MX9708637A - Antibioticos. - Google Patents

Antibioticos.

Info

Publication number
MX9708637A
MX9708637A MX9708637A MX9708637A MX9708637A MX 9708637 A MX9708637 A MX 9708637A MX 9708637 A MX9708637 A MX 9708637A MX 9708637 A MX9708637 A MX 9708637A MX 9708637 A MX9708637 A MX 9708637A
Authority
MX
Mexico
Prior art keywords
alkyl
compounds
general formula
antibiotics
relates
Prior art date
Application number
MX9708637A
Other languages
English (en)
Other versions
MXPA97008637A (es
Inventor
Edward Borowski
Jolanta Grzybowska
Pawel Sowinski
Jerzy Gumieniak
Andrze Czerwinski
Original Assignee
British Tech Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Tech Group filed Critical British Tech Group
Publication of MXPA97008637A publication Critical patent/MXPA97008637A/es
Publication of MX9708637A publication Critical patent/MX9708637A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a derivados de N-alquil-N-glicosilo de ésteres alquílos de antibioticos antifungales del grupo de macrolidos de polieno de la formula general (1a), en donde M representa residuos de antibioticos de macrolido de polieno, R representa una parte variable del residuo de azucar, y cada un de R1 y R2 representa un grupo alquilo de 1 a 4 átomos de carbono; sus sales de la formula general (2a), en donde R, R1, R2 y M son como se definen en la presente y A representa un anion de ácido orgánico o inorgánico. Los compuestos de la formula (1b y 2b) en donde los grupos de ésteres N-alquílicos y alquílicos se representan por metilo, son de particular interés. La invencion también de refiere a procedimientos para la preparacion de los compuestos, a las composiciones que contienen estos compuestos y a su uso en la terapia y el tratamiento de infecciones fungales externas e internas en humanos y animales.
MX9708637A 1995-05-13 1996-05-10 Antibioticos. MX9708637A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL308583 1995-05-13
PL95308583A PL180253B1 (pl) 1995-05-13 1995-05-13 Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
PCT/GB1996/001144 WO1996035701A1 (en) 1995-05-13 1996-05-10 Antibiotics

Publications (2)

Publication Number Publication Date
MXPA97008637A MXPA97008637A (es) 1998-02-01
MX9708637A true MX9708637A (es) 1998-02-28

Family

ID=20065009

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708637A MX9708637A (es) 1995-05-13 1996-05-10 Antibioticos.

Country Status (11)

Country Link
EP (1) EP0825995A1 (es)
JP (1) JPH11504647A (es)
KR (1) KR19990014843A (es)
AU (1) AU716883B2 (es)
CA (1) CA2220771A1 (es)
IL (1) IL118233A0 (es)
MX (1) MX9708637A (es)
NZ (1) NZ307592A (es)
PL (1) PL180253B1 (es)
WO (1) WO1996035701A1 (es)
ZA (1) ZA963787B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
CA2394833A1 (en) 2000-01-14 2001-07-19 Binh T. Dang Derivatives of polyene macrolides and preparation and use thereof
KR100687748B1 (ko) * 2005-06-23 2007-02-27 한국전자통신연구원 이동 단말에 독립적인 빠른 핸드오버 수행을 위한 방법 및그 시스템
GB0712881D0 (en) 2007-07-03 2007-08-15 Biosergen As Compounds
IN2014DN07481A (es) 2012-03-09 2015-04-24 Blirt S A
RU2014152459A (ru) 2012-06-15 2016-08-10 Блирт С.А. N-замещенные производные второго поколения противогрибкового антибиотика амфотерицина в и способы их получения и применения
CA2951516C (en) 2014-06-12 2019-04-02 Shionogi & Co., Ltd. Polyene macrolide derivative
CA3213127A1 (en) * 2015-04-15 2016-10-20 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
CN112920238B (zh) * 2021-01-27 2022-09-30 河南农业大学 一种糖胺类Amadori衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI60877C (fi) * 1971-08-13 1982-04-13 Politechnika Gdanska Foerfarande foer framstaellning av terapeutiskt aktiva i vatten laett dispergerbara polyenmakrolidantibiot-n-glykosylderivat
US4002741A (en) * 1974-04-24 1977-01-11 Valter Osvaldovich Kulbakh Meglumine complex fungicidal polyene macrolide antibiotic compositions and treatment method
US4195172A (en) * 1976-04-22 1980-03-25 Politechnika Gdanska Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation
US4144328A (en) * 1977-02-28 1979-03-13 Vainshtein Viktor A N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition
FR2654339B1 (fr) * 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.

Also Published As

Publication number Publication date
EP0825995A1 (en) 1998-03-04
NZ307592A (en) 1999-01-28
CA2220771A1 (en) 1996-11-14
IL118233A0 (en) 1996-09-12
PL308583A1 (en) 1996-11-25
JPH11504647A (ja) 1999-04-27
WO1996035701A1 (en) 1996-11-14
PL180253B1 (pl) 2001-01-31
ZA963787B (en) 1997-11-13
AU5698396A (en) 1996-11-29
KR19990014843A (ko) 1999-02-25
AU716883B2 (en) 2000-03-09

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