MXPA02012263A - 5-aminoalquil-pirazol[4,3-d]pirimidinas. - Google Patents
5-aminoalquil-pirazol[4,3-d]pirimidinas.Info
- Publication number
- MXPA02012263A MXPA02012263A MXPA02012263A MXPA02012263A MXPA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A MX PA02012263 A MXPA02012263 A MX PA02012263A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazolo
- phosphodiesterase
- pyrimidines
- inhibiting effect
- aminoalkyl
- Prior art date
Links
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title abstract 2
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- AEUWLJSEFXGQHI-UHFFFAOYSA-N 1h-pyrazolo[4,3-d]pyrimidin-5-ylmethanamine Chemical class NCC1=NC=C2NN=CC2=N1 AEUWLJSEFXGQHI-UHFFFAOYSA-N 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10031584A DE10031584A1 (de) | 2000-06-29 | 2000-06-29 | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
| PCT/EP2001/007378 WO2002000660A1 (de) | 2000-06-29 | 2001-06-28 | 5-aminoalkyl-pyrazolo[4,3-d]pyrimidine mit phosphodiesterase v inhibierender wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02012263A true MXPA02012263A (es) | 2003-04-25 |
Family
ID=7647151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02012263A MXPA02012263A (es) | 2000-06-29 | 2001-06-28 | 5-aminoalquil-pirazol[4,3-d]pirimidinas. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7060823B2 (https=) |
| EP (1) | EP1296986B1 (https=) |
| JP (1) | JP4964388B2 (https=) |
| KR (1) | KR20030017558A (https=) |
| CN (1) | CN1439011A (https=) |
| AR (1) | AR028772A1 (https=) |
| AT (1) | ATE519761T1 (https=) |
| AU (2) | AU7970001A (https=) |
| BR (1) | BR0111915A (https=) |
| CA (1) | CA2410399C (https=) |
| CZ (1) | CZ20024054A3 (https=) |
| DE (1) | DE10031584A1 (https=) |
| ES (1) | ES2367704T3 (https=) |
| HU (1) | HUP0301587A3 (https=) |
| MX (1) | MXPA02012263A (https=) |
| NO (1) | NO20026247D0 (https=) |
| PL (1) | PL358551A1 (https=) |
| RU (1) | RU2271359C2 (https=) |
| SK (1) | SK17632002A3 (https=) |
| WO (1) | WO2002000660A1 (https=) |
| ZA (1) | ZA200209728B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
| DE10058662A1 (de) * | 2000-11-25 | 2002-05-29 | Merck Patent Gmbh | Verwendung von Pyrazolo[4,3-d]pyrimidinen |
| OA13050A (en) | 2003-04-29 | 2006-11-10 | Pfizer Ltd | 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension. |
| UA80871C2 (en) * | 2003-04-29 | 2007-11-12 | Pfizer Ltd | 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| CA2562251C (en) * | 2004-04-07 | 2009-04-28 | Pfizer Inc. | Pyrazolo'4,3-d pyrimidines |
| EP1809632A2 (en) * | 2004-10-28 | 2007-07-25 | Pharmacia & Upjohn Company LLC | Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors |
| CA2608018C (en) | 2005-05-12 | 2010-07-13 | Pfizer Inc. | Anhydrous crystalline forms of n-[1-(2-ethoxyethyl)-5-(n-ethyl-n-methylamino)-7-(4-methylpyridin-2-yl-amino)-1h-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide |
| NL2000291C2 (nl) | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| DE102012200360A1 (de) * | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| CA2782774A1 (en) * | 2012-07-06 | 2014-01-06 | Pharmascience Inc. | Protein kinase inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1739850A3 (ru) * | 1987-08-31 | 1992-06-07 | Такеда Кемикал Индастриз, Лтд (Фирма) | Способ получени конденсированных производных пиразоло[3,4- @ ]пиримидина |
| US5075310A (en) * | 1988-07-01 | 1991-12-24 | Smith Kline & French Laboratories, Ltd. | Pyrimidone derivatives as bronchodilators |
| GB9119704D0 (en) * | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic agents |
| JP2657760B2 (ja) | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| GB9423911D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
-
2000
- 2000-06-29 DE DE10031584A patent/DE10031584A1/de not_active Withdrawn
-
2001
- 2001-06-28 KR KR1020027017571A patent/KR20030017558A/ko not_active Withdrawn
- 2001-06-28 CN CN01811801A patent/CN1439011A/zh active Pending
- 2001-06-28 EP EP01957901A patent/EP1296986B1/de not_active Expired - Lifetime
- 2001-06-28 CA CA2410399A patent/CA2410399C/en not_active Expired - Fee Related
- 2001-06-28 MX MXPA02012263A patent/MXPA02012263A/es unknown
- 2001-06-28 HU HU0301587A patent/HUP0301587A3/hu unknown
- 2001-06-28 BR BR0111915-0A patent/BR0111915A/pt not_active IP Right Cessation
- 2001-06-28 SK SK1763-2002A patent/SK17632002A3/sk unknown
- 2001-06-28 AU AU7970001A patent/AU7970001A/xx active Pending
- 2001-06-28 RU RU2003100508/04A patent/RU2271359C2/ru not_active IP Right Cessation
- 2001-06-28 JP JP2002505784A patent/JP4964388B2/ja not_active Expired - Fee Related
- 2001-06-28 US US10/312,766 patent/US7060823B2/en not_active Expired - Fee Related
- 2001-06-28 AT AT01957901T patent/ATE519761T1/de active
- 2001-06-28 PL PL01358551A patent/PL358551A1/xx unknown
- 2001-06-28 ES ES01957901T patent/ES2367704T3/es not_active Expired - Lifetime
- 2001-06-28 CZ CZ20024054A patent/CZ20024054A3/cs unknown
- 2001-06-28 AU AU2001279700A patent/AU2001279700B2/en not_active Ceased
- 2001-06-28 WO PCT/EP2001/007378 patent/WO2002000660A1/de not_active Ceased
- 2001-06-29 AR ARP010103144A patent/AR028772A1/es unknown
-
2002
- 2002-11-29 ZA ZA200209728A patent/ZA200209728B/en unknown
- 2002-12-27 NO NO20026247A patent/NO20026247D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20040029900A1 (en) | 2004-02-12 |
| PL358551A1 (en) | 2004-08-09 |
| NO20026247L (no) | 2002-12-27 |
| ZA200209728B (en) | 2004-03-12 |
| DE10031584A1 (de) | 2002-01-10 |
| AR028772A1 (es) | 2003-05-21 |
| NO20026247D0 (no) | 2002-12-27 |
| CZ20024054A3 (cs) | 2003-04-16 |
| JP2004501921A (ja) | 2004-01-22 |
| ES2367704T3 (es) | 2011-11-07 |
| EP1296986B1 (de) | 2011-08-10 |
| AU7970001A (en) | 2002-01-08 |
| CN1439011A (zh) | 2003-08-27 |
| SK17632002A3 (sk) | 2003-05-02 |
| CA2410399A1 (en) | 2002-01-03 |
| AU2001279700B2 (en) | 2006-08-24 |
| RU2271359C2 (ru) | 2006-03-10 |
| US7060823B2 (en) | 2006-06-13 |
| ATE519761T1 (de) | 2011-08-15 |
| JP4964388B2 (ja) | 2012-06-27 |
| KR20030017558A (ko) | 2003-03-03 |
| BR0111915A (pt) | 2003-05-13 |
| WO2002000660A1 (de) | 2002-01-03 |
| HUP0301587A2 (hu) | 2003-09-29 |
| HUP0301587A3 (en) | 2005-11-28 |
| CA2410399C (en) | 2010-02-16 |
| EP1296986A1 (de) | 2003-04-02 |
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