MXPA04005366A - Produccion de alfa-aminoacidos de n-sulfonilo y alfa-aminoacidos quiralmente puros. - Google Patents
Produccion de alfa-aminoacidos de n-sulfonilo y alfa-aminoacidos quiralmente puros.Info
- Publication number
- MXPA04005366A MXPA04005366A MXPA04005366A MXPA04005366A MXPA04005366A MX PA04005366 A MXPA04005366 A MX PA04005366A MX PA04005366 A MXPA04005366 A MX PA04005366A MX PA04005366 A MXPA04005366 A MX PA04005366A MX PA04005366 A MXPA04005366 A MX PA04005366A
- Authority
- MX
- Mexico
- Prior art keywords
- alpha
- amino acids
- chirally pure
- salt
- sulfonyl
- Prior art date
Links
- 235000008206 alpha-amino acids Nutrition 0.000 title abstract 7
- 150000001371 alpha-amino acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000047 product Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- ZNGSVRYVWHOWLX-KHFUBBAMSA-N (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;hydrate Chemical compound O.CN[C@@H](C)[C@H](O)C1=CC=CC=C1.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 ZNGSVRYVWHOWLX-KHFUBBAMSA-N 0.000 abstract 1
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical compound CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/014,304 US6610734B2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
| US10/166,896 US6657070B2 (en) | 2000-12-13 | 2002-06-11 | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
| PCT/US2002/038117 WO2003050062A2 (en) | 2001-12-11 | 2002-11-26 | PRODUCTION OF CHIRALLY PURE α-AMINO ACIDS ADN N-SULFONYL α-AMINO ACIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04005366A true MXPA04005366A (es) | 2004-09-27 |
Family
ID=46204648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04005366A MXPA04005366A (es) | 2001-12-11 | 2002-11-26 | Produccion de alfa-aminoacidos de n-sulfonilo y alfa-aminoacidos quiralmente puros. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1461332A4 (https=) |
| JP (1) | JP4615861B2 (https=) |
| AU (2) | AU2002351170B8 (https=) |
| CA (1) | CA2470111A1 (https=) |
| MX (1) | MXPA04005366A (https=) |
| TW (1) | TWI260316B (https=) |
| WO (1) | WO2003050062A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0303857A3 (en) | 2000-12-13 | 2007-07-30 | Wyeth Corp | Heterocyclic sulifonamide inhibitors of beta amyloid production |
| BRPI0408962A (pt) | 2003-03-31 | 2006-04-04 | Wyeth Corp | inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados |
| ES2330451T3 (es) | 2004-01-16 | 2009-12-10 | Wyeth | Inhibidores a base de sulfonamidas heterociclicas de la produccion de beta-amiloides que contienen un azol. |
| JP2009534385A (ja) | 2006-04-21 | 2009-09-24 | ワイス | キラル的に純粋なアミノアルコール中間体、それらの誘導体の製造、及びそれらの使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3802981A1 (de) * | 1988-02-02 | 1989-08-10 | Basf Ag | Verfahren zur reduktion reduzierbarer verbindungen |
| US5264577A (en) * | 1992-04-22 | 1993-11-23 | Warner-Lambert Company | Cyclic amino acids and derivatives thereof |
| ATE218541T1 (de) * | 1992-08-25 | 2002-06-15 | Searle & Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US6191306B1 (en) * | 1999-08-03 | 2001-02-20 | Eastman Chemical Company | Process for the preparation of cyclopropylglycine |
-
2002
- 2002-11-26 JP JP2003551090A patent/JP4615861B2/ja not_active Expired - Fee Related
- 2002-11-26 WO PCT/US2002/038117 patent/WO2003050062A2/en not_active Ceased
- 2002-11-26 CA CA002470111A patent/CA2470111A1/en not_active Abandoned
- 2002-11-26 MX MXPA04005366A patent/MXPA04005366A/es active IP Right Grant
- 2002-11-26 AU AU2002351170A patent/AU2002351170B8/en not_active Ceased
- 2002-11-26 EP EP02786817A patent/EP1461332A4/en not_active Withdrawn
- 2002-12-10 TW TW091135621A patent/TWI260316B/zh active
-
2009
- 2009-12-24 AU AU2009251195A patent/AU2009251195A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003050062A3 (en) | 2003-11-20 |
| AU2002351170B2 (en) | 2009-09-24 |
| WO2003050062A2 (en) | 2003-06-19 |
| JP2005511727A (ja) | 2005-04-28 |
| EP1461332A2 (en) | 2004-09-29 |
| TWI260316B (en) | 2006-08-21 |
| AU2009251195A1 (en) | 2010-01-21 |
| EP1461332A4 (en) | 2009-10-21 |
| CA2470111A1 (en) | 2003-06-19 |
| AU2002351170A1 (en) | 2003-06-23 |
| TW200306292A (en) | 2003-11-16 |
| AU2002351170B8 (en) | 2009-10-08 |
| JP4615861B2 (ja) | 2011-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |