JP4615861B2 - キラル的に純粋なα−アミノ酸およびＮ−スルホニルα−アミノ酸の生産 - Google Patents

キラル的に純粋なα−アミノ酸およびＮ−スルホニルα−アミノ酸の生産 Download PDF

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Publication number
JP4615861B2
JP4615861B2 JP2003551090A JP2003551090A JP4615861B2 JP 4615861 B2 JP4615861 B2 JP 4615861B2 JP 2003551090 A JP2003551090 A JP 2003551090A JP 2003551090 A JP2003551090 A JP 2003551090A JP 4615861 B2 JP4615861 B2 JP 4615861B2
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JP
Japan
Prior art keywords
substituted
alkyl
group
amino
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2003551090A
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English (en)
Japanese (ja)
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JP2005511727A (ja
JP2005511727A5 (https=
Inventor
リン・レズニック
Original Assignee
ワイス・エルエルシー
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46204648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4615861(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/014,304 external-priority patent/US6610734B2/en
Priority claimed from US10/166,896 external-priority patent/US6657070B2/en
Application filed by ワイス・エルエルシー filed Critical ワイス・エルエルシー
Publication of JP2005511727A publication Critical patent/JP2005511727A/ja
Publication of JP2005511727A5 publication Critical patent/JP2005511727A5/ja
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Publication of JP4615861B2 publication Critical patent/JP4615861B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003551090A 2001-12-11 2002-11-26 キラル的に純粋なα−アミノ酸およびＮ−スルホニルα−アミノ酸の生産 Expired - Fee Related JP4615861B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/014,304 US6610734B2 (en) 2000-12-13 2001-12-11 Heterocyclic sulfonamide inhibitors of beta amyloid production
US10/166,896 US6657070B2 (en) 2000-12-13 2002-06-11 Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
PCT/US2002/038117 WO2003050062A2 (en) 2001-12-11 2002-11-26 PRODUCTION OF CHIRALLY PURE α-AMINO ACIDS ADN N-SULFONYL α-AMINO ACIDS

Publications (3)

Publication Number Publication Date
JP2005511727A JP2005511727A (ja) 2005-04-28
JP2005511727A5 JP2005511727A5 (https=) 2006-01-05
JP4615861B2 true JP4615861B2 (ja) 2011-01-19

Family

ID=46204648

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003551090A Expired - Fee Related JP4615861B2 (ja) 2001-12-11 2002-11-26 キラル的に純粋なα−アミノ酸およびＮ−スルホニルα−アミノ酸の生産

Country Status (7)

Country Link
EP (1) EP1461332A4 (https=)
JP (1) JP4615861B2 (https=)
AU (2) AU2002351170B8 (https=)
CA (1) CA2470111A1 (https=)
MX (1) MXPA04005366A (https=)
TW (1) TWI260316B (https=)
WO (1) WO2003050062A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0303857A3 (en) 2000-12-13 2007-07-30 Wyeth Corp Heterocyclic sulifonamide inhibitors of beta amyloid production
BRPI0408962A (pt) 2003-03-31 2006-04-04 Wyeth Corp inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados
ES2330451T3 (es) 2004-01-16 2009-12-10 Wyeth Inhibidores a base de sulfonamidas heterociclicas de la produccion de beta-amiloides que contienen un azol.
JP2009534385A (ja) 2006-04-21 2009-09-24 ワイス キラル的に純粋なアミノアルコール中間体、それらの誘導体の製造、及びそれらの使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3802981A1 (de) * 1988-02-02 1989-08-10 Basf Ag Verfahren zur reduktion reduzierbarer verbindungen
US5264577A (en) * 1992-04-22 1993-11-23 Warner-Lambert Company Cyclic amino acids and derivatives thereof
ATE218541T1 (de) * 1992-08-25 2002-06-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6191306B1 (en) * 1999-08-03 2001-02-20 Eastman Chemical Company Process for the preparation of cyclopropylglycine

Also Published As

Publication number Publication date
WO2003050062A3 (en) 2003-11-20
AU2002351170B2 (en) 2009-09-24
WO2003050062A2 (en) 2003-06-19
MXPA04005366A (es) 2004-09-27
JP2005511727A (ja) 2005-04-28
EP1461332A2 (en) 2004-09-29
TWI260316B (en) 2006-08-21
AU2009251195A1 (en) 2010-01-21
EP1461332A4 (en) 2009-10-21
CA2470111A1 (en) 2003-06-19
AU2002351170A1 (en) 2003-06-23
TW200306292A (en) 2003-11-16
AU2002351170B8 (en) 2009-10-08

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