MXPA02005258A - Composicion y metodo para tratar otitis media. - Google Patents
Composicion y metodo para tratar otitis media.Info
- Publication number
- MXPA02005258A MXPA02005258A MXPA02005258A MXPA02005258A MXPA02005258A MX PA02005258 A MXPA02005258 A MX PA02005258A MX PA02005258 A MXPA02005258 A MX PA02005258A MX PA02005258 A MXPA02005258 A MX PA02005258A MX PA02005258 A MXPA02005258 A MX PA02005258A
- Authority
- MX
- Mexico
- Prior art keywords
- mixture
- lipid crystals
- lumen
- eustachian tube
- mammalian
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 206010033078 Otitis media Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 5
- 239000013078 crystal Substances 0.000 abstract 4
- 210000002388 eustachian tube Anatomy 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000003380 propellant Substances 0.000 abstract 2
- 239000000443 aerosol Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 210000000959 ear middle Anatomy 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/450,884 US6156294A (en) | 1999-11-28 | 1999-11-28 | Composition and method for treatment of otitis media |
| PCT/US2000/023540 WO2001037806A1 (en) | 1999-11-28 | 2000-08-28 | Composition and method for treatment of otitis media |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02005258A true MXPA02005258A (es) | 2004-04-21 |
Family
ID=23789905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02005258A MXPA02005258A (es) | 1999-11-28 | 2000-08-28 | Composicion y metodo para tratar otitis media. |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6156294A (https=) |
| EP (1) | EP1233753B1 (https=) |
| JP (1) | JP2003514842A (https=) |
| AU (1) | AU776647B2 (https=) |
| CA (1) | CA2392367C (https=) |
| DK (1) | DK1233753T3 (https=) |
| ES (1) | ES2663082T3 (https=) |
| MX (1) | MXPA02005258A (https=) |
| WO (1) | WO2001037806A1 (https=) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6645467B2 (en) * | 1999-11-28 | 2003-11-11 | Scientific Development And Research, Inc. | Composition and method for decreasing upper respiratory airway resistance |
| US7064132B2 (en) * | 1999-11-28 | 2006-06-20 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis external |
| US6676930B2 (en) * | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| NZ523693A (en) * | 2000-07-10 | 2004-08-27 | Chiron Corp | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
| US6599441B1 (en) * | 2000-07-18 | 2003-07-29 | Emerald Biostructures, Inc. | Crystallization solutions |
| FR2812545B1 (fr) * | 2000-08-03 | 2003-03-28 | Air Liquide Sante Int | Aerosol medicamenteux inhalable dans le traitement ou la prevention de la douceur |
| DE10105592A1 (de) | 2001-02-06 | 2002-08-08 | Achim Goepferich | Platzhalter zur Arzneistofffreigabe in der Stirnhöhle |
| US20040022740A1 (en) * | 2001-07-10 | 2004-02-05 | Baker William R. | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
| TWI324934B (en) * | 2001-08-28 | 2010-05-21 | Schering Corp | Pharmaceutical compositions for the treatment of asthma |
| US8317816B2 (en) | 2002-09-30 | 2012-11-27 | Acclarent, Inc. | Balloon catheters and methods for treating paranasal sinuses |
| WO2004052236A2 (en) * | 2002-12-06 | 2004-06-24 | Arriva Pharmaceuticals, Inc. | Methods and compositions for treatment of otitis media |
| DK1638524T3 (da) * | 2003-07-02 | 2010-12-20 | Swimseal Internat Pty Ltd | Sammensætning og fremgangsmåde til behandling af vandrelaterede øreproblemer |
| US8940321B2 (en) | 2003-12-12 | 2015-01-27 | Otic Pharma Ltd. | Compositions for treatment of ear disorders and methods of use thereof |
| WO2005055921A2 (en) * | 2003-12-12 | 2005-06-23 | Eran Eilat | Compositions for treatment of ear disorders and methods of use thereof |
| WO2005058879A1 (ja) * | 2003-12-17 | 2005-06-30 | Kansai Medical University | 滲出性中耳炎の予防および/または治療剤 |
| WO2005104691A2 (en) * | 2004-04-15 | 2005-11-10 | Graco Minnesota Inc. | Automatic dose size selection for multi-component fluid proportioners |
| US20070208252A1 (en) | 2004-04-21 | 2007-09-06 | Acclarent, Inc. | Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses |
| US7462175B2 (en) | 2004-04-21 | 2008-12-09 | Acclarent, Inc. | Devices, systems and methods for treating disorders of the ear, nose and throat |
| US8764729B2 (en) | 2004-04-21 | 2014-07-01 | Acclarent, Inc. | Frontal sinus spacer |
| US20060004323A1 (en) | 2004-04-21 | 2006-01-05 | Exploramed Nc1, Inc. | Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures |
| US7410480B2 (en) | 2004-04-21 | 2008-08-12 | Acclarent, Inc. | Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders |
| US7419497B2 (en) | 2004-04-21 | 2008-09-02 | Acclarent, Inc. | Methods for treating ethmoid disease |
| US9554691B2 (en) | 2004-04-21 | 2017-01-31 | Acclarent, Inc. | Endoscopic methods and devices for transnasal procedures |
| US9399121B2 (en) | 2004-04-21 | 2016-07-26 | Acclarent, Inc. | Systems and methods for transnasal dilation of passageways in the ear, nose or throat |
| US7559925B2 (en) | 2006-09-15 | 2009-07-14 | Acclarent Inc. | Methods and devices for facilitating visualization in a surgical environment |
| US20190314620A1 (en) | 2004-04-21 | 2019-10-17 | Acclarent, Inc. | Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures |
| US20060063973A1 (en) | 2004-04-21 | 2006-03-23 | Acclarent, Inc. | Methods and apparatus for treating disorders of the ear, nose and throat |
| US9089258B2 (en) | 2004-04-21 | 2015-07-28 | Acclarent, Inc. | Endoscopic methods and devices for transnasal procedures |
| US8146400B2 (en) | 2004-04-21 | 2012-04-03 | Acclarent, Inc. | Endoscopic methods and devices for transnasal procedures |
| US8894614B2 (en) | 2004-04-21 | 2014-11-25 | Acclarent, Inc. | Devices, systems and methods useable for treating frontal sinusitis |
| US20070167682A1 (en) | 2004-04-21 | 2007-07-19 | Acclarent, Inc. | Endoscopic methods and devices for transnasal procedures |
| US9101384B2 (en) | 2004-04-21 | 2015-08-11 | Acclarent, Inc. | Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat |
| US8747389B2 (en) | 2004-04-21 | 2014-06-10 | Acclarent, Inc. | Systems for treating disorders of the ear, nose and throat |
| US7803150B2 (en) | 2004-04-21 | 2010-09-28 | Acclarent, Inc. | Devices, systems and methods useable for treating sinusitis |
| US8932276B1 (en) | 2004-04-21 | 2015-01-13 | Acclarent, Inc. | Shapeable guide catheters and related methods |
| US7361168B2 (en) | 2004-04-21 | 2008-04-22 | Acclarent, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
| US7654997B2 (en) | 2004-04-21 | 2010-02-02 | Acclarent, Inc. | Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat |
| US8702626B1 (en) | 2004-04-21 | 2014-04-22 | Acclarent, Inc. | Guidewires for performing image guided procedures |
| US10188413B1 (en) | 2004-04-21 | 2019-01-29 | Acclarent, Inc. | Deflectable guide catheters and related methods |
| US9351750B2 (en) | 2004-04-21 | 2016-05-31 | Acclarent, Inc. | Devices and methods for treating maxillary sinus disease |
| CA2567334A1 (en) * | 2004-05-20 | 2005-12-08 | Discovery Laboratories, Inc. | Methods , systems and devices for noninvasive pulmonary delivery |
| US8337481B2 (en) | 2005-01-25 | 2012-12-25 | Patrick Slater | Method for treating otitis externa |
| US7981104B2 (en) * | 2005-01-25 | 2011-07-19 | Patrick Slater | Method for treating otitis externa |
| EP1858506A2 (en) * | 2005-03-10 | 2007-11-28 | 3M Innovative Properties Company | Methods of treating ear infections |
| US8028697B2 (en) | 2005-04-28 | 2011-10-04 | Trudell Medical International | Ventilator circuit and method for the use thereof |
| US8951225B2 (en) | 2005-06-10 | 2015-02-10 | Acclarent, Inc. | Catheters with non-removable guide members useable for treatment of sinusitis |
| US8114113B2 (en) | 2005-09-23 | 2012-02-14 | Acclarent, Inc. | Multi-conduit balloon catheter |
| US20070173463A1 (en) * | 2006-01-20 | 2007-07-26 | Brechtelsbauer Paul B | Method and composition for treating otitis media |
| AU2007221150B2 (en) * | 2006-02-27 | 2012-09-20 | Ahm Technologies, Inc. | Eustachian tube device and method |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US20070264296A1 (en) * | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
| US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US8190389B2 (en) | 2006-05-17 | 2012-05-29 | Acclarent, Inc. | Adapter for attaching electromagnetic image guidance components to a medical device |
| US9820688B2 (en) | 2006-09-15 | 2017-11-21 | Acclarent, Inc. | Sinus illumination lightwire device |
| US8439687B1 (en) | 2006-12-29 | 2013-05-14 | Acclarent, Inc. | Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices |
| US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| WO2008124787A2 (en) | 2007-04-09 | 2008-10-16 | Acclarent, Inc. | Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis |
| US8118757B2 (en) | 2007-04-30 | 2012-02-21 | Acclarent, Inc. | Methods and devices for ostium measurement |
| US8485199B2 (en) | 2007-05-08 | 2013-07-16 | Acclarent, Inc. | Methods and devices for protecting nasal turbinate during surgery |
| US20100198191A1 (en) | 2007-12-20 | 2010-08-05 | Acclarent, Inc. | Method and system for treating target tissue within the eustachian tube |
| US10206821B2 (en) | 2007-12-20 | 2019-02-19 | Acclarent, Inc. | Eustachian tube dilation balloon with ventilation path |
| US8182432B2 (en) | 2008-03-10 | 2012-05-22 | Acclarent, Inc. | Corewire design and construction for medical devices |
| HUE028653T2 (en) | 2008-03-17 | 2016-12-28 | Discovery Lab Inc | Respiratory circuit adapter and direct aerosol delivery system |
| KR101621726B1 (ko) * | 2008-05-27 | 2016-05-17 | 더 유니버시티 오브 멜버른 | 유스타키오관 기능장애 치료용 국소 약학적 조성물 |
| CA2727432C (en) | 2008-06-12 | 2016-10-11 | Medtronic Xomed, Inc. | Method for treating chronic wounds with an extracellular polymeric substance solvating system |
| KR101653180B1 (ko) | 2008-07-30 | 2016-09-01 | 아클라런트, 인코포레이션 | 부비 개구 탐지기 장치 및 방법 |
| RU2506056C2 (ru) | 2008-09-18 | 2014-02-10 | Аккларент, Инк. | Способы и аппарат для лечения заболеваний уха, горла, носа |
| EP2346324A4 (en) | 2008-10-06 | 2012-10-10 | Microbial Defense Systems Llc | ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING |
| US8596265B2 (en) | 2008-10-22 | 2013-12-03 | Trudell Medical International | Modular aerosol delivery system |
| US20100241155A1 (en) | 2009-03-20 | 2010-09-23 | Acclarent, Inc. | Guide system with suction |
| US7978742B1 (en) | 2010-03-24 | 2011-07-12 | Corning Incorporated | Methods for operating diode lasers |
| US8435290B2 (en) | 2009-03-31 | 2013-05-07 | Acclarent, Inc. | System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx |
| US9155492B2 (en) | 2010-09-24 | 2015-10-13 | Acclarent, Inc. | Sinus illumination lightwire device |
| US10653133B2 (en) | 2011-05-10 | 2020-05-19 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
| US8758836B2 (en) * | 2011-09-09 | 2014-06-24 | Nina S. YOSHPE | Method and formulation for treating dry ear inflammation with cortisone |
| CN103796573A (zh) | 2011-09-15 | 2014-05-14 | 优瑟夫·雅阿科比 | 一种治疗耳病的系统和方法 |
| US9629684B2 (en) | 2013-03-15 | 2017-04-25 | Acclarent, Inc. | Apparatus and method for treatment of ethmoid sinusitis |
| US9433437B2 (en) | 2013-03-15 | 2016-09-06 | Acclarent, Inc. | Apparatus and method for treatment of ethmoid sinusitis |
| US9895311B2 (en) * | 2014-09-25 | 2018-02-20 | Pharmiva Ab | Foam-forming compositions and methods for delivering an active to a body cavity |
| CN107847713A (zh) | 2015-03-31 | 2018-03-27 | 阿克拉伦特公司 | 具有通气路径的咽鼓管扩张球囊 |
| MX2018006575A (es) * | 2015-11-30 | 2018-12-06 | Novus Therapeutics Inc | Composiciones y metodos para profilaxis otologica y tratamiento. |
| US11795192B2 (en) | 2017-03-10 | 2023-10-24 | Lakewood Amedex, Inc. | Antimicrobial compounds, compositions, and uses thereof |
| CA3063208A1 (en) | 2017-05-23 | 2018-11-29 | Pharmiva Ab | Foam-forming compositions for delivering an active to a body cavity |
| FI3638251T3 (fi) | 2017-06-12 | 2024-04-29 | Lakewood Amedex Inc | Bisfosfosiinin geeliformulaatioita ja niiden käyttötapoja |
| US11331269B2 (en) * | 2018-09-06 | 2022-05-17 | Massachusetts Institute Of Technology | Methods and compositions targeting lung microbiota and its responding immune pathways for lung cancer treatment |
| SG11202103180QA (en) | 2018-10-17 | 2021-05-28 | Lakewood Amedex Inc | Methods and compositions for treating oral mucositis |
| EP3914323A4 (en) * | 2019-01-23 | 2022-10-05 | Alrich Partners, Inc. | METHOD FOR IMPROVING EUSTACHE POLE PERMEABILITY AND TREATMENT OF OTITIS MEDIA |
| JP2024522372A (ja) * | 2021-06-11 | 2024-06-18 | アンク、ライフ、サイエンシズ、リミテッド | 有効薬剤の組合せの局所送達のための安定性が向上した脂質結晶性組成物 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141674A (en) * | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
| JPH0753661B2 (ja) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| GB8501015D0 (en) * | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
| US5192528A (en) | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| DE3686025T2 (de) * | 1985-05-22 | 1993-01-07 | Liposome Technology Inc | Verfahren und system zum einatmen von liposomen. |
| US4826821A (en) | 1985-06-26 | 1989-05-02 | The Regents Of The University Of California | Lung surfactant compositions |
| FR2586587B1 (fr) | 1985-08-30 | 1987-10-23 | Adir | Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| SE462894B (sv) * | 1985-10-28 | 1990-09-17 | Biogram Ab | Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning |
| US5013720A (en) | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
| SE8603812D0 (sv) | 1986-09-12 | 1986-09-12 | Draco Ab | Administration of liposomes to mammals |
| CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
| IT1203873B (it) | 1987-04-08 | 1989-02-23 | Chiesi Farma Spa | Composizioni farmaceutiche che lo surfattante polmonare naturale, contengono. metodo di preparazione e |
| JP2656944B2 (ja) | 1987-04-30 | 1997-09-24 | クーパー ラボラトリーズ | タンパク質性治療剤のエアロゾール化 |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| JPH01258620A (ja) * | 1988-04-08 | 1989-10-16 | Dai Ichi Seiyaku Co Ltd | 耳疾患用局所製剤 |
| MX9203504A (es) | 1988-04-20 | 1992-07-01 | Liposome Co Inc | Complejo agente: lipido activo de alta proporcion. |
| JPH01313423A (ja) * | 1988-06-03 | 1989-12-18 | Biogal Gyogyszergyar | 耳炎用点耳薬の新規製薬組成物 |
| US4906476A (en) | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
| US5134129A (en) | 1989-03-15 | 1992-07-28 | Board Of Regents, The University Of Texas System | Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy |
| US5174988A (en) * | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
| US5238920A (en) | 1989-08-22 | 1993-08-24 | Abbott Laboratories | Pulmonary surfactant protein fragments |
| US5888505A (en) | 1991-02-21 | 1999-03-30 | Eoe, Inc. | Method for selectively inhibiting the growth of microbes using a haloperoxidase-halide-peroxide system |
| CA2108782C (en) * | 1991-04-29 | 2002-05-07 | Joseph R. Di Bartolomeo | Composition and method for treatment of patulous eustachian tube syndrome and atrophic rhinitis |
| ZA926834B (en) | 1991-09-09 | 1993-03-15 | American Cyanamid Co | Antibiotic LL-E19020 Gamma. |
| GB9120005D0 (en) | 1991-09-19 | 1991-11-06 | Wellcome Found | Method of administering phospholipid dispersions |
| ES2079994B1 (es) | 1992-10-07 | 1996-08-01 | Cusi Lab | Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica. |
| IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| AR002009A1 (es) | 1994-12-22 | 1998-01-07 | Astra Ab | Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco. |
| CA2213638C (en) | 1995-02-24 | 2004-05-04 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
| AU5417796A (en) | 1995-03-07 | 1996-09-23 | University Of Pittsburgh | A dry powder formulation for gene therapy |
| DZ2028A1 (fr) * | 1995-05-03 | 2002-10-23 | Smithkline Beecham Plc | Médicaments destinés au traitement d'infections bactériennes en pédiatrie. |
| US5843930A (en) | 1995-06-06 | 1998-12-01 | Bayer Corporation | Method of treating otitis with ciprofloxacin-hydrocortisone suspension |
| DE69620136T2 (de) | 1995-06-06 | 2002-08-01 | Bayer Ag | Antibakterielle präparate für die ohren ohne irritierende, sensibilisierende und ototoxische wirkungen |
| US6129934A (en) | 1995-06-07 | 2000-10-10 | Ony, Inc. | Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction |
| WO1997029738A1 (en) * | 1996-02-16 | 1997-08-21 | The Administrators Of The Tulane Educational Fund | Methods and compositions for treating eustachian tube dysfunction by inhalation |
| US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
| WO1997035882A1 (en) | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5958378A (en) | 1996-07-03 | 1999-09-28 | Research Development Foundation | High dose liposomal aerosol formulations containing cyclosporin A or budesonide |
| US5954682A (en) | 1996-09-25 | 1999-09-21 | Advanced Medical Instruments | Therapeutic applicator apparatus and method |
| KR20000048812A (ko) * | 1996-10-01 | 2000-07-25 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 병원성 유기체에 의한 비인두 전이증식 관련 세균 감염 치료용약제를 제조하기 위한 뮤피로신의 용도 |
| US6040463A (en) | 1996-10-07 | 2000-03-21 | Merck & Co., Inc. | Sordarin derivatives |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| EP1005327A1 (en) | 1997-07-02 | 2000-06-07 | Sdg, Inc. | Targeted liposomal constructs for diagnostic and therapeutic uses |
| US5925334A (en) | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| ES2191355T3 (es) | 1997-12-24 | 2003-09-01 | Britannia Pharmaceuticals Ltd | Uso de un tensioactivo para la preparacion de un medicamento para el tratamiento de trastornos del oido medio. |
| GB9807298D0 (en) * | 1998-04-03 | 1998-06-03 | Britannia Pharmaceuticals Ltd | Medicament |
| US6200598B1 (en) | 1998-06-18 | 2001-03-13 | Duke University | Temperature-sensitive liposomal formulation |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
-
1999
- 1999-11-28 US US09/450,884 patent/US6156294A/en not_active Expired - Lifetime
-
2000
- 2000-08-16 US US09/639,730 patent/US6521213B1/en not_active Expired - Lifetime
- 2000-08-16 US US09/639,739 patent/US6572841B1/en not_active Expired - Lifetime
- 2000-08-16 US US09/639,682 patent/US6616913B1/en not_active Expired - Lifetime
- 2000-08-28 JP JP2001539421A patent/JP2003514842A/ja active Pending
- 2000-08-28 ES ES00959479.7T patent/ES2663082T3/es not_active Expired - Lifetime
- 2000-08-28 AU AU70798/00A patent/AU776647B2/en not_active Ceased
- 2000-08-28 CA CA002392367A patent/CA2392367C/en not_active Expired - Lifetime
- 2000-08-28 DK DK00959479.7T patent/DK1233753T3/en active
- 2000-08-28 EP EP00959479.7A patent/EP1233753B1/en not_active Expired - Lifetime
- 2000-08-28 MX MXPA02005258A patent/MXPA02005258A/es active IP Right Grant
- 2000-08-28 WO PCT/US2000/023540 patent/WO2001037806A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US6156294A (en) | 2000-12-05 |
| AU7079800A (en) | 2001-06-04 |
| WO2001037806A1 (en) | 2001-05-31 |
| US6572841B1 (en) | 2003-06-03 |
| US6616913B1 (en) | 2003-09-09 |
| EP1233753A1 (en) | 2002-08-28 |
| DK1233753T3 (en) | 2018-05-22 |
| CA2392367A1 (en) | 2001-05-31 |
| US6521213B1 (en) | 2003-02-18 |
| EP1233753B1 (en) | 2018-02-14 |
| EP1233753A4 (en) | 2009-09-23 |
| AU776647B2 (en) | 2004-09-16 |
| ES2663082T3 (es) | 2018-04-11 |
| CA2392367C (en) | 2009-08-04 |
| JP2003514842A (ja) | 2003-04-22 |
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