MXPA04000267A - Compuestos novedosos, los cuales son inhibidores potentes del mecanismo de intercambio de na+/ca2+ y son utiles en el tratamiento de arritmias. - Google Patents
Compuestos novedosos, los cuales son inhibidores potentes del mecanismo de intercambio de na+/ca2+ y son utiles en el tratamiento de arritmias.Info
- Publication number
- MXPA04000267A MXPA04000267A MXPA04000267A MXPA04000267A MXPA04000267A MX PA04000267 A MXPA04000267 A MX PA04000267A MX PA04000267 A MXPA04000267 A MX PA04000267A MX PA04000267 A MXPA04000267 A MX PA04000267A MX PA04000267 A MXPA04000267 A MX PA04000267A
- Authority
- MX
- Mexico
- Prior art keywords
- independently
- acyl
- lower alkyl
- potent inhibitors
- new compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003389 potentiating effect Effects 0.000 title abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20011507A FI20011507A0 (fi) | 2001-07-10 | 2001-07-10 | Uusia yhdisteitä |
| PCT/FI2002/000621 WO2003006452A1 (en) | 2001-07-10 | 2002-07-10 | New compounds, which are potent inhibitors of na+/ca2+ exchange mechanism and are useful in the treatment of arrhythmias |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04000267A true MXPA04000267A (es) | 2004-07-23 |
Family
ID=8561628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04000267A MXPA04000267A (es) | 2001-07-10 | 2002-07-10 | Compuestos novedosos, los cuales son inhibidores potentes del mecanismo de intercambio de na+/ca2+ y son utiles en el tratamiento de arritmias. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7425568B2 (enExample) |
| EP (1) | EP1412343B1 (enExample) |
| JP (1) | JP4113839B2 (enExample) |
| KR (1) | KR20040025697A (enExample) |
| CN (1) | CN1281597C (enExample) |
| AR (1) | AR036236A1 (enExample) |
| AT (1) | ATE338038T1 (enExample) |
| AU (1) | AU2002321339B2 (enExample) |
| BR (1) | BR0211070A (enExample) |
| CA (1) | CA2452918C (enExample) |
| DE (1) | DE60214388T2 (enExample) |
| DK (1) | DK1412343T3 (enExample) |
| EA (1) | EA006580B1 (enExample) |
| ES (1) | ES2269746T3 (enExample) |
| FI (1) | FI20011507A0 (enExample) |
| HR (1) | HRP20040133A2 (enExample) |
| HU (1) | HUP0400391A3 (enExample) |
| IL (2) | IL159647A0 (enExample) |
| MX (1) | MXPA04000267A (enExample) |
| NO (1) | NO20035821L (enExample) |
| NZ (1) | NZ530490A (enExample) |
| PL (1) | PL367958A1 (enExample) |
| PT (1) | PT1412343E (enExample) |
| RS (1) | RS50886B (enExample) |
| UA (1) | UA76168C2 (enExample) |
| WO (1) | WO2003006452A1 (enExample) |
| ZA (1) | ZA200400145B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20030030A0 (fi) * | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
| US8017649B2 (en) | 2005-03-11 | 2011-09-13 | Howard Florey Institute Of Experimental Physiology And Medicine | Flavonoid compounds and uses thereof |
| JP5941637B2 (ja) * | 2011-09-12 | 2016-06-29 | サノフイ | 置換2−(クロマン−6−イルオキシ)−チアゾール及び医薬としてのその使用 |
| EP2567958B1 (en) | 2011-09-12 | 2014-10-29 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| CA2846347C (en) * | 2011-09-12 | 2019-05-21 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| US8912224B2 (en) | 2011-09-12 | 2014-12-16 | Sanofi | Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals |
| CN102993195B (zh) * | 2011-09-14 | 2017-05-17 | 赛诺菲 | 取代的2‑(色满‑6‑基氧基)噻唑及其作为药物的用途 |
| CN103030646B (zh) * | 2011-09-29 | 2016-08-24 | 上海恒瑞医药有限公司 | 苯并二氧六环类衍生物、其制备方法及其在医药上的应用 |
| TWI633095B (zh) * | 2013-03-08 | 2018-08-21 | 賽諾菲公司 | 經取代-6-基氧基-環烷類及其作為醫藥品之用途 |
| GB201416186D0 (en) | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| WO2019175464A1 (en) | 2018-03-14 | 2019-09-19 | Orion Corporation | Compounds useful as inhibitors of sodium-calcium exchanger (ncx) |
| US11858930B2 (en) | 2020-07-28 | 2024-01-02 | Jazz Pharmaceuticals Ireland Limited | Fused bicyclic RAF inhibitors and methods for use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2820817A (en) * | 1954-02-04 | 1958-01-21 | Mcneilab Inc | Oxygenated indan compounds and method of making the same |
| US3862232A (en) * | 1963-07-03 | 1975-01-21 | Upjohn Co | 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof |
| BE650081A (enExample) | 1963-07-03 | |||
| GB1154119A (en) | 1968-05-20 | 1969-06-04 | Merck Ag E | 3-Alkyl-Flavanones |
| FR2733685B1 (fr) | 1995-05-05 | 1997-05-30 | Adir | Utilisation des derives du benzopyrane pour l'obtention de compositions pharmaceutiques destinees au traitement des pathologies liees a l'echangeur c1-/hc03-, na+ independant |
| JPH0967336A (ja) | 1995-09-04 | 1997-03-11 | Kanebo Ltd | 新規なイソチオウレア誘導体 |
| AU726239B2 (en) | 1997-03-27 | 2000-11-02 | Taisho Pharmaceutical Co., Ltd. | 2-phenoxyaniline derivatives |
| JPH1149752A (ja) | 1997-08-05 | 1999-02-23 | Taisho Pharmaceut Co Ltd | フェノキシピリジン誘導体 |
| DE19742508A1 (de) | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| US6162832A (en) | 1997-10-20 | 2000-12-19 | Taisho Pharmaceutical Co., Inc. | 2-Phenoxyaniline derivatives |
| JPH11302235A (ja) | 1998-04-15 | 1999-11-02 | Taisho Pharmaceut Co Ltd | フェノキシアルキルアミン誘導体 |
| AU4360200A (en) | 1999-04-23 | 2000-11-10 | Bristol-Myers Squibb Company | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method |
| US6589983B1 (en) | 1999-09-17 | 2003-07-08 | Nissan Chemical Industries, Ltd. | Benzopyran derivative |
| FI20030030A0 (fi) | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
-
2001
- 2001-07-10 FI FI20011507A patent/FI20011507A0/fi unknown
-
2002
- 2002-07-10 EP EP02755036A patent/EP1412343B1/en not_active Expired - Lifetime
- 2002-07-10 MX MXPA04000267A patent/MXPA04000267A/es active IP Right Grant
- 2002-07-10 EA EA200400161A patent/EA006580B1/ru not_active IP Right Cessation
- 2002-07-10 IL IL15964702A patent/IL159647A0/xx active IP Right Grant
- 2002-07-10 DK DK02755036T patent/DK1412343T3/da active
- 2002-07-10 ES ES02755036T patent/ES2269746T3/es not_active Expired - Lifetime
- 2002-07-10 NZ NZ530490A patent/NZ530490A/en not_active IP Right Cessation
- 2002-07-10 CN CNB028138635A patent/CN1281597C/zh not_active Expired - Fee Related
- 2002-07-10 US US10/482,396 patent/US7425568B2/en not_active Expired - Fee Related
- 2002-07-10 KR KR10-2004-7000332A patent/KR20040025697A/ko not_active Ceased
- 2002-07-10 HR HR20040133A patent/HRP20040133A2/hr not_active Application Discontinuation
- 2002-07-10 BR BR0211070-9A patent/BR0211070A/pt not_active IP Right Cessation
- 2002-07-10 DE DE60214388T patent/DE60214388T2/de not_active Expired - Fee Related
- 2002-07-10 AR ARP020102586A patent/AR036236A1/es unknown
- 2002-07-10 JP JP2003512224A patent/JP4113839B2/ja not_active Expired - Fee Related
- 2002-07-10 PT PT02755036T patent/PT1412343E/pt unknown
- 2002-07-10 WO PCT/FI2002/000621 patent/WO2003006452A1/en not_active Ceased
- 2002-07-10 RS YUP-6/04A patent/RS50886B/sr unknown
- 2002-07-10 PL PL02367958A patent/PL367958A1/xx unknown
- 2002-07-10 HU HU0400391A patent/HUP0400391A3/hu unknown
- 2002-07-10 AT AT02755036T patent/ATE338038T1/de not_active IP Right Cessation
- 2002-07-10 CA CA2452918A patent/CA2452918C/en not_active Expired - Fee Related
- 2002-07-10 AU AU2002321339A patent/AU2002321339B2/en not_active Ceased
- 2002-10-07 UA UA2004020928A patent/UA76168C2/uk unknown
-
2003
- 2003-12-23 NO NO20035821A patent/NO20035821L/no not_active Application Discontinuation
- 2003-12-30 IL IL159647A patent/IL159647A/en not_active IP Right Cessation
-
2004
- 2004-01-08 ZA ZA200400145A patent/ZA200400145B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA04000267A (es) | Compuestos novedosos, los cuales son inhibidores potentes del mecanismo de intercambio de na+/ca2+ y son utiles en el tratamiento de arritmias. | |
| NL1001124A1 (nl) | Met alkoxyfenyl gesubstitueerde bisacylfosfineoxiden. | |
| MY137830A (en) | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| ATE314365T1 (de) | Cyanopyrrole als progesteronrezeptoragonisten | |
| DE69014901D1 (de) | Muscarin-rezeptor-antagonisten. | |
| FI905769A0 (fi) | Nya isoindolonderivat, deras framstaellning och dessa innehaollande farmaceutiska kompositioner. | |
| DK0586471T3 (da) | Perhydroisoindolderivater og deres fremstilling | |
| YU13502A (sh) | Derivati amino-triazolopiridina | |
| AR007077A1 (es) | Derivados tetrahidroisoquinolina, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, el uso de los mismos parala fabricacion de un medicamento | |
| NZ514542A (en) | Vasopressin antagonists for the treatment of pulmonary hypertension | |
| AR042733A1 (es) | Derivados de piridinas utilizados como inhibidores del mecanismo de intercambio na+/ca2+ | |
| MX9207595A (es) | Compuestos de tiazolidina, su preparacion y sus usos terapeuticos. | |
| AR030456A1 (es) | Derivados de 10-aril-11 h-benzo[b]fluoreno y analogos para uso en tratamientos relacionados con los receptores de estrogenos | |
| NO995590D0 (no) | 20-Aryl-5<alfa>-pregnan-derivater | |
| AR029745A1 (es) | Acidos aril sulfonicos y derivados como antagonistas de fsh | |
| CO5160261A1 (es) | Derivados de bifenilo sustituidos que son antagonistas nk-1, su procedimiento de sintesis y composiciones farmaceuticas que los contienen | |
| AR043847A1 (es) | Derivados de 3-azabiciclo [3.2.1.] octano | |
| BR0004548A (pt) | Derivados i de quinolin-4-ila | |
| TR199900286A2 (xx) | Pirolidin ve piperidin t�revleri. | |
| NO179865C (no) | Nytt -fenylisoserinderivat og dets fremstilling | |
| FR2815033B1 (fr) | Derives de 7-carboxy-flavones, porcede pour leur preparation et leur application en therapeutique | |
| ATE181734T1 (de) | N-benzoylmethylsubstituierte paroxetinderivate | |
| HRP20060448T3 (hr) | Novi spojevi s 14 i 15-članim prstenovima | |
| DE60116514D1 (de) | Amlodipin-hemimaleat | |
| DE69513679D1 (de) | 6-polyfluoralkoxy und 6-polyfluoralkyl-2-amino benzothiazole-derivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |