MXPA05002129A - Derivados de pirazol composicion medicinal que los contiene, su uso en medicina, e intermediarios para su produccion. - Google Patents
Derivados de pirazol composicion medicinal que los contiene, su uso en medicina, e intermediarios para su produccion.Info
- Publication number
- MXPA05002129A MXPA05002129A MXPA05002129A MXPA05002129A MXPA05002129A MX PA05002129 A MXPA05002129 A MX PA05002129A MX PA05002129 A MXPA05002129 A MX PA05002129A MX PA05002129 A MXPA05002129 A MX PA05002129A MX PA05002129 A MXPA05002129 A MX PA05002129A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- carbon atoms
- alkyl
- inhibitor
- hydroxy
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title claims abstract description 90
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000000203 mixture Substances 0.000 title claims description 9
- 125000005843 halogen group Chemical group 0.000 claims abstract description 123
- 150000003839 salts Chemical class 0.000 claims abstract description 89
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 49
- 229940002612 prodrug Drugs 0.000 claims abstract description 47
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 36
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- 201000009104 prediabetes syndrome Diseases 0.000 claims abstract description 20
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- 230000005856 abnormality Effects 0.000 claims abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
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- 229940124597 therapeutic agent Drugs 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 924
- 125000000217 alkyl group Chemical group 0.000 claims description 430
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 197
- 125000001424 substituent group Chemical group 0.000 claims description 193
- 125000003277 amino group Chemical group 0.000 claims description 175
- 125000006239 protecting group Chemical group 0.000 claims description 136
- 150000001875 compounds Chemical class 0.000 claims description 121
- 125000003545 alkoxy group Chemical group 0.000 claims description 119
- -1 hydroxymethylglutaryl Chemical group 0.000 claims description 118
- 239000003112 inhibitor Substances 0.000 claims description 113
- 238000006243 chemical reaction Methods 0.000 claims description 83
- 238000000034 method Methods 0.000 claims description 83
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 77
- 125000003118 aryl group Chemical group 0.000 claims description 71
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 69
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 60
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 55
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 51
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 43
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- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims description 31
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- 125000004414 alkyl thio group Chemical group 0.000 claims description 23
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- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 19
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 18
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 18
- 229910052708 sodium Inorganic materials 0.000 claims description 18
- 229940083542 sodium Drugs 0.000 claims description 18
- 125000004442 acylamino group Chemical group 0.000 claims description 17
- 125000004429 atom Chemical group 0.000 claims description 17
- 239000011734 sodium Substances 0.000 claims description 17
- UPSFNXFLBMJUQW-UHFFFAOYSA-N 5-hydroxy-1-methylimidazolidine-2,4-dione Chemical compound CN1C(O)C(=O)NC1=O UPSFNXFLBMJUQW-UHFFFAOYSA-N 0.000 claims description 16
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 16
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- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 16
- 230000003914 insulin secretion Effects 0.000 claims description 16
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 15
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 13
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- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 12
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- ROJNYKZWTOHRNU-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide Chemical compound CNC(=O)NC1=CC=C(OC)C(NC(=O)NC(=O)C=2C(=CC(F)=C(F)C=2)Cl)=C1 ROJNYKZWTOHRNU-UHFFFAOYSA-N 0.000 claims description 10
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- NMOVJBAGBXIKCG-VKAVYKQESA-N (3z)-n-(2-hydroxy-3-piperidin-1-ylpropoxy)pyridine-3-carboximidoyl chloride Chemical compound C1CCCCN1CC(O)CO\N=C(/Cl)C1=CC=CN=C1 NMOVJBAGBXIKCG-VKAVYKQESA-N 0.000 claims description 9
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- A61P31/04—Antibacterial agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
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- Cardiology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
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- Biotechnology (AREA)
- Neurosurgery (AREA)
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- Emergency Medicine (AREA)
- Psychology (AREA)
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- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002244381 | 2002-08-23 | ||
| JP2002324076A JP2004137245A (ja) | 2002-08-23 | 2002-11-07 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| PCT/JP2003/010551 WO2004018491A1 (ja) | 2002-08-23 | 2003-08-21 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05002129A true MXPA05002129A (es) | 2005-06-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05002129A MXPA05002129A (es) | 2002-08-23 | 2003-08-21 | Derivados de pirazol composicion medicinal que los contiene, su uso en medicina, e intermediarios para su produccion. |
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| Country | Link |
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| EP (1) | EP1548024B1 (enExample) |
| JP (2) | JP2004137245A (enExample) |
| KR (1) | KR100985504B1 (enExample) |
| AU (1) | AU2003262263B8 (enExample) |
| BR (1) | BRPI0313694B8 (enExample) |
| CA (1) | CA2496329C (enExample) |
| ES (1) | ES2386140T3 (enExample) |
| IL (1) | IL167038A (enExample) |
| MX (1) | MXPA05002129A (enExample) |
| NO (1) | NO330569B1 (enExample) |
| NZ (1) | NZ538423A (enExample) |
| PL (1) | PL213094B1 (enExample) |
| RU (1) | RU2369613C2 (enExample) |
| TW (1) | TW200410980A (enExample) |
| WO (1) | WO2004018491A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE469161T1 (de) * | 2002-08-08 | 2010-06-15 | Kissei Pharmaceutical | Pyrazolderivat, dieses enthaltende medizinische zusammensetzung, medizinische verwendung davon, und zwischenprodukt für dessen herstellung |
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| WO2004019958A1 (ja) * | 2002-08-27 | 2004-03-11 | Kissei Pharmaceutical Co., Ltd. | ピラゾール誘導体、それを含有する医薬組成物及びその医薬用途 |
| EP1568380A4 (en) * | 2002-12-04 | 2009-10-21 | Kissei Pharmaceutical | PREVENTION OR TREATMENT OF DISEASES DUE TO HYPERGLYCEMIA |
| EP1577317A4 (en) * | 2002-12-25 | 2007-05-09 | Kissei Pharmaceutical | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, MEDICINAL COMPOSITIONS COMPRISING SAID DERIVATIVES AND MEDICAL USE OF SAID DERIVATIVES |
| US7375090B2 (en) * | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| DE102004028241B4 (de) * | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
| US7750145B2 (en) | 2004-11-18 | 2010-07-06 | Kissei Pharmaceutical Co., Ltd. | 1-substituted-3-β-D-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same |
| JP2008007405A (ja) * | 2004-12-07 | 2008-01-17 | Takeda Chem Ind Ltd | カルボキサミド誘導体 |
| KR20080036112A (ko) * | 2005-07-22 | 2008-04-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 피라졸-ｏ-글리코시드 유도체의 제조 방법 및 당해 방법의신규한 중간체 |
| UY30082A1 (es) | 2006-01-11 | 2007-08-31 | Boehringer Ingelheim Int | Forma cristalina de 1-(1-metiletil)-4`-((2-fluoro-4-metoxifenil)metil)-5`- metil-1h-pirazol-3`-o-b-d-glucopiranosido, un metodo para su preparacion y el uso de la misma para preparar medicamentos |
| JP2009167103A (ja) * | 2006-05-02 | 2009-07-30 | Taisho Pharmaceutical Co Ltd | ピラゾリル５−チオグリコシド化合物 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| CA2652707A1 (en) * | 2006-05-19 | 2007-11-29 | Taisho Pharmaceutical Co., Ltd. | C-phenyl glycitol compound |
| EP2036901B1 (en) | 2006-06-29 | 2013-05-01 | Taisho Pharmaceutical Co., Ltd | C-phenyl 1-thioglucitol compound |
| RU2009126767A (ru) | 2006-12-14 | 2011-01-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производное 1-фенил-1-тио-d-глюцитола |
| ES2548578T3 (es) * | 2007-12-27 | 2015-10-19 | Kissei Pharmaceutical Co., Ltd. | Monosebacato de un derivado de pirazol |
| JP5467040B2 (ja) * | 2008-04-16 | 2014-04-09 | キッセイ薬品工業株式会社 | ピラゾール誘導体の１／２フマル酸塩 |
| KR101338540B1 (ko) | 2008-08-28 | 2013-12-06 | 화이자 인코포레이티드 | 다이옥사-바이사이클로[3.2.1]옥테인-2,3,4-트라이올 유도체 |
| JP5505741B2 (ja) | 2009-02-23 | 2014-05-28 | 大正製薬株式会社 | Ｓｇｌｔ１阻害剤としての４−イソプロピルフェニルグルシトール化合物 |
| TW201105336A (en) * | 2009-07-01 | 2011-02-16 | Kissei Pharmaceutical | Combined medicine of pyrazole derivative and biguanide drug |
| JPWO2011002012A1 (ja) * | 2009-07-01 | 2012-12-13 | キッセイ薬品工業株式会社 | Ｓｇｌｔ１阻害薬とインスリン抵抗性改善薬を組み合わせてなる医薬 |
| TW201105338A (en) * | 2009-07-01 | 2011-02-16 | Kissei Pharmaceutical | Medicine derived from a combination of SGLT1-inhibitor and DPP-IV inhibitor |
| CN102574776A (zh) | 2009-07-31 | 2012-07-11 | 桑多斯股份公司 | ω-氨基-烷酰胺和ω-氨基-烷硫酰胺的制备方法及该方法的中间体 |
| EP2298782A1 (en) * | 2009-08-26 | 2011-03-23 | Sanofi-Aventis | Method for producing pyrazole glycoside derivatives |
| EP2482823A2 (en) | 2009-10-02 | 2012-08-08 | Sanofi | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| CN102510867A (zh) | 2009-10-20 | 2012-06-20 | 诺瓦提斯公司 | 糖苷衍生物及其用途 |
| KR101426180B1 (ko) | 2009-11-02 | 2014-07-31 | 화이자 인코포레이티드 | 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012010651A2 (en) | 2010-07-23 | 2012-01-26 | Sandoz Ag | Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method |
| RU2013112368A (ru) | 2010-08-20 | 2014-09-27 | Тайсо Фармасьютикал Ко., Лтд. | Кристаллическая форма 4-изопропилфенилглюцитольного соединения и способ ее получения |
| ES2546253T3 (es) | 2010-08-20 | 2015-09-22 | Taisho Pharmaceutical Co., Ltd. | Compuesto 4-isopropil-6-metoxifenilglucitol |
| BR112013026361A2 (pt) | 2011-04-14 | 2016-12-27 | Novartis Ag | derivados de glicosídeo e usos dos mesmos |
| US8614195B2 (en) | 2011-04-14 | 2013-12-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| EP2848254B1 (en) | 2012-05-07 | 2016-08-03 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative and use thereof for medical purposes |
| UA113086C2 (xx) | 2012-05-10 | 2016-12-12 | Піразольні сполуки як інгібітори sglt1 | |
| TW201425326A (zh) * | 2012-10-05 | 2014-07-01 | Lilly Co Eli | 新穎脲化合物 |
| ES2728246T3 (es) | 2012-11-20 | 2019-10-23 | Lexicon Pharmaceuticals Inc | Inhibidores del cotransportador 1 de sodio-glucosa |
| JP5807767B2 (ja) | 2013-02-04 | 2015-11-10 | 大正製薬株式会社 | 便秘症の予防又は治療薬 |
| EP2774619B1 (de) | 2013-03-04 | 2016-05-18 | BioActive Food GmbH | Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| AR098670A1 (es) | 2013-11-08 | 2016-06-08 | Lilly Co Eli | Inhibidor de sglt1 |
| EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| US11186602B2 (en) | 2018-01-31 | 2021-11-30 | Sunshine Lake Pharma Co., Ltd. | Glucopyranosyl derivative and use thereof |
| CN112469407B (zh) * | 2018-03-28 | 2024-10-01 | 阿沃林特有限公司 | 用于治疗餐后低血糖症的方法 |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2020242537A1 (en) * | 2019-05-31 | 2020-12-03 | Avolynt | Compositions and methods for treating metabolic disease |
| WO2024254302A1 (en) * | 2023-06-06 | 2024-12-12 | Vogenx | Compositions and methods for treating hyperinsulinemic hypoglycemia |
| WO2024254354A1 (en) * | 2023-06-06 | 2024-12-12 | Vogenx | Compositions and methods for treating refractory or intractable epilepsy |
| WO2025117962A1 (en) * | 2023-12-01 | 2025-06-05 | Vogenx | Compositions and methods for treating glucose-dependent insulinotropic peptide-dependent cushing's syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL351898A1 (en) * | 1999-04-06 | 2003-06-30 | Sankyo Co | O-substituted derivatives of carboxylic acids |
| CN1145635C (zh) * | 1999-08-31 | 2004-04-14 | 橘生药品工业株式会社 | 吡喃葡糖氧基吡唑衍生物、含该衍生物的药物组合物及其制备中的中间体 |
| EP1338603B1 (en) * | 2000-11-02 | 2010-01-20 | Ajinomoto Co., Inc. | Novel pyrazole derivatives and diabetes remedies containing the same |
| DE60138768D1 (de) | 2000-12-28 | 2009-07-02 | Kissei Pharmaceutical | Glucopyranosylpyrazolderivate und deren verwendung in arzneimitteln |
| ATE469161T1 (de) * | 2002-08-08 | 2010-06-15 | Kissei Pharmaceutical | Pyrazolderivat, dieses enthaltende medizinische zusammensetzung, medizinische verwendung davon, und zwischenprodukt für dessen herstellung |
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| AU2003272903A1 (en) * | 2002-10-04 | 2004-04-23 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same |
| ATE541854T1 (de) * | 2003-06-20 | 2012-02-15 | Kissei Pharmaceutical | Pyrazolderivat, arzneimittelzusammensetzung, die dieses enthält, und zwischenprodukt für dessen herstellung |
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2002
- 2002-11-07 JP JP2002324076A patent/JP2004137245A/ja active Pending
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2003
- 2003-08-21 NZ NZ538423A patent/NZ538423A/en not_active IP Right Cessation
- 2003-08-21 US US10/525,197 patent/US7635684B2/en active Active
- 2003-08-21 MX MXPA05002129A patent/MXPA05002129A/es active IP Right Grant
- 2003-08-21 CA CA2496329A patent/CA2496329C/en not_active Expired - Lifetime
- 2003-08-21 EP EP03792760A patent/EP1548024B1/en not_active Expired - Lifetime
- 2003-08-21 ES ES03792760T patent/ES2386140T3/es not_active Expired - Lifetime
- 2003-08-21 AU AU2003262263A patent/AU2003262263B8/en not_active Expired
- 2003-08-21 BR BRPI0313694A patent/BRPI0313694B8/pt not_active IP Right Cessation
- 2003-08-21 KR KR1020057003117A patent/KR100985504B1/ko not_active Expired - Lifetime
- 2003-08-21 WO PCT/JP2003/010551 patent/WO2004018491A1/ja not_active Ceased
- 2003-08-21 PL PL375551A patent/PL213094B1/pl unknown
- 2003-08-21 RU RU2005108055/04A patent/RU2369613C2/ru active
- 2003-08-21 JP JP2005501231A patent/JP4597048B2/ja not_active Expired - Lifetime
- 2003-08-22 TW TW092123126A patent/TW200410980A/zh not_active IP Right Cessation
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2005
- 2005-02-22 IL IL167038A patent/IL167038A/en unknown
- 2005-03-17 NO NO20051411A patent/NO330569B1/no not_active IP Right Cessation
-
2009
- 2009-04-09 US US12/421,236 patent/US8324176B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1082744A1 (zh) | 2006-06-16 |
| NO330569B1 (no) | 2011-05-16 |
| EP1548024A1 (en) | 2005-06-29 |
| JP4597048B2 (ja) | 2010-12-15 |
| PL213094B1 (pl) | 2013-01-31 |
| NO20051411L (no) | 2005-04-26 |
| ES2386140T3 (es) | 2012-08-10 |
| AU2003262263B8 (en) | 2009-08-06 |
| AU2003262263B2 (en) | 2009-06-25 |
| NZ538423A (en) | 2007-02-23 |
| RU2005108055A (ru) | 2006-02-10 |
| JP2004137245A (ja) | 2004-05-13 |
| BRPI0313694B1 (pt) | 2017-12-19 |
| US20050272669A1 (en) | 2005-12-08 |
| KR20050038633A (ko) | 2005-04-27 |
| TW200410980A (en) | 2004-07-01 |
| JPWO2004018491A1 (ja) | 2005-12-08 |
| US7635684B2 (en) | 2009-12-22 |
| US8324176B2 (en) | 2012-12-04 |
| CA2496329C (en) | 2012-05-15 |
| WO2004018491A1 (ja) | 2004-03-04 |
| KR100985504B1 (ko) | 2010-10-05 |
| EP1548024A4 (en) | 2010-05-12 |
| EP1548024B1 (en) | 2012-06-06 |
| AU2003262263A1 (en) | 2004-03-11 |
| BR0313694A (pt) | 2005-07-05 |
| RU2369613C2 (ru) | 2009-10-10 |
| CA2496329A1 (en) | 2004-03-04 |
| IL167038A (en) | 2010-11-30 |
| BRPI0313694B8 (pt) | 2021-05-25 |
| TWI298071B (enExample) | 2008-06-21 |
| PL375551A1 (en) | 2005-11-28 |
| US20090203633A1 (en) | 2009-08-13 |
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