MX9703282A - Bencilglicosidos polianionicos como inhibidores de la proliferacion de las celulas del musculo liso. - Google Patents
Bencilglicosidos polianionicos como inhibidores de la proliferacion de las celulas del musculo liso.Info
- Publication number
- MX9703282A MX9703282A MX9703282A MX9703282A MX9703282A MX 9703282 A MX9703282 A MX 9703282A MX 9703282 A MX9703282 A MX 9703282A MX 9703282 A MX9703282 A MX 9703282A MX 9703282 A MX9703282 A MX 9703282A
- Authority
- MX
- Mexico
- Prior art keywords
- smooth muscle
- cell proliferation
- inhibitors
- muscle cell
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
Esta invencion se refiere al uso de bencilglicosidos polianionicos como inhibidores de la proliferacion de las células del musculo liso y a composiciones terapéuticas para tratar enfermedades y condiciones que se caracterizan por la proliferacion excesiva del musculo liso, tal como restenosis. Los compuestos de la invencion son aquellos de la formula (I) en donde cada uno de R1, R2, R3 y R4 son independientemente, H, SO3M, o (A); y cada grupo oligosacárido contiene 1 a 3 grupos azucar, M es litio, sodio, potasio o amonio; n es 1 o 2; X es hidrogeno, halogeno, alquilo inferior que tiene de 1 a 6 átomos de carbono, o alcoxi inferior que tiene de 1 a 6 átomos de carbono; Y es carbonilo o sulfonilo; Z es alquilo que tiene de 1 a 12 átomos de carbono (a), (b), (c) o (d); y X son como se definen anteriormente, o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/335,278 US5498775A (en) | 1994-11-07 | 1994-11-07 | Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation |
US08335278 | 1994-11-07 | ||
PCT/US1995/014686 WO1996014323A1 (en) | 1994-11-07 | 1995-11-03 | Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA97003282A MXPA97003282A (es) | 1997-08-01 |
MX9703282A true MX9703282A (es) | 1997-08-30 |
Family
ID=23311066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9703282A MX9703282A (es) | 1994-11-07 | 1995-11-03 | Bencilglicosidos polianionicos como inhibidores de la proliferacion de las celulas del musculo liso. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5498775A (es) |
EP (1) | EP0791006B1 (es) |
JP (1) | JPH10508606A (es) |
KR (1) | KR970707139A (es) |
AT (1) | ATE189227T1 (es) |
AU (1) | AU702104B2 (es) |
BR (1) | BR9509606A (es) |
DE (1) | DE69514823T2 (es) |
DK (1) | DK0791006T3 (es) |
ES (1) | ES2141395T3 (es) |
FI (1) | FI971935A0 (es) |
GR (1) | GR3032629T3 (es) |
IL (1) | IL115746A (es) |
MX (1) | MX9703282A (es) |
NZ (1) | NZ296828A (es) |
PT (1) | PT791006E (es) |
WO (1) | WO1996014323A1 (es) |
ZA (1) | ZA959444B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5595722A (en) | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
ATE377418T1 (de) | 1995-06-07 | 2007-11-15 | Poniard Pharmaceuticals Inc | Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen |
PL185372B1 (pl) * | 1995-06-29 | 2003-04-30 | Texas Biotechnology Corp | Inhibitory selektyny i kompozycja farmaceutyczna |
US6001159A (en) * | 1995-08-31 | 1999-12-14 | Ricoh Company, Ltd. | Reversible thermosensitive coloring composition and reversible thermosensitive recording medium using the same |
US5919768A (en) * | 1996-06-26 | 1999-07-06 | Texas Biotechnology Corporation | Di- and trivalent small molecule selectin inhibitors |
US6451767B1 (en) | 1998-11-24 | 2002-09-17 | Wyeth | Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation |
US6362170B1 (en) | 1998-11-24 | 2002-03-26 | American Home Products Corporation | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
US6664243B1 (en) | 1998-11-24 | 2003-12-16 | Wyeth | Benzyllactobionamides as inhibitors of smooth muscle cell proliferation |
US6258784B1 (en) | 1998-11-24 | 2001-07-10 | American Home Products Corp. | Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation |
US6291434B1 (en) | 1998-11-24 | 2001-09-18 | American Home Products Corp. | Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation |
US7081448B2 (en) * | 1998-11-24 | 2006-07-25 | Wyeth | Benzyllactobionamides as inhibitors of smooth muscle cell proliferation |
US6339064B1 (en) | 1998-11-24 | 2002-01-15 | American Home Products Corporation | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
US6187755B1 (en) | 1998-11-24 | 2001-02-13 | American Home Products Corporation | Benzylmaltosides as inhibitors of smooth muscle cell proliferation |
US7132402B2 (en) * | 1998-11-24 | 2006-11-07 | Wyeth | Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation |
US6340670B1 (en) | 1998-11-24 | 2002-01-22 | American Home Products Corporation | Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation |
AU3791200A (en) * | 1998-11-24 | 2000-06-26 | American Home Products Corporation | Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation |
EP2124948B1 (en) | 2007-02-21 | 2017-07-26 | NC bit, Inc. | Compositions for treating hyperproliferative vascular disorders and cancers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4431636A (en) * | 1982-05-24 | 1984-02-14 | American Cyanamid Company | Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use |
US4431638A (en) * | 1982-10-25 | 1984-02-14 | American Cyanamid Company | Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives |
US4435387A (en) * | 1982-10-25 | 1984-03-06 | American Cyanamid Company | Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives |
US4431637A (en) * | 1982-10-25 | 1984-02-14 | American Cyanamid Company | Polycation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives |
DE3734853A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Bis-aldonsaeureamide und verfahren zu ihrer herstellung |
DE3734815A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel |
US5019562A (en) * | 1988-01-19 | 1991-05-28 | The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation | Growth inhibiting agent and the use thereof |
FR2634485B1 (fr) * | 1988-07-21 | 1992-02-28 | Sanopi | Glycosaminoglycanes selectivement o-acyles, leur preparation et compositions pharmaceutiques les contenant |
US5032679A (en) * | 1988-12-15 | 1991-07-16 | Glycomed, Inc. | Heparin fragments as inhibitors of smooth muscle cell proliferation |
ES2060284T3 (es) * | 1990-04-23 | 1994-11-16 | Sanofi Elf | Un procedimiento para la preparacion de un derivado de carbohidrato que comprende una unidad de trisacarido. |
JPH07500843A (ja) * | 1991-11-11 | 1995-01-26 | ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルバニア | 再狭窄を抑制する方法 |
-
1994
- 1994-11-07 US US08/335,278 patent/US5498775A/en not_active Expired - Lifetime
-
1995
- 1995-10-24 IL IL11574695A patent/IL115746A/xx not_active IP Right Cessation
- 1995-11-03 EP EP95939897A patent/EP0791006B1/en not_active Expired - Lifetime
- 1995-11-03 KR KR1019970702981A patent/KR970707139A/ko not_active Application Discontinuation
- 1995-11-03 MX MX9703282A patent/MX9703282A/es not_active Application Discontinuation
- 1995-11-03 DK DK95939897T patent/DK0791006T3/da active
- 1995-11-03 JP JP8515529A patent/JPH10508606A/ja active Pending
- 1995-11-03 BR BR9509606A patent/BR9509606A/pt not_active Application Discontinuation
- 1995-11-03 DE DE69514823T patent/DE69514823T2/de not_active Expired - Fee Related
- 1995-11-03 ES ES95939897T patent/ES2141395T3/es not_active Expired - Lifetime
- 1995-11-03 AU AU41549/96A patent/AU702104B2/en not_active Ceased
- 1995-11-03 NZ NZ296828A patent/NZ296828A/en unknown
- 1995-11-03 WO PCT/US1995/014686 patent/WO1996014323A1/en not_active Application Discontinuation
- 1995-11-03 PT PT95939897T patent/PT791006E/pt unknown
- 1995-11-03 AT AT95939897T patent/ATE189227T1/de not_active IP Right Cessation
- 1995-11-07 ZA ZA9509444A patent/ZA959444B/xx unknown
-
1997
- 1997-05-06 FI FI971935A patent/FI971935A0/fi unknown
-
2000
- 2000-02-10 GR GR20000400327T patent/GR3032629T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5498775A (en) | 1996-03-12 |
JPH10508606A (ja) | 1998-08-25 |
IL115746A (en) | 1999-11-30 |
FI971935A (fi) | 1997-05-06 |
EP0791006A2 (en) | 1997-08-27 |
DE69514823T2 (de) | 2000-10-12 |
ES2141395T3 (es) | 2000-03-16 |
KR970707139A (ko) | 1997-12-01 |
PT791006E (pt) | 2000-06-30 |
NZ296828A (en) | 1999-04-29 |
AU702104B2 (en) | 1999-02-11 |
DK0791006T3 (da) | 2000-04-17 |
IL115746A0 (en) | 1996-01-19 |
WO1996014323A1 (en) | 1996-05-17 |
AU4154996A (en) | 1996-05-31 |
BR9509606A (pt) | 1997-10-28 |
EP0791006B1 (en) | 2000-01-26 |
ATE189227T1 (de) | 2000-02-15 |
ZA959444B (en) | 1997-08-07 |
FI971935A0 (fi) | 1997-05-06 |
GR3032629T3 (en) | 2000-05-31 |
DE69514823D1 (de) | 2000-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |