AU2003262263B8 - Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof - Google Patents
Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof Download PDFInfo
- Publication number
- AU2003262263B8 AU2003262263B8 AU2003262263A AU2003262263A AU2003262263B8 AU 2003262263 B8 AU2003262263 B8 AU 2003262263B8 AU 2003262263 A AU2003262263 A AU 2003262263A AU 2003262263 A AU2003262263 A AU 2003262263A AU 2003262263 B8 AU2003262263 B8 AU 2003262263B8
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- Australia
- Prior art keywords
- group
- alkyl
- inhibitor
- hydroxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003217 pyrazoles Chemical class 0.000 title claims description 92
- 239000000203 mixture Substances 0.000 title claims description 52
- 238000004519 manufacturing process Methods 0.000 title claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 324
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 197
- 125000001424 substituent group Chemical group 0.000 claims description 193
- 125000003277 amino group Chemical group 0.000 claims description 178
- 150000001875 compounds Chemical class 0.000 claims description 171
- 125000006239 protecting group Chemical group 0.000 claims description 143
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 122
- 238000000034 method Methods 0.000 claims description 120
- 125000005843 halogen group Chemical group 0.000 claims description 115
- 150000003839 salts Chemical class 0.000 claims description 93
- 239000003112 inhibitor Substances 0.000 claims description 79
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 76
- 125000003118 aryl group Chemical group 0.000 claims description 72
- 125000003545 alkoxy group Chemical group 0.000 claims description 64
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 55
- 229940002612 prodrug Drugs 0.000 claims description 49
- 239000000651 prodrug Substances 0.000 claims description 49
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 48
- 206010012601 diabetes mellitus Diseases 0.000 claims description 46
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- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims description 24
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- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical group NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 claims description 22
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- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 18
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- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 15
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 15
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- 230000003914 insulin secretion Effects 0.000 claims description 14
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 13
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- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 12
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 12
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- ROJNYKZWTOHRNU-UHFFFAOYSA-N 2-chloro-4,5-difluoro-n-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide Chemical compound CNC(=O)NC1=CC=C(OC)C(NC(=O)NC(=O)C=2C(=CC(F)=C(F)C=2)Cl)=C1 ROJNYKZWTOHRNU-UHFFFAOYSA-N 0.000 claims description 11
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- NMOVJBAGBXIKCG-VKAVYKQESA-N (3z)-n-(2-hydroxy-3-piperidin-1-ylpropoxy)pyridine-3-carboximidoyl chloride Chemical compound C1CCCCN1CC(O)CO\N=C(/Cl)C1=CC=CN=C1 NMOVJBAGBXIKCG-VKAVYKQESA-N 0.000 claims description 9
- SXKBTDJJEQQEGE-UHFFFAOYSA-N 3-(3,5-dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonic acid [4-(thiazol-2-ylsulfamoyl)-phenyl]-amide Chemical compound CCC=1OC2=CC(S(=O)(=O)NC=3C=CC(=CC=3)S(=O)(=O)NC=3SC=CN=3)=CC=C2C=1C(=O)C1=CC(Br)=C(O)C(Br)=C1 SXKBTDJJEQQEGE-UHFFFAOYSA-N 0.000 claims description 9
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002-244381 | 2002-08-23 | ||
| JP2002244381 | 2002-08-23 | ||
| JP2002324076A JP2004137245A (ja) | 2002-08-23 | 2002-11-07 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| JP2002-324076 | 2002-11-07 | ||
| PCT/JP2003/010551 WO2004018491A1 (ja) | 2002-08-23 | 2003-08-21 | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2003262263A1 AU2003262263A1 (en) | 2004-03-11 |
| AU2003262263B2 AU2003262263B2 (en) | 2009-06-25 |
| AU2003262263B8 true AU2003262263B8 (en) | 2009-08-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003262263A Expired AU2003262263B8 (en) | 2002-08-23 | 2003-08-21 | Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7635684B2 (enExample) |
| EP (1) | EP1548024B1 (enExample) |
| JP (2) | JP2004137245A (enExample) |
| KR (1) | KR100985504B1 (enExample) |
| AU (1) | AU2003262263B8 (enExample) |
| BR (1) | BRPI0313694B8 (enExample) |
| CA (1) | CA2496329C (enExample) |
| ES (1) | ES2386140T3 (enExample) |
| IL (1) | IL167038A (enExample) |
| MX (1) | MXPA05002129A (enExample) |
| NO (1) | NO330569B1 (enExample) |
| NZ (1) | NZ538423A (enExample) |
| PL (1) | PL213094B1 (enExample) |
| RU (1) | RU2369613C2 (enExample) |
| TW (1) | TW200410980A (enExample) |
| WO (1) | WO2004018491A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003254847B2 (en) * | 2002-08-08 | 2009-06-04 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof |
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| JP4606876B2 (ja) * | 2002-08-27 | 2011-01-05 | キッセイ薬品工業株式会社 | ピラゾール誘導体、それを含有する医薬組成物及びその医薬用途 |
| US20060035844A1 (en) * | 2002-12-04 | 2006-02-16 | Fumiaki Ito | Preventive or remedy for diseases caused by hyperglycemia |
| EP1577317A4 (en) * | 2002-12-25 | 2007-05-09 | Kissei Pharmaceutical | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, MEDICINAL COMPOSITIONS COMPRISING SAID DERIVATIVES AND MEDICAL USE OF SAID DERIVATIVES |
| US7375090B2 (en) * | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
| US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
| DE102004028241B4 (de) * | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
| CA2588963C (en) | 2004-11-18 | 2013-06-25 | Kissei Pharmaceutical Co., Ltd. | 1-substituted-3-.beta.-d-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same |
| JP2008007405A (ja) * | 2004-12-07 | 2008-01-17 | Takeda Chem Ind Ltd | カルボキサミド誘導体 |
| WO2007010015A1 (en) * | 2005-07-22 | 2007-01-25 | Boehringer Ingelheim International Gmbh | Processes for preparing pyrazole-o-glycoside derivatives and novel intermediates of said processes |
| UY30082A1 (es) | 2006-01-11 | 2007-08-31 | Boehringer Ingelheim Int | Forma cristalina de 1-(1-metiletil)-4`-((2-fluoro-4-metoxifenil)metil)-5`- metil-1h-pirazol-3`-o-b-d-glucopiranosido, un metodo para su preparacion y el uso de la misma para preparar medicamentos |
| JP2009167103A (ja) * | 2006-05-02 | 2009-07-30 | Taisho Pharmaceutical Co Ltd | ピラゾリル５−チオグリコシド化合物 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| BRPI0711949A2 (pt) | 2006-05-19 | 2012-01-17 | Taisho Pharmaceutical Co., Ltd. | composto c-fenil glicitol |
| KR20090023570A (ko) | 2006-06-29 | 2009-03-05 | 다이쇼 세이야꾸 가부시끼가이샤 | Ｃ-페닐 1-티오글루시톨 화합물 |
| RU2009126767A (ru) | 2006-12-14 | 2011-01-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производное 1-фенил-1-тио-d-глюцитола |
| BRPI0821773B8 (pt) * | 2007-12-27 | 2021-05-25 | Kissei Pharmaceutical | monossebacato cristalino de bis[3-(3-{4-[3-(beta-dglicopiranosilóxi)-5-isopropil-1h-pirazol-4-ilmetil]-3-metilfenóxi}propilamino)-2,2-dimetil-propionamida], composição farmacêutica e medicamento compreendendo o dito composto |
| EP2275430B1 (en) * | 2008-04-16 | 2012-05-16 | Kissei Pharmaceutical Co., Ltd. | Hemifumarate of a pyrazole derivative |
| CN102149717B (zh) | 2008-08-28 | 2014-05-14 | 辉瑞大药厂 | 二氧杂-双环[3.2.1]辛烷-2，3，4-三醇衍生物 |
| US8466113B2 (en) | 2009-02-23 | 2013-06-18 | Taisho Pharmaceutical Co., Ltd. | 4-isopropylphenyl glucitol compounds as SGLT1 inhibitors |
| WO2011002011A1 (ja) * | 2009-07-01 | 2011-01-06 | キッセイ薬品工業株式会社 | Sglt1阻害薬とdpp-iv阻害薬を組み合わせてなる医薬 |
| TW201105336A (en) * | 2009-07-01 | 2011-02-16 | Kissei Pharmaceutical | Combined medicine of pyrazole derivative and biguanide drug |
| JPWO2011002012A1 (ja) * | 2009-07-01 | 2012-12-13 | キッセイ薬品工業株式会社 | Ｓｇｌｔ１阻害薬とインスリン抵抗性改善薬を組み合わせてなる医薬 |
| WO2011012319A1 (en) | 2009-07-31 | 2011-02-03 | Sandoz Ag | Method for the preparation of w-amino-alkaneamides and w-amino-alkanethioamides as well as intermediates of this method |
| EP2298782A1 (en) * | 2009-08-26 | 2011-03-23 | Sanofi-Aventis | Method for producing pyrazole glycoside derivatives |
| CN102753184A (zh) | 2009-10-02 | 2012-10-24 | 赛诺菲 | 具有sglt-1/sglt-2抑制剂活性的化合物在制备用于治疗骨病的药物中的用途 |
| KR20120087950A (ko) | 2009-10-20 | 2012-08-07 | 노파르티스 아게 | 글리코시드 유도체 및 그의 용도 |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| PL2496583T3 (pl) | 2009-11-02 | 2015-04-30 | Pfizer | Pochodne dioksabicyklo[3.2.1]oktano-2,3,4-triolowe |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012010651A2 (en) | 2010-07-23 | 2012-01-26 | Sandoz Ag | Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method |
| US8822674B2 (en) | 2010-08-20 | 2014-09-02 | Taisho Pharmaceutical Co., Ltd | Crystal form of 4-isopropylphenyl glucitol compound and process for production thereof |
| US9161945B2 (en) | 2010-08-20 | 2015-10-20 | Taisho Pharmaceutical Co., Ltd. | 4-isopropyl-6-methoxyphenyl glucitol compound |
| US8614195B2 (en) | 2011-04-14 | 2013-12-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| CN103619862A (zh) | 2011-04-14 | 2014-03-05 | 诺瓦提斯公司 | 糖苷衍生物及其用途 |
| AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| PT2848254T (pt) | 2012-05-07 | 2016-10-05 | Kissei Pharmaceutical | Derivado de pirazol e utilização do mesmo para propósitos médicos |
| UA113086C2 (xx) | 2012-05-10 | 2016-12-12 | Піразольні сполуки як інгібітори sglt1 | |
| TW201425326A (zh) | 2012-10-05 | 2014-07-01 | Lilly Co Eli | 新穎脲化合物 |
| UA117574C2 (uk) | 2012-11-20 | 2018-08-27 | Лексікон Фармасьютікалз, Інк. | Інгібітори котранспортера натрій-глюкози 1 |
| JP5807767B2 (ja) | 2013-02-04 | 2015-11-10 | 大正製薬株式会社 | 便秘症の予防又は治療薬 |
| EP2774619B1 (de) | 2013-03-04 | 2016-05-18 | BioActive Food GmbH | Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| AR098670A1 (es) | 2013-11-08 | 2016-06-08 | Lilly Co Eli | Inhibidor de sglt1 |
| EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| CN111630058B (zh) | 2018-01-31 | 2022-02-15 | 广东东阳光药业有限公司 | 吡喃葡萄糖基衍生物及其用途 |
| BR112020019624A8 (pt) | 2018-03-28 | 2022-03-03 | Avolynt | Método para tratar a hipoglicemia pós-prandial |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| EP3976053A4 (en) * | 2019-05-31 | 2022-11-23 | Avolynt | COMPOSITIONS AND METHODS OF TREATING A METABOLIC DISEASE |
| WO2024254302A1 (en) * | 2023-06-06 | 2024-12-12 | Vogenx | Compositions and methods for treating hyperinsulinemic hypoglycemia |
| WO2024254354A1 (en) * | 2023-06-06 | 2024-12-12 | Vogenx | Compositions and methods for treating refractory or intractable epilepsy |
| WO2025117962A1 (en) * | 2023-12-01 | 2025-06-05 | Vogenx | Compositions and methods for treating glucose-dependent insulinotropic peptide-dependent cushing's syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2369871A1 (en) * | 1999-04-06 | 2000-10-12 | Takashi Fujita | .alpha.-substituted carboxylic acid derivatives |
| CN1145635C (zh) | 1999-08-31 | 2004-04-14 | 橘生药品工业株式会社 | 吡喃葡糖氧基吡唑衍生物、含该衍生物的药物组合物及其制备中的中间体 |
| ES2337127T3 (es) * | 2000-11-02 | 2010-04-21 | Ajinomoto Co., Inc. | Nuevos derivados de pirazol y remedios contra la diabetes que los contienen. |
| HU228915B1 (en) | 2000-12-28 | 2013-06-28 | Kissei Pharmaceutical | Glucopyranosyloxypyrazole derivatives and use thereof |
| AU2003254847B2 (en) * | 2002-08-08 | 2009-06-04 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof |
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| EP1550668A4 (en) * | 2002-10-04 | 2008-10-01 | Kissei Pharmaceutical | PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION COMPRISING THE DERIVATIVE, MEDICINAL USE THEREOF, AND INTERMEDIATE ENTERING THE PRODUCTION THEREOF |
| WO2004113359A1 (ja) * | 2003-06-20 | 2004-12-29 | Kissei Pharmaceutical Co., Ltd. | ピラゾール誘導体、それを含有する医薬組成物及びその製造中間体 |
-
2002
- 2002-11-07 JP JP2002324076A patent/JP2004137245A/ja active Pending
-
2003
- 2003-08-21 BR BRPI0313694A patent/BRPI0313694B8/pt not_active IP Right Cessation
- 2003-08-21 NZ NZ538423A patent/NZ538423A/en not_active IP Right Cessation
- 2003-08-21 AU AU2003262263A patent/AU2003262263B8/en not_active Expired
- 2003-08-21 KR KR1020057003117A patent/KR100985504B1/ko not_active Expired - Lifetime
- 2003-08-21 CA CA2496329A patent/CA2496329C/en not_active Expired - Lifetime
- 2003-08-21 JP JP2005501231A patent/JP4597048B2/ja not_active Expired - Lifetime
- 2003-08-21 RU RU2005108055/04A patent/RU2369613C2/ru active
- 2003-08-21 MX MXPA05002129A patent/MXPA05002129A/es active IP Right Grant
- 2003-08-21 ES ES03792760T patent/ES2386140T3/es not_active Expired - Lifetime
- 2003-08-21 PL PL375551A patent/PL213094B1/pl unknown
- 2003-08-21 EP EP03792760A patent/EP1548024B1/en not_active Expired - Lifetime
- 2003-08-21 WO PCT/JP2003/010551 patent/WO2004018491A1/ja not_active Ceased
- 2003-08-21 US US10/525,197 patent/US7635684B2/en active Active
- 2003-08-22 TW TW092123126A patent/TW200410980A/zh not_active IP Right Cessation
-
2005
- 2005-02-22 IL IL167038A patent/IL167038A/en unknown
- 2005-03-17 NO NO20051411A patent/NO330569B1/no not_active IP Right Cessation
-
2009
- 2009-04-09 US US12/421,236 patent/US8324176B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| RU2369613C2 (ru) | 2009-10-10 |
| NZ538423A (en) | 2007-02-23 |
| US8324176B2 (en) | 2012-12-04 |
| BRPI0313694B8 (pt) | 2021-05-25 |
| TWI298071B (enExample) | 2008-06-21 |
| JPWO2004018491A1 (ja) | 2005-12-08 |
| RU2005108055A (ru) | 2006-02-10 |
| EP1548024A1 (en) | 2005-06-29 |
| CA2496329C (en) | 2012-05-15 |
| BRPI0313694B1 (pt) | 2017-12-19 |
| PL213094B1 (pl) | 2013-01-31 |
| NO330569B1 (no) | 2011-05-16 |
| WO2004018491A1 (ja) | 2004-03-04 |
| HK1082744A1 (zh) | 2006-06-16 |
| PL375551A1 (en) | 2005-11-28 |
| JP4597048B2 (ja) | 2010-12-15 |
| AU2003262263B2 (en) | 2009-06-25 |
| EP1548024B1 (en) | 2012-06-06 |
| EP1548024A4 (en) | 2010-05-12 |
| AU2003262263A1 (en) | 2004-03-11 |
| US20090203633A1 (en) | 2009-08-13 |
| MXPA05002129A (es) | 2005-06-03 |
| CA2496329A1 (en) | 2004-03-04 |
| BR0313694A (pt) | 2005-07-05 |
| KR20050038633A (ko) | 2005-04-27 |
| US20050272669A1 (en) | 2005-12-08 |
| KR100985504B1 (ko) | 2010-10-05 |
| ES2386140T3 (es) | 2012-08-10 |
| IL167038A (en) | 2010-11-30 |
| US7635684B2 (en) | 2009-12-22 |
| NO20051411L (no) | 2005-04-26 |
| TW200410980A (en) | 2004-07-01 |
| JP2004137245A (ja) | 2004-05-13 |
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Free format text: IN VOL 23, NO 24, PAGE(S) 8790 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME KISSEI PHARMACEUTICAL CO., LTD., APPLICATION NO. 2003262263, UNDER INID (72) ADD CO-INVENTOR ISAJI, MASAYUKI |
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| FGA | Letters patent sealed or granted (standard patent) | ||
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