JP4683920B2 - Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用 - Google Patents

Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用 Download PDF

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Publication number
JP4683920B2
JP4683920B2 JP2004515703A JP2004515703A JP4683920B2 JP 4683920 B2 JP4683920 B2 JP 4683920B2 JP 2004515703 A JP2004515703 A JP 2004515703A JP 2004515703 A JP2004515703 A JP 2004515703A JP 4683920 B2 JP4683920 B2 JP 4683920B2
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JP
Japan
Prior art keywords
fluoropyridin
benzonitrile
treatment
metabotropic glutamate
glutamate receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004515703A
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English (en)
Japanese (ja)
Other versions
JP2006507225A5 (https=
JP2006507225A (ja
Inventor
リーマン，アンダーズ
マットソン，ジャン
トーマス，エム．ストーマン
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2006507225A publication Critical patent/JP2006507225A/ja
Publication of JP2006507225A5 publication Critical patent/JP2006507225A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2004515703A 2002-06-20 2003-06-19 Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用 Expired - Fee Related JP4683920B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201943A SE0201943D0 (sv) 2002-06-20 2002-06-20 New use
PCT/US2003/016223 WO2004000316A1 (en) 2002-06-20 2003-06-19 Use of mglur5 antagonists for the treatment of gerd

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010268162A Division JP2011068669A (ja) 2002-06-20 2010-12-01 Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用

Publications (3)

Publication Number Publication Date
JP2006507225A JP2006507225A (ja) 2006-03-02
JP2006507225A5 JP2006507225A5 (https=) 2006-07-20
JP4683920B2 true JP4683920B2 (ja) 2011-05-18

Family

ID=20288301

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004515703A Expired - Fee Related JP4683920B2 (ja) 2002-06-20 2003-06-19 Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用
JP2010268162A Pending JP2011068669A (ja) 2002-06-20 2010-12-01 Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010268162A Pending JP2011068669A (ja) 2002-06-20 2010-12-01 Ｇｅｒｄの治療のためのｍｇｌｕｒ５アンタゴニストの使用

Country Status (24)

Country Link
EP (1) EP1513525B1 (https=)
JP (2) JP4683920B2 (https=)
CN (1) CN100430056C (https=)
AT (1) ATE395059T1 (https=)
AU (1) AU2003241585B2 (https=)
BR (1) BR0311759A (https=)
CA (1) CA2489730C (https=)
CY (1) CY1107954T1 (https=)
DE (1) DE60320990D1 (https=)
DK (1) DK1513525T3 (https=)
ES (1) ES2304510T3 (https=)
IL (1) IL165138A0 (https=)
IS (1) IS7654A (https=)
MX (1) MXPA04012659A (https=)
NO (1) NO20050154L (https=)
NZ (1) NZ536559A (https=)
PL (1) PL372186A1 (https=)
PT (1) PT1513525E (https=)
RU (1) RU2324484C2 (https=)
SE (1) SE0201943D0 (https=)
SI (1) SI1513525T1 (https=)
UA (1) UA81627C2 (https=)
WO (1) WO2004000316A1 (https=)
ZA (1) ZA200409908B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964609B2 (en) 2002-06-20 2011-06-21 Astrazeneca Ab Use of mGluR5 antagonists for the treatment of gerd
SE0303418D0 (sv) * 2003-12-17 2003-12-17 Astrazeneca Ab New use 1
WO2005060971A1 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of reflux-related diseases
WO2005060961A2 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
WO2005077345A1 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
WO2005077368A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
RU2381226C2 (ru) * 2004-02-18 2010-02-10 Астразенека Аб Полигетероциклические соединения и их применение в качестве антагонистов метаботропного рецептора глутамата
BRPI0507499A (pt) * 2004-02-18 2007-07-24 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável ou hidrato dos mesmos, composição farmacêutica, uso do composto, e, métodos para tratar distúrbios mediados por mglur 5 e para inibir a ativação de receptores de mglur 5
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
EP2468727A1 (en) * 2006-03-29 2012-06-27 F. Hoffmann-La Roche AG Pyridine and pyrimidine derivatives as MGLUR2 antagonists
EP2272509A1 (en) 2006-09-11 2011-01-12 Novartis AG New Uses of metabotropic glutamate receptors
JP2008245225A (ja) * 2007-03-29 2008-10-09 Kddi Corp 波長パス経路決定装置、波長パス設定制御システム及びプログラム
WO2009024491A1 (en) * 2007-08-20 2009-02-26 F. Hoffmann-La Roche Ag Use of mglur5 antagonists for the treatment of gerd
EP2320892A2 (en) 2008-06-30 2011-05-18 Novartis AG Combination products
CN102573842A (zh) 2009-07-23 2012-07-11 诺瓦提斯公司 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
WO2011048150A1 (en) 2009-10-20 2011-04-28 Novartis Ag Use of 1h-quinazoline-2,4-diones
JP2013529622A (ja) 2010-06-24 2013-07-22 ノバルティス アーゲー １ｈ−キナゾリン−２，４−ジオンの使用
KR20140003580A (ko) 2011-01-27 2014-01-09 노파르티스 아게 니코틴성 아세틸콜린 수용체 알파 7 활성화제의 용도
CN103889427A (zh) 2011-09-07 2014-06-25 诺华股份有限公司 1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用
CN105263492B (zh) 2013-01-15 2018-04-10 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂在治疗发作性睡病中的应用
BR112015016992A8 (pt) 2013-01-15 2018-01-23 Novartis Ag uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
BR112022005579A2 (pt) * 2019-11-05 2022-06-21 Claes Thulin 4-[5-[(rac)-1-[5-(3-clorofenil)-3-isoxazolil]etoxi]-4-metil-4h-1,2,4-triazol-3-il]piridina para uso na prevenção e/ou no tratamento de surmenage em um mamífero

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250572A1 (en) * 1986-01-03 1988-01-07 The University Of Melbourne Gastro-oesophageal reflux composition
SE9603408D0 (sv) * 1996-09-18 1996-09-18 Astra Ab Medical use
CA2332774A1 (en) * 1998-05-15 1999-11-25 Dov Michaeli Method for the treatment of gastroesophageal reflux disease
RU2144331C1 (ru) * 1998-11-05 2000-01-20 Московский НИИ уха, горла и носа Способ лечения хронического гиперпластического ларингита
NZ517221A (en) * 1999-08-19 2004-01-30 Nps Pharma Inc Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CN1703403A (zh) * 2000-10-02 2005-11-30 詹森药业有限公司 趋代谢的谷氨酸盐受体拮抗剂

Also Published As

Publication number Publication date
HK1075833A1 (en) 2005-12-30
CN1662235A (zh) 2005-08-31
DE60320990D1 (de) 2008-06-26
CA2489730A1 (en) 2003-12-31
ATE395059T1 (de) 2008-05-15
PT1513525E (pt) 2008-06-24
EP1513525A1 (en) 2005-03-16
MXPA04012659A (es) 2006-05-25
CY1107954T1 (el) 2013-09-04
SE0201943D0 (sv) 2002-06-20
CA2489730C (en) 2011-11-22
WO2004000316A1 (en) 2003-12-31
ES2304510T3 (es) 2008-10-16
JP2011068669A (ja) 2011-04-07
PL372186A1 (en) 2005-07-11
NZ536559A (en) 2007-08-31
ZA200409908B (en) 2006-08-30
AU2003241585B2 (en) 2009-06-25
EP1513525B1 (en) 2008-05-14
RU2324484C2 (ru) 2008-05-20
JP2006507225A (ja) 2006-03-02
DK1513525T3 (da) 2008-08-11
SI1513525T1 (sl) 2008-08-31
IL165138A0 (en) 2005-12-18
BR0311759A (pt) 2005-03-08
IS7654A (is) 2005-01-19
AU2003241585A1 (en) 2004-01-06
NO20050154L (no) 2005-01-11
CN100430056C (zh) 2008-11-05
UA81627C2 (ru) 2008-01-25
RU2005101411A (ru) 2005-07-10

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