MXPA04005955A - SISTEMA DE CARBOHIDRATOS CO-PROCESADOS COMO UNA MATRIZ DE DISOLUCION RáPIDA PARA FORMAS DE DOSIFICACION SOLIDAS. - Google Patents
SISTEMA DE CARBOHIDRATOS CO-PROCESADOS COMO UNA MATRIZ DE DISOLUCION RáPIDA PARA FORMAS DE DOSIFICACION SOLIDAS.Info
- Publication number
- MXPA04005955A MXPA04005955A MXPA04005955A MXPA04005955A MXPA04005955A MX PA04005955 A MXPA04005955 A MX PA04005955A MX PA04005955 A MXPA04005955 A MX PA04005955A MX PA04005955 A MXPA04005955 A MX PA04005955A MX PA04005955 A MXPA04005955 A MX PA04005955A
- Authority
- MX
- Mexico
- Prior art keywords
- mannitol
- composition according
- sorbitol
- composition
- present
- Prior art date
Links
- 150000001720 carbohydrates Chemical class 0.000 title abstract description 49
- 239000007909 solid dosage form Substances 0.000 title abstract description 21
- 239000011159 matrix material Substances 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims abstract description 261
- 210000000214 mouth Anatomy 0.000 claims abstract description 30
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 113
- 229930195725 Mannitol Natural products 0.000 claims description 113
- 239000000594 mannitol Substances 0.000 claims description 113
- 235000010355 mannitol Nutrition 0.000 claims description 113
- 239000000600 sorbitol Substances 0.000 claims description 89
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 88
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 73
- 239000002245 particle Substances 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 55
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 47
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- 239000004480 active ingredient Substances 0.000 claims description 30
- 238000001035 drying Methods 0.000 claims description 30
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- 239000000126 substance Substances 0.000 claims description 18
- 229910002027 silica gel Inorganic materials 0.000 claims description 16
- 239000000741 silica gel Substances 0.000 claims description 16
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 14
- 239000008119 colloidal silica Substances 0.000 claims description 14
- 239000007884 disintegrant Substances 0.000 claims description 14
- 238000001694 spray drying Methods 0.000 claims description 12
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 11
- 229960000913 crospovidone Drugs 0.000 claims description 11
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 11
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 8
- 239000008109 sodium starch glycolate Substances 0.000 claims description 8
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 8
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 7
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 11
- 238000004090 dissolution Methods 0.000 description 11
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 7
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000004376 Sucralose Substances 0.000 description 5
- 238000005056 compaction Methods 0.000 description 5
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 5
- 238000005469 granulation Methods 0.000 description 5
- 229940034008 mannitol / sorbitol Drugs 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 5
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 5
- 235000019408 sucralose Nutrition 0.000 description 5
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- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 4
- 235000009754 Vitis X bourquina Nutrition 0.000 description 4
- 235000012333 Vitis X labruscana Nutrition 0.000 description 4
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- 229960004543 anhydrous citric acid Drugs 0.000 description 4
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- 239000003814 drug Substances 0.000 description 4
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- 239000007788 liquid Substances 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000004064 recycling Methods 0.000 description 4
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 4
- 238000010561 standard procedure Methods 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
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- 238000007907 direct compression Methods 0.000 description 3
- 239000011363 dried mixture Substances 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 239000000845 maltitol Substances 0.000 description 3
- 235000010449 maltitol Nutrition 0.000 description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 3
- 229940035436 maltitol Drugs 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
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- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
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- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
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- MBGGBVCUIVRRBF-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(=O)C1CCS(=O)C1=CC=CC=C1 MBGGBVCUIVRRBF-UHFFFAOYSA-N 0.000 description 1
- 229960003329 sulfinpyrazone Drugs 0.000 description 1
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- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34136601P | 2001-12-17 | 2001-12-17 | |
| US10/274,227 US7118765B2 (en) | 2001-12-17 | 2002-10-18 | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
| PCT/US2002/040506 WO2003051338A1 (en) | 2001-12-17 | 2002-12-17 | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04005955A true MXPA04005955A (es) | 2005-03-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| MXPA04005955A MXPA04005955A (es) | 2001-12-17 | 2002-12-17 | SISTEMA DE CARBOHIDRATOS CO-PROCESADOS COMO UNA MATRIZ DE DISOLUCION RáPIDA PARA FORMAS DE DOSIFICACION SOLIDAS. |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7118765B2 (enExample) |
| EP (1) | EP1465604B1 (enExample) |
| JP (1) | JP4472988B2 (enExample) |
| AU (1) | AU2002351396B2 (enExample) |
| CA (1) | CA2470601C (enExample) |
| ES (1) | ES2429529T3 (enExample) |
| MX (1) | MXPA04005955A (enExample) |
| WO (1) | WO2003051338A1 (enExample) |
| ZA (1) | ZA200404998B (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1128817A1 (en) * | 1998-10-27 | 2001-09-05 | Biovail Technologies Ltd | Microparticles containing peg and/or peg glyceryl esters |
| US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
| US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
| FR2834889B1 (fr) * | 2002-01-18 | 2004-04-02 | Roquette Freres | Forme pharmaceutique solide orodispersible |
| FR2834894B1 (fr) * | 2002-01-21 | 2004-02-27 | Servier Lab | Composition pharmaceutique orodispersible de piribedil |
| DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
| US7282217B1 (en) * | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
| JP3841804B2 (ja) | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
| US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
| EP1715853A4 (en) * | 2004-02-17 | 2012-07-18 | Transcept Pharmaceuticals Inc | COMPOSITIONS FOR THE DISTRIBUTION OF HYPNOTICS IN THE FIELD OF MUNICHCHLEIMHÄUTE AND USE METHOD THEREOF |
| US20050214365A1 (en) * | 2004-03-24 | 2005-09-29 | Gulf Pharmaceutical Industries | [Instant dissolving tablet composition for loratidine and desloratidine] |
| EA013211B1 (ru) * | 2004-07-01 | 2010-04-30 | Лек Фармасьютиклз Д.Д. | Быстрораспадающаяся диспергирующаяся во рту лекарственная форма и способ ее приготовления |
| ATE521343T1 (de) * | 2004-11-24 | 2011-09-15 | Teva Pharma | Im mund zerfallende zusammensetzungen von rasagilin |
| DE102005009240A1 (de) | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
| DE102005009241A1 (de) * | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit kontrollierter Bioverfügbarkeit |
| US20060263427A1 (en) * | 2005-05-03 | 2006-11-23 | Roberts Richard H | Quinine formulations |
| CN1686089B (zh) * | 2005-05-08 | 2010-08-18 | 北京健健康康生物技术有限公司 | 一种可直接压片的木糖醇颗粒及其制备方法 |
| US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| US20070123562A1 (en) | 2005-05-25 | 2007-05-31 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the-night insomnia |
| IL169678A (en) | 2005-07-14 | 2010-11-30 | Innova Sa | Sweetener compositions |
| WO2007039075A2 (en) * | 2005-09-29 | 2007-04-12 | Bayer Healthcare Ag | Pde inhibitors and combinations thereof for the treatment of urological disorders |
| US20070092553A1 (en) * | 2005-10-21 | 2007-04-26 | Pfab Lp | Compositions and methods of making rapidly dissolving lonically masked formulations |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8425935B2 (en) * | 2005-12-21 | 2013-04-23 | Basf Se | Pharmaceutical formulation for producing rapidly disintegrating tablets |
| FR2898492B1 (fr) * | 2006-03-15 | 2008-06-06 | Pierre Fabre Medicament Sa | Comprimes orodispersibles de domperidone |
| JP5535616B2 (ja) | 2006-03-31 | 2014-07-02 | ルビコン リサーチ プライベート リミテッド | 口腔内崩壊錠剤のための直接圧縮性複合材 |
| US9084434B2 (en) | 2006-09-27 | 2015-07-21 | Little Calumet Holdings Llc | Probiotic oral dosage forms |
| WO2008089772A1 (fr) * | 2007-01-22 | 2008-07-31 | Crd Saidal | Formulation d'un comprime orodispersible a base d'acide acetylsalicylique enrobe |
| WO2008089773A1 (fr) * | 2007-01-22 | 2008-07-31 | Crd Saidal | Formulation d'une matrice a desintegration rapide |
| WO2008148742A2 (de) | 2007-06-06 | 2008-12-11 | Basf Se | Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten |
| JP5420535B2 (ja) * | 2007-06-06 | 2014-02-19 | ビーエーエスエフ ソシエタス・ヨーロピア | 速崩性錠剤製造のための医薬製剤 |
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| EP2042160A1 (de) * | 2007-09-14 | 2009-04-01 | Basf Se | Mittel für die Behandlung von Mund und Rachen in Form von Tabletten |
| DE102008012295A1 (de) | 2008-03-03 | 2009-09-17 | Südzucker AG Mannheim/Ochsenfurt | Gemisch zur Herstellung von schnell zerfallenden Tabletten |
| WO2009124357A1 (en) * | 2008-04-10 | 2009-10-15 | Malvin Leonard Eutick | Fast dissolving oral formulations for critical drugs |
| RU2519768C2 (ru) * | 2008-06-20 | 2014-06-20 | Мерк Патент Гмбх | Поддающаяся прямому прессованию и быстро распадающаяся матрица таблетки |
| FR2933299B1 (fr) | 2008-07-04 | 2012-02-03 | Roquette Freres | Mannitol orodispersible |
| EP2385769A4 (en) * | 2008-12-15 | 2014-08-20 | Valeant Pharmaceuticals Luxembourg S R L | QUICKLY SOLUBLE VITAMIN FORMULATION AND METHOD FOR THEIR USE |
| US20110027374A1 (en) * | 2008-12-16 | 2011-02-03 | Maria Oksana Bachynsky | Capecitabine rapidly disintegrating tablets |
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-
2002
- 2002-10-18 US US10/274,227 patent/US7118765B2/en not_active Expired - Lifetime
- 2002-12-17 JP JP2003552271A patent/JP4472988B2/ja not_active Expired - Lifetime
- 2002-12-17 AU AU2002351396A patent/AU2002351396B2/en not_active Expired
- 2002-12-17 ES ES02787055T patent/ES2429529T3/es not_active Expired - Lifetime
- 2002-12-17 WO PCT/US2002/040506 patent/WO2003051338A1/en not_active Ceased
- 2002-12-17 CA CA 2470601 patent/CA2470601C/en not_active Expired - Lifetime
- 2002-12-17 EP EP20020787055 patent/EP1465604B1/en not_active Revoked
- 2002-12-17 MX MXPA04005955A patent/MXPA04005955A/es active IP Right Grant
-
2004
- 2004-06-24 ZA ZA2004/04998A patent/ZA200404998B/en unknown
-
2006
- 2006-06-06 US US11/448,523 patent/US8545889B2/en not_active Expired - Fee Related
-
2013
- 2013-09-27 US US14/038,924 patent/US9138413B2/en not_active Expired - Fee Related
-
2015
- 2015-08-31 US US14/840,232 patent/US10702605B2/en not_active Expired - Fee Related
Also Published As
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|---|---|
| EP1465604A1 (en) | 2004-10-13 |
| EP1465604A4 (en) | 2006-11-08 |
| ZA200404998B (en) | 2005-07-27 |
| US9138413B2 (en) | 2015-09-22 |
| JP4472988B2 (ja) | 2010-06-02 |
| AU2002351396A1 (en) | 2003-06-30 |
| AU2002351396B2 (en) | 2008-09-25 |
| WO2003051338A1 (en) | 2003-06-26 |
| US20060251716A1 (en) | 2006-11-09 |
| US20140023707A1 (en) | 2014-01-23 |
| HK1067544A1 (en) | 2005-04-15 |
| US20030118642A1 (en) | 2003-06-26 |
| EP1465604B1 (en) | 2013-07-17 |
| CA2470601A1 (en) | 2003-06-26 |
| US20160051680A1 (en) | 2016-02-25 |
| JP2005520796A (ja) | 2005-07-14 |
| CA2470601C (en) | 2012-10-02 |
| US8545889B2 (en) | 2013-10-01 |
| ES2429529T3 (es) | 2013-11-15 |
| US10702605B2 (en) | 2020-07-07 |
| US7118765B2 (en) | 2006-10-10 |
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