (en) | 2018-05-16 | 2020-01-14 | Forma Therapeutics, Inc. | Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile |
| US11013734B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation |
| US11311527B2 (en) | 2018-05-16 | 2022-04-26 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| RU2707554C1 (ru) * | 2019-02-27 | 2019-11-28 | Федеральное государственное бюджетное учреждение "Петербургский институт ядерной физики им. Б.П. Константинова Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт-ПИЯФ") | Композиция, ингибирующая рост и выживаемость опухолевых клеток |
| EP4121060A1 (en) | 2020-03-16 | 2023-01-25 | Board of Regents, The University of Texas System | Method of treating viral infections with hexose type monosaccharides and analogs thereof |
| US20230092706A1 (en) * | 2020-04-16 | 2023-03-23 | Buck Institute For Research On Aging | Treatment of viral pathologies with exogenous ketones |
| CN116940371A (zh) * | 2020-12-14 | 2023-10-24 | Trim生物科技有限公司 | 用于癌症免疫疗法的包含细菌的组合物 |
| WO2023062516A1 (en) * | 2021-10-11 | 2023-04-20 | Exploration Invest Pte Ltd | 2-deoxy-d-glucose for use in disease therapy |
| CN114617876B (zh) * | 2022-01-28 | 2023-04-07 | 四川大学华西医院 | 一种抗肿瘤联合用药物 |
| KR20240038394A (ko) | 2022-09-16 | 2024-03-25 | 이화여자대학교 산학협력단 | 해당과정 억제제 및 미토콘드리아 기능 억제제를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| EP4582080A1 (en) | 2024-01-02 | 2025-07-09 | G.ST Antivirals GmbH | Dispenser for mucosal administration comprising 2-deoxy-glucose or analogues thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS606630B2 (ja) | 1977-09-07 | 1985-02-19 | 藤沢薬品工業株式会社 | ２―デオキシ―ｄ―グルコースの製造法 |
| US4315001A (en) * | 1979-08-17 | 1982-02-09 | Blough Herbert A | 2-Deoxy glucose as an antiviral agent against herpes simplex |
| US5185325A (en) * | 1988-06-23 | 1993-02-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic composition |
| EP0565785A1 (en) | 1992-04-07 | 1993-10-20 | Harry H. Leveen | Use of glucose transport inhibitors for the treatment for acne |
| KR950009111B1 (ko) * | 1992-09-08 | 1995-08-14 | 주식회사럭키 | 광택 조절용 수지의 제조방법 |
| US5591429A (en) * | 1993-07-26 | 1997-01-07 | The United States Of America As Represented By The Secretary Of Agriculture | Composition containing 2-deoxy-D-glucose and Candida saitoana and a method of use for the biological control of postharvest diseases |
| US5643883A (en) * | 1995-01-19 | 1997-07-01 | Uab Research Foundation | Glucose-6-phosphate uptake inhibitors and novel uses thereof |
| DE19524515A1 (de) * | 1995-07-05 | 1997-01-09 | Deutsches Krebsforsch | Saccharid-Konjugate |
| US5652273A (en) * | 1995-11-30 | 1997-07-29 | Henry; James | Reduction of hair growth |
| US5565434A (en) * | 1996-02-23 | 1996-10-15 | University Of Iowa Research Foundation | Hexose and pentose prodrugs of ethacrynic acid |
| US5958892A (en) * | 1996-07-30 | 1999-09-28 | Board Of Regents, The University Of Texas System | 2-methoxyestradiol-induced apoptosis in cancer cells |
| US20020035071A1 (en) * | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
| GR1003713B (el) | 1998-03-20 | 2001-11-07 | Δεσοξυσακχαρα ως αντικαρκινικοι αναχαιτιστικοι παραγοντες. | |
| US20030072814A1 (en) * | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of warts |
| US6670330B1 (en) | 2000-05-01 | 2003-12-30 | Theodore J. Lampidis | Cancer chemotherapy with 2-deoxy-D-glucose |
| US6974664B2 (en) * | 2000-05-12 | 2005-12-13 | The Board Of Trustees Of The Leland Stanford University | Screening method for cancer therapeutics and stable antitumor drug |
| WO2002058741A2 (en) | 2000-12-18 | 2002-08-01 | Alex Wah Hin Yeung | Treatment of cancer with positron-emitting radiopharmaceuticals |
| US6661410B2 (en) * | 2001-09-07 | 2003-12-09 | Microsoft Corporation | Capacitive sensing and data input device power management |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795227B2 (en) | 2004-06-17 | 2010-09-14 | Wisconsin Alumni Research Foundation | Compounds and methods for treating seizure disorders |
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| EP1587519A2 (en) | 2005-10-26 |
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| WO2004062604A2 (en) | 2004-07-29 |
| EP1587519A4 (en) | 2006-05-31 |
| KR20050098244A (ko) | 2005-10-11 |
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| US6979675B2 (en) | 2005-12-27 |
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| WO2004062604A3 (en) | 2005-05-26 |
| NO20053782L (no) | 2005-09-27 |
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