MXPA04012659A - Uso de antagonistas de mglur5 para el tratamiento de gerd. - Google Patents
Uso de antagonistas de mglur5 para el tratamiento de gerd.Info
- Publication number
- MXPA04012659A MXPA04012659A MXPA04012659A MXPA04012659A MXPA04012659A MX PA04012659 A MXPA04012659 A MX PA04012659A MX PA04012659 A MXPA04012659 A MX PA04012659A MX PA04012659 A MXPA04012659 A MX PA04012659A MX PA04012659 A MXPA04012659 A MX PA04012659A
- Authority
- MX
- Mexico
- Prior art keywords
- antagonist
- glutamate receptor
- metabotropic glutamate
- prevention
- acceptable salt
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title claims abstract description 63
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 claims abstract description 54
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims abstract description 18
- 230000005764 inhibitory process Effects 0.000 claims abstract description 14
- 208000006673 asthma Diseases 0.000 claims abstract description 11
- 230000001052 transient effect Effects 0.000 claims abstract description 11
- 206010067171 Regurgitation Diseases 0.000 claims abstract description 8
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 claims abstract 26
- 238000000034 method Methods 0.000 claims description 27
- 230000002265 prevention Effects 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 19
- 230000003287 optical effect Effects 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 16
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 15
- 238000010992 reflux Methods 0.000 claims description 14
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- 108020003175 receptors Proteins 0.000 claims description 9
- 208000019693 Lung disease Diseases 0.000 claims description 5
- 230000036449 good health Effects 0.000 claims description 5
- NEWKHUASLBMWRE-UHFFFAOYSA-N 2-methyl-6-(phenylethynyl)pyridine Chemical compound CC1=CC=CC(C#CC=2C=CC=CC=2)=N1 NEWKHUASLBMWRE-UHFFFAOYSA-N 0.000 claims description 3
- 201000008197 Laryngitis Diseases 0.000 claims description 3
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- PKDHDJBNEKXCBI-UHFFFAOYSA-N 2-methyl-6-(phenylethynyl)pyridine hydrochloride Chemical compound Cl.CC1=CC=CC(C#CC=2C=CC=CC=2)=N1 PKDHDJBNEKXCBI-UHFFFAOYSA-N 0.000 claims description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- FOUQGIOHFGMUCO-UHFFFAOYSA-N 2-methyl-6-(2-phenylethyl)pyridine Chemical group CC1=CC=CC(CCC=2C=CC=CC=2)=N1 FOUQGIOHFGMUCO-UHFFFAOYSA-N 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- MCRNHLQVPJEMSQ-UHFFFAOYSA-N C(C=CC(=O)O)(=O)O.C(CCCCCCCCCCCCCCCCC)[Na] Chemical compound C(C=CC(=O)O)(=O)O.C(CCCCCCCCCCCCCCCCC)[Na] MCRNHLQVPJEMSQ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
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- 241000792859 Enema Species 0.000 description 1
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- 239000001828 Gelatine Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101150087728 Grm5 gene Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
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- 108010038421 metabotropic glutamate receptor 2 Proteins 0.000 description 1
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- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201943A SE0201943D0 (sv) | 2002-06-20 | 2002-06-20 | New use |
| PCT/US2003/016223 WO2004000316A1 (en) | 2002-06-20 | 2003-06-19 | Use of mglur5 antagonists for the treatment of gerd |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04012659A true MXPA04012659A (es) | 2006-05-25 |
Family
ID=20288301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04012659A MXPA04012659A (es) | 2002-06-20 | 2003-06-19 | Uso de antagonistas de mglur5 para el tratamiento de gerd. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1513525B1 (https=) |
| JP (2) | JP4683920B2 (https=) |
| CN (1) | CN100430056C (https=) |
| AT (1) | ATE395059T1 (https=) |
| AU (1) | AU2003241585B2 (https=) |
| BR (1) | BR0311759A (https=) |
| CA (1) | CA2489730C (https=) |
| CY (1) | CY1107954T1 (https=) |
| DE (1) | DE60320990D1 (https=) |
| DK (1) | DK1513525T3 (https=) |
| ES (1) | ES2304510T3 (https=) |
| IL (1) | IL165138A0 (https=) |
| IS (1) | IS7654A (https=) |
| MX (1) | MXPA04012659A (https=) |
| NO (1) | NO20050154L (https=) |
| NZ (1) | NZ536559A (https=) |
| PL (1) | PL372186A1 (https=) |
| PT (1) | PT1513525E (https=) |
| RU (1) | RU2324484C2 (https=) |
| SE (1) | SE0201943D0 (https=) |
| SI (1) | SI1513525T1 (https=) |
| UA (1) | UA81627C2 (https=) |
| WO (1) | WO2004000316A1 (https=) |
| ZA (1) | ZA200409908B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7964609B2 (en) | 2002-06-20 | 2011-06-21 | Astrazeneca Ab | Use of mGluR5 antagonists for the treatment of gerd |
| SE0303418D0 (sv) * | 2003-12-17 | 2003-12-17 | Astrazeneca Ab | New use 1 |
| WO2005060971A1 (en) * | 2003-12-18 | 2005-07-07 | Astrazeneca Ab | Treatment of reflux-related diseases |
| WO2005060961A2 (en) * | 2003-12-18 | 2005-07-07 | Astrazeneca Ab | Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd) |
| WO2005077345A1 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| WO2005077368A2 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| RU2381226C2 (ru) * | 2004-02-18 | 2010-02-10 | Астразенека Аб | Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата |
| BRPI0507499A (pt) * | 2004-02-18 | 2007-07-24 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável ou hidrato dos mesmos, composição farmacêutica, uso do composto, e, métodos para tratar distúrbios mediados por mglur 5 e para inibir a ativação de receptores de mglur 5 |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| EP2468727A1 (en) * | 2006-03-29 | 2012-06-27 | F. Hoffmann-La Roche AG | Pyridine and pyrimidine derivatives as MGLUR2 antagonists |
| EP2272509A1 (en) | 2006-09-11 | 2011-01-12 | Novartis AG | New Uses of metabotropic glutamate receptors |
| JP2008245225A (ja) * | 2007-03-29 | 2008-10-09 | Kddi Corp | 波長パス経路決定装置、波長パス設定制御システム及びプログラム |
| WO2009024491A1 (en) * | 2007-08-20 | 2009-02-26 | F. Hoffmann-La Roche Ag | Use of mglur5 antagonists for the treatment of gerd |
| EP2320892A2 (en) | 2008-06-30 | 2011-05-18 | Novartis AG | Combination products |
| CN102573842A (zh) | 2009-07-23 | 2012-07-11 | 诺瓦提斯公司 | 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途 |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| WO2011048150A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Use of 1h-quinazoline-2,4-diones |
| JP2013529622A (ja) | 2010-06-24 | 2013-07-22 | ノバルティス アーゲー | １ｈ−キナゾリン−２，４−ジオンの使用 |
| KR20140003580A (ko) | 2011-01-27 | 2014-01-09 | 노파르티스 아게 | 니코틴성 아세틸콜린 수용체 알파 7 활성화제의 용도 |
| CN103889427A (zh) | 2011-09-07 | 2014-06-25 | 诺华股份有限公司 | 1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用 |
| CN105263492B (zh) | 2013-01-15 | 2018-04-10 | 诺华有限公司 | α7烟碱型乙酰胆碱受体激动剂在治疗发作性睡病中的应用 |
| BR112015016992A8 (pt) | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
| BR112022005579A2 (pt) * | 2019-11-05 | 2022-06-21 | Claes Thulin | 4-[5-[(rac)-1-[5-(3-clorofenil)-3-isoxazolil]etoxi]-4-metil-4h-1,2,4-triazol-3-il]piridina para uso na prevenção e/ou no tratamento de surmenage em um mamífero |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0250572A1 (en) * | 1986-01-03 | 1988-01-07 | The University Of Melbourne | Gastro-oesophageal reflux composition |
| SE9603408D0 (sv) * | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
| CA2332774A1 (en) * | 1998-05-15 | 1999-11-25 | Dov Michaeli | Method for the treatment of gastroesophageal reflux disease |
| RU2144331C1 (ru) * | 1998-11-05 | 2000-01-20 | Московский НИИ уха, горла и носа | Способ лечения хронического гиперпластического ларингита |
| NZ517221A (en) * | 1999-08-19 | 2004-01-30 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| CN1703403A (zh) * | 2000-10-02 | 2005-11-30 | 詹森药业有限公司 | 趋代谢的谷氨酸盐受体拮抗剂 |
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- 2003-06-19 NZ NZ536559A patent/NZ536559A/en not_active IP Right Cessation
- 2003-06-19 UA UA20041210177A patent/UA81627C2/ru unknown
- 2003-06-19 CA CA2489730A patent/CA2489730C/en not_active Expired - Fee Related
- 2003-06-19 EP EP03731333A patent/EP1513525B1/en not_active Expired - Lifetime
- 2003-06-19 DK DK03731333T patent/DK1513525T3/da active
- 2003-06-19 RU RU2005101411/15A patent/RU2324484C2/ru not_active IP Right Cessation
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- 2003-06-19 AU AU2003241585A patent/AU2003241585B2/en not_active Ceased
- 2003-06-19 PT PT03731333T patent/PT1513525E/pt unknown
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- 2003-06-19 WO PCT/US2003/016223 patent/WO2004000316A1/en not_active Ceased
- 2003-06-19 SI SI200331220T patent/SI1513525T1/sl unknown
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- 2003-06-19 ES ES03731333T patent/ES2304510T3/es not_active Expired - Lifetime
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2005
- 2005-01-11 NO NO20050154A patent/NO20050154L/no not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| HK1075833A1 (en) | 2005-12-30 |
| CN1662235A (zh) | 2005-08-31 |
| DE60320990D1 (de) | 2008-06-26 |
| CA2489730A1 (en) | 2003-12-31 |
| ATE395059T1 (de) | 2008-05-15 |
| PT1513525E (pt) | 2008-06-24 |
| EP1513525A1 (en) | 2005-03-16 |
| CY1107954T1 (el) | 2013-09-04 |
| SE0201943D0 (sv) | 2002-06-20 |
| CA2489730C (en) | 2011-11-22 |
| WO2004000316A1 (en) | 2003-12-31 |
| ES2304510T3 (es) | 2008-10-16 |
| JP2011068669A (ja) | 2011-04-07 |
| PL372186A1 (en) | 2005-07-11 |
| NZ536559A (en) | 2007-08-31 |
| ZA200409908B (en) | 2006-08-30 |
| AU2003241585B2 (en) | 2009-06-25 |
| EP1513525B1 (en) | 2008-05-14 |
| RU2324484C2 (ru) | 2008-05-20 |
| JP2006507225A (ja) | 2006-03-02 |
| DK1513525T3 (da) | 2008-08-11 |
| SI1513525T1 (sl) | 2008-08-31 |
| JP4683920B2 (ja) | 2011-05-18 |
| IL165138A0 (en) | 2005-12-18 |
| BR0311759A (pt) | 2005-03-08 |
| IS7654A (is) | 2005-01-19 |
| AU2003241585A1 (en) | 2004-01-06 |
| NO20050154L (no) | 2005-01-11 |
| CN100430056C (zh) | 2008-11-05 |
| UA81627C2 (ru) | 2008-01-25 |
| RU2005101411A (ru) | 2005-07-10 |
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